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Protein
Submitted name:

Calpain

Gene
N/A
Organism
Schistosoma japonicum (Blood fluke)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei156PROSITE-ProRule annotation1
Active sitei315PROSITE-ProRule annotation1
Active sitei339PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteasePROSITE-ProRule annotationSAAS annotation

Protein family/group databases

MEROPSiC02.023.

Names & Taxonomyi

Protein namesi
Submitted name:
CalpainImported
OrganismiSchistosoma japonicum (Blood fluke)Imported
Taxonomic identifieri6182 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

Subcellular locationi

Structurei

3D structure databases

ProteinModelPortaliO45033.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini101 – 399Calpain catalyticInterPro annotationAdd BLAST299
Domaini660 – 695EF-handInterPro annotationAdd BLAST36
Domaini712 – 731EF-handInterPro annotationAdd BLAST20

Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
InterProiView protein in InterPro
IPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR036213. Calpain_III_sf.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
PfamiView protein in Pfam
PF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
PRINTSiPR00704. CALPAIN.
SMARTiView protein in SMART
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiView protein in PROSITE
PS50203. CALPAIN_CAT. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.

Sequencei

Sequence statusi: Fragment.

O45033-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ITKGRIQIVY SPDANVSGRV NHPGKEVVDP RSGKVIKVKR QTPDDYLNVL
60 70 80 90 100
KPVKGPKRLE FNPYLPKTLT PKGYAKLKLM MSIASKQYET LVKNTKAEGI
110 120 130 140 150
LWEDPDFPAN QDSIGNVQDI GVQLEWKRPH EIISNAKFFS DGASRFDIKQ
160 170 180 190 200
GALGDCWLLA VVASISGYPQ LFNQVVLKDQ ELKGPNYVGV IRFRFWRFGQ
210 220 230 240 250
WVEVLIDDRL PVRRGSNQLV FMHSSDPTEF WSALLEKAYA KLNGCYAHLS
260 270 280 290 300
GGTQSEAMED LTGGICLSIE LNQNERPQDL IEQLKIYAQR CCLMGCSIDS
310 320 330 340 350
TVIEQRLNDG LIAGHAYSLT GVYPVNYRGR TQWLMRLRNP WGDSHEWKGA
360 370 380 390 400
WCDGAPQWRE ISQKEKENIH LNFTEDGEFW MSFEDFVTCF SRVEVCHLGL
410 420 430 440 450
ESLEFNQDFH GKRRLEEAIF SGQWQRNVNA GGCINNRTTY WTNPQFLITV
460 470 480 490 500
EDPDPDDNDN KCSILVALMQ KETRKKVGAD FQPIGFMVYA VPDDQTTLMS
510 520 530 540 550
RAQLLTKTPI AKSQFINTRE VVGQFRVPPG RYVIIPSTFD PHIEANFILR
560 570 580 590 600
VISQIPITEQ ELDEDNTNRG LPDDIIESLK LEDTLLDEDK EIEMRFMALR
610 620 630 640 650
DPKTLAIDAT KMGELLNNST LQDMPSFKGF NKELCRSMVA SVDNNLTGLV
660 670 680 690 700
ELDEFMDLWI QAKGWKHIFL KHDIDQSGYF DAYELREALN DAGFRVSNLL
710 720 730 740 750
FNAIAHRYTD PGTDKISFED FMLCMVRLKT AFETIEAHPK NLEGTSLFMK
760
EDYLRFTVSI
Length:760
Mass (Da):86,834
Last modified:June 1, 1998 - v1
Checksum:iDC4C189F84561DB9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044407 mRNA. Translation: AAC00514.1.

Similar proteinsi

Entry informationi

Entry nameiO45033_SCHJA
AccessioniPrimary (citable) accession number: O45033
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: October 25, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation