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O44552 (MPIP1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
M-phase inducer phosphatase cdc-25.1

EC=3.1.3.48
Alternative name(s):
Cell division cycle-related protein 25.1
Gene names
Name:cdc-25.1
ORF Names:K06A5.7
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length604 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sequence similarities

Belongs to the MPI phosphatase family.

Contains 1 rhodanese domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 604604M-phase inducer phosphatase cdc-25.1
PRO_0000198655

Regions

Domain305 – 413109Rhodanese
Compositional bias42 – 10059Ser-rich

Sequences

Sequence LengthMass (Da)Tools
O44552 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 70721C95FA9F40DC

FASTA60467,892
        10         20         30         40         50         60 
MATTGEKAIY EDQNNVNIIE NVVDVANGIN ESPKTLFEED GSSRDSGVSM TSCSDKSDAS 

        70         80         90        100        110        120 
PEEDVDFSKL ESGRVALTDC SNFVSILQRN SSVSSSRSSS FYNYDTPTGR KMKTVFDLDS 

       130        140        150        160        170        180 
LDHSEYEKRV MSERPTDNHR KRTSSSMSPS VTLLDRKRSR NLSLVAPQSD KSCRYNGLNN 

       190        200        210        220        230        240 
PRDDPFGDED DEVFEQSNVR NSQVQNTSIF AQPAPRTATS LWDLAPPMFF ERKTSDTSGN 

       250        260        270        280        290        300 
GSFQERPKQI LRAMSVGEID SELPPTLEVK YTLPGVDNPQ RESQAFRSIS PTTLLLEFQR 

       310        320        330        340        350        360 
LGDDFDKKYI IVDCRFPFEY KGGHVKGAIN LFRHDKIKPI FFPENGEASS FQNRVPIFYC 

       370        380        390        400        410        420 
EYSQKRGPTM AHAVRSIDRV LNELRYPHVE YPEMYLLDYG YKSLWSTAEC RQICEPCSYI 

       430        440        450        460        470        480 
PMTHSSFSME FKSARLERHH SMASLKPNGE TSHREEKKKR CTRSVIRRNN SSLNMLSRSS 

       490        500        510        520        530        540 
SALTSTGSKT SSMENILYGL DDERRPKWVS AFDIQSTESE NDLDAALIYQ RNISSNASNA 

       550        560        570        580        590        600 
SSIVNLAEER IVQLGLQVIT PDFPDRPSES SSTTPAGEHL PLGEGGHQIP CGILDFSSIS 


DDAE 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"The four cdc25 genes from the nematode Caenorhabditis elegans."
Ashcroft N.R., Kosinski M.E., Wickramasinghe D., Donovan P.J., Golden A.
Gene 214:59-66(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO080960 Genomic DNA. Translation: CCD68116.1.
PIRT15091.
RefSeqNP_491862.1. NM_059461.3.
UniGeneCel.17290.

3D structure databases

ProteinModelPortalO44552.
SMRO44552. Positions 284-437.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid37805. 8 interactions.
DIPDIP-25238N.
MINTMINT-1048300.
STRING6239.K06A5.7.2.

Proteomic databases

PaxDbO44552.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaK06A5.7.1; K06A5.7.1; WBGene00000386.
K06A5.7.2; K06A5.7.2; WBGene00000386.
GeneID172353.
KEGGcel:CELE_K06A5.7.
UCSCK06A5.7.1. c. elegans.

Organism-specific databases

CTD172353.
WormBaseK06A5.7; CE11778; WBGene00000386; cdc-25.1.

Phylogenomic databases

eggNOGCOG5105.
GeneTreeENSGT00390000018747.
HOGENOMHOG000019787.
InParanoidO44552.
OMAHVEYPEM.

Family and domain databases

Gene3D3.40.250.10. 1 hit.
InterProIPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
[Graphical view]
PfamPF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSPR00716. MPIPHPHTASE.
SMARTSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMSSF52821. SSF52821. 1 hit.
PROSITEPS50206. RHODANESE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio875165.

Entry information

Entry nameMPIP1_CAEEL
AccessionPrimary (citable) accession number: O44552
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 1998
Last modified: June 11, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase