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Protein

Nuclear hormone receptor family member nhr-64

Gene

nhr-64

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan nuclear receptor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi67 – 142Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri70 – 90NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri106 – 130NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Chemistry databases

SwissLipidsiSLP:000000578.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear hormone receptor family member nhr-64
Gene namesi
Name:nhr-64
ORF Names:C45E1.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiC45E1.1a; CE39696; WBGene00003654; nhr-64.
C45E1.1b; CE39697; WBGene00003654; nhr-64.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000537921 – 369Nuclear hormone receptor family member nhr-64Add BLAST369

Proteomic databases

PaxDbiO44960.
PeptideAtlasiO44960.

Expressioni

Gene expression databases

BgeeiWBGene00003654.

Interactioni

Protein-protein interaction databases

BioGridi37361. 1 interactor.
DIPiDIP-26511N.
IntActiO44960. 1 interactor.
MINTiMINT-1104696.
STRINGi6239.C45E1.1a.

Structurei

3D structure databases

ProteinModelPortaliO44960.
SMRiO44960.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini120 – 352NR LBDPROSITE-ProRule annotationAdd BLAST233

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri70 – 90NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri106 – 130NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4215. Eukaryota.
ENOG410XQT8. LUCA.
GeneTreeiENSGT00760000118948.
HOGENOMiHOG000260822.
InParanoidiO44960.
KOiK07295.
OMAiHTDQIST.
OrthoDBiEOG091G0A89.
PhylomeDBiO44960.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR035500. NHR_like_dom_sf.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
PRINTSiPR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiView protein in SMART
SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiView protein in PROSITE
PS51843. NR_LBD. 1 hit.
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: O44960-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLEEKEEVS TSTSQSPQSS SFENVFCAIC GDRATGKHYG AMSCDGCKGF
60 70 80 90 100
FRRTIRKRHS YVCRFGEKCQ VDKAKRNSCR KCRFDVCLRK GMRRDAVQTE
110 120 130 140 150
RDRIRPANPL SNGSNGGIVP DDPLLDTLIR AEASTRGLRT TVITKTAEAR
160 170 180 190 200
KQATTNDVTD SMNQQLTLMV EWAKVLEGFQ RVDNITQVAL LRHFSAQHLV
210 220 230 240 250
MCAAFRSIHL SDAVWLTNET CLHKDSPKIP DMNRVAERII DQVTNPMRSL
260 270 280 290 300
HMNEIEYIAL KAIAFFDPLA KGITSESYSD VEEMRQRILE SFERHVRYVS
310 320 330 340 350
PYKDMPLRFA NLLLLLPPML AISRDLVEDV QLAKLFGLAS IDNLMLELML
360
PNEGKNTTDK TSPPIMCHQ
Length:369
Mass (Da):41,838
Last modified:September 5, 2006 - v2
Checksum:i492D12EE85CEFD7E
GO
Isoform b (identifier: O44960-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-73: Missing.

Show »
Length:344
Mass (Da):38,738
Checksum:i8E4F8657D00AB986
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01566949 – 73Missing in isoform b. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY204172 mRNA. Translation: AAO39176.1.
AY204173 mRNA. Translation: AAO39177.1.
AY204174 mRNA. Translation: AAO39178.1.
FO080867 Genomic DNA. Translation: CCD67352.1.
FO080867 Genomic DNA. Translation: CCD67353.1.
PIRiT32890.
RefSeqiNP_001021042.2. NM_001025871.3. [O44960-1]
NP_001021043.2. NM_001025872.4. [O44960-2]
UniGeneiCel.18405.

Genome annotation databases

EnsemblMetazoaiC45E1.1a; C45E1.1a; WBGene00003654. [O44960-1]
GeneIDi171884.
KEGGicel:CELE_C45E1.1.
UCSCiC45E1.1b. c. elegans. [O44960-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNHR64_CAEEL
AccessioniPrimary (citable) accession number: O44960
Secondary accession number(s): D4YW56
, D4YW57, Q688B5, Q86PK4, Q86PK5, Q86PK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: September 5, 2006
Last modified: January 31, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families