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O44757

- LIN59_CAEEL

UniProt

O44757 - LIN59_CAEEL

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Protein

Probable histone-lysine N-methyltransferase lin-59

Gene
lin-59, T12F5.4
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable histone methyltransferase By similarity. Essential protein required to maintain expression of homeotic genes egl-5 and mab-5. May play an analogous role to the trithorax Group (trxG) proteins. TrxG proteins form multiprotein complexes that are required to maintain the transcriptionally active state of homeotic genes throughout development. May act via a modification of chromatin.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri967 – 102761PHD-typeAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: InterPro
  2. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. ectodermal cell fate specification Source: WormBase
  2. embryo development ending in birth or egg hatching Source: WormBase
  3. embryonic digestive tract development Source: WormBase
  4. locomotion Source: WormBase
  5. nematode larval development Source: WormBase
  6. oviposition Source: WormBase
  7. positive regulation of transcription from RNA polymerase II promoter Source: WormBase
  8. regulation of multicellular organism growth Source: WormBase
  9. tail tip morphogenesis Source: WormBase
  10. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Methyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable histone-lysine N-methyltransferase lin-59 (EC:2.1.1.43)
Alternative name(s):
Abnormal cell lineage protein 59
Gene namesi
Name:lin-59
ORF Names:T12F5.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiT12F5.4; CE13601; WBGene00003040; lin-59.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13121312Probable histone-lysine N-methyltransferase lin-59PRO_0000084431Add
BLAST

Proteomic databases

PaxDbiO44757.
PRIDEiO44757.

Expressioni

Tissue specificityi

Widely expressed throughout embryonic development and into adulthood.1 Publication

Developmental stagei

Expressed from mid-blastula.

Interactioni

Protein-protein interaction databases

BioGridi57313. 2 interactions.
IntActiO44757. 3 interactions.
MINTiMINT-3385943.
STRINGi6239.T12F5.4.

Structurei

3D structure databases

ProteinModelPortaliO44757.
SMRiO44757. Positions 583-772, 968-1029, 1118-1299.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini590 – 63546AWSAdd
BLAST
Domaini638 – 750113SETAdd
BLAST
Domaini1100 – 1223124BAHAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi195 – 23036Asp-richAdd
BLAST

Sequence similaritiesi

Contains 1 AWS domain.
Contains 1 BAH domain.
Contains 1 SET domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri967 – 102761PHD-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG2940.
GeneTreeiENSGT00740000114921.
InParanoidiO44757.
KOiK06101.
OMAiMEAEVSS.
OrthoDBiEOG7ZPNJ4.
PhylomeDBiO44757.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR006560. AWS.
IPR001025. BAH_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01426. BAH. 1 hit.
PF00628. PHD. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00439. BAH. 1 hit.
SM00249. PHD. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS51038. BAH. 1 hit.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O44757-1 [UniParc]FASTAAdd to Basket

