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Protein

Cytochrome b-c1 complex subunit Rieske, mitochondrial

Gene

isp-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.UniRule annotation

Miscellaneous

The Rieske protein is a high potential 2Fe-2S protein.UniRule annotation

Catalytic activityi

Quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+.UniRule annotation

Cofactori

[2Fe-2S] clusterUniRule annotationNote: Binds 1 [2Fe-2S] cluster per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • mitochondrial electron transport, ubiquinol to cytochrome c Source: WormBase
  • negative regulation of gene expression Source: UniProtKB
  • negative regulation of protein phosphorylation Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of nematode larval development Source: UniProtKB
  • positive regulation of protein phosphorylation Source: UniProtKB

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transport, Respiratory chainUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit Rieske, mitochondrialUniRule annotation (EC:1.10.2.2UniRule annotation)
Gene namesi
Name:isp-1Imported
ORF Names:CELE_F42G8.12Imported, F42G8.12Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF42G8.12 ; CE17071 ; WBGene00002162 ; isp-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MitochondrionUniRule annotation

PTM / Processingi

Proteomic databases

EPDiO44512
PaxDbiO44512
PeptideAtlasiO44512

2D gel databases

World-2DPAGEi0011:O44512

Expressioni

Gene expression databases

BgeeiWBGene00002162

Interactioni

Protein-protein interaction databases

DIPiDIP-24805N
STRINGi6239.F42G8.12.2

Structurei

3D structure databases

ProteinModelPortaliO44512
SMRiO44512
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini205 – 273RieskeInterPro annotationAdd BLAST69

Phylogenomic databases

eggNOGiKOG1671 Eukaryota
COG0723 LUCA
GeneTreeiENSGT00390000001014
HOGENOMiHOG000255193
InParanoidiO44512
KOiK00411
OMAiERKAFSY
OrthoDBiEOG091G0MOP
PhylomeDBiO44512

Family and domain databases

Gene3Di1.20.5.270, 1 hit
2.102.10.10, 1 hit
InterProiView protein in InterPro
IPR037008 bc1_Rieske_TM_sf
IPR017941 Rieske_2Fe-2S
IPR036922 Rieske_2Fe-2S_sf
IPR014349 Rieske_Fe-S_prot
IPR005805 Rieske_Fe-S_prot_C
IPR004192 Rieske_TM
IPR006317 Ubiquinol_cyt_c_Rdtase_Fe-S-su
PANTHERiPTHR10134 PTHR10134, 1 hit
PfamiView protein in Pfam
PF00355 Rieske, 1 hit
PF02921 UCR_TM, 1 hit
PRINTSiPR00162 RIESKE
SUPFAMiSSF50022 SSF50022, 1 hit
TIGRFAMsiTIGR01416 Rieske_proteo, 1 hit
PROSITEiView protein in PROSITE
PS51296 RIESKE, 1 hit

Sequencei

Sequence statusi: Complete.

O44512-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLARSGGF AVKVISGSQQ HVNFVAATPA ADNVAAFRDV PAEFSTAEAR
60 70 80 90 100
QAAVSHSTGG VFTNGLAVKG INVTSRRLAH TDVTFPDMSN YRRDSTKNTQ
110 120 130 140 150
VPARDTEDQR RALPTALYYG AGGVLSLWAG KEVVQTLVSY KAMAADQRAL
160 170 180 190 200
ASIEINMADI PEGKTKTFEW RGKPVFVKHR TKAEIAKEKA VPVADLRHPQ
210 220 230 240 250
HDDERVQKDE WSVVIGVCTH LGCVPIADAG DYGGYYCPCH GSHYDASGRI
260 270
RKGPAPLNLH VPAYSFKDAT IVIGSS
Length:276
Mass (Da):29,710
Last modified:June 1, 1998 - v1
Checksum:i19E40B12F6EFDBF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CCD61411.1
PIRiT32640
RefSeqiNP_501361.1, NM_068960.3
UniGeneiCel.8806

Genome annotation databases

EnsemblMetazoaiF42G8.12; F42G8.12; WBGene00002162
GeneIDi177609
KEGGicel:CELE_F42G8.12
UCSCiF42G8.12.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiO44512_CAEEL
AccessioniPrimary (citable) accession number: O44512
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health