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Protein

BAG family molecular chaperone regulator 1

Gene

bag-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May inhibit the chaperone activity of HSP70/HSC70 by promoting substrate release in an ATP-dependent manner.By similarity

GO - Molecular functioni

  • chaperone binding Source: WormBase

GO - Biological processi

  • cell growth Source: WormBase
  • protein folding Source: WormBase

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
BAG family molecular chaperone regulator 1
Gene namesi
Name:bag-1
ORF Names:F57B10.11
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF57B10.11; CE11318; WBGene00000236; bag-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000888771 – 210BAG family molecular chaperone regulator 1Add BLAST210

Proteomic databases

EPDiO44739.
PaxDbiO44739.
PeptideAtlasiO44739.
PRIDEiO44739.

Expressioni

Gene expression databases

BgeeiWBGene00000236.

Interactioni

Subunit structurei

Homodimer or homotetramer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CELE_Y43F8B.2Q9XWX73EBI-323218,EBI-323231

GO - Molecular functioni

  • chaperone binding Source: WormBase

Protein-protein interaction databases

BioGridi37824. 5 interactors.
DIPiDIP-27094N.
IntActiO44739. 3 interactors.
MINTiMINT-1049483.
STRINGi6239.F57B10.11.

Structurei

Secondary structure

1210
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi77 – 79Combined sources3
Beta strandi81 – 86Combined sources6
Helixi88 – 121Combined sources34
Helixi126 – 155Combined sources30
Beta strandi157 – 159Combined sources3
Helixi165 – 167Combined sources3
Helixi170 – 200Combined sources31

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1T7SX-ray2.80A/B74-210[»]
ProteinModelPortaliO44739.
SMRiO44739.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO44739.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 85Ubiquitin-likePROSITE-ProRule annotationAdd BLAST78
Domaini108 – 194BAGPROSITE-ProRule annotationAdd BLAST87

Domaini

The BAG domain probably mediates direct interaction with HSP70.By similarity

Phylogenomic databases

eggNOGiENOG410IHYI. Eukaryota.
ENOG4111SUG. LUCA.
HOGENOMiHOG000095171.
InParanoidiO44739.
KOiK09555.
OMAiCEHPEDA.
OrthoDBiEOG091G0IO8.
PhylomeDBiO44739.

Family and domain databases

Gene3Di1.20.58.120. 1 hit.
InterProiView protein in InterPro
IPR017093. BAG-1.
IPR003103. BAG_domain.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
PfamiView protein in Pfam
PF02179. BAG. 1 hit.
PF00240. ubiquitin. 1 hit.
PIRSFiPIRSF037029. BAG_1. 1 hit.
SMARTiView protein in SMART
SM00264. BAG. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF63491. SSF63491. 1 hit.
PROSITEiView protein in PROSITE
PS51035. BAG. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O44739-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVNVSCSSV QTTIDILEEN QGEDESILTL GQLRDRIATD NDVDVETMKL
60 70 80 90 100
LHRGKFLQGA DDVSLSTLNF KENDKIIVMG GKNALVDDAG FKMLMQYEKH
110 120 130 140 150
NLSNLQKAYD LNLRDVADLE RGFLEKPKQV EMGKKLEKKV KYFNEEAERH
160 170 180 190 200
LETLDGMNII TETTPENQAK RNREKRKTLV NGIQTLLNQN DALLRRLQEY
210
QSVLNGDIPE
Length:210
Mass (Da):24,010
Last modified:June 1, 1998 - v1
Checksum:i1F72FD2C2CF3B157
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095788 mRNA. Translation: AAD16125.1.
FO081416 Genomic DNA. Translation: CCD71479.1.
PIRiT43666.
RefSeqiNP_491893.1. NM_059492.5.
UniGeneiCel.23233.

Genome annotation databases

EnsemblMetazoaiF57B10.11; F57B10.11; WBGene00000236.
GeneIDi172373.
KEGGicel:CELE_F57B10.11.
UCSCiF57B10.11. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiBAG1_CAEEL
AccessioniPrimary (citable) accession number: O44739
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 1998
Last modified: July 5, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references