O44712 (AHR_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aryl hydrocarbon receptor protein 1

Gene names

Name:	ahr-1
ORF Names:	C41G7.5

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	602 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable ligand-activated transcriptional activator. Acts as a transcriptional regulator in GABAergic motor neuron cell fate specification and development. Promotes cell-type-specific expression of guanylate cyclase genes that have key roles in aggregation behavior and hyperoxia avoidance. Has no role in carbon dioxide avoidance. Ref.1 Ref.3 Ref.4 Ref.5 Ref.6
Subunit structure	Interacts with daf-21/hsp90. Interacts with aha-1. Ref.1 Ref.7
Subcellular location	Nucleus Probable.
Tissue specificity	Expressed in many distinct neuronal cells including RMED, RMEV, RMEL and RMER. Functions in URX neurons to promote aggregation behavior. Ref.3 Ref.4 Ref.5
Developmental stage	Expressed during embyronic and larval development. Ref.3
Disruption phenotype	Defects in neuronal differentiation, axon branching, aberrant cell migration and abnormal aggregation behavior on lawns of bacterial food. Ref.3 Ref.4 Ref.5
Sequence similarities	Contains 1 basic helix-loop-helix (bHLH) domain. Contains 2 PAS (PER-ARNT-SIM) domains.

Ontologies

Keywords
Biological process	Behavior Neurogenesis Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Ligand	DNA-binding
Molecular function	Activator Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	behavior Inferred from electronic annotation. Source: UniProtKB-KW intracellular receptor mediated signaling pathway Traceable author statement Ref.1. Source: WormBase nervous system development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW response to xenobiotic stimulus Inferred from direct assay Ref.1. Source: WormBase transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from direct assay Ref.1. Source: WormBase RNA polymerase II transcription factor binding Inferred from physical interaction Ref.7. Source: WormBase receptor activity Inferred from electronic annotation. Source: UniProtKB-KW signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform a Ref.1 (identifier: O44712-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform b Ref.2 (identifier: O44712-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 2	2	By similarity UniProtKB P30561		PRO_0000388706
	Chain	3 – 602	600	Aryl hydrocarbon receptor protein 1		PRO_0000388707
Regions
	Domain	6 – 31	26	Basic motif
	Domain	32 – 72	41	Helix-loop-helix motif
	Domain	126 – 196	71	PAS
Natural variations
	Alternative sequence	1 – 42	42	Missing in isoform b. Ref.2		VSP_053164

