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Protein

Facilitated glucose transporter homolog

Gene

R09B5.11

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Appears to have no transport activity for glucose.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-CEL-189200. Hexose transport.
R-CEL-196836. Vitamin C (ascorbate) metabolism.
R-CEL-422356. Regulation of insulin secretion.
R-CEL-428790. Facilitative Na+-independent glucose transporters.
R-CEL-5653890. Lactose synthesis.
R-CEL-70153. Glucose transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Facilitated glucose transporter homolog1 Publication
Gene namesi
ORF Names:R09B5.11
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiR09B5.11; CE30296; WBGene00019979.

Subcellular locationi

  • Cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747CytoplasmicSequence analysisAdd
BLAST
Transmembranei48 – 6821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini69 – 10133ExtracellularSequence analysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini123 – 13816CytoplasmicSequence analysisAdd
BLAST
Transmembranei139 – 15921Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini160 – 1612ExtracellularSequence analysis
Transmembranei162 – 18221Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini183 – 20018CytoplasmicSequence analysisAdd
BLAST
Transmembranei201 – 22121Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini222 – 2221ExtracellularSequence analysis
Transmembranei223 – 24321Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini244 – 30663CytoplasmicSequence analysisAdd
BLAST
Transmembranei307 – 32721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini328 – 34417ExtracellularSequence analysisAdd
BLAST
Transmembranei345 – 36521Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini366 – 37611CytoplasmicSequence analysisAdd
BLAST
Transmembranei377 – 39721Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini398 – 40912ExtracellularSequence analysisAdd
BLAST
Transmembranei410 – 43021Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini431 – 44414CytoplasmicSequence analysisAdd
BLAST
Transmembranei445 – 46521Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini466 – 4716ExtracellularSequence analysis
Transmembranei472 – 49221Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini493 – 51624CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516Facilitated glucose transporter homologPRO_0000425147Add
BLAST

Proteomic databases

EPDiO44616.
PaxDbiO44616.

Expressioni

Tissue specificityi

Expressed in seam cells from the early embryonic stage through the L2 stage (at protein level).1 Publication

Interactioni

Protein-protein interaction databases

STRINGi6239.R09B5.11.

Structurei

3D structure databases

ProteinModelPortaliO44616.
SMRiO44616. Positions 44-499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
InParanoidiO44616.
OMAiFLPINNI.
OrthoDBiEOG7QVM2R.
PhylomeDBiO44616.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O44616-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAVVASQNK NDRSFSNMES ESSSNVEKSE KENHHQSLPD ENWTPFLFFC
60 70 80 90 100
ISSIALASFQ DGFQIGCINA PGPLIIDWIK KCHFELFGEV LSQYQADFIW
110 120 130 140 150
SVAVSMFSVG GMFGSFCSGF LADKFGRKST LLYNNILALL AAVCLSTSKL
160 170 180 190 200
FNFYPMIVFG RFLVGLNCGI TSGLVPMFLT ELAPANLRGK CGSFHQLNIS
210 220 230 240 250
VAIVLSQALG LPQIFGTQVG WPYIFACVAI PTFLQLATIP FCVESPKYLI
260 270 280 290 300
SKLNDREEAR RILEKLRGHT KVDEELEHMV QETMVTVEPL HQPGYVSLFK
310 320 330 340 350
GDNQWPMIVS ILMMFSQQFS GISAVTFYST LIFKRNGLSG NEPMYATVGF
360 370 380 390 400
GCIKLIATFG CLFLIDHPKF GRKRLHIAGL SGMCISSILI VITLTLSNAG
410 420 430 440 450
YHWASYMNVL FILSFVVTFA FGPGPIPWFF TSELFDSATR GRAAAVSATS
460 470 480 490 500
NWVANWMVGL TFLPINNIIH QYAFLMFTFF TFTFAIFTWK FVPETKGKSP
510
SAIRKELAFM RKRICS
Length:516
Mass (Da):57,609
Last modified:March 1, 2002 - v2
Checksum:i4152B72150088C9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081061 Genomic DNA. Translation: CCD68888.1.
PIRiC88950.
RefSeqiNP_503413.2. NM_071012.5.
UniGeneiCel.7764.

Genome annotation databases

EnsemblMetazoaiR09B5.11; R09B5.11; WBGene00019979.
GeneIDi178634.
KEGGicel:CELE_R09B5.11.
UCSCiR09B5.11. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081061 Genomic DNA. Translation: CCD68888.1.
PIRiC88950.
RefSeqiNP_503413.2. NM_071012.5.
UniGeneiCel.7764.

3D structure databases

ProteinModelPortaliO44616.
SMRiO44616. Positions 44-499.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.R09B5.11.

Proteomic databases

EPDiO44616.
PaxDbiO44616.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiR09B5.11; R09B5.11; WBGene00019979.
GeneIDi178634.
KEGGicel:CELE_R09B5.11.
UCSCiR09B5.11. c. elegans.

Organism-specific databases

CTDi178634.
WormBaseiR09B5.11; CE30296; WBGene00019979.

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
InParanoidiO44616.
OMAiFLPINNI.
OrthoDBiEOG7QVM2R.
PhylomeDBiO44616.

Enzyme and pathway databases

ReactomeiR-CEL-189200. Hexose transport.
R-CEL-196836. Vitamin C (ascorbate) metabolism.
R-CEL-422356. Regulation of insulin secretion.
R-CEL-428790. Facilitative Na+-independent glucose transporters.
R-CEL-5653890. Lactose synthesis.
R-CEL-70153. Glucose transport.

Miscellaneous databases

NextBioi901928.
PROiO44616.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.
  2. "FGT-1 is a mammalian GLUT2-like facilitative glucose transporter in Caenorhabditis elegans whose malfunction induces fat accumulation in intestinal cells."
    Kitaoka S., Morielli A.D., Zhao F.Q.
    PLoS ONE 8:E68475-E68475(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ABSENCE OF GLUCOSE TRANSPORTER ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: Bristol N21 Publication.

Entry informationi

Entry nameiFGTH1_CAEEL
AccessioniPrimary (citable) accession number: O44616
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 22, 2014
Last sequence update: March 1, 2002
Last modified: March 16, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.