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Protein

Cytochrome b-c1 complex subunit Rieske, mitochondrial

Gene

isp-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.UniRule annotation

Catalytic activityi

Quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+.UniRule annotation

Cofactori

[2Fe-2S] clusterUniRule annotationNote: Binds 1 [2Fe-2S] cluster per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • mitochondrial electron transport, ubiquinol to cytochrome c Source: WormBase
  • negative regulation of gene expression Source: UniProtKB
  • negative regulation of protein phosphorylation Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of nematode larval development Source: UniProtKB
  • positive regulation of protein phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotation, Transport

Keywords - Ligandi

2Fe-2SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit Rieske, mitochondrialUniRule annotation (EC:1.10.2.2UniRule annotation)
Gene namesi
Name:isp-1Imported
ORF Names:CELE_F42G8.12Imported, F42G8.12Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF42G8.12; CE17071; WBGene00002162; isp-1.

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MitochondrionUniRule annotation

PTM / Processingi

Proteomic databases

EPDiO44512.
PaxDbiO44512.
PeptideAtlasiO44512.

2D gel databases

World-2DPAGE0011:O44512.

Expressioni

Gene expression databases

BgeeiWBGene00002162.

Interactioni

Protein-protein interaction databases

DIPiDIP-24805N.
MINTiMINT-1101815.
STRINGi6239.F42G8.12.2.

Structurei

3D structure databases

ProteinModelPortaliO44512.
SMRiO44512.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini205 – 273RieskeInterPro annotationAdd BLAST69

Sequence similaritiesi

Contains 1 Rieske domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG1671. Eukaryota.
COG0723. LUCA.
GeneTreeiENSGT00390000001014.
HOGENOMiHOG000255193.
InParanoidiO44512.
KOiK00411.
OMAiPFYEFPD.
OrthoDBiEOG091G0MOP.
PhylomeDBiO44512.

Family and domain databases

Gene3Di1.20.5.270. 1 hit.
2.102.10.10. 1 hit.
InterProiIPR017941. Rieske_2Fe-2S.
IPR014349. Rieske_Fe-S_prot.
IPR005805. Rieske_Fe-S_prot_C.
IPR006317. Ubiquinol_cyt_c_Rdtase_Fe-S-su.
IPR004192. Ubiquinol_cyt_Rdtase_TM.
[Graphical view]
PANTHERiPTHR10134. PTHR10134. 1 hit.
PfamiPF00355. Rieske. 1 hit.
PF02921. UCR_TM. 1 hit.
[Graphical view]
PRINTSiPR00162. RIESKE.
SUPFAMiSSF50022. SSF50022. 1 hit.
TIGRFAMsiTIGR01416. Rieske_proteo. 1 hit.
PROSITEiPS51296. RIESKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O44512-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLARSGGF AVKVISGSQQ HVNFVAATPA ADNVAAFRDV PAEFSTAEAR
60 70 80 90 100
QAAVSHSTGG VFTNGLAVKG INVTSRRLAH TDVTFPDMSN YRRDSTKNTQ
110 120 130 140 150
VPARDTEDQR RALPTALYYG AGGVLSLWAG KEVVQTLVSY KAMAADQRAL
160 170 180 190 200
ASIEINMADI PEGKTKTFEW RGKPVFVKHR TKAEIAKEKA VPVADLRHPQ
210 220 230 240 250
HDDERVQKDE WSVVIGVCTH LGCVPIADAG DYGGYYCPCH GSHYDASGRI
260 270
RKGPAPLNLH VPAYSFKDAT IVIGSS
Length:276
Mass (Da):29,710
Last modified:June 1, 1998 - v1
Checksum:i19E40B12F6EFDBF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD61411.1.
PIRiT32640.
RefSeqiNP_501361.1. NM_068960.3.
UniGeneiCel.8806.

Genome annotation databases

EnsemblMetazoaiF42G8.12; F42G8.12; WBGene00002162.
GeneIDi177609.
KEGGicel:CELE_F42G8.12.
UCSCiF42G8.12.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD61411.1.
PIRiT32640.
RefSeqiNP_501361.1. NM_068960.3.
UniGeneiCel.8806.

3D structure databases

ProteinModelPortaliO44512.
SMRiO44512.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-24805N.
MINTiMINT-1101815.
STRINGi6239.F42G8.12.2.

2D gel databases

World-2DPAGE0011:O44512.

Proteomic databases

EPDiO44512.
PaxDbiO44512.
PeptideAtlasiO44512.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF42G8.12; F42G8.12; WBGene00002162.
GeneIDi177609.
KEGGicel:CELE_F42G8.12.
UCSCiF42G8.12.1. c. elegans.

Organism-specific databases

CTDi177609.
WormBaseiF42G8.12; CE17071; WBGene00002162; isp-1.

Phylogenomic databases

eggNOGiKOG1671. Eukaryota.
COG0723. LUCA.
GeneTreeiENSGT00390000001014.
HOGENOMiHOG000255193.
InParanoidiO44512.
KOiK00411.
OMAiPFYEFPD.
OrthoDBiEOG091G0MOP.
PhylomeDBiO44512.

Gene expression databases

BgeeiWBGene00002162.

Family and domain databases

Gene3Di1.20.5.270. 1 hit.
2.102.10.10. 1 hit.
InterProiIPR017941. Rieske_2Fe-2S.
IPR014349. Rieske_Fe-S_prot.
IPR005805. Rieske_Fe-S_prot_C.
IPR006317. Ubiquinol_cyt_c_Rdtase_Fe-S-su.
IPR004192. Ubiquinol_cyt_Rdtase_TM.
[Graphical view]
PANTHERiPTHR10134. PTHR10134. 1 hit.
PfamiPF00355. Rieske. 1 hit.
PF02921. UCR_TM. 1 hit.
[Graphical view]
PRINTSiPR00162. RIESKE.
SUPFAMiSSF50022. SSF50022. 1 hit.
TIGRFAMsiTIGR01416. Rieske_proteo. 1 hit.
PROSITEiPS51296. RIESKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO44512_CAEEL
AccessioniPrimary (citable) accession number: O44512
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The Rieske protein is a high potential 2Fe-2S protein.UniRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.