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Protein
Submitted name:

Thrombospondin

Gene

Thr1

Organism
Haemonchus contortus (Barber pole worm)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
ThrombospondinImported
Gene namesi
Name:Thr1Imported
OrganismiHaemonchus contortus (Barber pole worm)Imported
Taxonomic identifieri6289 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaStrongylidaTrichostrongyloideaHaemonchidaeHaemonchinaeHaemonchus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 15721556Sequence analysisPRO_5004159132Add
BLAST

Proteomic databases

PRIDEiO44938.

Structurei

3D structure databases

ProteinModelPortaliO44938.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1075 – 112753BPTI/Kunitz inhibitorInterPro annotationAdd
BLAST
Domaini1136 – 118853BPTI/Kunitz inhibitorInterPro annotationAdd
BLAST
Domaini1255 – 130551BPTI/Kunitz inhibitorInterPro annotationAdd
BLAST
Domaini1394 – 144451BPTI/Kunitz inhibitorInterPro annotationAdd
BLAST
Domaini1462 – 151251BPTI/Kunitz inhibitorInterPro annotationAdd
BLAST
Domaini1519 – 156951BPTI/Kunitz inhibitorInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 6 BPTI/Kunitz inhibitor domains.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3Di4.10.410.10. 6 hits.
InterProiIPR010294. ADAM_spacer1.
IPR002223. Kunitz_BPTI.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR020901. Prtase_inh_Kunz-CS.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF00014. Kunitz_BPTI. 6 hits.
PF00090. TSP_1. 6 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
PR00759. BASICPTASE.
SMARTiSM00131. KU. 6 hits.
SM00209. TSP1. 7 hits.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 6 hits.
SSF82895. SSF82895. 6 hits.
PROSITEiPS00280. BPTI_KUNITZ_1. 6 hits.
PS50279. BPTI_KUNITZ_2. 6 hits.
PS50092. TSP1. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O44938-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKALLQLVAL FHALDALSLS FLSNVEPTLP HLHPLSPPET NPAGARAKRQ
60 70 80 90 100
AYQVYVDGDS SVSLDKTGQS ESGPWGPWVP EQCSRTCGGG VQTEKRQCPG
110 120 130 140 150
DCTGPSVRYV SCNLEPCPEG TDFRAEQCAA HNDDPIDGQY HKWIPYKGKN
160 170 180 190 200
KCELLCKPEN GNFYYKWDDT VVDGTKCDSK GDDICVDGVC LPLGCDGKLG
210 220 230 240 250
SALKLDKCGV CDGDGSQCKT IEGSFDERNL SPGYHDVMRI PAGATAIRIE
260 270 280 290 300
EARPSSNNLA MKNSSDYYFL NGNSMIQVEK DVELNGVHFE YDDGKPERIT
310 320 330 340 350
AKGPLEEEVV VSVLIRKGNR DVSIKYEFSV PIVDEVDYMY KPGEWSACSV
360 370 380 390 400
TCGKGQQTRT PYCIETKTQA RVDDQLCDDA NSTKPEFEKP CETVDCQAEW
410 420 430 440 450
FKGEWEPCSQ TCGEQGEQYR VVYCHQVFAN GRRITVDDGN CTAERPAVRQ
460 470 480 490 500
VCNRFACPEW QAGPWSACSE KCGDAFQYRS VTCRSEKEGE EGKLLPAEAC
510 520 530 540 550
SSENTLESQR SCNLGPCTGL KFFTSEWKLC SKCNDTEETR EVTCKDSQGR
560 570 580 590 600
AYPLEKCLTD DEKEIPVDTR ACATQQPCNY EWTASQWSKC STECGHGHKT
610 620 630 640 650
RRVICAIHEE GDVTVVDEAL CQGEKPEVKM NCTNEEKCTG TWYSGPWSPC
660 670 680 690 700
SVECGGGKQE RVAVCLNYDK KPVPEWCDES EMPNLIQDCN TDECPSCFDS
710 720 730 740 750
