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Protein

Probable signal peptidase complex subunit 1

Gene

C34B2.10

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease

Names & Taxonomyi

Protein namesi
Recommended name:
Probable signal peptidase complex subunit 1 (EC:3.4.-.-)
Alternative name(s):
Microsomal signal peptidase 12 kDa subunit
Short name:
SPase 12 kDa subunit
Gene namesi
ORF Names:C34B2.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiC34B2.10; CE16898; WBGene00016395.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32CytoplasmicSequence analysisAdd BLAST32
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Topological domaini54 – 56LumenalSequence analysis3
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Topological domaini78 – 105CytoplasmicSequence analysisAdd BLAST28

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002151581 – 105Probable signal peptidase complex subunit 1Add BLAST105

Proteomic databases

EPDiO44953.
PaxDbiO44953.
PeptideAtlasiO44953.
PRIDEiO44953.

Expressioni

Gene expression databases

BgeeiWBGene00016395.

Interactioni

Subunit structurei

Complex of five different proteins: SEC11L1, SEC11L3, SPCS1, SPCS2 and SPCS3.By similarity

Protein-protein interaction databases

STRINGi6239.C34B2.10.

Structurei

3D structure databases

ProteinModelPortaliO44953.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPCS1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4112. Eukaryota.
ENOG411274V. LUCA.
GeneTreeiENSGT00390000018321.
HOGENOMiHOG000171962.
InParanoidiO44953.
KOiK12946.
OMAiFKTIPTH.
OrthoDBiEOG091H0AOY.
PhylomeDBiO44953.

Family and domain databases

InterProiView protein in InterPro
IPR009542. SPC12.
PANTHERiPTHR13202. PTHR13202. 1 hit.
PfamiView protein in Pfam
PF06645. SPC12. 1 hit.

Sequencei

Sequence statusi: Complete.

O44953-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGMIAMLPA PLQKLSSHID FQGQKVAERT YQVILTIAGI IGFLVGFWTQ
60 70 80 90 100
QLSYAMFTVL GASAFTALII LPPWPFLFRK NPIVWHTPAE PQESGDKKKE

TKKTK
Length:105
Mass (Da):11,777
Last modified:June 1, 1998 - v1
Checksum:i1C041B5D94A5C471
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080220 Genomic DNA. Translation: CCD62128.1.
PIRiT32884.
RefSeqiNP_492797.1. NM_060396.4.
UniGeneiCel.7734.

Genome annotation databases

EnsemblMetazoaiC34B2.10; C34B2.10; WBGene00016395.
GeneIDi172967.
KEGGicel:CELE_C34B2.10.
UCSCiC34B2.10.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080220 Genomic DNA. Translation: CCD62128.1.
PIRiT32884.
RefSeqiNP_492797.1. NM_060396.4.
UniGeneiCel.7734.

3D structure databases

ProteinModelPortaliO44953.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C34B2.10.

Proteomic databases

EPDiO44953.
PaxDbiO44953.
PeptideAtlasiO44953.
PRIDEiO44953.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC34B2.10; C34B2.10; WBGene00016395.
GeneIDi172967.
KEGGicel:CELE_C34B2.10.
UCSCiC34B2.10.1. c. elegans.

Organism-specific databases

CTDi172967.
WormBaseiC34B2.10; CE16898; WBGene00016395.

Phylogenomic databases

eggNOGiKOG4112. Eukaryota.
ENOG411274V. LUCA.
GeneTreeiENSGT00390000018321.
HOGENOMiHOG000171962.
InParanoidiO44953.
KOiK12946.
OMAiFKTIPTH.
OrthoDBiEOG091H0AOY.
PhylomeDBiO44953.

Miscellaneous databases

PROiO44953.

Gene expression databases

BgeeiWBGene00016395.

Family and domain databases

InterProiView protein in InterPro
IPR009542. SPC12.
PANTHERiPTHR13202. PTHR13202. 1 hit.
PfamiView protein in Pfam
PF06645. SPC12. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSPCS1_CAEEL
AccessioniPrimary (citable) accession number: O44953
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: June 1, 1998
Last modified: February 15, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.