Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot O44712 (AHR_CAEEL)

Last modified November 24, 2009. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Aryl hydrocarbon receptor protein 1
Gene names
Name: ahr-1
ORF Names: C41G7.5
OrganismCaenorhabditis elegans [Complete proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Hide | Top

Protein attributes

Sequence length602 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

Hide | Top

General annotation (Comments)

Function

Probable ligand-activated transcriptional activator. Acts as a transcriptional regulator in GABAergic motor neuron cell fate specification and development. Promotes cell-type-specific expression of guanylate cyclase genes that have key roles in aggregation behavior and hyperoxia avoidance. Has no role in carbon dioxide avoidance. Ref.1 Ref.3 Ref.4 Ref.5 Ref.6

Subunit structure

Interacts with daf-21/hsp90. Interacts with aha-1. Ref.1 Ref.7

Subcellular location

Nucleus Probable.

Tissue specificity

Expressed in many distinct neuronal cells including RMED, RMEV, RMEL and RMER. Functions in URX neurons to promote aggregation behavior. Ref.3 Ref.4 Ref.5

Developmental stage

Expressed during embyronic and larval development. Ref.3

Disruption phenotype

Defects in neuronal differentiation, axon branching, aberrant cell migration and abnormal aggregation behavior on lawns of bacterial food. Ref.3 Ref.4 Ref.5

Sequence similarities

Contains 1 basic helix-loop-helix (bHLH) domain.

Contains 2 PAS (PER-ARNT-SIM) domains.

Hide | Top

Ontologies

Keywords
   Biological processBehavior
Neurogenesis
Transcription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   LigandDNA-binding
   Molecular functionActivator
Receptor
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processregulation of transcription, DNA-dependent

Inferred from electronic annotation. Source: InterPro

signal transduction

Inferred from electronic annotation. Source: InterPro

transcription

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

transcription regulator activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Hide | Top

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform a Ref.1 (identifier: O44712-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform b Ref.2 (identifier: O44712-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
Note: No experimental confirmation available.

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 22 By similarity UniProtKB P30561
PRO_0000388706
Chain3 – 602600Aryl hydrocarbon receptor protein 1
PRO_0000388707

Regions

Domain6 – 3126Basic motif
Domain32 – 7241Helix-loop-helix motif
Domain126 – 19671PAS

Natural variations

Alternative sequence1 – 4242Missing in isoform b. Ref.2
VSP_053164

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Isoform a [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 6A891C2950B3FD36

FASTA60268,232
        10         20         30         40         50         60 
MYASKRRQRN FKRVRDPPKQ LTNTNPSKRH RERLNGELET VAMLLPYDSS TISRLDKLSV 

        70         80         90        100        110        120 
LRLAVSFLQC KAHFQACLHN SQFLSAGFPM STHSYSYQPH PPIPFSNKVP TIFDLRIGTP 

       130        140        150        160        170        180 
MLDPEESNFE EISLKSLGGF ILVLNDNGEI YYASENVENY LGFHQSDVLH QPVYDLIHSE 

       190        200        210        220        230        240 
DRDDIRQQLD SNFHIPTSSA SNQFDVFAPQ NSKYLERNVN ARFRCLLDNT CGFLRIDMRG 

       250        260        270        280        290        300 
KLMSLHGLPS SYVMGRTASG PVLGMICVCT PFVPPSTSDL ASEDMILKTK HQLDGALVSM 

       310        320        330        340        350        360 
DQKVYEMLEI DETDLPMPLY NLVHVEDAVC MAEAHKEAIK NGSSGLLVYR LVSTKTRRTY 

       370        380        390        400        410        420 
FVQSSCRMFY KNSKPESIGL THRLLNEVEG TMLLEKRSTL KAKLLSFDDS FLQSPRNLQS 

       430        440        450        460        470        480 
TAALPLPSVL KDDQDCLEPS TSNSLFPSVP VPTPTTTKAN RRRKENSHEI VPTIPSIPIP 

       490        500        510        520        530        540 
THFDMQMFDP SWNHGVHPPA WPHDVYHLTQ YPPTYPHPPG TVGYPDVQIA PVDYPGWHPN 

       550        560        570        580        590        600 
DIHMTQLPHG FTPDAQKLVP PHPQMSHFTE YPTPSTHHDL HHHPLKQDNF HLISEVTNLL 


GT

« Hide

Isoform b.

