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Protein

Death-associated protein kinase dapk-1

Gene

dapk-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Negative regulator of barrier repair and innate immune responses to wounding. Appears to act downstream from or in parallel to muscarinic signaling in the regulation of autophagy.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei57ATPPROSITE-ProRule annotationBy similarity1
Active sitei155Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 42ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Immunity, Innate immunity

Keywords - Ligandi

ATP-binding, GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiO44997.

Names & Taxonomyi

Protein namesi
Recommended name:
Death-associated protein kinase dapk-1 (EC:2.7.11.1)
Gene namesi
Name:dapk-1Imported
Synonyms:mor-3, tag-119
ORF Names:K12C11.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiK12C11.4; CE40262; WBGene00003400; dapk-1.

Pathology & Biotechi

Disruption phenotypei

Beginning in the L3 stage, animals display striking and progressive defects in morphology of the epidermis and cuticle in several body regions, particularly in the nose, tail, vulva, and the dorsal midline in the region of the posterior pharyngeal bulb. The cuticle in these regions becomes up to 5-10 times thicker than the wild type, at the expense of underlying epidermis. Up-regulates innate immune responses to damage. Decreases starvation-induced autophagy.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004000891 – 1425Death-associated protein kinase dapk-1Add BLAST1425

Proteomic databases

PaxDbiO44997.
PeptideAtlasiO44997.
PRIDEiO44997.

Expressioni

Tissue specificityi

Expressed in epidermis, muscles and neurons.1 Publication

Developmental stagei

Present from late embryogenesis onwards.1 Publication

Gene expression databases

BgeeiWBGene00003400.
ExpressionAtlasiO44997. differential.

Interactioni

Protein-protein interaction databases

STRINGi6239.K12C11.4.

Structurei

3D structure databases

ProteinModelPortaliO44997.
SMRiO44997.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 289Protein kinasePROSITE-ProRule annotationAdd BLAST262
Repeati392 – 421ANK 1Sequence analysisAdd BLAST30
Repeati425 – 454ANK 2Sequence analysisAdd BLAST30
Repeati458 – 487ANK 3Sequence analysisAdd BLAST30
Repeati491 – 520ANK 4Sequence analysisAdd BLAST30
Repeati524 – 553ANK 5Sequence analysisAdd BLAST30
Repeati557 – 586ANK 6Sequence analysisAdd BLAST30
Repeati590 – 619ANK 7Sequence analysisAdd BLAST30
Repeati623 – 652ANK 8Sequence analysisAdd BLAST30
Domaini695 – 950RocPROSITE-ProRule annotationAdd BLAST256
Repeati810 – 841ANK 9Sequence analysisAdd BLAST32
Repeati934 – 963ANK 10Sequence analysisAdd BLAST30
Domaini1308 – 1389DeathPROSITE-ProRule annotationAdd BLAST82

