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Protein

Cytoplasmic FMR1-interacting protein homolog

Gene

gex-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for initial steps of body morphogenesis (PubMed:11877381). May play a role in egg laying and yolk protein clatherin-mediated endocytosis by oocytes during oogenesis (PubMed:19798448).2 Publications

GO - Biological processi

  • cell migration Source: UniProtKB
  • embryonic body morphogenesis Source: UniProtKB
  • positive regulation of clathrin-dependent endocytosis Source: UniProtKB
  • positive regulation of oviposition Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Enzyme and pathway databases

ReactomeiR-CEL-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-CEL-5663213. RHO GTPases Activate WASPs and WAVEs.
R-CEL-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic FMR1-interacting protein homolog
Alternative name(s):
Gut on exterior protein 2
Gene namesi
Name:gex-2Imported
ORF Names:F56A11.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF56A11.1; CE31351; WBGene00001579; gex-2.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: WormBase
  • SCAR complex Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Worms display embryonic lethality with cells differentiating, but failing to become organized (PubMed:11877381). The external hypodermal cells fail to spread over and enclose the embryo, but instead cluster on the dorsal side (PubMed:11877381). RNAi-mediated knockdown results in reduced egg laying and in defective endocytosis by oocytes characterized by an accumulation of aggregated yolk protein in the pseudocoelomatic space (PubMed:19798448).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002797131 – 1262Cytoplasmic FMR1-interacting protein homologAdd BLAST1262

Proteomic databases

EPDiO44518.
PaxDbiO44518.
PeptideAtlasiO44518.
PRIDEiO44518.

Expressioni

Gene expression databases

BgeeiWBGene00001579.

Interactioni

Subunit structurei

Interacts with gex-3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
gex-3P551634EBI-1570205,EBI-1570181

Protein-protein interaction databases

IntActiO44518. 1 interactor.
STRINGi6239.F56A11.1.

Structurei

3D structure databases

ProteinModelPortaliO44518.
SMRiO44518.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CYFIP family.Sequence analysis

Phylogenomic databases

eggNOGiKOG3534. Eukaryota.
ENOG410XPKW. LUCA.
GeneTreeiENSGT00500000044831.
HOGENOMiHOG000272573.
InParanoidiO44518.
KOiK05749.
OMAiCPLEDKT.
OrthoDBiEOG091G0105.
PhylomeDBiO44518.

Family and domain databases

InterProiIPR008081. Cytoplasmic_FMR1-int.
IPR009828. DUF1394.
[Graphical view]
PANTHERiPTHR12195. PTHR12195. 1 hit.
PfamiPF07159. DUF1394. 1 hit.
PF05994. FragX_IP. 1 hit.
[Graphical view]
PIRSFiPIRSF008153. FMR1_interacting. 1 hit.
PRINTSiPR01698. CYTOFMRPINTP.

Sequencei

Sequence statusi: Complete.