« Hide

MHGAGEQQQR YRYNARSDEQ HHHPSTSSHQ YQQQGARQMH QMHPIQATLM     50
CTPTTTSAAA STSSSGGSNS SGGSGGHRQQ GNILRIGNSI KIGDNILEPA 100
GTLVFSQADG TPWTGQRIVV NGSTHAVVKA NLFPIGTTPP VLNMQSNQNW 150
YMNQPSGTVP MSSNAPATTS SATPDSGIQS VPTSPPSPSY AMMNDVDIGD 200
HDDEEDDDGP ADFTDMPLLK PVDEDDDCYD VPCTSEGPPP NNSNPAITTI 250
PSSCSTPAPP KESLPTGMNV EEWGSFLIAS NMDREEIVRR LMAHDPEMAK 300
AIAMRIRELS AEESKKKKDM EAEVSSTTPT TPRARGTRTR NKCATRSTNS 350
PDVTTSNLPE EPSTSTMGLV KENEDVEKVE GKRRGRKPKK RRGFHKESFE 400
DLESDAKKSK AEQHEDHLPE ASCSSRPESV IPPPVDPIQF RLKVREMMER 450
KLEQLTQKMS EDMTELRLSH LTSSKMVNGE RGKRRESFLR QLNEQSKKLR 500
KGGMLGRKRL RMFMTESDIL EENKDNIKKE VKEESTPPPT KLRGRLPSRR 550
TREPSEIVNP EPVEKKFNGE YFEITKSVPS SDDIIPLWMA PSLTCGCTKG 600
ACTSDMDCLN RALRVQCSSD CSVPYCSNRR FWKEDCGNKL CVSNGPRSKR 650
VLKTKIARRA GEFLCEYAGE VITREQAQEK FAQDRDPRII AIAAHLFVDA 700
TKRSNIARFI KHSCKPNSRL EVWSVNGFYR AGVFALSDLN PNAEITVDKS 750
DLLPFDMACN CGATECKRVI RGVRWRCADP NEKIVTRRFV IRNRRKTIER 800
SSHSGLPAIL QTPMDENSSI RLKMKQVLAA FAFRVRKIDG SMSRTMLPHY 850
TLIIKFLKTK GNNPNPVEFV SLFRKWLEAI DDDDLERAFV AIESHYMSSS 900
ILSSSLQSKK AKDNAPRARA LSTSCPSPVP SKRGDADLSY LESLYPIGSY 950
DPDDAWESYS TNKKGNAVRC ICGALDEEGT MVQCDTCHFW LHVDCCQYVV 1000
RSNEKAQKSK NPPSDDGEYI CDFCTNKQNG LRPSADVKLT EQPDVRFENC 1050
DYYRSLINRR GIQVVLNETV YVNRVLPEDH KAMLRNLREE KKGSKQKDTN 1100
KYRFPKAATS PLPIEKVDRK NARIFRVERL FVCPGNNRFV FGSFYAWPHE 1150
TYADAGRVFS KKEVFATPYY ETLPLDEVIG RCLVLDTATW CKGRPKVPKF 1200
KEDDVFLCEM QIGKTQRVFE KVPPKNRYPI NTNSYVFTEF THPKKVVRDF 1250
RPYDPSNPSP KPPKTSSIPS TSSIDPPQSS SDGLPEVDTK KLSKRHIQRV 1300
LKRLVKNGSR RS 1312
Length:1,312
Mass (Da):147,583
Last modified:June 1, 1998 - v1
Checksum:i9DC16CEF07E65163
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF163019 mRNA. Translation: AAD49324.1.
FO081191 Genomic DNA. Translation: CCD69785.1.
PIRiT32758.
RefSeqiNP_491206.1. NM_058805.5.
UniGeneiCel.17896.

Genome annotation databases

EnsemblMetazoaiT12F5.4; T12F5.4; WBGene00003040.
GeneIDi266825.
KEGGicel:CELE_T12F5.4.
UCSCiT12F5.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF163019 mRNA. Translation: AAD49324.1 .
FO081191 Genomic DNA. Translation: CCD69785.1 .
PIRi T32758.
RefSeqi NP_491206.1. NM_058805.5.
UniGenei Cel.17896.

3D structure databases

ProteinModelPortali O44757.
SMRi O44757. Positions 583-772, 968-1029, 1118-1299.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 57313. 2 interactions.
IntActi O44757. 3 interactions.
MINTi MINT-3385943.
STRINGi 6239.T12F5.4.

Proteomic databases

PaxDbi O44757.
PRIDEi O44757.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai T12F5.4 ; T12F5.4 ; WBGene00003040 .
GeneIDi 266825.
KEGGi cel:CELE_T12F5.4.
UCSCi T12F5.4. c. elegans.

Organism-specific databases

CTDi 266825.
WormBasei T12F5.4 ; CE13601 ; WBGene00003040 ; lin-59.

Phylogenomic databases

eggNOGi COG2940.
GeneTreei ENSGT00740000114921.
InParanoidi O44757.
KOi K06101.
OMAi MEAEVSS.
OrthoDBi EOG7ZPNJ4.
PhylomeDBi O44757.

Miscellaneous databases

NextBioi 953172.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR006560. AWS.
IPR001025. BAH_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF01426. BAH. 1 hit.
PF00628. PHD. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00570. AWS. 1 hit.
SM00439. BAH. 1 hit.
SM00249. PHD. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 1 hit.
PROSITEi PS51215. AWS. 1 hit.
PS51038. BAH. 1 hit.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The bromodomain protein LIN-49 and trithorax-related protein LIN-59 affect development and gene expression in Caenorhabditis elegans."
    Chamberlin H.M., Thomas J.H.
    Development 127:713-723(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiLIN59_CAEEL
AccessioniPrimary (citable) accession number: O44757
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: June 1, 1998
Last modified: June 11, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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