O44628 (MPIP2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
M-phase inducer phosphatase cdc-25.2
EC=3.1.3.48

Alternative name(s):
Cell division cycle-related protein 25.2

Gene names

Name:	cdc-25.2
ORF Names:	F16B4.8

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	480 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Sequence similarities	Belongs to the MPI phosphatase family. Contains 1 rhodanese domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 480	480	M-phase inducer phosphatase cdc-25.2		PRO_0000198656
Regions
	Domain	243 – 349	107	Rhodanese

Sequences

	Sequence		Length	Mass (Da)
	O44628 [UniParc]. Last modified October 1, 2001. Version 2. Checksum: 19B11B138D582FA5	FASTA	480	55,737
	10 20 30 40 50 60 MNRPSQISQD VAQPLSNQHE TAMMSSDEDS MSRDSGICEL MDENTPVCFS SMSTESTTVQ 70 80 90 100 110 120 VEECMEIDED ENLQPGPVSR RQKKVTFRRE KSSCQVRLFD ESPTSHKMFM RPQAPLSVRS 130 140 150 160 170 180 ENQQLLQQRK RKFEKSEQSS DHFHLEPMSV EAMDDDEIVM MDQNTTKWEP GFRAPNHKKG 190 200 210 220 230 240 RLTRSATAFP SLETFEEEEH EEQHHLNVKY HLKTVAKESS KGFRRITAET LRDIFFRLSE 250 260 270 280 290 300 KEFDDKYILI DCRYPYEYNR GHIKNAINHF DRVTVSKIFY DENGRKRCNK IPIFYCEFSQ 310 320 330 340 350 360 ARGPKMAYAL RQVDRELNVN HYPKCDYEEM YVLDLGYRNF FFAANEANIT NLCQPHAYCE 370 380 390 400 410 420 MHDKEHTMEL KKYNFHNKGQ SVLRTVSMSR SFKSLPTGSA FNFVASSASF TSAPSTSTEN 430 440 450 460 470 480 IDTNDDCQKS RTPAVPRIAS RRNLFSDPSH SPTNFAQFPL TCSRETPSPH KHPLTCPRFS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"The four cdc25 genes from the nematode Caenorhabditis elegans." Ashcroft N.R., Kosinski M.E., Wickramasinghe D., Donovan P.J., Golden A. Gene 214:59-66(1998) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO081161 Genomic DNA. Translation: CCD69573.1.
PIR	B88953. T32663. T32665.
RefSeq	NP_503446.1. NM_071045.3.
3D structure databases
ProteinModelPortal	O44628.
SMR	O44628. Positions 245-370.
ModBase	Search...
Protein-protein interaction databases
STRING	6239.F16B4.8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F16B4.8; F16B4.8; F16B4.8.
GeneID	178645.
KEGG	cel:CELE_F16B4.8.
UCSC	F16B4.8. c. elegans.
Organism-specific databases
CTD	178645.
WormBase	F16B4.8; CE19796; WBGene00000387; cdc-25.2.
Phylogenomic databases
eggNOG	COG5105.
GeneTree	ENSGT00390000018747.
InParanoid	O44628.
OMA	SGICELM.
Family and domain databases
Gene3D	3.40.250.10. 1 hit.
InterPro	IPR000751. MPI_Phosphatase. IPR001763. Rhodanese-like_dom. [Graphical view]
PANTHER	PTHR10828. PTHR10828. 1 hit.
Pfam	PF00581. Rhodanese. 1 hit. [Graphical view]
PRINTS	PR00716. MPIPHPHTASE.
SMART	SM00450. RHOD. 1 hit. [Graphical view]
SUPFAM	SSF52821. Rhodanese-like. 1 hit.
PROSITE	PS50206. RHODANESE_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	901978.

Entry information

Entry name

MPIP2_CAEEL

Accession

Primary (citable) accession number: O44628

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 1, 2001
Last modified:	May 1, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project