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O44552

- MPIP1_CAEEL

UniProt

O44552 - MPIP1_CAEEL

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Protein

M-phase inducer phosphatase cdc-25.1

Gene

cdc-25.1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: WormBase
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell proliferation Source: WormBase
  2. meiotic nuclear division Source: WormBase
  3. meiotic spindle organization Source: WormBase
  4. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiREACT_218111. Polo-like kinase mediated events.
REACT_218728. Cyclin A/B1 associated events during G2/M transition.
REACT_230732. G0 and Early G1.
REACT_234286. E2F-enabled inhibition of pre-replication complex formation.
REACT_238173. Activation of ATR in response to replication stress.
REACT_244835. Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.
REACT_250477. Cyclin B2 mediated events.
REACT_250616. Cyclin A:Cdk2-associated events at S phase entry.
REACT_263599. p53-Independent DNA Damage Response.
REACT_263687. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.

Names & Taxonomyi

Protein namesi
Recommended name:
M-phase inducer phosphatase cdc-25.1 (EC:3.1.3.48)
Alternative name(s):
Cell division cycle-related protein 25.1
Gene namesi
Name:cdc-25.1
ORF Names:K06A5.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiK06A5.7; CE11778; WBGene00000386; cdc-25.1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 604604M-phase inducer phosphatase cdc-25.1PRO_0000198655Add
BLAST

Proteomic databases

PaxDbiO44552.

Interactioni

Protein-protein interaction databases

BioGridi37805. 8 interactions.
DIPiDIP-25238N.
MINTiMINT-1048300.
STRINGi6239.K06A5.7.2.

Structurei

3D structure databases

ProteinModelPortaliO44552.
SMRiO44552. Positions 284-437.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini305 – 413109RhodanesePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi42 – 10059Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the MPI phosphatase family.Curated
Contains 1 rhodanese domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5105.
GeneTreeiENSGT00390000018747.
HOGENOMiHOG000019787.
InParanoidiO44552.
OMAiHVEYPEM.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
InterProiIPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
[Graphical view]
PfamiPF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSiPR00716. MPIPHPHTASE.
SMARTiSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O44552-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATTGEKAIY EDQNNVNIIE NVVDVANGIN ESPKTLFEED GSSRDSGVSM
60 70 80 90 100
TSCSDKSDAS PEEDVDFSKL ESGRVALTDC SNFVSILQRN SSVSSSRSSS
110 120 130 140 150
FYNYDTPTGR KMKTVFDLDS LDHSEYEKRV MSERPTDNHR KRTSSSMSPS
160 170 180 190 200
VTLLDRKRSR NLSLVAPQSD KSCRYNGLNN PRDDPFGDED DEVFEQSNVR
210 220 230 240 250
NSQVQNTSIF AQPAPRTATS LWDLAPPMFF ERKTSDTSGN GSFQERPKQI
260 270 280 290 300
LRAMSVGEID SELPPTLEVK YTLPGVDNPQ RESQAFRSIS PTTLLLEFQR
310 320 330 340 350
LGDDFDKKYI IVDCRFPFEY KGGHVKGAIN LFRHDKIKPI FFPENGEASS
360 370 380 390 400
FQNRVPIFYC EYSQKRGPTM AHAVRSIDRV LNELRYPHVE YPEMYLLDYG
410 420 430 440 450
YKSLWSTAEC RQICEPCSYI PMTHSSFSME FKSARLERHH SMASLKPNGE
460 470 480 490 500
TSHREEKKKR CTRSVIRRNN SSLNMLSRSS SALTSTGSKT SSMENILYGL
510 520 530 540 550
DDERRPKWVS AFDIQSTESE NDLDAALIYQ RNISSNASNA SSIVNLAEER
560 570 580 590 600
IVQLGLQVIT PDFPDRPSES SSTTPAGEHL PLGEGGHQIP CGILDFSSIS

DDAE
Length:604
Mass (Da):67,892
Last modified:June 1, 1998 - v1
Checksum:i70721C95FA9F40DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080960 Genomic DNA. Translation: CCD68116.1.
PIRiT15091.
RefSeqiNP_491862.1. NM_059461.3.
UniGeneiCel.17290.

Genome annotation databases

EnsemblMetazoaiK06A5.7.1; K06A5.7.1; WBGene00000386.
K06A5.7.2; K06A5.7.2; WBGene00000386.
GeneIDi172353.
KEGGicel:CELE_K06A5.7.
UCSCiK06A5.7.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080960 Genomic DNA. Translation: CCD68116.1 .
PIRi T15091.
RefSeqi NP_491862.1. NM_059461.3.
UniGenei Cel.17290.

3D structure databases

ProteinModelPortali O44552.
SMRi O44552. Positions 284-437.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 37805. 8 interactions.
DIPi DIP-25238N.
MINTi MINT-1048300.
STRINGi 6239.K06A5.7.2.

Proteomic databases

PaxDbi O44552.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai K06A5.7.1 ; K06A5.7.1 ; WBGene00000386 .
K06A5.7.2 ; K06A5.7.2 ; WBGene00000386 .
GeneIDi 172353.
KEGGi cel:CELE_K06A5.7.
UCSCi K06A5.7.1. c. elegans.

Organism-specific databases

CTDi 172353.
WormBasei K06A5.7 ; CE11778 ; WBGene00000386 ; cdc-25.1.

Phylogenomic databases

eggNOGi COG5105.
GeneTreei ENSGT00390000018747.
HOGENOMi HOG000019787.
InParanoidi O44552.
OMAi HVEYPEM.

Enzyme and pathway databases

Reactomei REACT_218111. Polo-like kinase mediated events.
REACT_218728. Cyclin A/B1 associated events during G2/M transition.
REACT_230732. G0 and Early G1.
REACT_234286. E2F-enabled inhibition of pre-replication complex formation.
REACT_238173. Activation of ATR in response to replication stress.
REACT_244835. Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.
REACT_250477. Cyclin B2 mediated events.
REACT_250616. Cyclin A:Cdk2-associated events at S phase entry.
REACT_263599. p53-Independent DNA Damage Response.
REACT_263687. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.

Miscellaneous databases

NextBioi 875165.

Family and domain databases

Gene3Di 3.40.250.10. 1 hit.
InterProi IPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
[Graphical view ]
Pfami PF00581. Rhodanese. 1 hit.
[Graphical view ]
PRINTSi PR00716. MPIPHPHTASE.
SMARTi SM00450. RHOD. 1 hit.
[Graphical view ]
SUPFAMi SSF52821. SSF52821. 1 hit.
PROSITEi PS50206. RHODANESE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "The four cdc25 genes from the nematode Caenorhabditis elegans."
    Ashcroft N.R., Kosinski M.E., Wickramasinghe D., Donovan P.J., Golden A.
    Gene 214:59-66(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiMPIP1_CAEEL
AccessioniPrimary (citable) accession number: O44552
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 1998
Last modified: November 26, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3