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Protein

TATA-box-binding protein

Gene

Tbp

Organism
Bombyx mori (Silk moth)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
TATA-box-binding protein
Alternative name(s):
TATA sequence-binding protein
TATA-binding factor
TATA-box factor
Transcription initiation factor TFIID TBP subunit
Gene namesi
Name:Tbp
OrganismiBombyx mori (Silk moth)
Taxonomic identifieri7091 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaBombycidaeBombycinaeBombyx
Proteomesi
  • UP000005204 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307TATA-box-binding proteinPRO_0000153963Add
BLAST

Interactioni

Subunit structurei

Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Binds DNA as monomer.

Protein-protein interaction databases

STRINGi7091.BGIBMGA010619-TA.

Structurei

3D structure databases

ProteinModelPortaliO45211.
SMRiO45211. Positions 129-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati134 – 210771Add
BLAST
Repeati224 – 301782Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi33 – 4311Poly-GlnAdd
BLAST

Sequence similaritiesi

Belongs to the TBP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3302. Eukaryota.
COG2101. LUCA.
InParanoidiO45211.
KOiK03120.
OMAiHMMPMSE.

Family and domain databases

CDDicd04516. TBP_eukaryotes. 1 hit.
Gene3Di3.30.310.10. 2 hits.
HAMAPiMF_00408. TATA_bind_prot_arch. 1 hit.
InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
IPR030491. TBP_CS.
IPR033710. TBP_eukaryotic.
[Graphical view]
PANTHERiPTHR10126. PTHR10126. 1 hit.
PfamiPF00352. TBP. 2 hits.
[Graphical view]
PRINTSiPR00686. TIFACTORIID.
PROSITEiPS00351. TFIID. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O45211-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDHMLPSPYN IPGIGTPLHQ PEEDQQILPN AMQQQQLQQQ QSQAQPSLAA
60 70 80 90 100
LGSSPIVGFG AIMGTPQRSM HTYAPTASYA TPQQMMQPQT PQNMMSPMIA
110 120 130 140 150
AGNLSSQQML SQASPAPMTP LTPLSADPGI LPQLQNIVST VNLDCKLDLK
160 170 180 190 200
KIALHARNAE YNPKRFAAVI MRIREPRTTA LIFSSGKMVC TGAKSEEDSR
210 220 230 240 250
LAARKYARII QKLGFTAKFL DFKIQNMVGS CDVKFPIRLE GLVLTHGQFS
260 270 280 290 300
SYEPELFPGL IYRMVKPRIV LLIFVSGKVV LTGAKVREEI YEAFDNIYPI

LKSFKKQ
Length:307
Mass (Da):33,989
Last modified:June 1, 1998 - v1
Checksum:i3C3E5668807AD0EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ222806 mRNA. Translation: CAA11000.1.
RefSeqiNP_001037059.1. NM_001043594.1.
UniGeneiBmo.148.

Genome annotation databases

EnsemblMetazoaiBGIBMGA010619-RA; BGIBMGA010619-TA; BGIBMGA010619.
GeneIDi692612.
KEGGibmor:692612.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ222806 mRNA. Translation: CAA11000.1.
RefSeqiNP_001037059.1. NM_001043594.1.
UniGeneiBmo.148.

3D structure databases

ProteinModelPortaliO45211.
SMRiO45211. Positions 129-306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7091.BGIBMGA010619-TA.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiBGIBMGA010619-RA; BGIBMGA010619-TA; BGIBMGA010619.
GeneIDi692612.
KEGGibmor:692612.

Organism-specific databases

CTDi6908.

Phylogenomic databases

eggNOGiKOG3302. Eukaryota.
COG2101. LUCA.
InParanoidiO45211.
KOiK03120.
OMAiHMMPMSE.

Family and domain databases

CDDicd04516. TBP_eukaryotes. 1 hit.
Gene3Di3.30.310.10. 2 hits.
HAMAPiMF_00408. TATA_bind_prot_arch. 1 hit.
InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
IPR030491. TBP_CS.
IPR033710. TBP_eukaryotic.
[Graphical view]
PANTHERiPTHR10126. PTHR10126. 1 hit.
PfamiPF00352. TBP. 2 hits.
[Graphical view]
PRINTSiPR00686. TIFACTORIID.
PROSITEiPS00351. TFIID. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBP_BOMMO
AccessioniPrimary (citable) accession number: O45211
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.