Sequences

	Sequence		Length	Mass (Da)
	Isoform a [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 6A891C2950B3FD36	FASTA	602	68,232
	10 20 30 40 50 60 MYASKRRQRN FKRVRDPPKQ LTNTNPSKRH RERLNGELET VAMLLPYDSS TISRLDKLSV 70 80 90 100 110 120 LRLAVSFLQC KAHFQACLHN SQFLSAGFPM STHSYSYQPH PPIPFSNKVP TIFDLRIGTP 130 140 150 160 170 180 MLDPEESNFE EISLKSLGGF ILVLNDNGEI YYASENVENY LGFHQSDVLH QPVYDLIHSE 190 200 210 220 230 240 DRDDIRQQLD SNFHIPTSSA SNQFDVFAPQ NSKYLERNVN ARFRCLLDNT CGFLRIDMRG 250 260 270 280 290 300 KLMSLHGLPS SYVMGRTASG PVLGMICVCT PFVPPSTSDL ASEDMILKTK HQLDGALVSM 310 320 330 340 350 360 DQKVYEMLEI DETDLPMPLY NLVHVEDAVC MAEAHKEAIK NGSSGLLVYR LVSTKTRRTY 370 380 390 400 410 420 FVQSSCRMFY KNSKPESIGL THRLLNEVEG TMLLEKRSTL KAKLLSFDDS FLQSPRNLQS 430 440 450 460 470 480 TAALPLPSVL KDDQDCLEPS TSNSLFPSVP VPTPTTTKAN RRRKENSHEI VPTIPSIPIP 490 500 510 520 530 540 THFDMQMFDP SWNHGVHPPA WPHDVYHLTQ YPPTYPHPPG TVGYPDVQIA PVDYPGWHPN 550 560 570 580 590 600 DIHMTQLPHG FTPDAQKLVP PHPQMSHFTE YPTPSTHHDL HHHPLKQDNF HLISEVTNLL GT
	Isoform b [UniParc]. Checksum: 813BD9C8C058EC06	FASTA	560	63,170
	10 20 30 40 50 60 MLLPYDSSTI SRLDKLSVLR LAVSFLQCKA HFQACLHNSQ FLSAGFPMST HSYSYQPHPP 70 80 90 100 110 120 IPFSNKVPTI FDLRIGTPML DPEESNFEEI SLKSLGGFIL VLNDNGEIYY ASENVENYLG 130 140 150 160 170 180 FHQSDVLHQP VYDLIHSEDR DDIRQQLDSN FHIPTSSASN QFDVFAPQNS KYLERNVNAR 190 200 210 220 230 240 FRCLLDNTCG FLRIDMRGKL MSLHGLPSSY VMGRTASGPV LGMICVCTPF VPPSTSDLAS 250 260 270 280 290 300 EDMILKTKHQ LDGALVSMDQ KVYEMLEIDE TDLPMPLYNL VHVEDAVCMA EAHKEAIKNG 310 320 330 340 350 360 SSGLLVYRLV STKTRRTYFV QSSCRMFYKN SKPESIGLTH RLLNEVEGTM LLEKRSTLKA 370 380 390 400 410 420 KLLSFDDSFL QSPRNLQSTA ALPLPSVLKD DQDCLEPSTS NSLFPSVPVP TPTTTKANRR 430 440 450 460 470 480 RKENSHEIVP TIPSIPIPTH FDMQMFDPSW NHGVHPPAWP HDVYHLTQYP PTYPHPPGTV 490 500 510 520 530 540 GYPDVQIAPV DYPGWHPNDI HMTQLPHGFT PDAQKLVPPH PQMSHFTEYP TPSTHHDLHH 550 560 HPLKQDNFHL ISEVTNLLGT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Caenorhabditis elegans orthologs of the aryl hydrocarbon receptor and its heterodimerization partner the aryl hydrocarbon receptor nuclear translocator." Powell-Coffman J.A., Bradfield C.A., Wood W.B. Proc. Natl. Acad. Sci. U.S.A. 95:2844-2849(1998) [PubMed: 9501178] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, INTERACTION WITH DAF-21.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: Bristol N2.
[3]	"The Caenorhabditis elegans aryl hydrocarbon receptor, AHR-1, regulates neuronal development." Qin H., Powell-Coffman J.A. Dev. Biol. 270:64-75(2004) [PubMed: 15136141] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
[4]	"The AHR-1 aryl hydrocarbon receptor and its co-factor the AHA-1 aryl hydrocarbon receptor nuclear translocator specify GABAergic neuron cell fate in C. elegans." Huang X., Powell-Coffman J.A., Jin Y. Development 131:819-828(2004) [PubMed: 14757639] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
[5]	"The Caenorhabditis elegans AHR-1 transcription complex controls expression of soluble guanylate cyclase genes in the URX neurons and regulates aggregation behavior." Qin H., Zhai Z., Powell-Coffman J.A. Dev. Biol. 298:606-615(2006) [PubMed: 16919260] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
[6]	"Acute carbon dioxide avoidance in Caenorhabditis elegans." Hallem E.A., Sternberg P.W. Proc. Natl. Acad. Sci. U.S.A. 105:8038-8043(2008) [PubMed: 18524955] [Abstract] Cited for: FUNCTION.
[7]	"A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors." Grove C.A., De Masi F., Barrasa M.I., Newburger D.E., Alkema M.J., Bulyk M.L., Walhout A.J.M. Cell 138:314-327(2009) [PubMed: 19632181] [Abstract] Cited for: INTERACTION WITH AHA-1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF039570 mRNA. Translation: AAC00000.1. Z81048 Genomic DNA. Translation: CAB51463.1. Z81048 Genomic DNA. Translation: CAI79126.1.
PIR	T19898.
RefSeq	NP_001021036.1. NM_001025865.2. NP_001021037.1. NM_001025866.2.
UniGene	Cel.19551.
3D structure databases
ProteinModelPortal	O44712.
SMR	O44712. Positions 20-70, 140-190.
ModBase	Search...
Protein-protein interaction databases
IntAct	O44712. 2 interactions.
STRING	O44712.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	C41G7.5a; C41G7.5a; C41G7.5.
GeneID	172788.
KEGG	cel:C41G7.5.
UCSC	C41G7.5a. c. elegans.
Organism-specific databases
CTD	172788.
WormBase	C41G7.5a; CE20561; WBGene00000096; ahr-1. C41G7.5b; CE38293; WBGene00000096; ahr-1.
Phylogenomic databases
eggNOG	meNOG04300.
GeneTree	EMGT00050000001333.
InParanoid	O44712.
OMA	SEGLIFY.
PhylomeDB	O44712.
Family and domain databases
InterPro	IPR011598. HLH_DNA-bd. IPR000014. PAS. IPR013767. PAS_fold. IPR013655. PAS_fold_3. [Graphical view]
Pfam	PF00989. PAS. 1 hit. PF08447. PAS_3. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. SM00091. PAS. 1 hit. [Graphical view]
PROSITE	PS50888. HLH. 1 hit. PS50112. PAS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	877003.

Entry information

Entry name

AHR_CAEEL

Accession

Primary (citable) accession number: O44712
Secondary accession number(s): Q564W4, Q93369

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 3, 2009
Last sequence update:	June 1, 1998
Last modified:	October 19, 2011
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project