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Protein

Facilitated glucose transporter homolog

Gene

R09B5.11

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Appears to have no transport activity for glucose.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-CEL-189200. Hexose transport.
R-CEL-196836. Vitamin C (ascorbate) metabolism.
R-CEL-422356. Regulation of insulin secretion.
R-CEL-428790. Facilitative Na+-independent glucose transporters.
R-CEL-5653890. Lactose synthesis.
R-CEL-6798695. Neutrophil degranulation.
R-CEL-70153. Glucose transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Facilitated glucose transporter homolog1 Publication
Gene namesi
ORF Names:R09B5.11
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiR09B5.11; CE30296; WBGene00019979.

Subcellular locationi

  • Cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47CytoplasmicSequence analysisAdd BLAST47
Transmembranei48 – 68Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini69 – 101ExtracellularSequence analysisAdd BLAST33
Transmembranei102 – 122Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini123 – 138CytoplasmicSequence analysisAdd BLAST16
Transmembranei139 – 159Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini160 – 161ExtracellularSequence analysis2
Transmembranei162 – 182Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini183 – 200CytoplasmicSequence analysisAdd BLAST18
Transmembranei201 – 221Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini222ExtracellularSequence analysis1
Transmembranei223 – 243Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini244 – 306CytoplasmicSequence analysisAdd BLAST63
Transmembranei307 – 327Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini328 – 344ExtracellularSequence analysisAdd BLAST17
Transmembranei345 – 365Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini366 – 376CytoplasmicSequence analysisAdd BLAST11
Transmembranei377 – 397Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini398 – 409ExtracellularSequence analysisAdd BLAST12
Transmembranei410 – 430Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini431 – 444CytoplasmicSequence analysisAdd BLAST14
Transmembranei445 – 465Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini466 – 471ExtracellularSequence analysis6
Transmembranei472 – 492Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini493 – 516CytoplasmicSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004251471 – 516Facilitated glucose transporter homologAdd BLAST516

Proteomic databases

EPDiO44616.
PaxDbiO44616.

Expressioni

Tissue specificityi

Expressed in seam cells from the early embryonic stage through the L2 stage (at protein level).1 Publication

Gene expression databases

BgeeiWBGene00019979.

Interactioni

Protein-protein interaction databases

STRINGi6239.R09B5.11.

Structurei

3D structure databases

ProteinModelPortaliO44616.
SMRiO44616.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
InParanoidiO44616.
OMAiFLPINNI.
OrthoDBiEOG091G0A9K.
PhylomeDBiO44616.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O44616-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAVVASQNK NDRSFSNMES ESSSNVEKSE KENHHQSLPD ENWTPFLFFC
60 70 80 90 100
ISSIALASFQ DGFQIGCINA PGPLIIDWIK KCHFELFGEV LSQYQADFIW
110 120 130 140 150
SVAVSMFSVG GMFGSFCSGF LADKFGRKST LLYNNILALL AAVCLSTSKL
160 170 180 190 200
FNFYPMIVFG RFLVGLNCGI TSGLVPMFLT ELAPANLRGK CGSFHQLNIS
210 220 230 240 250
VAIVLSQALG LPQIFGTQVG WPYIFACVAI PTFLQLATIP FCVESPKYLI
260 270 280 290 300
SKLNDREEAR RILEKLRGHT KVDEELEHMV QETMVTVEPL HQPGYVSLFK
310 320 330 340 350
GDNQWPMIVS ILMMFSQQFS GISAVTFYST LIFKRNGLSG NEPMYATVGF
360 370 380 390 400
GCIKLIATFG CLFLIDHPKF GRKRLHIAGL SGMCISSILI VITLTLSNAG
410 420 430 440 450
YHWASYMNVL FILSFVVTFA FGPGPIPWFF TSELFDSATR GRAAAVSATS
460 470 480 490 500
NWVANWMVGL TFLPINNIIH QYAFLMFTFF TFTFAIFTWK FVPETKGKSP
510
SAIRKELAFM RKRICS
Length:516
Mass (Da):57,609
Last modified:March 1, 2002 - v2
Checksum:i4152B72150088C9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081061 Genomic DNA. Translation: CCD68888.1.
PIRiC88950.
RefSeqiNP_503413.2. NM_071012.5.
UniGeneiCel.7764.

Genome annotation databases

EnsemblMetazoaiR09B5.11; R09B5.11; WBGene00019979.
GeneIDi178634.
KEGGicel:CELE_R09B5.11.
UCSCiR09B5.11. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081061 Genomic DNA. Translation: CCD68888.1.
PIRiC88950.
RefSeqiNP_503413.2. NM_071012.5.
UniGeneiCel.7764.

3D structure databases

ProteinModelPortaliO44616.
SMRiO44616.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.R09B5.11.

Proteomic databases

EPDiO44616.
PaxDbiO44616.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiR09B5.11; R09B5.11; WBGene00019979.
GeneIDi178634.
KEGGicel:CELE_R09B5.11.
UCSCiR09B5.11. c. elegans.

Organism-specific databases

CTDi178634.
WormBaseiR09B5.11; CE30296; WBGene00019979.

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
InParanoidiO44616.
OMAiFLPINNI.
OrthoDBiEOG091G0A9K.
PhylomeDBiO44616.

Enzyme and pathway databases

ReactomeiR-CEL-189200. Hexose transport.
R-CEL-196836. Vitamin C (ascorbate) metabolism.
R-CEL-422356. Regulation of insulin secretion.
R-CEL-428790. Facilitative Na+-independent glucose transporters.
R-CEL-5653890. Lactose synthesis.
R-CEL-6798695. Neutrophil degranulation.
R-CEL-70153. Glucose transport.

Miscellaneous databases

PROiO44616.

Gene expression databases

BgeeiWBGene00019979.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFGTH1_CAEEL
AccessioniPrimary (citable) accession number: O44616
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 22, 2014
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.