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O44477

- TIM17_CAEEL

UniProt

O44477 - TIM17_CAEEL

Protein

Probable mitochondrial import inner membrane translocase subunit Tim17

Gene

tim-17

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.By similarity

    GO - Molecular functioni

    1. P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. intracellular protein transport Source: InterPro

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Enzyme and pathway databases

    ReactomeiREACT_183227. Mitochondrial protein import.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable mitochondrial import inner membrane translocase subunit Tim17
    Gene namesi
    Name:tim-17
    ORF Names:E04A4.5
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome IV

    Organism-specific databases

    WormBaseiE04A4.5; CE16966; WBGene00017119.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane presequence translocase complex Source: InterPro

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 181181Probable mitochondrial import inner membrane translocase subunit Tim17PRO_0000210289Add
    BLAST

    Proteomic databases

    PaxDbiO44477.

    Interactioni

    Subunit structurei

    Component of the TIM23 complex at least composed of tim-23, tim-17 and tim-50. The complex interacts with the tim-44 component of the PAM complex By similarity.By similarity

    Protein-protein interaction databases

    STRINGi6239.E04A4.5.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei61 – 8121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei109 – 12921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Tim17/Tim22/Tim23 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5596.
    GeneTreeiENSGT00390000017780.
    HOGENOMiHOG000183190.
    InParanoidiO44477.
    KOiK17795.
    OMAiFSTFDCG.
    PhylomeDBiO44477.

    Family and domain databases

    InterProiIPR005678. Tim17.
    IPR003397. Tim17/Tim22/Tim23/PMP24.
    [Graphical view]
    PfamiPF02466. Tim17. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00980. 3a0801so1tim17. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O44477-1 [UniParc]FASTAAdd to Basket

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    MEEYTREPCP YRIGDDIGSA FAMGLVGGSI FQAFGGYKNA AKGKKLVGMM    50
    REVRMRSTLT GVQFAAWGGM FSTIDCCLVA IRKKEDPINS IVSGGLTGAL 100
    LAIRSGPKVM AGSAILGSVI LAMIEGVGLV TTRWMGAMMD PTQPPPEALD 150
    DPRSLGQKSQ AEPGLDQTRP FGIPTGLPNL S 181
    Length:181
    Mass (Da):19,096
    Last modified:June 1, 1998 - v1
    Checksum:i505D8F8CB2BBE9DB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081039 Genomic DNA. Translation: CCD68707.1.
    PIRiT32609.
    RefSeqiNP_500627.1. NM_068226.5.
    UniGeneiCel.6756.

    Genome annotation databases

    EnsemblMetazoaiE04A4.5; E04A4.5; WBGene00017119.
    GeneIDi177242.
    KEGGicel:CELE_E04A4.5.
    UCSCiE04A4.5. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081039 Genomic DNA. Translation: CCD68707.1 .
    PIRi T32609.
    RefSeqi NP_500627.1. NM_068226.5.
    UniGenei Cel.6756.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.E04A4.5.

    Proteomic databases

    PaxDbi O44477.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai E04A4.5 ; E04A4.5 ; WBGene00017119 .
    GeneIDi 177242.
    KEGGi cel:CELE_E04A4.5.
    UCSCi E04A4.5. c. elegans.

    Organism-specific databases

    CTDi 177242.
    WormBasei E04A4.5 ; CE16966 ; WBGene00017119 .

    Phylogenomic databases

    eggNOGi COG5596.
    GeneTreei ENSGT00390000017780.
    HOGENOMi HOG000183190.
    InParanoidi O44477.
    KOi K17795.
    OMAi FSTFDCG.
    PhylomeDBi O44477.

    Enzyme and pathway databases

    Reactomei REACT_183227. Mitochondrial protein import.

    Miscellaneous databases

    NextBioi 895950.
    PROi O44477.

    Family and domain databases

    InterProi IPR005678. Tim17.
    IPR003397. Tim17/Tim22/Tim23/PMP24.
    [Graphical view ]
    Pfami PF02466. Tim17. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00980. 3a0801so1tim17. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiTIM17_CAEEL
    AccessioniPrimary (citable) accession number: O44477
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3