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Protein
Submitted name:

Ligand-Gated ion Channel

Gene

lgc-9

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-975298. Ligand-gated ion channel transport.

Names & Taxonomyi

Protein namesi
Submitted name:
Ligand-Gated ion ChannelImported
Gene namesi
Name:lgc-9Imported
ORF Names:C04C3.2Imported, CELE_C04C3.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC04C3.2; CE29558; WBGene00015412; lgc-9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei247 – 26923HelicalSequence analysisAdd
BLAST
Transmembranei281 – 30121HelicalSequence analysisAdd
BLAST
Transmembranei313 – 33523HelicalSequence analysisAdd
BLAST
Transmembranei430 – 45526HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiO44452.

Expressioni

Gene expression databases

BgeeiWBGene00015412.

Interactioni

Protein-protein interaction databases

DIPiDIP-25695N.
IntActiO44452. 1 interaction.
MINTiMINT-1129182.
STRINGi6239.C04C3.2.

Structurei

3D structure databases

ProteinModelPortaliO44452.
SMRiO44452. Positions 44-361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 245204Neur_chan_LBDInterPro annotationAdd
BLAST
Domaini252 – 34796Neur_chan_membInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000017780.
InParanoidiO44452.
KOiK05312.
OMAiLCRINID.
OrthoDBiEOG091G06O1.
PhylomeDBiO44452.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O44452-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYFIQLLSVL ISMKVGHIRS SRLLQHSQHG HYEDDYIKTE PTHLIETIQR
60 70 80 90 100
RYDKRVRPFA ESNRPVIVHM TIVLGILTEV RENQQVASFV ISHVQKWRDP
110 120 130 140 150
KLAWNPADHS GLTQVVMPRS LVWVPKLFIY NSMDTKDMLT DDRYDVRIQH
160 170 180 190 200
TGHVKVNSPQ FVSTLCRINI DLFPFDTQFC AIALASPLLS VEEMDVNATQ
210 220 230 240 250
PPVDSYFSGN AEWQVMNVTV KQMKFMEEGE YRAEVHYILH LNRRPTYYIT
260 270 280 290 300
VIVVPTFLIS ALSILGIFSP GSNDGPRNEK VSLGLGSLLA MTVLLDIVAG
310 320 330 340 350
AMPKSDAIPL LGYYIMLVIL LCAIGVAVSM AMLSMSRSCI QTSKMPPPHY
360 370 380 390 400
YRLLFLNVCR VVKQNSGLNG VAMNEKPTAI TPRFPDLIAI YNQLIEVARA
410 420 430 440 450
QRTYRERIEK QKWQHRVEIE WNKIFARIDF FFLFLFEMFN VLILVLFLRC
460
AFLPVPPLPE NFSI
Length:464
Mass (Da):53,308
Last modified:December 1, 2001 - v2
Checksum:iDC47B9961960FA4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD62195.1.
PIRiT32599.
RefSeqiNP_500341.1. NM_067940.4.
UniGeneiCel.13608.

Genome annotation databases

EnsemblMetazoaiC04C3.2; C04C3.2; WBGene00015412.
GeneIDi182195.
KEGGicel:CELE_C04C3.2.
UCSCiC04C3.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD62195.1.
PIRiT32599.
RefSeqiNP_500341.1. NM_067940.4.
UniGeneiCel.13608.

3D structure databases

ProteinModelPortaliO44452.
SMRiO44452. Positions 44-361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-25695N.
IntActiO44452. 1 interaction.
MINTiMINT-1129182.
STRINGi6239.C04C3.2.

Proteomic databases

PaxDbiO44452.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC04C3.2; C04C3.2; WBGene00015412.
GeneIDi182195.
KEGGicel:CELE_C04C3.2.
UCSCiC04C3.2. c. elegans.

Organism-specific databases

CTDi182195.
WormBaseiC04C3.2; CE29558; WBGene00015412; lgc-9.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000017780.
InParanoidiO44452.
KOiK05312.
OMAiLCRINID.
OrthoDBiEOG091G06O1.
PhylomeDBiO44452.

Enzyme and pathway databases

ReactomeiR-CEL-975298. Ligand-gated ion channel transport.

Gene expression databases

BgeeiWBGene00015412.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO44452_CAEEL
AccessioniPrimary (citable) accession number: O44452
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.