Checksum: 813BD9C8C058EC06
Show »

FASTA56063,170

Hide | Top

References

« Hide 'large scale' references
[1]"Caenorhabditis elegans orthologs of the aryl hydrocarbon receptor and its heterodimerization partner the aryl hydrocarbon receptor nuclear translocator."
Powell-Coffman J.A., Bradfield C.A., Wood W.B.
Proc. Natl. Acad. Sci. U.S.A. 95:2844-2849(1998) [PubMed: 9501178] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, INTERACTION WITH DAF-21.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: Bristol N2.
[3]"The Caenorhabditis elegans aryl hydrocarbon receptor, AHR-1, regulates neuronal development."
Qin H., Powell-Coffman J.A.
Dev. Biol. 270:64-75(2004) [PubMed: 15136141] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
[4]"The AHR-1 aryl hydrocarbon receptor and its co-factor the AHA-1 aryl hydrocarbon receptor nuclear translocator specify GABAergic neuron cell fate in C. elegans."
Huang X., Powell-Coffman J.A., Jin Y.
Development 131:819-828(2004) [PubMed: 14757639] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
[5]"The Caenorhabditis elegans AHR-1 transcription complex controls expression of soluble guanylate cyclase genes in the URX neurons and regulates aggregation behavior."
Qin H., Zhai Z., Powell-Coffman J.A.
Dev. Biol. 298:606-615(2006) [PubMed: 16919260] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
[6]"Acute carbon dioxide avoidance in Caenorhabditis elegans."
Hallem E.A., Sternberg P.W.
Proc. Natl. Acad. Sci. U.S.A. 105:8038-8043(2008) [PubMed: 18524955] [Abstract]
Cited for: FUNCTION.
[7]"A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors."
Grove C.A., De Masi F., Barrasa M.I., Newburger D.E., Alkema M.J., Bulyk M.L., Walhout A.J.M.
Cell 138:314-327(2009) [PubMed: 19632181] [Abstract]
Cited for: INTERACTION WITH AHA-1.
+Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

AF039570 mRNA. Translation: AAC00000.1.
Z81048 Genomic DNA. Translation: CAB51463.1.
Z81048 Genomic DNA. Translation: CAI79126.1.
PIRT19898.
RefSeqNP_001021036.1.
NP_001021037.1.
UniGeneCel.19551

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActO44712. 1 interaction.
STRINGO44712.

Genome annotation databases

EnsemblC41G7.5a; C41G7.5a; C41G7.5; Caenorhabditis elegans. [Genome view]
GeneID172788.
KEGGcel:C41G7.5.
UCSCC41G7.5a. c. elegans.

Organism-specific databases

CTD172788.
WormBaseWBGene00000096. ahr-1.
WormPepC41G7.5a. CE20561. [WorfDB]
C41G7.5b. CE38293. [WorfDB]

Phylogenomic databases

OMAFLQCKAH
PhylomeDBO44712.

Family and domain databases

InterProIPR001092. HLH_basic.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR013655. PAS_fold_3.
[Graphical view]
PfamPF00010. HLH. 1 hit.
PF00989. PAS. 1 hit.
PF08447. PAS_3. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
PROSITEPS50888. HLH. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio877003.

Hide | Top

Entry information

Entry nameAHR_CAEEL
AccessionPrimary (citable) accession number: O44712
Secondary accession number(s): Q564W4, Q93369
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: June 1, 1998
Last modified: November 24, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectCaenorhabditis annotation project

Hide | Top

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents