O45228 (PROD_CAEEL) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 79.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Proline dehydrogenase 1, mitochondrial EC=1.5.99.8 Alternative name(s): Proline oxidase | ||
| Gene names |
| ||
| Organism | Caenorhabditis elegans | ||
| Taxonomic identifier | 6239 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 616 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Converts proline to delta-1-pyrroline-5-carboxylate By similarity. |
| Catalytic activity | L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor. |
| Cofactor | FAD By similarity. |
| Pathway | |
| Subcellular location | Mitochondrion matrix By similarity. |
| Sequence similarities | Belongs to the proline oxidase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Proline metabolism |
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Ligand | FAD Flavoprotein |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | glutamate biosynthetic process Inferred from electronic annotation. Source: InterPro proline catabolic processInferred from electronic annotation. Source: InterPro |
| Cellular component | mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | calcium ion binding Inferred from electronic annotation. Source: InterPro proline dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |
Molecule processing | ||||||
|---|---|---|---|---|---|---|
| Transit peptide | 1 – ? | Mitochondrion Potential | ||||
| Chain | ? – 616 | Proline dehydrogenase 1, mitochondrial | PRO_0000025802 | |||
Sequences
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References
| [1] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | Z82256 Genomic DNA. Translation: CAB05117.2. |
| PIR | T18776. |
| RefSeq | NP_502669.2. NM_070268.3. |
| UniGene | Cel.5441. |
3D structure databases | |
| ProteinModelPortal | O45228. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | O45228. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblMetazoa | B0513.5.1; B0513.5.1; B0513.5. B0513.5.2; B0513.5.2; B0513.5. |
| GeneID | 178350. |
| KEGG | cel:B0513.5. |
| NMPDR | fig|6239.3.peg.15837. |
| UCSC | B0513.5. c. elegans. |
Organism-specific databases | |
| CTD | 178350. |
| WormBase | B0513.5; CE37309; WBGene00007197. |
Phylogenomic databases | |
| eggNOG | meNOG04062. |
| GeneTree | EMGT00050000014441. |
| HOGENOM | HBG409841. |
| InParanoid | O45228. |
| OMA | YASEAKC. |
| PhylomeDB | O45228. |
Family and domain databases | |
| InterPro | IPR011992. EF-hand-like_dom. IPR002872. Proline_DH. IPR015659. Proline_oxidase. [Graphical view] |
| Gene3D | G3DSA:1.10.238.10. EF-Hand_type. 1 hit. |
| KO | K00318. |
| PANTHER | PTHR13914. Proline_oxidase. 1 hit. |
| Pfam | PF01619. Pro_dh. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 900770. |
Entry information
| Entry name | PROD_CAEEL | ||||||||
| Accession | Primary (citable) accession number: O45228 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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