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O44757

- LIN59_CAEEL

UniProt

O44757 - LIN59_CAEEL

Protein

Probable histone-lysine N-methyltransferase lin-59

Gene

lin-59

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Probable histone methyltransferase By similarity. Essential protein required to maintain expression of homeotic genes egl-5 and mab-5. May play an analogous role to the trithorax Group (trxG) proteins. TrxG proteins form multiprotein complexes that are required to maintain the transcriptionally active state of homeotic genes throughout development. May act via a modification of chromatin.By similarity1 Publication

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri967 – 102761PHD-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: InterPro
    2. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. ectodermal cell fate specification Source: WormBase
    2. embryo development ending in birth or egg hatching Source: WormBase
    3. embryonic digestive tract development Source: WormBase
    4. locomotion Source: WormBase
    5. nematode larval development Source: WormBase
    6. nematode male tail tip morphogenesis Source: WormBase
    7. oviposition Source: WormBase
    8. positive regulation of transcription from RNA polymerase II promoter Source: WormBase
    9. regulation of multicellular organism growth Source: WormBase
    10. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Chromatin regulator, Methyltransferase, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, S-adenosyl-L-methionine, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable histone-lysine N-methyltransferase lin-59 (EC:2.1.1.43)
    Alternative name(s):
    Abnormal cell lineage protein 59
    Gene namesi
    Name:lin-59
    ORF Names:T12F5.4
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome I

    Organism-specific databases

    WormBaseiT12F5.4; CE13601; WBGene00003040; lin-59.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13121312Probable histone-lysine N-methyltransferase lin-59PRO_0000084431Add
    BLAST

    Proteomic databases

    PaxDbiO44757.
    PRIDEiO44757.

    Expressioni

    Tissue specificityi

    Widely expressed throughout embryonic development and into adulthood.1 Publication

    Developmental stagei

    Expressed from mid-blastula.

    Interactioni

    Protein-protein interaction databases

    BioGridi57313. 2 interactions.
    IntActiO44757. 3 interactions.
    MINTiMINT-3385943.
    STRINGi6239.T12F5.4.

    Structurei

    3D structure databases

    ProteinModelPortaliO44757.
    SMRiO44757. Positions 583-772, 968-1029, 1118-1299.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini590 – 63546AWSPROSITE-ProRule annotationAdd
    BLAST
    Domaini638 – 750113SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini1100 – 1223124BAHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi195 – 23036Asp-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation
    Contains 1 AWS domain.PROSITE-ProRule annotation
    Contains 1 BAH domain.PROSITE-ProRule annotation
    Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri967 – 102761PHD-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG2940.
    GeneTreeiENSGT00740000114921.
    InParanoidiO44757.
    KOiK06101.
    OMAiMEAEVSS.
    OrthoDBiEOG7ZPNJ4.
    PhylomeDBiO44757.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR006560. AWS.
    IPR001025. BAH_dom.
    IPR001214. SET_dom.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF01426. BAH. 1 hit.
    PF00628. PHD. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00570. AWS. 1 hit.
    SM00439. BAH. 1 hit.
    SM00249. PHD. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 1 hit.
    PROSITEiPS51215. AWS. 1 hit.
    PS51038. BAH. 1 hit.
    PS50280. SET. 1 hit.
    PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O44757-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHGAGEQQQR YRYNARSDEQ HHHPSTSSHQ YQQQGARQMH QMHPIQATLM     50
    CTPTTTSAAA STSSSGGSNS SGGSGGHRQQ GNILRIGNSI KIGDNILEPA 100
    GTLVFSQADG TPWTGQRIVV NGSTHAVVKA NLFPIGTTPP VLNMQSNQNW 150
    YMNQPSGTVP MSSNAPATTS SATPDSGIQS VPTSPPSPSY AMMNDVDIGD 200
    HDDEEDDDGP ADFTDMPLLK PVDEDDDCYD VPCTSEGPPP NNSNPAITTI 250
    PSSCSTPAPP KESLPTGMNV EEWGSFLIAS NMDREEIVRR LMAHDPEMAK 300
    AIAMRIRELS AEESKKKKDM EAEVSSTTPT TPRARGTRTR NKCATRSTNS 350
    PDVTTSNLPE EPSTSTMGLV KENEDVEKVE GKRRGRKPKK RRGFHKESFE 400
    DLESDAKKSK AEQHEDHLPE ASCSSRPESV IPPPVDPIQF RLKVREMMER 450
    KLEQLTQKMS EDMTELRLSH LTSSKMVNGE RGKRRESFLR QLNEQSKKLR 500
    KGGMLGRKRL RMFMTESDIL EENKDNIKKE VKEESTPPPT KLRGRLPSRR 550
    TREPSEIVNP EPVEKKFNGE YFEITKSVPS SDDIIPLWMA PSLTCGCTKG 600
    ACTSDMDCLN RALRVQCSSD CSVPYCSNRR FWKEDCGNKL CVSNGPRSKR 650
    VLKTKIARRA GEFLCEYAGE VITREQAQEK FAQDRDPRII AIAAHLFVDA 700
    TKRSNIARFI KHSCKPNSRL EVWSVNGFYR AGVFALSDLN PNAEITVDKS 750
    DLLPFDMACN CGATECKRVI RGVRWRCADP NEKIVTRRFV IRNRRKTIER 800
    SSHSGLPAIL QTPMDENSSI RLKMKQVLAA FAFRVRKIDG SMSRTMLPHY 850
    TLIIKFLKTK GNNPNPVEFV SLFRKWLEAI DDDDLERAFV AIESHYMSSS 900
    ILSSSLQSKK AKDNAPRARA LSTSCPSPVP SKRGDADLSY LESLYPIGSY 950
    DPDDAWESYS TNKKGNAVRC ICGALDEEGT MVQCDTCHFW LHVDCCQYVV 1000
    RSNEKAQKSK NPPSDDGEYI CDFCTNKQNG LRPSADVKLT EQPDVRFENC 1050
    DYYRSLINRR GIQVVLNETV YVNRVLPEDH KAMLRNLREE KKGSKQKDTN 1100
    KYRFPKAATS PLPIEKVDRK NARIFRVERL FVCPGNNRFV FGSFYAWPHE 1150
    TYADAGRVFS KKEVFATPYY ETLPLDEVIG RCLVLDTATW CKGRPKVPKF 1200
    KEDDVFLCEM QIGKTQRVFE KVPPKNRYPI NTNSYVFTEF THPKKVVRDF 1250
    RPYDPSNPSP KPPKTSSIPS TSSIDPPQSS SDGLPEVDTK KLSKRHIQRV 1300
    LKRLVKNGSR RS 1312
    Length:1,312
    Mass (Da):147,583
    Last modified:June 1, 1998 - v1
    Checksum:i9DC16CEF07E65163
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF163019 mRNA. Translation: AAD49324.1.
    FO081191 Genomic DNA. Translation: CCD69785.1.
    PIRiT32758.
    RefSeqiNP_491206.1. NM_058805.5.
    UniGeneiCel.17896.

