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Protein
Submitted name:

CYtochrome P450 family

Gene

cyp-34a8

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-156581. Methylation.
R-CEL-193048. Androgen biosynthesis.
R-CEL-193993. Mineralocorticoid biosynthesis.
R-CEL-194002. Glucocorticoid biosynthesis.
R-CEL-211957. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.
R-CEL-211976. Endogenous sterols.
R-CEL-211981. Xenobiotics.
R-CEL-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-CEL-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
R-CEL-5423646. Aflatoxin activation and detoxification.

Names & Taxonomyi

Protein namesi
Submitted name:
CYtochrome P450 familyImported
Gene namesi
Name:cyp-34a8Imported
Synonyms:cyp-34A8Imported
ORF Names:B0213.14Imported, CELE_B0213.14Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiB0213.14; CE41971; WBGene00015043; cyp-34A8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 499483Sequence analysisPRO_5004158387Add
BLAST

Proteomic databases

EPDiO44658.
PaxDbiO44658.
PRIDEiO44658.

Interactioni

Protein-protein interaction databases

STRINGi6239.B0213.14.

Structurei

3D structure databases

ProteinModelPortaliO44658.
SMRiO44658. Positions 25-496.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00840000129897.
HOGENOMiHOG000036993.
InParanoidiO44658.
KOiK17956.
OrthoDBiEOG7RBZ85.
PhylomeDBiO44658.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O44658-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLILILLAV AAVLTANLWR ARQKLPKGPT PLPLIGNFHQ LFYLSWKTGS
60 70 80 90 100
LVAAFNELKK QYGKVFTVWM GPKPSVYICD YDIAHETHVK RANIFGTRYS
110 120 130 140 150
VGGMEYIREG RGIIGSNGDF WLEHRRFALM TLRNFGVGRT IMEDKIMDEY
160 170 180 190 200
RYRFKDFKRT HFKNGAIQVN ASSIFDLLVG SIINQLLVSE RFEQDDQEFE
210 220 230 240 250
KLKTSLAEAL ENISIIEGFL PLWVLKSPLM KWRTKITFAP FDFIFELGNR
260 270 280 290 300
GIQRRVAAIE NGTHTLSEEG DDFVDAFIVK MEKDKKEGID SSFTLETLAI
310 320 330 340 350
DLFDLWQAGQ ETTSTTLTWA CVCLLNHPEV VEKLRKELTE VTGGTRGVSL
360 370 380 390 400
TDRTKTPYLN ANINEFQRIA SILNVNLFRV LEEDTTIDSQ PVPAGALVTT
410 420 430 440 450
NLSMLHTDEE IFKNPQEFRP ERFMENNNLE KRLIPFGIGK RACPGESLAR
460 470 480 490
AELFLITGNM ILDYDLEPVG TLPKIETTTP FAPMKRPPVY DIRFVPRSQ
Length:499
Mass (Da):56,933
Last modified:February 5, 2008 - v2
Checksum:i8B6DC8E88E277BDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD61368.1.
RefSeqiNP_504102.2. NM_071701.4.
UniGeneiCel.9461.

Genome annotation databases

EnsemblMetazoaiB0213.14; B0213.14; WBGene00015043.
GeneIDi181850.
KEGGicel:CELE_B0213.14.
UCSCiB0213.14. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD61368.1.
RefSeqiNP_504102.2. NM_071701.4.
UniGeneiCel.9461.

3D structure databases

ProteinModelPortaliO44658.
SMRiO44658. Positions 25-496.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.B0213.14.

Proteomic databases

EPDiO44658.
PaxDbiO44658.
PRIDEiO44658.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0213.14; B0213.14; WBGene00015043.
GeneIDi181850.
KEGGicel:CELE_B0213.14.
UCSCiB0213.14. c. elegans.

Organism-specific databases

CTDi181850.
WormBaseiB0213.14; CE41971; WBGene00015043; cyp-34A8.

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00840000129897.
HOGENOMiHOG000036993.
InParanoidiO44658.
KOiK17956.
OrthoDBiEOG7RBZ85.
PhylomeDBiO44658.

Enzyme and pathway databases

ReactomeiR-CEL-156581. Methylation.
R-CEL-193048. Androgen biosynthesis.
R-CEL-193993. Mineralocorticoid biosynthesis.
R-CEL-194002. Glucocorticoid biosynthesis.
R-CEL-211957. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.
R-CEL-211976. Endogenous sterols.
R-CEL-211981. Xenobiotics.
R-CEL-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-CEL-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
R-CEL-5423646. Aflatoxin activation and detoxification.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiO44658_CAEEL
AccessioniPrimary (citable) accession number: O44658
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: February 5, 2008
Last modified: July 6, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.