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Protein

BAG family molecular chaperone regulator 1

Gene

bag-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May inhibit the chaperone activity of HSP70/HSC70 by promoting substrate release in an ATP-dependent manner.By similarity

GO - Molecular functioni

  • chaperone binding Source: WormBase

GO - Biological processi

  • cell growth Source: WormBase
  • protein folding Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
BAG family molecular chaperone regulator 1
Gene namesi
Name:bag-1
ORF Names:F57B10.11
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF57B10.11; CE11318; WBGene00000236; bag-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210BAG family molecular chaperone regulator 1PRO_0000088877Add
BLAST

Proteomic databases

EPDiO44739.
PaxDbiO44739.
PRIDEiO44739.

Interactioni

Subunit structurei

Homodimer or homotetramer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CELE_Y43F8B.2Q9XWX73EBI-323218,EBI-323231

GO - Molecular functioni

  • chaperone binding Source: WormBase

Protein-protein interaction databases

BioGridi37824. 5 interactions.
DIPiDIP-27094N.
IntActiO44739. 3 interactions.
MINTiMINT-1049483.
STRINGi6239.F57B10.11.

Structurei

Secondary structure

1
210
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi77 – 793Combined sources
Beta strandi81 – 866Combined sources
Helixi88 – 12134Combined sources
Helixi126 – 15530Combined sources
Beta strandi157 – 1593Combined sources
Helixi165 – 1673Combined sources
Helixi170 – 20031Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1T7SX-ray2.80A/B74-210[»]
ProteinModelPortaliO44739.
SMRiO44739. Positions 74-202.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO44739.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 8578Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST
Domaini108 – 19487BAGPROSITE-ProRule annotationAdd
BLAST

Domaini

The BAG domain probably mediates direct interaction with HSP70.By similarity

Sequence similaritiesi

Contains 1 BAG domain.PROSITE-ProRule annotation
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IHYI. Eukaryota.
ENOG4111SUG. LUCA.
HOGENOMiHOG000095171.
InParanoidiO44739.
KOiK09555.
OMAiCEHPEDA.
OrthoDBiEOG7J4482.
PhylomeDBiO44739.

Family and domain databases

Gene3Di1.20.58.120. 1 hit.
InterProiIPR003103. BAG_domain.
IPR017093. Molecular_chp_reg_BAG_1.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF02179. BAG. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
PIRSFiPIRSF037029. BAG_1. 1 hit.
SMARTiSM00264. BAG. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF63491. SSF63491. 1 hit.
PROSITEiPS51035. BAG. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O44739-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVNVSCSSV QTTIDILEEN QGEDESILTL GQLRDRIATD NDVDVETMKL
60 70 80 90 100
LHRGKFLQGA DDVSLSTLNF KENDKIIVMG GKNALVDDAG FKMLMQYEKH
110 120 130 140 150
NLSNLQKAYD LNLRDVADLE RGFLEKPKQV EMGKKLEKKV KYFNEEAERH
160 170 180 190 200
LETLDGMNII TETTPENQAK RNREKRKTLV NGIQTLLNQN DALLRRLQEY
210
QSVLNGDIPE
Length:210
Mass (Da):24,010
Last modified:June 1, 1998 - v1
Checksum:i1F72FD2C2CF3B157
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095788 mRNA. Translation: AAD16125.1.
FO081416 Genomic DNA. Translation: CCD71479.1.
PIRiT43666.
RefSeqiNP_491893.1. NM_059492.5.
UniGeneiCel.23233.

Genome annotation databases

EnsemblMetazoaiF57B10.11; F57B10.11; WBGene00000236.
GeneIDi172373.
KEGGicel:CELE_F57B10.11.
UCSCiF57B10.11. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095788 mRNA. Translation: AAD16125.1.
FO081416 Genomic DNA. Translation: CCD71479.1.
PIRiT43666.
RefSeqiNP_491893.1. NM_059492.5.
UniGeneiCel.23233.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1T7SX-ray2.80A/B74-210[»]
ProteinModelPortaliO44739.
SMRiO44739. Positions 74-202.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi37824. 5 interactions.
DIPiDIP-27094N.
IntActiO44739. 3 interactions.
MINTiMINT-1049483.
STRINGi6239.F57B10.11.

Proteomic databases

EPDiO44739.
PaxDbiO44739.
PRIDEiO44739.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF57B10.11; F57B10.11; WBGene00000236.
GeneIDi172373.
KEGGicel:CELE_F57B10.11.
UCSCiF57B10.11. c. elegans.

Organism-specific databases

CTDi172373.
WormBaseiF57B10.11; CE11318; WBGene00000236; bag-1.

Phylogenomic databases

eggNOGiENOG410IHYI. Eukaryota.
ENOG4111SUG. LUCA.
HOGENOMiHOG000095171.
InParanoidiO44739.
KOiK09555.
OMAiCEHPEDA.
OrthoDBiEOG7J4482.
PhylomeDBiO44739.

Miscellaneous databases

EvolutionaryTraceiO44739.
NextBioi875249.
PROiO44739.

Family and domain databases

Gene3Di1.20.58.120. 1 hit.
InterProiIPR003103. BAG_domain.
IPR017093. Molecular_chp_reg_BAG_1.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF02179. BAG. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
PIRSFiPIRSF037029. BAG_1. 1 hit.
SMARTiSM00264. BAG. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF63491. SSF63491. 1 hit.
PROSITEiPS51035. BAG. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators."
    Takayama S., Xie Z., Reed J.C.
    J. Biol. Chem. 274:781-786(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "Structural genomics of Caenorhabditis elegans: structure of the BAG domain."
    Symersky J., Zhang Y., Schormann N., Li S., Bunzel R., Pruett P., Luan C.-H., Luo M.
    Acta Crystallogr. D 60:1606-1610(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 74-210, SUBUNIT.

Entry informationi

Entry nameiBAG1_CAEEL
AccessioniPrimary (citable) accession number: O44739
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 1998
Last modified: May 11, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.