Sequence similaritiesi

Contains 10 ANK repeats.PROSITE-ProRule annotation
Contains 1 death domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 Roc domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
GeneTreeiENSGT00760000118877.
HOGENOMiHOG000082489.
InParanoidiO44997.
KOiK08803.
OMAiIDVQDKG.
OrthoDBiEOG091G0J2O.
PhylomeDBiO44997.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
1.25.40.20. 3 hits.
3.40.50.300. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR011009. Kinase-like_dom.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR020859. ROC_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF00531. Death. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 9 hits.
SM00005. DEATH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF48403. SSF48403. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 7 hits.
PS50017. DEATH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS51424. ROC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O44997-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDDVNSSAT STSSSTVHFD DTPFEDVYEI ETELGSGQFA VVRRVRDRKT
60 70 80 90 100
GEKYAAKFIK KRRYATSRRG VTRQNIEREV RVLQKIRGNS NVVELHAVYE
110 120 130 140 150
TASDVIIVLE LVSGGELFDH VCAKECLDEV EAAAFIKQIL LAVRHLHSLH
160 170 180 190 200
IVHLDIKPEN VMLKQRGDSQ IKIIDFGLSR EIEPGAVVKD MVGTPEFVAP
210 220 230 240 250
EVVNYEALSP ATDMWAVGVV TYILLSGGSP FLGDNRDETF SNITRVRYHF
260 270 280 290 300
SDRYFKNTSK HAKDFIYRLF VRDVDQRATV EECLQHPWIR GPEGNAIDIR
310 320 330 340 350
KASCITISHI QSFKTRQRWK RCVELVMVLL KASKSSRRIG DGRFDEEDMV
360 370 380 390 400
ASCTLICAEE GNLRALHKLS ALHKLLPNAT RKSLKSSFSE PNGATAMHCA
410 420 430 440 450
AKYGHAEVFN YFHMKGGNIC ARDDNGDTPL HVACRFAQHT VAGYVANEKI
460 470 480 490 500
DVDSINKTGE TALHCAVESA DTRVVRLLLQ LRPRLDLPNA SGDTVLHLAA
510 520 530 540 550
DSINPRIVPL LVCLAPPLHL RNIREETPLH VAAARGHVDC VQALLDANSP
560 570 580 590 600
IDAVEQDGKT ALIIALENGN VDIASILITN GCDINHADHH GDTALHIASK
610 620 630 640 650
HGLLQAVQTL CHCAVTVDSV NANKKTALHL AAHYGHVDII RVLLLARADV
660 670 680 690 700
TLRGDDGLTA ELVAVAAERL EAHSLLKMVK SQEIREEYIS QLYPLDTSLR
710 720 730 740 750
RIKLKLLGHS QSGKTRLVQT LHSSRGISSF LESVTRRISD HYSPSSSMKD
760 770 780 790 800
DGIHSTNGSF VSESNNNSSF DLAAAAGSKY APPHSQYTRG IDVQTVNING
810 820 830 840 850
CGEFSVWEFG GYEPMHTCYD HFVGNADCIH LILYRTSDPT EVQYKQILYW
860 870 880 890 900
MNFLKGRVTP FEPIGHCGFS SRRSKVIIVG THATSSLFPQ MNQEGEYVSS
910 920 930 940 950
DIEAMLNTVR LRFETHFDMD HRLILLDATN PSCIGMKTLK MELAKCRTNI
960 970 980 990 1000
LAKLLKPLAI LDTVVNHLNL VRKKHANFPV ITWPDFIQLV RNEINPLTGD
1010 1020 1030 1040 1050
AHCRQIVQQL QLIGELVYLR NDLCDADYVV LNAEWFGTHI LGQLLSAEFL
1060 1070 1080 1090 1100
SKASPNGSYH TSSLAKIFPE IPEQSDLMTI LEVLQLCAPD ARTGAHEFPV
1110 1120 1130 1140 1150
FIQTEAPDSI WRPYSLKEKE RDTVYGGVRI LPMRGMERSL HSTFPRIQVA
1160 1170 1180 1190 1200
LRRSINDYQP AKDTQLHQWS ECSKLVSQDR EAVIRMVGDA VEIRARGPSE
1210 1220 1230 1240 1250
SATSMFYFME DLINLVEHAA AEVGPGISLE RHFISPKHLK EHREHPALFP
1260 1270 1280 1290 1300
PESMMEMQQR ESLSVKGTQD EEELFTDVVC FGSRDVARHL TLGIDVGVAD
1310 1320 1330 1340 1350
LQMASRCELA CLLDPPHAMG RDWSILAVKL QLTDQVPDVD STGQSLSRTD
1360 1370 1380 1390 1400
QLLNEWAIHH PEQASVGNLC RILVELGRCD ARDALYRTVP LYVFAPLEDQ
1410 1420
FLLETNDSGV VSSCHSSSEH NPINI
Length:1,425
Mass (Da):158,968
Last modified:July 11, 2006 - v2
Checksum:i1118403F098DAFC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY733040 mRNA. Translation: AAW57534.1.
FO081631 Genomic DNA. Translation: CCD72943.1.
PIRiT32930.
RefSeqiNP_490840.2. NM_058439.4.
UniGeneiCel.18457.

Genome annotation databases

EnsemblMetazoaiK12C11.4a; K12C11.4a; WBGene00003400.
GeneIDi187322.
KEGGicel:CELE_K12C11.4.
UCSCiK12C11.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY733040 mRNA. Translation: AAW57534.1.
FO081631 Genomic DNA. Translation: CCD72943.1.
PIRiT32930.
RefSeqiNP_490840.2. NM_058439.4.
UniGeneiCel.18457.

3D structure databases

ProteinModelPortaliO44997.
SMRiO44997.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.K12C11.4.

Proteomic databases

PaxDbiO44997.
PeptideAtlasiO44997.
PRIDEiO44997.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK12C11.4a; K12C11.4a; WBGene00003400.
GeneIDi187322.
KEGGicel:CELE_K12C11.4.
UCSCiK12C11.4. c. elegans.

Organism-specific databases

CTDi187322.
WormBaseiK12C11.4; CE40262; WBGene00003400; dapk-1.

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
GeneTreeiENSGT00760000118877.
HOGENOMiHOG000082489.
InParanoidiO44997.
KOiK08803.
OMAiIDVQDKG.
OrthoDBiEOG091G0J2O.
PhylomeDBiO44997.

Enzyme and pathway databases

SignaLinkiO44997.

Miscellaneous databases

PROiO44997.

Gene expression databases

BgeeiWBGene00003400.
ExpressionAtlasiO44997. differential.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
1.25.40.20. 3 hits.
3.40.50.300. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR011009. Kinase-like_dom.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR020859. ROC_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF00531. Death. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 9 hits.
SM00005. DEATH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF48403. SSF48403. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 7 hits.
PS50017. DEATH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS51424. ROC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDAPK_CAEEL
AccessioniPrimary (citable) accession number: O44997
Secondary accession number(s): Q3ZLV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: July 11, 2006
Last modified: November 30, 2016
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.