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O44628

- MPIP2_CAEEL

UniProt

O44628 - MPIP2_CAEEL

Protein

M-phase inducer phosphatase cdc-25.2

Gene

cdc-25.2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    M-phase inducer phosphatase cdc-25.2 (EC:3.1.3.48)
    Alternative name(s):
    Cell division cycle-related protein 25.2
    Gene namesi
    Name:cdc-25.2
    ORF Names:F16B4.8
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome V

    Organism-specific databases

    WormBaseiF16B4.8; CE19796; WBGene00000387; cdc-25.2.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 480480M-phase inducer phosphatase cdc-25.2PRO_0000198656Add
    BLAST

    Proteomic databases

    PRIDEiO44628.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.F16B4.8.

    Structurei

    3D structure databases

    ProteinModelPortaliO44628.
    SMRiO44628. Positions 245-370.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini243 – 349107RhodanesePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MPI phosphatase family.Curated
    Contains 1 rhodanese domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5105.
    GeneTreeiENSGT00390000018747.
    InParanoidiO44628.
    OMAiSGICELM.
    OrthoDBiEOG757D02.
    PhylomeDBiO44628.

    Family and domain databases

    Gene3Di3.40.250.10. 1 hit.
    InterProiIPR000751. MPI_Phosphatase.
    IPR001763. Rhodanese-like_dom.
    [Graphical view]
    PfamiPF00581. Rhodanese. 1 hit.
    [Graphical view]
    PRINTSiPR00716. MPIPHPHTASE.
    SMARTiSM00450. RHOD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52821. SSF52821. 1 hit.
    PROSITEiPS50206. RHODANESE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O44628-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNRPSQISQD VAQPLSNQHE TAMMSSDEDS MSRDSGICEL MDENTPVCFS    50
    SMSTESTTVQ VEECMEIDED ENLQPGPVSR RQKKVTFRRE KSSCQVRLFD 100
    ESPTSHKMFM RPQAPLSVRS ENQQLLQQRK RKFEKSEQSS DHFHLEPMSV 150
    EAMDDDEIVM MDQNTTKWEP GFRAPNHKKG RLTRSATAFP SLETFEEEEH 200
    EEQHHLNVKY HLKTVAKESS KGFRRITAET LRDIFFRLSE KEFDDKYILI 250
    DCRYPYEYNR GHIKNAINHF DRVTVSKIFY DENGRKRCNK IPIFYCEFSQ 300
    ARGPKMAYAL RQVDRELNVN HYPKCDYEEM YVLDLGYRNF FFAANEANIT 350
    NLCQPHAYCE MHDKEHTMEL KKYNFHNKGQ SVLRTVSMSR SFKSLPTGSA 400
    FNFVASSASF TSAPSTSTEN IDTNDDCQKS RTPAVPRIAS RRNLFSDPSH 450
    SPTNFAQFPL TCSRETPSPH KHPLTCPRFS 480
    Length:480
    Mass (Da):55,737
    Last modified:October 1, 2001 - v2
    Checksum:i19B11B138D582FA5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081161 Genomic DNA. Translation: CCD69573.1.
    PIRiB88953.
    T32663.
    T32665.
    RefSeqiNP_503446.1. NM_071045.3.
    UniGeneiCel.23180.

    Genome annotation databases

    EnsemblMetazoaiF16B4.8; F16B4.8; WBGene00000387.
    GeneIDi178645.
    KEGGicel:CELE_F16B4.8.
    UCSCiF16B4.8. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081161 Genomic DNA. Translation: CCD69573.1 .
    PIRi B88953.
    T32663.
    T32665.
    RefSeqi NP_503446.1. NM_071045.3.
    UniGenei Cel.23180.

    3D structure databases

    ProteinModelPortali O44628.
    SMRi O44628. Positions 245-370.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.F16B4.8.

    Proteomic databases

    PRIDEi O44628.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F16B4.8 ; F16B4.8 ; WBGene00000387 .
    GeneIDi 178645.
    KEGGi cel:CELE_F16B4.8.
    UCSCi F16B4.8. c. elegans.

    Organism-specific databases

    CTDi 178645.
    WormBasei F16B4.8 ; CE19796 ; WBGene00000387 ; cdc-25.2.

    Phylogenomic databases

    eggNOGi COG5105.
    GeneTreei ENSGT00390000018747.
    InParanoidi O44628.
    OMAi SGICELM.
    OrthoDBi EOG757D02.
    PhylomeDBi O44628.

    Miscellaneous databases

    NextBioi 901978.

    Family and domain databases

    Gene3Di 3.40.250.10. 1 hit.
    InterProi IPR000751. MPI_Phosphatase.
    IPR001763. Rhodanese-like_dom.
    [Graphical view ]
    Pfami PF00581. Rhodanese. 1 hit.
    [Graphical view ]
    PRINTSi PR00716. MPIPHPHTASE.
    SMARTi SM00450. RHOD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52821. SSF52821. 1 hit.
    PROSITEi PS50206. RHODANESE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "The four cdc25 genes from the nematode Caenorhabditis elegans."
      Ashcroft N.R., Kosinski M.E., Wickramasinghe D., Donovan P.J., Golden A.
      Gene 214:59-66(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiMPIP2_CAEEL
    AccessioniPrimary (citable) accession number: O44628
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3