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Protein
Submitted name:

CYtochrome P450 family

Gene

cyp-34a6

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-156581. Methylation.
R-CEL-193048. Androgen biosynthesis.
R-CEL-193993. Mineralocorticoid biosynthesis.
R-CEL-194002. Glucocorticoid biosynthesis.
R-CEL-211957. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.
R-CEL-211976. Endogenous sterols.
R-CEL-211981. Xenobiotics.
R-CEL-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-CEL-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
R-CEL-5423646. Aflatoxin activation and detoxification.

Names & Taxonomyi

Protein namesi
Submitted name:
CYtochrome P450 familyImported
Gene namesi
Name:cyp-34a6Imported
Synonyms:cyp-34A6Imported
ORF Names:B0213.11Imported, CELE_B0213.11Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiB0213.11a; CE35205; WBGene00015041; cyp-34A6.

PTM / Processingi

Proteomic databases

EPDiO44656.
PaxDbiO44656.

Expressioni

Gene expression databases

ExpressionAtlasiO44656. baseline and differential.

Interactioni

Protein-protein interaction databases

DIPiDIP-25949N.
MINTiMINT-1078821.
STRINGi6239.B0213.11a.

Structurei

3D structure databases

ProteinModelPortaliO44656.
SMRiO44656. Positions 24-498.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00840000129897.
HOGENOMiHOG000036993.
InParanoidiO44656.
KOiK17956.
OrthoDBiEOG7RBZ85.
PhylomeDBiO44656.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O44656-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFILILTAT VLILTVNIWR AWRKLPNGPL PIPLIGNFHQ LFYYAWRFGG
60 70 80 90 100
IVEGIKEMKK QYGKVFTLWM GPLPMVNICD YDIAYETHVK RANIFVNRYI
110 120 130 140 150
HGATEYIREG RGIIGSNGDF WLEHRRFALT TFRNFGIGRN IIEGKIMEEY
160 170 180 190 200
NYRFEDFHET HFKNGAIQVS ASMFFDLLVG SIINQLLVSE RFEQDDKEFE
210 220 230 240 250
ELKTKLTMAL ENSSIIEGVM PLWLLKSKFM KWRTKTTFAP FDFIYEVGQK
260 270 280 290 300
GIQRRVAAIE NGTHVLSEEG DDFVDAFIIK IEKDSKEEVE STFTLETLAV
310 320 330 340 350
DLFDLWVAGQ ETTSTTLCWA FVCLMNYPEV VEKLRNELTE VTGGMRSVSL
360 370 380 390 400
ADRSSTLYLN ATINEIQRIA SILNVNLPRV LEEDALIDGV LVPAGTAFAT
410 420 430 440 450
QLSAMHTDDE TFKNHKEFNP ERFMENNNLE KKLIPFGIGK RSCPGESLAR
460 470 480 490
AELYLIIANI VMEYEIEPVG ATPKMKTPTP FSLLKRPPSY EIRFVKRS
Length:498
Mass (Da):57,191
Last modified:October 1, 2003 - v2
Checksum:i4A6CF031F4713D85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD61361.1.
PIRiB89015.
RefSeqiNP_001256031.1. NM_001269102.1.
UniGeneiCel.24697.

Genome annotation databases

EnsemblMetazoaiB0213.11a; B0213.11a; WBGene00015041.
GeneIDi181848.
KEGGicel:CELE_B0213.11.
UCSCiB0213.11. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD61361.1.
PIRiB89015.
RefSeqiNP_001256031.1. NM_001269102.1.
UniGeneiCel.24697.

3D structure databases

ProteinModelPortaliO44656.
SMRiO44656. Positions 24-498.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-25949N.
MINTiMINT-1078821.
STRINGi6239.B0213.11a.

Proteomic databases

EPDiO44656.
PaxDbiO44656.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0213.11a; B0213.11a; WBGene00015041.
GeneIDi181848.
KEGGicel:CELE_B0213.11.
UCSCiB0213.11. c. elegans.

Organism-specific databases

CTDi181848.
WormBaseiB0213.11a; CE35205; WBGene00015041; cyp-34A6.

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00840000129897.
HOGENOMiHOG000036993.
InParanoidiO44656.
KOiK17956.
OrthoDBiEOG7RBZ85.
PhylomeDBiO44656.

Enzyme and pathway databases

ReactomeiR-CEL-156581. Methylation.
R-CEL-193048. Androgen biosynthesis.
R-CEL-193993. Mineralocorticoid biosynthesis.
R-CEL-194002. Glucocorticoid biosynthesis.
R-CEL-211957. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.
R-CEL-211976. Endogenous sterols.
R-CEL-211981. Xenobiotics.
R-CEL-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-CEL-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
R-CEL-5423646. Aflatoxin activation and detoxification.

Gene expression databases

ExpressionAtlasiO44656. baseline and differential.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiO44656_CAEEL
AccessioniPrimary (citable) accession number: O44656
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: October 1, 2003
Last modified: July 6, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.