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Protein
Submitted name:

Myosin heavy chain isoform A

Gene
N/A
Organism
Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei242 – 2421ADPCombined sources
Binding sitei246 – 2461ADPCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi124 – 1274ADPCombined sources
Nucleotide bindingi179 – 1846ADPCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, MyosinSAAS annotation

Keywords - Ligandi

Actin-bindingSAAS annotation, ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Myosin heavy chain isoform AImported
OrganismiDoryteuthis pealeii (Longfin inshore squid) (Loligo pealeii)Imported
Taxonomic identifieri1051067 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaCephalopodaColeoideaNeocoleoideaDecapodiformesTeuthidaMyopsinaLoliginidaeDoryteuthis

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3I5FX-ray3.10A1-839[»]
3I5GX-ray2.60A1-839[»]
3I5HX-ray3.40A1-839[»]
3I5IX-ray3.30A1-839[»]
ProteinModelPortaliO44934.
SMRiO44934. Positions 1-839.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO44934.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini83 – 777695Myosin motorInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili841 – 1043203Sequence analysisAdd
BLAST
Coiled coili1051 – 107828Sequence analysisAdd
BLAST
Coiled coili1086 – 115570Sequence analysisAdd
BLAST
Coiled coili1163 – 124078Sequence analysisAdd
BLAST
Coiled coili1248 – 130356Sequence analysisAdd
BLAST
Coiled coili1311 – 137363Sequence analysisAdd
BLAST
Coiled coili1382 – 144463Sequence analysisAdd
BLAST
Coiled coili1452 – 151463Sequence analysisAdd
BLAST
Coiled coili1522 – 159574Sequence analysisAdd
BLAST
Coiled coili1607 – 1718112Sequence analysisAdd
BLAST
Coiled coili1726 – 177146Sequence analysisAdd
BLAST
Coiled coili1804 – 183835Sequence analysisAdd
BLAST
Coiled coili1853 – 192270Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.SAAS annotation
Contains IQ domain.SAAS annotation
Contains myosin motor domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysisSAAS annotation

