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Protein

BAG family molecular chaperone regulator 1

Gene

bag-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May inhibit the chaperone activity of HSP70/HSC70 by promoting substrate release in an ATP-dependent manner.By similarity

GO - Molecular functioni

  • chaperone binding Source: WormBase

GO - Biological processi

  • chaperone cofactor-dependent protein refolding Source: WormBase

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
BAG family molecular chaperone regulator 1
Gene namesi
Name:bag-1
ORF Names:F57B10.11
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi

Organism-specific databases

WormBaseiF57B10.11 ; CE11318 ; WBGene00000236 ; bag-1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000888771 – 210BAG family molecular chaperone regulator 1Add BLAST210

Proteomic databases

EPDiO44739
PaxDbiO44739
PeptideAtlasiO44739
PRIDEiO44739

Expressioni

Gene expression databases

BgeeiWBGene00000236

Interactioni

Subunit structurei

Homodimer or homotetramer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CELE_Y43F8B.2Q9XWX73EBI-323218,EBI-323231

GO - Molecular functioni

  • chaperone binding Source: WormBase

Protein-protein interaction databases

BioGridi37824, 5 interactors
DIPiDIP-27094N
IntActiO44739, 3 interactors
STRINGi6239.F57B10.11

Structurei

Secondary structure

1210
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi77 – 79Combined sources3
Beta strandi81 – 86Combined sources6
Helixi88 – 121Combined sources34
Helixi126 – 155Combined sources30
Beta strandi157 – 159Combined sources3
Helixi165 – 167Combined sources3
Helixi170 – 200Combined sources31

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1T7SX-ray2.80A/B74-210[»]
ProteinModelPortaliO44739
SMRiO44739
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO44739

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 85Ubiquitin-likePROSITE-ProRule annotationAdd BLAST78
Domaini108 – 194BAGPROSITE-ProRule annotationAdd BLAST87

Domaini

The BAG domain probably mediates direct interaction with HSP70.By similarity

Phylogenomic databases

eggNOGiENOG410IHYI Eukaryota
ENOG4111SUG LUCA
HOGENOMiHOG000095171
InParanoidiO44739
KOiK09555
OMAiCEHPEDA
OrthoDBiEOG091G0IO8
PhylomeDBiO44739

Family and domain databases

Gene3Di1.20.58.120, 1 hit
InterProiView protein in InterPro
IPR017093 BAG-1
IPR036533 BAG_dom_sf
IPR003103 BAG_domain
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PANTHERiPTHR12329:SF16 PTHR12329:SF16, 1 hit
PfamiView protein in Pfam
PF02179 BAG, 1 hit
PF00240 ubiquitin, 1 hit
PIRSFiPIRSF037029 BAG_1, 1 hit
SMARTiView protein in SMART
SM00264 BAG, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
SSF63491 SSF63491, 1 hit
PROSITEiView protein in PROSITE
PS51035 BAG, 1 hit
PS50053 UBIQUITIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

O44739-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVNVSCSSV QTTIDILEEN QGEDESILTL GQLRDRIATD NDVDVETMKL
60 70 80 90 100
LHRGKFLQGA DDVSLSTLNF KENDKIIVMG GKNALVDDAG FKMLMQYEKH
110 120 130 140 150
NLSNLQKAYD LNLRDVADLE RGFLEKPKQV EMGKKLEKKV KYFNEEAERH
160 170 180 190 200
LETLDGMNII TETTPENQAK RNREKRKTLV NGIQTLLNQN DALLRRLQEY
210
QSVLNGDIPE
Length:210
Mass (Da):24,010
Last modified:June 1, 1998 - v1
Checksum:i1F72FD2C2CF3B157
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095788 mRNA Translation: AAD16125.1
FO081416 Genomic DNA Translation: CCD71479.1
PIRiT43666
RefSeqiNP_491893.1, NM_059492.5
UniGeneiCel.23233

Genome annotation databases

EnsemblMetazoaiF57B10.11; F57B10.11; WBGene00000236
GeneIDi172373
KEGGicel:CELE_F57B10.11
UCSCiF57B10.11 c. elegans

Entry informationi

Entry nameiBAG1_CAEEL
AccessioniPrimary (citable) accession number: O44739
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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