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Protein

TATA-box-binding protein

Gene

Tbp

Organism
Bombyx mori (Silk moth)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription

Names & Taxonomyi

Protein namesi
Recommended name:
TATA-box-binding protein
Alternative name(s):
TATA sequence-binding protein
TATA-binding factor
TATA-box factor
Transcription initiation factor TFIID TBP subunit
Gene namesi
Name:Tbp
OrganismiBombyx mori (Silk moth)
Taxonomic identifieri7091 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaLepidopteraGlossataDitrysiaBombycoideaBombycidaeBombycinaeBombyx
Proteomesi
  • UP000005204 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001539631 – 307TATA-box-binding proteinAdd BLAST307

Interactioni

Subunit structurei

Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Binds DNA as monomer.

Protein-protein interaction databases

STRINGi7091.BGIBMGA010619-TA

Structurei

3D structure databases

ProteinModelPortaliO45211
SMRiO45211
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati134 – 2101Add BLAST77
Repeati224 – 3012Add BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 43Poly-GlnAdd BLAST11

Sequence similaritiesi

Belongs to the TBP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3302 Eukaryota
COG2101 LUCA
InParanoidiO45211
KOiK03120
OMAiMDQMLPS

Family and domain databases

CDDicd04516 TBP_eukaryotes, 1 hit
Gene3Di3.30.310.10, 2 hits
HAMAPiMF_00408 TATA_bind_prot_arch, 1 hit
InterProiView protein in InterPro
IPR000814 TBP
IPR030491 TBP_CS
IPR012295 TBP_dom_sf
IPR033710 TBP_eukaryotic
PANTHERiPTHR10126 PTHR10126, 1 hit
PfamiView protein in Pfam
PF00352 TBP, 2 hits
PRINTSiPR00686 TIFACTORIID
PROSITEiView protein in PROSITE
PS00351 TFIID, 2 hits

Sequencei

Sequence statusi: Complete.

O45211-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDHMLPSPYN IPGIGTPLHQ PEEDQQILPN AMQQQQLQQQ QSQAQPSLAA
60 70 80 90 100
LGSSPIVGFG AIMGTPQRSM HTYAPTASYA TPQQMMQPQT PQNMMSPMIA
110 120 130 140 150
AGNLSSQQML SQASPAPMTP LTPLSADPGI LPQLQNIVST VNLDCKLDLK
160 170 180 190 200
KIALHARNAE YNPKRFAAVI MRIREPRTTA LIFSSGKMVC TGAKSEEDSR
210 220 230 240 250
LAARKYARII QKLGFTAKFL DFKIQNMVGS CDVKFPIRLE GLVLTHGQFS
260 270 280 290 300
SYEPELFPGL IYRMVKPRIV LLIFVSGKVV LTGAKVREEI YEAFDNIYPI

LKSFKKQ
Length:307
Mass (Da):33,989
Last modified:June 1, 1998 - v1
Checksum:i3C3E5668807AD0EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ222806 mRNA Translation: CAA11000.1
RefSeqiNP_001037059.1, NM_001043594.1
UniGeneiBmo.148

Genome annotation databases

EnsemblMetazoaiBGIBMGA010619-RA; BGIBMGA010619-TA; BGIBMGA010619
GeneIDi692612
KEGGibmor:692612

Similar proteinsi

Entry informationi

Entry nameiTBP_BOMMO
AccessioniPrimary (citable) accession number: O45211
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 1, 1998
Last modified: March 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health