EFGCCPDNTT FASGDFNQGC SNCSLSEFGC CADNYTEATG KGGRGCEEFV
760 770 780 790 800
EQPLNLEEAS EGSGEEKTGE CQVTSENGDV AAVDCSAANA TTTDLEGLFG
810 820 830 840 850
NGTDTNATMH CSKSEFGCCP DWFTPAEGPN NAGCPVFVLG ACNETEYGCC
860 870 880 890 900
HDDVTLARGP NLEGCGEPTC AGSLYGCCKD RKTIAFGPHY AGCERSSFPC
910 920 930 940 950
ELSEFGCCAD GETAALGANG TGCGENCLTT KYGCCPDGKG AAKGHHNEGC
960 970 980 990 1000
GCVYAQYGCC PDGKTSAKGA GFYGCPDSCA QSQFGCCPDG KTPARGSHKE
1010 1020 1030 1040 1050
GCPCQYTRYG CCPDGETTAL GPRNDGCDDC RYAKYGCCPD GESKAIGPDY
1060 1070 1080 1090 1100
AGCPSTTLAP FLLGGTVAPS KISSCALPQD QGTVCSSGYK LVWYYDTAEG
1110 1120 1130 1140 1150
RCSQFWYGGC DGNDNRFATK EQCETICVEP PGIGRCYLPK VEGPLRCDQP
1160 1170 1180 1190 1200
QAKYWYDYNT KQCAAFWWRG CHGNANNFAS WEECSTFCKD VGPFAIPTTA
1210 1220 1230 1240 1250
VPAPQPPQIP HMPQIESMEV EHQVVAHPIP DEAPLKDRRN DLRPRPPMPT
1260 1270 1280 1290 1300
IEEVCRSTQD SGPCQDYSDQ FYYDAYKGTC QTFIYGGCGG NLNRFRTEEE
1310 1320 1330 1340 1350
CMQRCGFLNP TASSAYQAQQ SPLHEGAQQE PHPIHQRGQG AGQAQSQQQE
1360 1370 1380 1390 1400
YEQPRQPPYP DQHQQGPVRP PPPVVPQQPS YGIHAHSAKS RQSCHLPLDV
1410 1420 1430 1440 1450
GKCQGSFDSW YYEMATGSCV EFKYSGCSGN ANRFASREEC ENTCVRHSEP
1460 1470 1480 1490 1500
HSDTTSHGTS VCDEAKETGP CTNFATKWYY NKADGTCNRF HYGGCEGTRN
1510 1520 1530 1540 1550
RFDNEQSCKA ACANHQDACT LPKVQGPCSG KHEYYYFNTV SMSCEKFTYG
1560 1570
GCLGNTNRFS TLDECQSRCQ RK
Length:1,572
Mass (Da):171,872
Last modified:June 1, 2001 - v2
Checksum:i2260B30DC2F903EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043121 mRNA. Translation: AAB99830.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043121 mRNA. Translation: AAB99830.2.

3D structure databases

ProteinModelPortaliO44938.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO44938.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di4.10.410.10. 6 hits.
InterProiIPR010294. ADAM_spacer1.
IPR002223. Kunitz_BPTI.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR020901. Prtase_inh_Kunz-CS.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF00014. Kunitz_BPTI. 6 hits.
PF00090. TSP_1. 6 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
PR00759. BASICPTASE.
SMARTiSM00131. KU. 6 hits.
SM00209. TSP1. 7 hits.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 6 hits.
SSF82895. SSF82895. 6 hits.
PROSITEiPS00280. BPTI_KUNITZ_1. 6 hits.
PS50279. BPTI_KUNITZ_2. 6 hits.
PS50092. TSP1. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterisation of thrombospondin, a novel multidomain glycoprotein found in association with a host protective gut extract from Haemonchus contortus."
    Skuce P.J., Newlands G.F., Stewart E.M., Pettit D., Smith S.K., Smith W.D., Knox D.P.
    Mol. Biochem. Parasitol. 117:241-244(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MoredunImported.

Entry informationi

Entry nameiO44938_HAECO
AccessioniPrimary (citable) accession number: O44938
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 2001
Last modified: December 9, 2015
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.