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Protein
Submitted name:

HAlF transporter (PGP related)

Gene

haf-9

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • lysosomal transport Source: WormBase
  • multicellular organism growth Source: WormBase
  • RNA interference Source: WormBase
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-382556. ABC-family proteins mediated transport.
R-CEL-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Submitted name:
HAlF transporter (PGP related)Imported
Gene namesi
Name:haf-9Imported
ORF Names:CELE_ZK484.2Imported, ZK484.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiZK484.2a; CE27353; WBGene00001819; haf-9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalSequence analysisAdd
BLAST
Transmembranei92 – 11524HelicalSequence analysisAdd
BLAST
Transmembranei127 – 14923HelicalSequence analysisAdd
BLAST
Transmembranei204 – 22623HelicalSequence analysisAdd
BLAST
Transmembranei246 – 26318HelicalSequence analysisAdd
BLAST
Transmembranei324 – 34219HelicalSequence analysisAdd
BLAST
Transmembranei348 – 36821HelicalSequence analysisAdd
BLAST
Transmembranei424 – 44825HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • lysosomal membrane Source: WormBase
  • membrane Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

EPDiO44897.
PaxDbiO44897.
PRIDEiO44897.

Expressioni

Gene expression databases

ExpressionAtlasiO44897. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiO44897. 1 interaction.
STRINGi6239.ZK484.2a.2.

Structurei

3D structure databases

ProteinModelPortaliO44897.
SMRiO44897. Positions 193-795.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini208 – 489282ABC transmembrane type-1InterPro annotationAdd
BLAST
Domaini522 – 759238ABC transporterInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transporter domain.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0058. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00550000074497.
InParanoidiO44897.
KOiK05656.
OMAiVESVDAW.
PhylomeDBiO44897.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR013305. ABC_Tap-like.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR00958. 3a01208. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O44897-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSLYTGGQ ALFICLAFIG LDLLVNVFGL AWNGKYFTFD NIAHWFDLAN
60 70 80 90 100
YSFLKNPVDF LAVALIRDSI LLGGAVSAWA SPSGFSQVAE NVKNVVFAMM
110 120 130 140 150
LLIVAFAPSK LLAFYEDDNI RLAVGDWILM IWCIFASLLL QGIWTSVLAH
160 170 180 190 200
VTEVAAGTGD SLLFGDAEHE ERLRQEEAEK AAEQRETFQL LFRLLGYMGR
210 220 230 240 250
QWKYYGMAFF FLFCYSLSRV FIPYYTGEVV TAVFGDKASY EKLHKTVFIM
260 270 280 290 300
GMLSLASTVF GGLRGGSFTY AHATIDRQIR NDLFRSVVKQ EIGFFDMNKT
310 320 330 340 350
GEICSRLSAD CQTMSNTLSL YMNVLTRNLT MLFGSLIFMF TLSWKLSMIT
360 370 380 390 400
LINIPIIFLV NKIFGVWYDM LSEETQNSVA KANDVAEEVL SSIRTVKSFA
410 420 430 440 450
CENYESSRFM TFLNVTLKIA TRKVFVVIGL IWSNELLQMG ILTIVLWYGG
460 470 480 490 500
HLVIENKVES GLLVSFLLYQ FQLGENLREL GEVWNGLMQA VGASRKVFEF
510 520 530 540 550
IDRPPRVENT GTYAPDGMTG KIEFRHVAFS YPIRPDLPIM EDLTFTVEPG
560 570 580 590 600
EVVALVGPSG GGKSSCIAML EHFYEPTSGE VLIDGVPVRE YDHKFLHTKV
610 620 630 640 650
ALVGQEPVLY ARSVTENIGY GLDKYDDDMV QNSAKLANAH TFIMNDTTDG
660 670 680 690 700
YNTNVGEKGS QMSGGQKQRI AIARALVRQP VVLLLDEATS ALDAESEHTV
710 720 730 740 750
QEAISKNLKG KTVILIAHRL STVENADKIV VINKGKVEQL GNHKTLMEQE
760 770 780 790 800
GLYKQLVQRQ MMSGEDGLDD EIEEPEPARE GGSGRSTRAG ARRIRSPSQS
810
VSQSFLGTSF ASSYL
Length:815
Mass (Da):90,793
Last modified:June 1, 2001 - v2
Checksum:i71119D4C43C8D06C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CCD65798.1.
RefSeqiNP_491754.1. NM_059353.4.
UniGeneiCel.20814.

Genome annotation databases

EnsemblMetazoaiZK484.2a.1; ZK484.2a.1; WBGene00001819.
ZK484.2a.2; ZK484.2a.2; WBGene00001819.
ZK484.2a.3; ZK484.2a.3; WBGene00001819.
GeneIDi172288.
KEGGicel:CELE_ZK484.2.
UCSCiZK484.2b. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CCD65798.1.
RefSeqiNP_491754.1. NM_059353.4.
UniGeneiCel.20814.

3D structure databases

ProteinModelPortaliO44897.
SMRiO44897. Positions 193-795.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO44897. 1 interaction.
STRINGi6239.ZK484.2a.2.

Proteomic databases

EPDiO44897.
PaxDbiO44897.
PRIDEiO44897.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK484.2a.1; ZK484.2a.1; WBGene00001819.
ZK484.2a.2; ZK484.2a.2; WBGene00001819.
ZK484.2a.3; ZK484.2a.3; WBGene00001819.
GeneIDi172288.
KEGGicel:CELE_ZK484.2.
UCSCiZK484.2b. c. elegans.

Organism-specific databases

CTDi172288.
WormBaseiZK484.2a; CE27353; WBGene00001819; haf-9.

Phylogenomic databases

eggNOGiKOG0058. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00550000074497.
InParanoidiO44897.
KOiK05656.
OMAiVESVDAW.
PhylomeDBiO44897.

Enzyme and pathway databases

ReactomeiR-CEL-382556. ABC-family proteins mediated transport.
R-CEL-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

NextBioi874853.

Gene expression databases

ExpressionAtlasiO44897. baseline and differential.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR013305. ABC_Tap-like.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR00958. 3a01208. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiO44897_CAEEL
AccessioniPrimary (citable) accession number: O44897
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.