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O44477

- TIM17_CAEEL

UniProt

O44477 - TIM17_CAEEL

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Protein
Probable mitochondrial import inner membrane translocase subunit Tim17
Gene
tim-17, E04A4.5
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane By similarity.

GO - Molecular functioni

  1. P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. intracellular protein transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_183227. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mitochondrial import inner membrane translocase subunit Tim17
Gene namesi
Name:tim-17
ORF Names:E04A4.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiE04A4.5; CE16966; WBGene00017119.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721Helical; Reviewed prediction
Add
BLAST
Transmembranei61 – 8121Helical; Reviewed prediction
Add
BLAST
Transmembranei109 – 12921Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane presequence translocase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Probable mitochondrial import inner membrane translocase subunit Tim17
PRO_0000210289Add
BLAST

Proteomic databases

PaxDbiO44477.

Interactioni

Subunit structurei

Component of the TIM23 complex at least composed of tim-23, tim-17 and tim-50. The complex interacts with the tim-44 component of the PAM complex By similarity.

Protein-protein interaction databases

STRINGi6239.E04A4.5.

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5596.
GeneTreeiENSGT00390000017780.
HOGENOMiHOG000183190.
InParanoidiO44477.
KOiK17795.
OMAiFSTFDCG.
PhylomeDBiO44477.

Family and domain databases

InterProiIPR005678. Tim17.
IPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00980. 3a0801so1tim17. 1 hit.

Sequencei

Sequence statusi: Complete.

O44477-1 [UniParc]FASTAAdd to Basket

« Hide

MEEYTREPCP YRIGDDIGSA FAMGLVGGSI FQAFGGYKNA AKGKKLVGMM    50
REVRMRSTLT GVQFAAWGGM FSTIDCCLVA IRKKEDPINS IVSGGLTGAL 100
LAIRSGPKVM AGSAILGSVI LAMIEGVGLV TTRWMGAMMD PTQPPPEALD 150
DPRSLGQKSQ AEPGLDQTRP FGIPTGLPNL S 181
Length:181
Mass (Da):19,096
Last modified:June 1, 1998 - v1
Checksum:i505D8F8CB2BBE9DB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081039 Genomic DNA. Translation: CCD68707.1.
PIRiT32609.
RefSeqiNP_500627.1. NM_068226.5.
UniGeneiCel.6756.

Genome annotation databases

EnsemblMetazoaiE04A4.5; E04A4.5; WBGene00017119.
GeneIDi177242.
KEGGicel:CELE_E04A4.5.
UCSCiE04A4.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081039 Genomic DNA. Translation: CCD68707.1 .
PIRi T32609.
RefSeqi NP_500627.1. NM_068226.5.
UniGenei Cel.6756.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.E04A4.5.

Proteomic databases

PaxDbi O44477.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai E04A4.5 ; E04A4.5 ; WBGene00017119 .
GeneIDi 177242.
KEGGi cel:CELE_E04A4.5.
UCSCi E04A4.5. c. elegans.

Organism-specific databases

CTDi 177242.
WormBasei E04A4.5 ; CE16966 ; WBGene00017119 .

Phylogenomic databases

eggNOGi COG5596.
GeneTreei ENSGT00390000017780.
HOGENOMi HOG000183190.
InParanoidi O44477.
KOi K17795.
OMAi FSTFDCG.
PhylomeDBi O44477.

Enzyme and pathway databases

Reactomei REACT_183227. Mitochondrial protein import.

Miscellaneous databases

NextBioi 895950.
PROi O44477.

Family and domain databases

InterProi IPR005678. Tim17.
IPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view ]
Pfami PF02466. Tim17. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00980. 3a0801so1tim17. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiTIM17_CAEEL
AccessioniPrimary (citable) accession number: O44477
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: June 1, 1998
Last modified: September 3, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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