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Protein
Submitted name:

CYtochrome P450 family

Gene

cyp-35a5

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • innate immune response Source: WormBase
  • response to xenobiotic stimulus Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-156581. Methylation.
R-CEL-193048. Androgen biosynthesis.
R-CEL-193993. Mineralocorticoid biosynthesis.
R-CEL-194002. Glucocorticoid biosynthesis.
R-CEL-211957. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.
R-CEL-211976. Endogenous sterols.
R-CEL-211981. Xenobiotics.
R-CEL-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-CEL-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
R-CEL-5423646. Aflatoxin activation and detoxification.

Names & Taxonomyi

Protein namesi
Submitted name:
CYtochrome P450 familyImported
Gene namesi
Name:cyp-35a5Imported
Synonyms:cyp-35A5Imported
ORF Names:CELE_K07C6.5Imported, K07C6.5Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiK07C6.5; CE17176; WBGene00019473; cyp-35A5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 494476Sequence analysisPRO_5004159093Add
BLAST

Proteomic databases

PaxDbiO44649.
PRIDEiO44649.

Expressioni

Gene expression databases

BgeeiWBGene00019473.

Interactioni

Protein-protein interaction databases

STRINGi6239.K07C6.5.

Structurei

3D structure databases

ProteinModelPortaliO44649.
SMRiO44649. Positions 24-477.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00840000129897.
HOGENOMiHOG000036993.
InParanoidiO44649.
KOiK17957.
OrthoDBiEOG091G0BT8.
PhylomeDBiO44649.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O44649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFILIVSLI LTWLIVRQYQ KVSRLPPGPV SLPLIGNLPQ IVYYLWTTGG
60 70 80 90 100
IVSTLDLFRK RYGNIFTLWV GPVPHVSIAD YETSYEVFVK QGNKLADVAH
110 120 130 140 150
SPVLKEFSRG VGLIRCNGEH WQVMRRFALQ TFRNMGFGKE PMEIKIMEEL
160 170 180 190 200
DARCAEIDQA SINGVTVTSA SEFFDLTVGS IINSMLVGTR FEDHNKQEFL
210 220 230 240 250
DIKNTMEESI GMFSPFDLTM PVWIMKSFFR KRYDFLVGAQ ESARVLVASE
260 270 280 290 300
ALKRYDDIKS GKYVIDENNL QDYTDAFLLK IVKGEDEKNF NIQALKTMLY
310 320 330 340 350
DLWLTGQETT TVTLLCGFNH LLAHPEVMDK AREELLKITE NRARSLSLSD
360 370 380 390 400
RPTTPYLNAM IGEIQRHASI LNVTFWKINK ELTYMGGHPV DSGAVVTAQL
410 420 430 440 450
GALHVNDTIF KNPREFDPER FIRDDTLLQK VIPFGVGKRN CLGESLARSE
460 470 480 490
LYLILGNLLL RYKFEPHGKL STEETMPYSI AKRAFNLEMK FVKI
Length:494
Mass (Da):56,441
Last modified:June 1, 1998 - v1
Checksum:i8EDDA8DB726663DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD72734.1.
PIRiT32685.
RefSeqiNP_504092.1. NM_071691.5.
UniGeneiCel.3089.

Genome annotation databases

EnsemblMetazoaiK07C6.5; K07C6.5; WBGene00019473.
GeneIDi178802.
KEGGicel:CELE_K07C6.5.
UCSCiK07C6.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD72734.1.
PIRiT32685.
RefSeqiNP_504092.1. NM_071691.5.
UniGeneiCel.3089.

3D structure databases

ProteinModelPortaliO44649.
SMRiO44649. Positions 24-477.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.K07C6.5.

Proteomic databases

PaxDbiO44649.
PRIDEiO44649.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK07C6.5; K07C6.5; WBGene00019473.
GeneIDi178802.
KEGGicel:CELE_K07C6.5.
UCSCiK07C6.5. c. elegans.

Organism-specific databases

CTDi178802.
WormBaseiK07C6.5; CE17176; WBGene00019473; cyp-35A5.

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00840000129897.
HOGENOMiHOG000036993.
InParanoidiO44649.
KOiK17957.
OrthoDBiEOG091G0BT8.
PhylomeDBiO44649.

Enzyme and pathway databases

ReactomeiR-CEL-156581. Methylation.
R-CEL-193048. Androgen biosynthesis.
R-CEL-193993. Mineralocorticoid biosynthesis.
R-CEL-194002. Glucocorticoid biosynthesis.
R-CEL-211957. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.
R-CEL-211976. Endogenous sterols.
R-CEL-211981. Xenobiotics.
R-CEL-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-CEL-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
R-CEL-5423646. Aflatoxin activation and detoxification.

Gene expression databases

BgeeiWBGene00019473.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO44649_CAEEL
AccessioniPrimary (citable) accession number: O44649
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.