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Protein
Submitted name:

LAMinin related. See also lmb

Gene

lam-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • pharynx development Source: WormBase
  • positive regulation of locomotion Source: WormBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-CEL-373752. Netrin-1 signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
LAMinin related. See also lmbImported
Gene namesi
Name:lam-1Imported
ORF Names:CELE_W03F8.5Imported, W03F8.5Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiW03F8.5a; CE47338; WBGene00002247; lam-1.

Subcellular locationi

GO - Cellular componenti

  • basement membrane Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500415836922 – 1790Sequence analysisAdd BLAST1769

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

EPDiO44565.
PaxDbiO44565.
PeptideAtlasiO44565.

Expressioni

Gene expression databases

BgeeiWBGene00002247.
ExpressionAtlasiO44565. differential.

Interactioni

Protein-protein interaction databases

STRINGi6239.W03F8.5.

Structurei

3D structure databases

SMRiO44565.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 274Laminin N-terminalInterPro annotationAdd BLAST242
Domaini275 – 343Laminin EGF-likeInterPro annotationAdd BLAST69
Domaini344 – 406Laminin EGF-likeInterPro annotationAdd BLAST63
Domaini407 – 466Laminin EGF-likeInterPro annotationAdd BLAST60
Domaini467 – 517Laminin EGF-likeInterPro annotationAdd BLAST51
Domaini518 – 559Laminin EGF-likeInterPro annotationAdd BLAST42
Domaini557 – 773Laminin IV type BInterPro annotationAdd BLAST217
Domaini779 – 826Laminin EGF-likeInterPro annotationAdd BLAST48
Domaini827 – 873Laminin EGF-likeInterPro annotationAdd BLAST47
Domaini874 – 923Laminin EGF-likeInterPro annotationAdd BLAST50
Domaini924 – 985Laminin EGF-likeInterPro annotationAdd BLAST62
Domaini986 – 1037Laminin EGF-likeInterPro annotationAdd BLAST52
Domaini1038 – 1088Laminin EGF-likeInterPro annotationAdd BLAST51
Domaini1089 – 1145Laminin EGF-likeInterPro annotationAdd BLAST57
Domaini1146 – 1192Laminin EGF-likeInterPro annotationAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1227 – 1271Sequence analysisAdd BLAST45
Coiled coili1286 – 1320Sequence analysisAdd BLAST35
Coiled coili1357 – 1395Sequence analysisAdd BLAST39
Coiled coili1476 – 1513Sequence analysisAdd BLAST38
Coiled coili1578 – 1615Sequence analysisAdd BLAST38
Coiled coili1683 – 1710Sequence analysisAdd BLAST28
Coiled coili1751 – 1778Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, Laminin EGF-like domainSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0994. Eukaryota.
ENOG410XPEG. LUCA.
GeneTreeiENSGT00780000121851.
HOGENOMiHOG000007552.
InParanoidiO44565.
KOiK05636.
OMAiCHRCECN.
OrthoDBiEOG091G009B.

