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Protein
Submitted name:

Biogenic Amine Synthesis related

Gene

bas-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  • L-dopa decarboxylase activity Source: WormBase
  • pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  • dopamine biosynthetic process from tyrosine Source: WormBase
  • locomotion involved in locomotory behavior Source: WormBase
  • oviposition Source: WormBase
  • sensory perception of chemical stimulus Source: WormBase
  • serotonin biosynthetic process Source: WormBase
  • turning behavior involved in mating Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

ReactomeiR-CEL-209905. Catecholamine biosynthesis.
R-CEL-209931. Serotonin and melatonin biosynthesis.

Names & Taxonomyi

Protein namesi
Submitted name:
Biogenic Amine Synthesis relatedImported
Gene namesi
Name:bas-1Imported
ORF Names:C05D2.4Imported, CELE_C05D2.4Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC05D2.4b; CE37081; WBGene00000239; bas-1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: WormBase
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei352 – 3521N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

EPDiO45137.
PaxDbiO45137.
PRIDEiO45137.

Expressioni

Gene expression databases

ExpressionAtlasiO45137. baseline.

Interactioni

Protein-protein interaction databases

DIPiDIP-26854N.
IntActiO45137. 1 interaction.
MINTiMINT-1090138.
STRINGi6239.C05D2.4b.

Structurei

3D structure databases

ProteinModelPortaliO45137.
SMRiO45137. Positions 1-523.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0628. Eukaryota.
COG0076. LUCA.
GeneTreeiENSGT00760000119205.
HOGENOMiHOG000121941.
InParanoidiO45137.
OMAiIGFTWKS.
PhylomeDBiO45137.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
3.90.1150.10. 1 hit.
InterProiIPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 2 hits.
[Graphical view]
PRINTSiPR00800. YHDCRBOXLASE.
SUPFAMiSSF53383. SSF53383. 2 hits.

Sequencei

Sequence statusi: Complete.

O45137-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSQKLRTEG KKMLDFVADY WDGIRDRKPL PDVKPGYIND LVPAQAPATP
60 70 80 90 100
EDWAKIFDDL ENVVVNGATH WHHPHFFAYF PTALSYQSIM ADILSGGIAG
110 120 130 140 150
IGFTWKSCPS MTELEMSSLD WVVDLMGLPE HFKNSHNGPG CGIIQSTASD
160 170 180 190 200
STMIAIMAAR ATHVERIKSE PTFMKWVSET GVGKTLKNIF DRVKVNKTLV
210 220 230 240 250
ARASVTVDDE ASGMITPYFH DPTVFERFVM YCSDQAHSSV EKGAMLSAVR
260 270 280 290 300
MRKLKATRGF LGNYGVSRET LQNAIKEDRA RGYIPFMFLA TVGTTCSCGV
310 320 330 340 350
DQVDELGPVC VEEGLYLHVD AAYAGTFALC EEFKYLIRGM EHVDSFNFNL
360 370 380 390 400
HKAGMVNFDC SPMWFKNGTH VSRYFNVDAV YLAHEYQTTA SDYRHLQVAL
410 420 430 440 450
GRRFRSLKIW FVLRNMGVDK IREYLRRTEL LAAEFSKLIL ENGKFEHFVP
460 470 480 490 500
QHLGLTCFRL KNSTNADNEK LCNAINDDRR IHLVPSTVHG TYFLRMVVCS
510 520
QLTTLDDIIY ARDVIFELAE KLF
Length:523
Mass (Da):59,200
Last modified:September 13, 2004 - v2
Checksum:iEA952FB5EC1BFE56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CCD63123.1.
PIRiT32990.
RefSeqiNP_001021151.1. NM_001025980.2.
UniGeneiCel.10893.

Genome annotation databases

EnsemblMetazoaiC05D2.4b; C05D2.4b; WBGene00000239.
GeneIDi175778.
KEGGicel:CELE_C05D2.4.
UCSCiC05D2.4b. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CCD63123.1.
PIRiT32990.
RefSeqiNP_001021151.1. NM_001025980.2.
UniGeneiCel.10893.

3D structure databases

ProteinModelPortaliO45137.
SMRiO45137. Positions 1-523.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-26854N.
IntActiO45137. 1 interaction.
MINTiMINT-1090138.
STRINGi6239.C05D2.4b.

Proteomic databases

EPDiO45137.
PaxDbiO45137.
PRIDEiO45137.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC05D2.4b; C05D2.4b; WBGene00000239.
GeneIDi175778.
KEGGicel:CELE_C05D2.4.
UCSCiC05D2.4b. c. elegans.

Organism-specific databases

CTDi175778.
WormBaseiC05D2.4b; CE37081; WBGene00000239; bas-1.

Phylogenomic databases

eggNOGiKOG0628. Eukaryota.
COG0076. LUCA.
GeneTreeiENSGT00760000119205.
HOGENOMiHOG000121941.
InParanoidiO45137.
OMAiIGFTWKS.
PhylomeDBiO45137.

Enzyme and pathway databases

ReactomeiR-CEL-209905. Catecholamine biosynthesis.
R-CEL-209931. Serotonin and melatonin biosynthesis.

Miscellaneous databases

NextBioi889626.

Gene expression databases

ExpressionAtlasiO45137. baseline.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
3.90.1150.10. 1 hit.
InterProiIPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 2 hits.
[Graphical view]
PRINTSiPR00800. YHDCRBOXLASE.
SUPFAMiSSF53383. SSF53383. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiO45137_CAEEL
AccessioniPrimary (citable) accession number: O45137
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: September 13, 2004
Last modified: May 11, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.