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Protein

Probable mitochondrial import inner membrane translocase subunit Tim17

Gene

tim-17

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.By similarity

GO - Molecular functioni

  1. P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. intracellular protein transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_183227. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mitochondrial import inner membrane translocase subunit Tim17
Gene namesi
Name:tim-17
ORF Names:E04A4.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiE04A4.5; CE16966; WBGene00017119.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence AnalysisAdd
BLAST
Transmembranei61 – 8121HelicalSequence AnalysisAdd
BLAST
Transmembranei109 – 12921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane presequence translocase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Probable mitochondrial import inner membrane translocase subunit Tim17PRO_0000210289Add
BLAST

Proteomic databases

PaxDbiO44477.

Interactioni

Subunit structurei

Component of the TIM23 complex at least composed of tim-23, tim-17 and tim-50. The complex interacts with the tim-44 component of the PAM complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi6239.E04A4.5.

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5596.
GeneTreeiENSGT00390000017780.
HOGENOMiHOG000183190.
InParanoidiO44477.
KOiK17795.
OMAiTIDCSLV.
PhylomeDBiO44477.

Family and domain databases

InterProiIPR005678. Tim17.
IPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00980. 3a0801so1tim17. 1 hit.

Sequencei

Sequence statusi: Complete.

O44477-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEYTREPCP YRIGDDIGSA FAMGLVGGSI FQAFGGYKNA AKGKKLVGMM
60 70 80 90 100
REVRMRSTLT GVQFAAWGGM FSTIDCCLVA IRKKEDPINS IVSGGLTGAL
110 120 130 140 150
LAIRSGPKVM AGSAILGSVI LAMIEGVGLV TTRWMGAMMD PTQPPPEALD
160 170 180
DPRSLGQKSQ AEPGLDQTRP FGIPTGLPNL S
Length:181
Mass (Da):19,096
Last modified:June 1, 1998 - v1
Checksum:i505D8F8CB2BBE9DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081039 Genomic DNA. Translation: CCD68707.1.
PIRiT32609.
RefSeqiNP_500627.1. NM_068226.5.
UniGeneiCel.6756.

Genome annotation databases

EnsemblMetazoaiE04A4.5; E04A4.5; WBGene00017119.
GeneIDi177242.
KEGGicel:CELE_E04A4.5.
UCSCiE04A4.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081039 Genomic DNA. Translation: CCD68707.1.
PIRiT32609.
RefSeqiNP_500627.1. NM_068226.5.
UniGeneiCel.6756.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.E04A4.5.

Proteomic databases

PaxDbiO44477.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiE04A4.5; E04A4.5; WBGene00017119.
GeneIDi177242.
KEGGicel:CELE_E04A4.5.
UCSCiE04A4.5. c. elegans.

Organism-specific databases

CTDi177242.
WormBaseiE04A4.5; CE16966; WBGene00017119.

Phylogenomic databases

eggNOGiCOG5596.
GeneTreeiENSGT00390000017780.
HOGENOMiHOG000183190.
InParanoidiO44477.
KOiK17795.
OMAiTIDCSLV.
PhylomeDBiO44477.

Enzyme and pathway databases

ReactomeiREACT_183227. Mitochondrial protein import.

Miscellaneous databases

NextBioi895950.
PROiO44477.

Family and domain databases

InterProiIPR005678. Tim17.
IPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00980. 3a0801so1tim17. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiTIM17_CAEEL
AccessioniPrimary (citable) accession number: O44477
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: June 1, 1998
Last modified: January 7, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.