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR008979. Galactose-bd-like.
IPR002049. Laminin_EGF.
IPR013015. Laminin_IV_B.
IPR008211. Laminin_N.
[Graphical view]
PfamiPF00053. Laminin_EGF. 13 hits.
PF00055. Laminin_N. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 8 hits.
SM00180. EGF_Lam. 13 hits.
SM00136. LamNT. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 9 hits.
PS01186. EGF_2. 2 hits.
PS01248. EGF_LAM_1. 11 hits.
PS50027. EGF_LAM_2. 13 hits.
PS51116. LAMININ_IVB. 1 hit.
PS51117. LAMININ_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O44565-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRPPFWLGL LLSLLLVFIE AQHPLQQNED RCQDRSCYPI TGNLLIGRKS
60 70 80 90 100
QLKATSTCGS QGRQRFCIVS HLEEQTKCFY CDSRTEWKPQ REPYRLSHRI
110 120 130 140 150
ENVVTEVMDD KNRNWYQSEN GAQNVSISFD LEAEFHFTHL IMTFKSFRPA
160 170 180 190 200
AMIIERSADF GKTWQVYRYF AYDCDSSFPG IPEGPPKKHT DVICTSQYSD
210 220 230 240 250
VAPSTGGEIV YKVISPHIVT ENPYADEIST LLKITNLRFN FTKLHTLGDD
260 270 280 290 300
LLDYRPEIDE KYYYAIYEIV VRGSCSCYGH ASRCIPIDPH VSPNTVMERA
310 320 330 340 350
DIVHGRCECM HNTEGLNCEK CKAFYNDLPW RPAIGDEKNE CRQCNCNRHA
360 370 380 390 400
LRCHFDRAVY ESSGFVSGGV CDDCMHNTQG KNCEQCKPFF YRDPRRTIDD
410 420 430 440 450
PHVCLPCECD KAGSQNKGIC EGEEDAERGL VAGKCYCKTN VDGNRCDRCK
460 470 480 490 500
NGYWNLTETN VDGCVACTCN LLGTYNNEGC DKYTGMCTCK RLVTGENCDQ
510 520 530 540 550
CLPEHYGLSE HVDGCKACDC DIGGSYDNTC EITTGQCKCR EGFSGRRCET
560 570 580 590 600
ADSSFYCADI THYVYEAEYA NLTRGEVKTR EWPSQPHEQT FTGEGFAQAV
610 620 630 640 650
EGTIITVNPI VEVSQKYNVI IRHDGARDPV GWENIQITVV RPEAEGDGSC
660 670 680 690 700
SDAPPSDDFL IARIYPGSRY IEVQPAICLE AGVQYELRIQ FNEKRGNSHP
710 720 730 740 750
QERAAANILI DSILLAPPTS ELHIFQGSAR AEQHLTEYNR YQCRHLALSL
760 770 780 790 800
SLFKDQRNEV CERYVCPIAA ALLNKTSECN CDATGSVSGI CNVQGGQCEC
810 820 830 840 850
KPNVVGRRCD QCAIGTYGFG PSGCKKCDCD AVGSLGNDCD KQSGQCVCRE
860 870 880 890 900
KGIYGRQCNQ CQPGFWGFPE CRTCQCNDHA NICDQSSGAC IECRDLTTGH
910 920 930 940 950
YCDRCQDGYY GDPRLGVGIP CKPCPCPGGP TSGYQHADTC YLRNSGNNTQ
960 970 980 990 1000
DIVCNCKSGY QGERCGECAQ NHWGSPREVG GTCERCDCNG NIDMAMEGSC
1010 1020 1030 1040 1050
DAATGECLKC LHHTEGAQCE HCVDGYYGDA KLKTCQRCVC NELGTNSTKG
1060 1070 1080 1090 1100
ACDRVSGQCP CHDNIIGMQC DQCAENHFNL ASGAGCEACG CDSNGVVLNH
1110 1120 1130 1140 1150
EGVPHLQCNI FDGQCQCKPG RGGRKCDQCE DLYWGDPTTP DGCHRCECNP
1160 1170 1180 1190 1200
TGSKSLQCHR NNGTCECQAG SGGALCNECA RGYTGQWPYC NPCGECFHQW
1210 1220 1230 1240 1250
DNIMQKLQKQ VHALIDTANN IEDTGVASAY DADFEKMEET LKETKKALSD
1260 1270 1280 1290 1300
ANISKEDIEE MSKKLALLKK QVIAGREKLG AIETRISNIT QAVDFAQKDL
1310 1320 1330 1340 1350
EHLQKEVDKV TKATIELEDK ASKIKEADVL GAFNITRESA SKSLDAQRRT
1360 1370 1380 1390 1400
DAAIGKLAAA ENQALRASEL LEKNKNDFEK QYVENEEALN EAETLLGGLE
1410 1420 1430 1440 1450
SVLPKLNEQV CGASSAPCDA LCGGPGSCGF CGGQSCMEGA VSKANQAKSF
1460 1470 1480 1490 1500
ATEADTRLDE KQKEAEEVLS IVRDVLTETT KAKAKAEKAY EVAKNTAQRA
1510 1520 1530 1540 1550
NSSRAELDKI AEEIGEFLTA QKSSPEQIRN LAEEVLGKEI SLTPDQITDL
1560 1570 1580 1590 1600
TGKIKESLAK INNIDEILNE TRGNKSIAAN LESRAVKANK EAELLQKAME
1610 1620 1630 1640 1650
EIREALQLAD QAYNNVTSVL EEIDTMQVQA RELIDKARNS TEAVEGKAQA
1660 1670 1680 1690 1700
ANTTLAELEG VMSGVKVEYL QISESAKNAL TTVDAALAAA TNAEQKNKQI
1710 1720 1730 1740 1750
QTDLERATEL LEKRMEGNVA PQQRAEKLRE RAAKLLYQAQ RHNDDIDNLS
1760 1770 1780 1790
KDSTEMRLDD YETILADLNS RLERVTRDIH EKTDFHATCG
Length:1,790
Mass (Da):197,954
Last modified:May 16, 2012 - v3
Checksum:i0BB482941EA81545
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD65512.2.
RefSeqiNP_500734.3. NM_068333.3.
UniGeneiCel.5477.

Genome annotation databases

EnsemblMetazoaiW03F8.5a; W03F8.5a; WBGene00002247.
GeneIDi177292.
KEGGicel:CELE_W03F8.5.
UCSCiW03F8.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD65512.2.
RefSeqiNP_500734.3. NM_068333.3.
UniGeneiCel.5477.

3D structure databases

SMRiO44565.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.W03F8.5.

Proteomic databases

EPDiO44565.
PaxDbiO44565.
PeptideAtlasiO44565.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiW03F8.5a; W03F8.5a; WBGene00002247.
GeneIDi177292.
KEGGicel:CELE_W03F8.5.
UCSCiW03F8.5. c. elegans.

Organism-specific databases

CTDi177292.
WormBaseiW03F8.5a; CE47338; WBGene00002247; lam-1.

Phylogenomic databases

eggNOGiKOG0994. Eukaryota.
ENOG410XPEG. LUCA.
GeneTreeiENSGT00780000121851.
HOGENOMiHOG000007552.
InParanoidiO44565.
KOiK05636.
OMAiCHRCECN.
OrthoDBiEOG091G009B.

Enzyme and pathway databases

ReactomeiR-CEL-373752. Netrin-1 signaling.

Gene expression databases

BgeeiWBGene00002247.
ExpressionAtlasiO44565. differential.

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR008979. Galactose-bd-like.
IPR002049. Laminin_EGF.
IPR013015. Laminin_IV_B.
IPR008211. Laminin_N.
[Graphical view]
PfamiPF00053. Laminin_EGF. 13 hits.
PF00055. Laminin_N. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 8 hits.
SM00180. EGF_Lam. 13 hits.
SM00136. LamNT. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 9 hits.
PS01186. EGF_2. 2 hits.
PS01248. EGF_LAM_1. 11 hits.
PS50027. EGF_LAM_2. 13 hits.
PS51116. LAMININ_IVB. 1 hit.
PS51117. LAMININ_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO44565_CAEEL
AccessioniPrimary (citable) accession number: O44565
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: May 16, 2012
Last modified: November 30, 2016
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.