Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable signal peptidase complex subunit 1

Gene

C34B2.10

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Names & Taxonomyi

Protein namesi
Recommended name:
Probable signal peptidase complex subunit 1 (EC:3.4.-.-)
Alternative name(s):
Microsomal signal peptidase 12 kDa subunit
Short name:
SPase 12 kDa subunit
Gene namesi
ORF Names:C34B2.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiC34B2.10; CE16898; WBGene00016395.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232CytoplasmicSequence analysisAdd
BLAST
Transmembranei33 – 5321HelicalSequence analysisAdd
BLAST
Topological domaini54 – 563LumenalSequence analysis
Transmembranei57 – 7721HelicalSequence analysisAdd
BLAST
Topological domaini78 – 10528CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 105105Probable signal peptidase complex subunit 1PRO_0000215158Add
BLAST

Proteomic databases

EPDiO44953.
PaxDbiO44953.
PRIDEiO44953.

Interactioni

Subunit structurei

Complex of five different proteins: SEC11L1, SEC11L3, SPCS1, SPCS2 and SPCS3.By similarity

Protein-protein interaction databases

STRINGi6239.C34B2.10.

Family & Domainsi

Sequence similaritiesi

Belongs to the SPCS1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4112. Eukaryota.
ENOG411274V. LUCA.
GeneTreeiENSGT00390000018321.
HOGENOMiHOG000171962.
InParanoidiO44953.
KOiK12946.
OMAiFKTIPTH.
OrthoDBiEOG73FQNV.
PhylomeDBiO44953.

Family and domain databases

InterProiIPR009542. SPC12.
[Graphical view]
PANTHERiPTHR13202. PTHR13202. 1 hit.
PfamiPF06645. SPC12. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O44953-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGMIAMLPA PLQKLSSHID FQGQKVAERT YQVILTIAGI IGFLVGFWTQ
60 70 80 90 100
QLSYAMFTVL GASAFTALII LPPWPFLFRK NPIVWHTPAE PQESGDKKKE

TKKTK
Length:105
Mass (Da):11,777
Last modified:June 1, 1998 - v1
Checksum:i1C041B5D94A5C471
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080220 Genomic DNA. Translation: CCD62128.1.
PIRiT32884.
RefSeqiNP_492797.1. NM_060396.4.
UniGeneiCel.7734.

Genome annotation databases

EnsemblMetazoaiC34B2.10; C34B2.10; WBGene00016395.
GeneIDi172967.
KEGGicel:CELE_C34B2.10.
UCSCiC34B2.10.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080220 Genomic DNA. Translation: CCD62128.1.
PIRiT32884.
RefSeqiNP_492797.1. NM_060396.4.
UniGeneiCel.7734.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C34B2.10.

Proteomic databases

EPDiO44953.
PaxDbiO44953.
PRIDEiO44953.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC34B2.10; C34B2.10; WBGene00016395.
GeneIDi172967.
KEGGicel:CELE_C34B2.10.
UCSCiC34B2.10.1. c. elegans.

Organism-specific databases

CTDi172967.
WormBaseiC34B2.10; CE16898; WBGene00016395.

Phylogenomic databases

eggNOGiKOG4112. Eukaryota.
ENOG411274V. LUCA.
GeneTreeiENSGT00390000018321.
HOGENOMiHOG000171962.
InParanoidiO44953.
KOiK12946.
OMAiFKTIPTH.
OrthoDBiEOG73FQNV.
PhylomeDBiO44953.

Miscellaneous databases

PROiO44953.

Family and domain databases

InterProiIPR009542. SPC12.
[Graphical view]
PANTHERiPTHR13202. PTHR13202. 1 hit.
PfamiPF06645. SPC12. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiSPCS1_CAEEL
AccessioniPrimary (citable) accession number: O44953
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: June 1, 1998
Last modified: June 8, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.