O45228 (PROD_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Proline dehydrogenase 1, mitochondrial
EC=1.5.99.8

Alternative name(s):
Proline oxidase

Gene names

ORF Names:

B0513.5

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	616 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts proline to delta-1-pyrroline-5-carboxylate By similarity.
Catalytic activity	L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.
Cofactor	FAD By similarity.
Pathway	Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the proline oxidase family.

Ontologies

Keywords
Biological process	Proline metabolism
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glutamate biosynthetic process Inferred from electronic annotation. Source: InterPro proline catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro proline dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 616		Proline dehydrogenase 1, mitochondrial		PRO_0000025802

Sequences

	Sequence		Length	Mass (Da)
	O45228 [UniParc]. Last modified May 10, 2005. Version 2. Checksum: 1A3F2B280CDF5D58	FASTA	616	69,823
	10 20 30 40 50 60 MQAALIGLNF PLQRRFLSGV LTTTSSAKRC YSGDTGKPYD CTSAEHKKEL EECYNRLDLS 70 80 90 100 110 120 FENTKEAFKS KSNTELVRAL VVLRLCGIQT LVNQNQIILN TMRRVLGKNL FKKTLKNTFF 130 140 150 160 170 180 GHFVAGETEE EVRHVVEKLR NYGVKSILDY SVEADITSQE ATDKTVKGTS VATVKPAAMT 190 200 210 220 230 240 PVVDAKTLET TRERYTVHEE FGDRRQGVSS ARTYFYEGEE QCDKNRDIFK DSINAVASAT 250 260 270 280 290 300 KNEGFVAVKI TALGRPQLLL KLSEAIVQTQ NFFKALTGGM SLQEGRLTSQ EFYKRLGELG 310 320 330 340 350 360 VKTDTESVKK FFDEVDFDSD GIVDLHGWNH ILDDHVKLGQ LFQVLNIKTG SLEPLIQNLS 370 380 390 400 410 420 NEEEQEFRNM VRRTLDVAEY AIEKGVRIMV DAEQTYLQPA ISKITIEMMK KYNKGRGNIF 430 440 450 460 470 480 NTYQAYLKGT LQNMEADMQV ARREGWHFGA KLVRGAYMEQ ERARAKAIGY EDPINDNFEA 490 500 510 520 530 540 TSKMYESCLT RIADEVHRRG KTNVSVMVAS HNEDTVRFAL NLMKEKCISP SERVMCMAQL 550 560 570 580 590 600 YGMCDQVSFS LGQAGFSVYK YLPYGPVEEV LPYLSRRALE NGSVLKKANK ERDLLWKELK 610 RRISSGEFKA RSSSSS

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z82256 Genomic DNA. Translation: CAB05117.2.
PIR	T18776.
RefSeq	NP_502669.2. NM_070268.3.
UniGene	Cel.5441.
3D structure databases
ProteinModelPortal	O45228.
ModBase	Search...
Protein-protein interaction databases
STRING	O45228.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	B0513.5.1; B0513.5.1; B0513.5. B0513.5.2; B0513.5.2; B0513.5.
GeneID	178350.
KEGG	cel:B0513.5.
NMPDR	fig|6239.3.peg.15837.
UCSC	B0513.5. c. elegans.
Organism-specific databases
CTD	178350.
WormBase	B0513.5; CE37309; WBGene00007197.
Phylogenomic databases
eggNOG	meNOG04062.
GeneTree	EMGT00050000014441.
HOGENOM	HBG409841.
InParanoid	O45228.
OMA	YASEAKC.
PhylomeDB	O45228.
Family and domain databases
InterPro	IPR011992. EF-hand-like_dom. IPR002872. Proline_DH. IPR015659. Proline_oxidase. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 1 hit.
KO	K00318.
PANTHER	PTHR13914. Proline_oxidase. 1 hit.
Pfam	PF01619. Pro_dh. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	900770.

Entry information

Entry name

PROD_CAEEL

Accession

Primary (citable) accession number: O45228

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 10, 2005
Last modified:	November 16, 2011
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project