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 1 hit.
PF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O44934-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMDFSDPDM EFLCLTRQKL MEATSIPFDG KKNCWVPDPD FGFVGAEIQS
60 70 80 90 100
TKGDEVTVKT DKTQETRVVK KDDIGQRNPP KFEMNMDMAN LTFLNEASIL
110 120 130 140 150
HNLRSRYESG FIYTYSGLFC IAINPYRRLP IYTQGLVDKY RGKRRAEMPP
160 170 180 190 200
HLFSIADNAY QYMLQDRENQ SMLITGESGA GKTENTKKVI QYFALVAASL
210 220 230 240 250
AGKKDKKEEE KKKDEKKGTL EDQIVQCNPV LEAYGNAETT RNNNSSRFGK
260 270 280 290 300
FIRIHFGTQG KIAGADIETY LLEKSRVTYQ QSAERNYHIF YQLLSPAFPE
310 320 330 340 350
NIEKILAVPD PGLYGFINQG TLTVDGIDDE EEMGLTDTAF DVLGFTDEEK
360 370 380 390 400
LSMYKCTGCI LHLGEMKWKQ RGEQAEADGT AEAEKVAFLL GVNAGDLLKC
410 420 430 440 450
LLKPKIKVGT EYVTQGRNKD QVTNSIAALA KSLYDRMFNW LVRRVNQTLD
460 470 480 490 500
TKAKRQFFIG VLDIAGFEIF DFNSFEQLCI NYTNERLQQF FNHHMFVLEQ
510 520 530 540 550
EEYKKEGIVW EFIDFGLDLQ ACIELIEKPM GILSILEEEC MFPKASDTSF
560 570 580 590 600
KNKLYDNHLG KNPMFGKPKP PKAGCAEAHF CLHHYAGSVS YSIAGWLDKN
610 620 630 640 650
KDPINENVVE LLQNSKEPIV KMLFTPPRIL TPGGKKKKGK SAAFQTISSV
660 670 680 690 700
HKESLNKLMK NLYSTHPHFV RCIIPNELKT PGLIDAALVL HQLRCNGVLE
710 720 730 740 750
GIRICRKGFP NRIIYSEFKQ RYSILAPNAV PSGFADGKVV TDKVLSALQL
760 770 780 790 800
DPNEYRLGNT KVFFKAGVLG MLEDMRDERL SKIISMFQAH IRGYLMRKAY
810 820 830 840 850
KKLQDQRIGL TLIQRNVRKW LVLRNWEWWR LFNKVKPLLN IARQEDENKK
860 870 880 890 900
AQEEFAKMKE EFASCEQMRK ELEEQNTVLM QQKNDLVIAM SSGEDAIGDA
910 920 930 940 950
EEKIEQLIKQ KSDFETQIKE LEDKLMDEED AATELSAQKK KSDAEIGELK
960 970 980 990 1000
KDVEDLEAGL AKAEQEKTTK DNQIKTLQDE MAQQDEHLSK LNKEKKNLEE
1010 1020 1030 1040 1050
VQKKTLEDLQ AEEDKVNHLS KLKTKLEQTL DELEDNLERE KKIPGDVDKA
1060 1070 1080 1090 1100
KRKVEQDLKT TQETVEDLER VKRDLEDAGR KKDMEINGLN SKLEDEQNLV
1110 1120 1130 1140 1150
AQLQKKIKEL QARIEELEEE LEAERQARTK VEKQRTELSR ELEELGERLD
1160 1170 1180 1190 1200
EAGGATAAQM ELNKKREQEL LRLRRDLEEA TMQHESQIAT LRKKNQEATN
1210 1220 1230 1240 1250
ELGDQIDQLQ KVKSRLEKEK TQLRAEMDDV QSQVEHAGKN RGCSEKMSKQ
1260 1270 1280 1290 1300
MEAQLSELNA KIDDQARSVS ELTSQKSRLQ TEAADLTRQL EEAEHNVGQL
1310 1320 1330 1340 1350
TKLKSSLGAS LEDAKRSLED EGRLRAKLQA EVRNLNSDID GIRESLEEEA
1360 1370 1380 1390 1400
ESKSDLQRAL SRANAEVQQW RSKFESEGAA RADELEDAKR KLQAKLSEAE
1410 1420 1430 1440 1450
QTADTLHSKC AGLEKAKSRL QGELEDLAID VERSSAHANN LEKKQRNFDK
1460 1470 1480 1490 1500
VVSEWQHKCN DLQAELENAQ KEARSYSAEL FRVRAQCEEV GDTVASLRRE
1510 1520 1530 1540 1550
NKNLADEIHD LTDQLGEGGR NTHELEKARK HLALEKEELQ AALEEAEGAL
1560 1570 1580 1590 1600
EQEEAKVMRA TLEISQIRQE IDRRLQEKEE EFDNTRRNHQ RAIESMQASL
1610 1620 1630 1640 1650
EAEAKGKAEA LRIKKKLEGD INELEIALDA TNRGKAELEK NVKKYQGQIR
1660 1670 1680 1690 1700
ELQSQVEEEQ AQRDEAKEHY QMAERRCAAI NGELEELRTI LEQAERARKA
1710 1720 1730 1740 1750
AENELADASD RVNELQAQVS TVGSQKRKLE GDVTAMQSDL DELNNELKDA
1760 1770 1780 1790 1800
DERAKHAMAD ATRLADELRQ EQDHGLSVEK MRKSLESQVK ELQVRLDESE
1810 1820 1830 1840 1850
AAALKGGKKM IQKLESRVRE LEAELDSEQR RHAETQKSMR KVDRRVKELS
1860 1870 1880 1890 1900
FQQEEDRKNY ERMQELVDKL QNKIKTYKRQ VEEAEEIAAI NLAKFRKVQQ
1910 1920 1930
ELEDAEERAD QSEGALQKLR AKNRSSVSAA RTSPM
Length:1,935
Mass (Da):221,531
Last modified:November 1, 1998 - v2
Checksum:i7C4245EA440DB124
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042349 mRNA. Translation: AAC24207.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042349 mRNA. Translation: AAC24207.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3I5FX-ray3.10A1-839[»]
3I5GX-ray2.60A1-839[»]
3I5HX-ray3.40A1-839[»]
3I5IX-ray3.30A1-839[»]
ProteinModelPortaliO44934.
SMRiO44934. Positions 1-839.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiO44934.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 1 hit.
PF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Ventral siphon muscleImported.
  2. "Rigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor."
    Yang Y., Gourinath S., Kovacs M., Nyitray L., Reutzel R., Himmel D.M., O'Neall-Hennessey E., Reshetnikova L., Szent-Gyorgyi A.G., Brown J.H., Cohen C.
    Structure 15:553-564(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 1-839 IN COMPLEX WITH ADP.

Entry informationi

Entry nameiO44934_DORPE
AccessioniPrimary (citable) accession number: O44934
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.