O44518-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNANVTVDDA ISNVNLLDTL AIPDDLPDIE ARALPLLYRS NFDTNFEDRS
60 70 80 90 100
AFVTGIAKYS EEATRHAQFN DMLSEGLQHA ANMYTWRCCS RAVPMAKSND
110 120 130 140 150
QPNRTEINEM VVEVLKPEVS KLGSFMRFTL TAIQRFCEEV RRLCHSEKRR
160 170 180 190 200
DFVSEAYLLT LGRFINMFAV LDELKNMKAS IKNDFSTFRR ASQFLTAMSD
210 220 230 240 250
TQAVHDMQNL SMFLATQNKI KDDLKLQMKT IEGYEELLCD VVNICAHMYE
260 270 280 290 300
HQLYLSPNEK HMFVKVIAFS LFLMDGDAAN VAKLDQKKRL SISRLDKIFK
310 320 330 340 350
TLEVVPLYGD MQIQPFAFVR RSSHYEPSKW PLSDKESDRC HVNIVEKVQS
360 370 380 390 400
IRSDHESYVT QFAKINNEVA ICDRPGNDSE NREITSLALS GIQLLCQWSC
410 420 430 440 450
AVVETISWKL LNPTNPKDNR ECPENAEEYE RATRYNYSPA EKTALIQIIA
460 470 480 490 500
MIKGLQSMLG KTESDMSNST RKCVYVELQA FIHHTINEPL QKAVKHKKDL
510 520 530 540 550
LASILQSVKD SISDAGNELN RMTDVKGKKK SSAPKGDSAN SSSSDIRIPR
560 570 580 590 600
RTAAPGSTQL YMARTQLESL ISDKLCGGKK ILRKELDSKT IEKISVFLRK
610 620 630 640 650
SAHWPALFRL SDSMTEAGEL SQLWFREFYL EMTMGQRIQF PIEMSMPWIL
660 670 680 690 700
TDYILSCNEP SLIESALYQL DLYNDAAQYS LFNFNKQFLY DEVEAEVNLC
710 720 730 740 750
FDQFVYKLSE MVFTHYKQLA SCMLLDKRFK AEILRSGTMI RSPSAARFES
760 770 780 790 800
LLQQRHVQLL GRSVDLNRVV SQRVNMALLK ALDAAIWKFE SEPLSSIVEL
810 820 830 840 850
DMLIDTNRLC HTLLSDVLHS IAPFDDLFQE ANHAVNSPHG RITLHVFWEL
860 870 880 890 900
NYDFVPNFVY NGSTHRFVRA RHVFRKTPAR EKPPQVGQVY YWGSKSLMAA
910 920 930 940 950
FMNICNAYSQ CIGTQHLKAI TRLLHYQGIA VILDELLKMT NRLLNDKIRR
960 970 980 990 1000
HVRNVFNMMP KVCKLPRSDY GSNALLQYYV HHLEAVGKYP ELKSEFCQDL
1010 1020 1030 1040 1050
RELGNMIVFC QQLEVALGQE EAHDLFLAAA YTGTVPQPPA RNAQEQMKQL
1060 1070 1080 1090 1100
AKLEDKYSRI HLTEIIDKIS PDDGQAAIAK DAELMTKERL CCGLNAFENF
1110 1120 1130 1140 1150
LVRIKQMLAA DDIWTGGYPT NGVFWIDECV EWYRVYSALQ FFLCQPTRDD
1160 1170 1180 1190 1200
NEVYAEELFG DSLQWGGLTL ITLLGQHRRF EVLDFCYHLH RVNKADGKDE
1210 1220 1230 1240 1250
VISGIRLAKM VERIRRFQLL NNQIFIILEN QLNENNDDPN ERVREFAPPV
1260
HPNYANHAAR RQ
Length:1,262
Mass (Da):145,013
Last modified:October 1, 2002 - v4
Checksum:i34FBE7B43260A188
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073209 mRNA. Translation: BAB70472.1.
FO080624 Genomic DNA. Translation: CCD65256.1.
PIRiT32647.
RefSeqiNP_499949.2. NM_067548.4.
UniGeneiCel.6538.

Genome annotation databases

EnsemblMetazoaiF56A11.1; F56A11.1; WBGene00001579.
GeneIDi176885.
KEGGicel:CELE_F56A11.1.
UCSCiF56A11.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073209 mRNA. Translation: BAB70472.1.
FO080624 Genomic DNA. Translation: CCD65256.1.
PIRiT32647.
RefSeqiNP_499949.2. NM_067548.4.
UniGeneiCel.6538.

3D structure databases

ProteinModelPortaliO44518.
SMRiO44518.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO44518. 1 interactor.
STRINGi6239.F56A11.1.

Proteomic databases

EPDiO44518.
PaxDbiO44518.
PeptideAtlasiO44518.
PRIDEiO44518.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF56A11.1; F56A11.1; WBGene00001579.
GeneIDi176885.
KEGGicel:CELE_F56A11.1.
UCSCiF56A11.1. c. elegans.

Organism-specific databases

CTDi176885.
WormBaseiF56A11.1; CE31351; WBGene00001579; gex-2.

Phylogenomic databases

eggNOGiKOG3534. Eukaryota.
ENOG410XPKW. LUCA.
GeneTreeiENSGT00500000044831.
HOGENOMiHOG000272573.
InParanoidiO44518.
KOiK05749.
OMAiCPLEDKT.
OrthoDBiEOG091G0105.
PhylomeDBiO44518.

Enzyme and pathway databases

ReactomeiR-CEL-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-CEL-5663213. RHO GTPases Activate WASPs and WAVEs.
R-CEL-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiO44518.

Gene expression databases

BgeeiWBGene00001579.

Family and domain databases

InterProiIPR008081. Cytoplasmic_FMR1-int.
IPR009828. DUF1394.
[Graphical view]
PANTHERiPTHR12195. PTHR12195. 1 hit.
PfamiPF07159. DUF1394. 1 hit.
PF05994. FragX_IP. 1 hit.
[Graphical view]
PIRSFiPIRSF008153. FMR1_interacting. 1 hit.
PRINTSiPR01698. CYTOFMRPINTP.
ProtoNetiSearch...

Entry informationi

Entry nameiCYFIP_CAEEL
AccessioniPrimary (citable) accession number: O44518
Secondary accession number(s): Q95YG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 103 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.