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O44552

- MPIP1_CAEEL

UniProt

O44552 - MPIP1_CAEEL

Protein

M-phase inducer phosphatase cdc-25.1

Gene

cdc-25.1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: WormBase
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell proliferation Source: WormBase
    2. meiotic nuclear division Source: WormBase
    3. meiotic spindle organization Source: WormBase
    4. mitotic nuclear division Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    M-phase inducer phosphatase cdc-25.1 (EC:3.1.3.48)
    Alternative name(s):
    Cell division cycle-related protein 25.1
    Gene namesi
    Name:cdc-25.1
    ORF Names:K06A5.7
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome I

    Organism-specific databases

    WormBaseiK06A5.7; CE11778; WBGene00000386; cdc-25.1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: WormBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 604604M-phase inducer phosphatase cdc-25.1PRO_0000198655Add
    BLAST

    Proteomic databases

    PaxDbiO44552.

    Interactioni

    Protein-protein interaction databases

    BioGridi37805. 8 interactions.
    DIPiDIP-25238N.
    MINTiMINT-1048300.
    STRINGi6239.K06A5.7.2.

    Structurei

    3D structure databases

    ProteinModelPortaliO44552.
    SMRiO44552. Positions 284-437.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini305 – 413109RhodanesePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi42 – 10059Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MPI phosphatase family.Curated
    Contains 1 rhodanese domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5105.
    GeneTreeiENSGT00390000018747.
    HOGENOMiHOG000019787.
    InParanoidiO44552.
    OMAiHVEYPEM.

    Family and domain databases

    Gene3Di3.40.250.10. 1 hit.
    InterProiIPR000751. MPI_Phosphatase.
    IPR001763. Rhodanese-like_dom.
    [Graphical view]
    PfamiPF00581. Rhodanese. 1 hit.
    [Graphical view]
    PRINTSiPR00716. MPIPHPHTASE.
    SMARTiSM00450. RHOD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52821. SSF52821. 1 hit.
    PROSITEiPS50206. RHODANESE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O44552-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATTGEKAIY EDQNNVNIIE NVVDVANGIN ESPKTLFEED GSSRDSGVSM    50
    TSCSDKSDAS PEEDVDFSKL ESGRVALTDC SNFVSILQRN SSVSSSRSSS 100
    FYNYDTPTGR KMKTVFDLDS LDHSEYEKRV MSERPTDNHR KRTSSSMSPS 150
    VTLLDRKRSR NLSLVAPQSD KSCRYNGLNN PRDDPFGDED DEVFEQSNVR 200
    NSQVQNTSIF AQPAPRTATS LWDLAPPMFF ERKTSDTSGN GSFQERPKQI 250
    LRAMSVGEID SELPPTLEVK YTLPGVDNPQ RESQAFRSIS PTTLLLEFQR 300
    LGDDFDKKYI IVDCRFPFEY KGGHVKGAIN LFRHDKIKPI FFPENGEASS 350
    FQNRVPIFYC EYSQKRGPTM AHAVRSIDRV LNELRYPHVE YPEMYLLDYG 400
    YKSLWSTAEC RQICEPCSYI PMTHSSFSME FKSARLERHH SMASLKPNGE 450
    TSHREEKKKR CTRSVIRRNN SSLNMLSRSS SALTSTGSKT SSMENILYGL 500
    DDERRPKWVS AFDIQSTESE NDLDAALIYQ RNISSNASNA SSIVNLAEER 550
    IVQLGLQVIT PDFPDRPSES SSTTPAGEHL PLGEGGHQIP CGILDFSSIS 600
    DDAE 604
    Length:604
    Mass (Da):67,892
    Last modified:June 1, 1998 - v1
    Checksum:i70721C95FA9F40DC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080960 Genomic DNA. Translation: CCD68116.1.
    PIRiT15091.
    RefSeqiNP_491862.1. NM_059461.3.
    UniGeneiCel.17290.

    Genome annotation databases

    EnsemblMetazoaiK06A5.7.1; K06A5.7.1; WBGene00000386.
    K06A5.7.2; K06A5.7.2; WBGene00000386.
    GeneIDi172353.
    KEGGicel:CELE_K06A5.7.
    UCSCiK06A5.7.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080960 Genomic DNA. Translation: CCD68116.1 .
    PIRi T15091.
    RefSeqi NP_491862.1. NM_059461.3.
    UniGenei Cel.17290.

    3D structure databases

    ProteinModelPortali O44552.
    SMRi O44552. Positions 284-437.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 37805. 8 interactions.
    DIPi DIP-25238N.
    MINTi MINT-1048300.
    STRINGi 6239.K06A5.7.2.

    Proteomic databases

    PaxDbi O44552.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai K06A5.7.1 ; K06A5.7.1 ; WBGene00000386 .
    K06A5.7.2 ; K06A5.7.2 ; WBGene00000386 .
    GeneIDi 172353.
    KEGGi cel:CELE_K06A5.7.
    UCSCi K06A5.7.1. c. elegans.

    Organism-specific databases

    CTDi 172353.
    WormBasei K06A5.7 ; CE11778 ; WBGene00000386 ; cdc-25.1.

    Phylogenomic databases

    eggNOGi COG5105.
    GeneTreei ENSGT00390000018747.
    HOGENOMi HOG000019787.
    InParanoidi O44552.
    OMAi HVEYPEM.

    Miscellaneous databases

    NextBioi 875165.

    Family and domain databases

    Gene3Di 3.40.250.10. 1 hit.
    InterProi IPR000751. MPI_Phosphatase.
    IPR001763. Rhodanese-like_dom.
    [Graphical view ]
    Pfami PF00581. Rhodanese. 1 hit.
    [Graphical view ]
    PRINTSi PR00716. MPIPHPHTASE.
    SMARTi SM00450. RHOD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52821. SSF52821. 1 hit.
    PROSITEi PS50206. RHODANESE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "The four cdc25 genes from the nematode Caenorhabditis elegans."
      Ashcroft N.R., Kosinski M.E., Wickramasinghe D., Donovan P.J., Golden A.
      Gene 214:59-66(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiMPIP1_CAEEL
    AccessioniPrimary (citable) accession number: O44552
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3