    Genome annotation databases

    EnsemblMetazoaiT12F5.4; T12F5.4; WBGene00003040.
    GeneIDi266825.
    KEGGicel:CELE_T12F5.4.
    UCSCiT12F5.4. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF163019 mRNA. Translation: AAD49324.1 .
    FO081191 Genomic DNA. Translation: CCD69785.1 .
    PIRi T32758.
    RefSeqi NP_491206.1. NM_058805.5.
    UniGenei Cel.17896.

    3D structure databases

    ProteinModelPortali O44757.
    SMRi O44757. Positions 583-772, 968-1029, 1118-1299.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 57313. 2 interactions.
    IntActi O44757. 3 interactions.
    MINTi MINT-3385943.
    STRINGi 6239.T12F5.4.

    Proteomic databases

    PaxDbi O44757.
    PRIDEi O44757.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai T12F5.4 ; T12F5.4 ; WBGene00003040 .
    GeneIDi 266825.
    KEGGi cel:CELE_T12F5.4.
    UCSCi T12F5.4. c. elegans.

    Organism-specific databases

    CTDi 266825.
    WormBasei T12F5.4 ; CE13601 ; WBGene00003040 ; lin-59.

    Phylogenomic databases

    eggNOGi COG2940.
    GeneTreei ENSGT00740000114921.
    InParanoidi O44757.
    KOi K06101.
    OMAi MEAEVSS.
    OrthoDBi EOG7ZPNJ4.
    PhylomeDBi O44757.

    Miscellaneous databases

    NextBioi 953172.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR006560. AWS.
    IPR001025. BAH_dom.
    IPR001214. SET_dom.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF01426. BAH. 1 hit.
    PF00628. PHD. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00570. AWS. 1 hit.
    SM00439. BAH. 1 hit.
    SM00249. PHD. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 1 hit.
    PROSITEi PS51215. AWS. 1 hit.
    PS51038. BAH. 1 hit.
    PS50280. SET. 1 hit.
    PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The bromodomain protein LIN-49 and trithorax-related protein LIN-59 affect development and gene expression in Caenorhabditis elegans."
      Chamberlin H.M., Thomas J.H.
      Development 127:713-723(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiLIN59_CAEEL
    AccessioniPrimary (citable) accession number: O44757
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 23, 2003
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3