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Reviewed, UniProtKB/Swiss-Prot O45145 (ACASE_CAEEL)

Last modified November 3, 2009. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Alkaline ceramidase
      Short name=AlkCDase
    EC=3.5.1.23
Alternative name(s):
    Alkaline N-acylsphingosine amidohydrolase
    Alkaline acylsphingosine deacylase
Gene names
ORF Names: W02F12.2
OrganismCaenorhabditis elegans [Complete proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid By similarity.

Catalytic activity

N-acylsphingosine + H2O = a carboxylate + sphingosine.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the alkaline ceramidase family.

Ontologies

Keywords
   Biological processLipid metabolism
   Cellular componentMembrane
   DomainTransmembrane
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processceramide metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentGolgi membrane

Inferred from electronic annotation. Source: InterPro

endoplasmic reticulum membrane

Inferred from electronic annotation. Source: InterPro

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionceramidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 272272Alkaline ceramidase
PRO_0000247751

Regions

Transmembrane34 – 5421 Potential
Transmembrane61 – 8121 Potential
Transmembrane96 – 11621 Potential
Transmembrane124 – 14421 Potential
Transmembrane148 – 16821 Potential
Transmembrane183 – 20321 Potential
Transmembrane214 – 23421 Potential

Amino acid modifications

Glycosylation2561N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O45145-1 [UniParc].

Last modified June 1, 2003. Version 2.
Checksum: B9E5357A054D10C4

FASTA27231,162
        10         20         30         40         50         60 
MESSSINRWF EYESGHAWCE SAYKYQTLPY VAEFANTCTN LPIIVLPLVN IMLLRRYLHD 

        70         80         90        100        110        120 
VNGGLIFPQL LLTFNGLAST YYHATLNLFG QLVDELSLVW IITVFLVVYI PVMKWFPEKF 

       130        140        150        160        170        180 
SKRLTLVRWV VLIVTALVSG LCFLEPNLNA IALMLFSIPA AVVINYEGKQ SGIPDIESFP 

       190        200        210        220        230        240 
SRILALWGVA FSFWFADRLL CDFWLYLGTP YLHALFHLLA GLAGYTIFIM FSMIDIESRT 

       250        260        270 
KTHKYTAAVR YFPGKNGSIF SFPYISLKER SQ 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.

Cross-references

Sequence databases

AF047653 Genomic DNA. Translation: AAC04458.2.
PIRT32993.
RefSeqNP_504697.2.
UniGeneCel.2046

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblW02F12.2; W02F12.2; W02F12.2; Caenorhabditis elegans. [Genome view]
GeneID189124.
KEGGcel:W02F12.2.
NMPDRfig|6239.3.peg.18220.
UCSCW02F12.2. c. elegans.

Organism-specific databases

CTD189124.
WormBaseWBGene00020947. W02F12.2.
WormPepW02F12.2. CE33333. [WorfDB]

Phylogenomic databases

OMAFQYSELV.

Enzyme and pathway databases

BRENDA3.5.1.23. 672.

Gene expression databases

ArrayExpressO45145.

Family and domain databases

InterProIPR008901. APHC.
[Graphical view]
PfamPF05875. aPHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio941292.

Entry information

Entry nameACASE_CAEEL
AccessionPrimary (citable) accession number: O45145
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: June 1, 2003
Last modified: November 3, 2009
This is version 51 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents