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O44786

- MIFH_WUCBA

UniProt

O44786 - MIFH_WUCBA

Protein

Macrophage migration inhibitory factor homolog

Gene

MIF

Organism
Wuchereria bancrofti
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Tautomerization of the methyl ester of L-dopachrome. Inhibits migration of human peripheral blood mononuclear cells By similarity.By similarity

    Catalytic activityi

    L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.
    Keto-phenylpyruvate = enol-phenylpyruvate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Proton acceptor; via imino nitrogenBy similarity
    Binding sitei33 – 331SubstrateBy similarity
    Binding sitei65 – 651Substrate; via amide nitrogenBy similarity

    GO - Molecular functioni

    1. dopachrome isomerase activity Source: UniProtKB-EC
    2. phenylpyruvate tautomerase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Cytokine, Isomerase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Macrophage migration inhibitory factor homolog (EC:5.3.2.1)
    Short name:
    MIF
    Alternative name(s):
    L-dopachrome isomerase
    L-dopachrome tautomerase (EC:5.3.3.12)
    Phenylpyruvate tautomerase
    Gene namesi
    Name:MIF
    OrganismiWuchereria bancrofti
    Taxonomic identifieri6293 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaSpiruridaFilarioideaOnchocercidaeWuchereria

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 115114Macrophage migration inhibitory factor homologPRO_0000158077Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO44786.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MIF family.Curated

    Family and domain databases

    InterProiIPR001398. Macrophage_inhib_fac.
    IPR019829. Macrophage_inhib_fac_CS.
    IPR014347. Tautomerase/MIF_sf.
    [Graphical view]
    PANTHERiPTHR11954. PTHR11954. 1 hit.
    PfamiPF01187. MIF. 1 hit.
    [Graphical view]
    ProDomiPD004816. Macrophage_inhib_fac. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF55331. SSF55331. 1 hit.
    PROSITEiPS01158. MIF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O44786-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPYFTIDTNK PQDSISSAFL KKAPNVVPKA LGKPESYVSI HVNGGQPMVF    50
    GGSEDPCPVC VLKSIGCVGP KVNNSHAEKL YKLLADELKI PKNRCYIESV 100
    DIEASSMAFN GSTFG 115
    Length:115
    Mass (Da):12,364
    Last modified:January 23, 2007 - v3
    Checksum:iFEF29CBBFCD2A8E6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF040629 mRNA. Translation: AAC82615.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF040629 mRNA. Translation: AAC82615.1 .

    3D structure databases

    ProteinModelPortali O44786.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR001398. Macrophage_inhib_fac.
    IPR019829. Macrophage_inhib_fac_CS.
    IPR014347. Tautomerase/MIF_sf.
    [Graphical view ]
    PANTHERi PTHR11954. PTHR11954. 1 hit.
    Pfami PF01187. MIF. 1 hit.
    [Graphical view ]
    ProDomi PD004816. Macrophage_inhib_fac. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF55331. SSF55331. 1 hit.
    PROSITEi PS01158. MIF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Scott A.L., Josh S., Pastrana D., Eisinger S.W., Marson A., Ragahavan N.
      Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Brazil.

    Entry informationi

    Entry nameiMIFH_WUCBA
    AccessioniPrimary (citable) accession number: O44786
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3