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Protein
Submitted name:

Protein CYP-33C1

Gene

cyp-33c1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. heme binding Source: GO_Central
  2. iron ion binding Source: InterPro
  3. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: GO_Central
  4. oxygen binding Source: GO_Central
  5. steroid hydroxylase activity Source: GO_Central

GO - Biological processi

  1. exogenous drug catabolic process Source: GO_Central
  2. organic acid metabolic process Source: GO_Central
  3. oxidation-reduction process Source: GO_Central
  4. xenobiotic metabolic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_104244. Androgen biosynthesis.
REACT_183198. PPARA activates gene expression.
REACT_230635. Endogenous sterols.
REACT_233130. Mineralocorticoid biosynthesis.
REACT_235031. Glucocorticoid biosynthesis.
REACT_238303. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
REACT_241876. Methylation.
REACT_249452. Xenobiotics.
REACT_254239. Aflatoxin activation and detoxification.
REACT_258653. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_263534. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein CYP-33C1Imported
Gene namesi
Name:cyp-33c1Imported
Synonyms:cyp-33C1Imported
ORF Names:C45H4.2Imported, CELE_C45H4.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome V

Organism-specific databases

WormBaseiC45H4.2; CE46272; WBGene00016686; cyp-33C1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: GO_Central
  2. intracellular membrane-bounded organelle Source: GO_Central
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiO44704.

Structurei

3D structure databases

ProteinModelPortaliO44704.
SMRiO44704. Positions 25-488.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118992.
HOGENOMiHOG000036993.
InParanoidiO44704.
KOiK17955.
OrthoDBiEOG7RBZ85.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O44704-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIIILLLTFL TIYFVYELYW KRRNFPPGPC PLPVFGNLLS IANPPPGYKA
60 70 80 90 100
FERWTKKYGD VYTFWIGNTP HIMINTWDKI KETFIRDADT YTNKVVLPMV
110 120 130 140 150
TLSRGGEYGI IDSNGAMWRE HRRFALSTMR DFGLGKNLMQ ENILMEVQDV
160 170 180 190 200
FARLDAKLGS ETDVPEVFDH AVANVVNQLL FGYRFMGPKE NEYQELKHII
210 220 230 240 250
DSPAEIFGKL HIFLAMNIPI FAKLLPESLY EGPIKTFRDT TLAFFNKQIE
260 270 280 290 300
AHRHRIDFED LNSESTDFVE TFLKEQKRRE SEGDSETYSN IQLLNVCIDL
310 320 330 340 350
WFAGLNTTTN TITWAISYVL HHPEVQDKIH EELDKVIGSD RLITTADKND
360 370 380 390 400
LPYFNASINE SQRGINILPL NLQHATTRDT VIDGFKIPKG TGVVAQISTV
410 420 430 440 450
MNNEEVFPDP YTFNPDRFID ENGKLKKVDE LAPFSVGKRS CPGEGLARME
460 470 480 490
LFLFIANFLN RYKIHPSKEG LPSMAKGSGP VVAPRLFTAI LTRRF
Length:495
Mass (Da):56,725
Last modified:January 25, 2012 - v2
Checksum:i056D9DDF95F5621C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080875 Genomic DNA. Translation: CCD67429.1.
RefSeqiNP_503592.2. NM_071191.2.
UniGeneiCel.4504.

Genome annotation databases

EnsemblMetazoaiC45H4.2; C45H4.2; WBGene00016686.
GeneIDi183484.
KEGGicel:CELE_C45H4.2.
UCSCiC45H4.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080875 Genomic DNA. Translation: CCD67429.1.
RefSeqiNP_503592.2. NM_071191.2.
UniGeneiCel.4504.

3D structure databases

ProteinModelPortaliO44704.
SMRiO44704. Positions 25-488.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO44704.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC45H4.2; C45H4.2; WBGene00016686.
GeneIDi183484.
KEGGicel:CELE_C45H4.2.
UCSCiC45H4.2. c. elegans.

Organism-specific databases

CTDi183484.
WormBaseiC45H4.2; CE46272; WBGene00016686; cyp-33C1.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118992.
HOGENOMiHOG000036993.
InParanoidiO44704.
KOiK17955.
OrthoDBiEOG7RBZ85.

Enzyme and pathway databases

ReactomeiREACT_104244. Androgen biosynthesis.
REACT_183198. PPARA activates gene expression.
REACT_230635. Endogenous sterols.
REACT_233130. Mineralocorticoid biosynthesis.
REACT_235031. Glucocorticoid biosynthesis.
REACT_238303. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
REACT_241876. Methylation.
REACT_249452. Xenobiotics.
REACT_254239. Aflatoxin activation and detoxification.
REACT_258653. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_263534. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.

Miscellaneous databases

NextBioi921304.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiO44704_CAEEL
AccessioniPrimary (citable) accession number: O44704
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: January 25, 2012
Last modified: February 4, 2015
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.