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O44628

- MPIP2_CAEEL

UniProt

O44628 - MPIP2_CAEEL

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Protein

M-phase inducer phosphatase cdc-25.2

Gene

cdc-25.2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
M-phase inducer phosphatase cdc-25.2 (EC:3.1.3.48)
Alternative name(s):
Cell division cycle-related protein 25.2
Gene namesi
Name:cdc-25.2
ORF Names:F16B4.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome V

Organism-specific databases

WormBaseiF16B4.8; CE19796; WBGene00000387; cdc-25.2.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480M-phase inducer phosphatase cdc-25.2PRO_0000198656Add
BLAST

Proteomic databases

PRIDEiO44628.

Interactioni

Protein-protein interaction databases

STRINGi6239.F16B4.8.

Structurei

3D structure databases

ProteinModelPortaliO44628.
SMRiO44628. Positions 245-370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini243 – 349107RhodanesePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MPI phosphatase family.Curated
Contains 1 rhodanese domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5105.
GeneTreeiENSGT00390000018747.
InParanoidiO44628.
OMAiSGICELM.
OrthoDBiEOG757D02.
PhylomeDBiO44628.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
InterProiIPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
[Graphical view]
PfamiPF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSiPR00716. MPIPHPHTASE.
SMARTiSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O44628-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNRPSQISQD VAQPLSNQHE TAMMSSDEDS MSRDSGICEL MDENTPVCFS
60 70 80 90 100
SMSTESTTVQ VEECMEIDED ENLQPGPVSR RQKKVTFRRE KSSCQVRLFD
110 120 130 140 150
ESPTSHKMFM RPQAPLSVRS ENQQLLQQRK RKFEKSEQSS DHFHLEPMSV
160 170 180 190 200
EAMDDDEIVM MDQNTTKWEP GFRAPNHKKG RLTRSATAFP SLETFEEEEH
210 220 230 240 250
EEQHHLNVKY HLKTVAKESS KGFRRITAET LRDIFFRLSE KEFDDKYILI
260 270 280 290 300
DCRYPYEYNR GHIKNAINHF DRVTVSKIFY DENGRKRCNK IPIFYCEFSQ
310 320 330 340 350
ARGPKMAYAL RQVDRELNVN HYPKCDYEEM YVLDLGYRNF FFAANEANIT
360 370 380 390 400
NLCQPHAYCE MHDKEHTMEL KKYNFHNKGQ SVLRTVSMSR SFKSLPTGSA
410 420 430 440 450
FNFVASSASF TSAPSTSTEN IDTNDDCQKS RTPAVPRIAS RRNLFSDPSH
460 470 480
SPTNFAQFPL TCSRETPSPH KHPLTCPRFS
Length:480
Mass (Da):55,737
Last modified:October 1, 2001 - v2
Checksum:i19B11B138D582FA5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081161 Genomic DNA. Translation: CCD69573.1.
PIRiB88953.
T32663.
T32665.
RefSeqiNP_503446.1. NM_071045.3.
UniGeneiCel.23180.

Genome annotation databases

EnsemblMetazoaiF16B4.8; F16B4.8; WBGene00000387.
GeneIDi178645.
KEGGicel:CELE_F16B4.8.
UCSCiF16B4.8. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081161 Genomic DNA. Translation: CCD69573.1 .
PIRi B88953.
T32663.
T32665.
RefSeqi NP_503446.1. NM_071045.3.
UniGenei Cel.23180.

3D structure databases

ProteinModelPortali O44628.
SMRi O44628. Positions 245-370.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.F16B4.8.

Proteomic databases

PRIDEi O44628.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F16B4.8 ; F16B4.8 ; WBGene00000387 .
GeneIDi 178645.
KEGGi cel:CELE_F16B4.8.
UCSCi F16B4.8. c. elegans.

Organism-specific databases

CTDi 178645.
WormBasei F16B4.8 ; CE19796 ; WBGene00000387 ; cdc-25.2.

Phylogenomic databases

eggNOGi COG5105.
GeneTreei ENSGT00390000018747.
InParanoidi O44628.
OMAi SGICELM.
OrthoDBi EOG757D02.
PhylomeDBi O44628.

Miscellaneous databases

NextBioi 901978.

Family and domain databases

Gene3Di 3.40.250.10. 1 hit.
InterProi IPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
[Graphical view ]
Pfami PF00581. Rhodanese. 1 hit.
[Graphical view ]
PRINTSi PR00716. MPIPHPHTASE.
SMARTi SM00450. RHOD. 1 hit.
[Graphical view ]
SUPFAMi SSF52821. SSF52821. 1 hit.
PROSITEi PS50206. RHODANESE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "The four cdc25 genes from the nematode Caenorhabditis elegans."
    Ashcroft N.R., Kosinski M.E., Wickramasinghe D., Donovan P.J., Golden A.
    Gene 214:59-66(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiMPIP2_CAEEL
AccessioniPrimary (citable) accession number: O44628
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 1, 2001
Last modified: October 1, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3