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O45145 (ACASE_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alkaline ceramidase

Short name=AlkCDase
EC=3.5.1.23
Alternative name(s):
Alkaline N-acylsphingosine amidohydrolase
Alkaline acylsphingosine deacylase
Gene names
ORF Names:W02F12.2
OrganismCaenorhabditis elegans
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid By similarity.

Catalytic activity

N-acylsphingosine + H2O = a carboxylate + sphingosine.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the alkaline ceramidase family.

Ontologies

Keywords
   Biological processLipid metabolism
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processceramide metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionceramidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 272272Alkaline ceramidase
PRO_0000247751

Regions

Transmembrane34 – 5421Helical; Potential
Transmembrane61 – 8121Helical; Potential
Transmembrane96 – 11621Helical; Potential
Transmembrane124 – 14421Helical; Potential
Transmembrane148 – 16821Helical; Potential
Transmembrane183 – 20321Helical; Potential
Transmembrane214 – 23421Helical; Potential

Amino acid modifications

Glycosylation2561N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O45145 [UniParc].

Last modified June 1, 2003. Version 2.
Checksum: B9E5357A054D10C4

FASTA27231,162
        10         20         30         40         50         60 
MESSSINRWF EYESGHAWCE SAYKYQTLPY VAEFANTCTN LPIIVLPLVN IMLLRRYLHD 

        70         80         90        100        110        120 
VNGGLIFPQL LLTFNGLAST YYHATLNLFG QLVDELSLVW IITVFLVVYI PVMKWFPEKF 

       130        140        150        160        170        180 
SKRLTLVRWV VLIVTALVSG LCFLEPNLNA IALMLFSIPA AVVINYEGKQ SGIPDIESFP 

       190        200        210        220        230        240 
SRILALWGVA FSFWFADRLL CDFWLYLGTP YLHALFHLLA GLAGYTIFIM FSMIDIESRT 

       250        260        270 
KTHKYTAAVR YFPGKNGSIF SFPYISLKER SQ 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO081630 Genomic DNA. Translation: CCD72931.1.
PIRT32993.
RefSeqNP_504697.2. NM_072296.4.
UniGeneCel.2046.

3D structure databases

ProteinModelPortalO45145.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaW02F12.2; W02F12.2; W02F12.2.
GeneID189124.
KEGGcel:W02F12.2.
NMPDRfig|6239.3.peg.18220.
UCSCW02F12.2. c. elegans.

Organism-specific databases

CTD189124.
WormBaseW02F12.2; CE33333; WBGene00020947.

Phylogenomic databases

eggNOGmeNOG05933.
GeneTreeEMGT00050000016840.
HOGENOMHBG386102.
InParanoidO45145.
OMAKRCDNVR.
PhylomeDBO45145.

Gene expression databases

ArrayExpressO45145.

Family and domain databases

InterProIPR008901. Ceramidase.
[Graphical view]
PfamPF05875. Ceramidase. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio941292.

Entry information

Entry nameACASE_CAEEL
AccessionPrimary (citable) accession number: O45145
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: June 1, 2003
Last modified: December 14, 2011
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families