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O44628 (MPIP2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
M-phase inducer phosphatase cdc-25.2

EC=3.1.3.48
Alternative name(s):
Cell division cycle-related protein 25.2
Gene names
Name:cdc-25.2
ORF Names:F16B4.8
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sequence similarities

Belongs to the MPI phosphatase family.

Contains 1 rhodanese domain.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Mitosis
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmitosis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 480480M-phase inducer phosphatase cdc-25.2
PRO_0000198656

Regions

Domain243 – 349107Rhodanese

Sequences

Sequence LengthMass (Da)Tools
O44628 [UniParc].

Last modified October 1, 2001. Version 2.
Checksum: 19B11B138D582FA5

FASTA48055,737
        10         20         30         40         50         60 
MNRPSQISQD VAQPLSNQHE TAMMSSDEDS MSRDSGICEL MDENTPVCFS SMSTESTTVQ 

        70         80         90        100        110        120 
VEECMEIDED ENLQPGPVSR RQKKVTFRRE KSSCQVRLFD ESPTSHKMFM RPQAPLSVRS 

       130        140        150        160        170        180 
ENQQLLQQRK RKFEKSEQSS DHFHLEPMSV EAMDDDEIVM MDQNTTKWEP GFRAPNHKKG 

       190        200        210        220        230        240 
RLTRSATAFP SLETFEEEEH EEQHHLNVKY HLKTVAKESS KGFRRITAET LRDIFFRLSE 

       250        260        270        280        290        300 
KEFDDKYILI DCRYPYEYNR GHIKNAINHF DRVTVSKIFY DENGRKRCNK IPIFYCEFSQ 

       310        320        330        340        350        360 
ARGPKMAYAL RQVDRELNVN HYPKCDYEEM YVLDLGYRNF FFAANEANIT NLCQPHAYCE 

       370        380        390        400        410        420 
MHDKEHTMEL KKYNFHNKGQ SVLRTVSMSR SFKSLPTGSA FNFVASSASF TSAPSTSTEN 

       430        440        450        460        470        480 
IDTNDDCQKS RTPAVPRIAS RRNLFSDPSH SPTNFAQFPL TCSRETPSPH KHPLTCPRFS 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"The four cdc25 genes from the nematode Caenorhabditis elegans."
Ashcroft N.R., Kosinski M.E., Wickramasinghe D., Donovan P.J., Golden A.
Gene 214:59-66(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO081161 Genomic DNA. Translation: CCD69573.1.
PIRB88953.
T32663.
T32665.
RefSeqNP_503446.1. NM_071045.3.
UniGeneCel.23180.

3D structure databases

ProteinModelPortalO44628.
SMRO44628. Positions 202-379.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.F16B4.8.

Proteomic databases

PRIDEO44628.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF16B4.8; F16B4.8; F16B4.8.
GeneID178645.
KEGGcel:CELE_F16B4.8.
UCSCF16B4.8. c. elegans.

Organism-specific databases

CTD178645.
WormBaseF16B4.8; CE19796; WBGene00000387; cdc-25.2.

Phylogenomic databases

eggNOGCOG5105.
InParanoidO44628.
OMASGICELM.
OrthoDBEOG757D02.
PhylomeDBO44628.

Family and domain databases

Gene3D3.40.250.10. 1 hit.
InterProIPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
[Graphical view]
PfamPF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSPR00716. MPIPHPHTASE.
SMARTSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMSSF52821. SSF52821. 1 hit.
PROSITEPS50206. RHODANESE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio901978.

Entry information

Entry nameMPIP2_CAEEL
AccessionPrimary (citable) accession number: O44628
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 1, 2001
Last modified: April 16, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase