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Protein

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

Gene

pdhb-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.By similarity

Cofactori

thiamine diphosphateBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei81Thiamine pyrophosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

ReactomeiR-CEL-204174. Regulation of pyruvate dehydrogenase (PDH) complex.
R-CEL-389661. Glyoxylate metabolism and glycine degradation.
R-CEL-5362517. Signaling by Retinoic Acid.
R-CEL-70268. Pyruvate metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (EC:1.2.4.1)
Short name:
PDHE1-B
Gene namesi
Name:pdhb-1
ORF Names:C04C3.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC04C3.3; CE27647; WBGene00015413; pdhb-1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrion Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 21MitochondrionSequence analysisAdd BLAST21
ChainiPRO_000004263822 – 352Pyruvate dehydrogenase E1 component subunit beta, mitochondrialAdd BLAST331

Proteomic databases

EPDiO44451.
PaxDbiO44451.
PeptideAtlasiO44451.
PRIDEiO44451.

Expressioni

Gene expression databases

BgeeiWBGene00015413.

Interactioni

Subunit structurei

Tetramer of 2 alpha and 2 beta subunits.By similarity

Protein-protein interaction databases

BioGridi42248. 6 interactors.
DIPiDIP-24348N.
IntActiO44451. 5 interactors.
MINTiMINT-1052850.
STRINGi6239.C04C3.3.2.

Structurei

3D structure databases

ProteinModelPortaliO44451.
SMRiO44451.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0524. Eukaryota.
COG0022. LUCA.
GeneTreeiENSGT00530000063423.
HOGENOMiHOG000281450.
InParanoidiO44451.
KOiK00162.
OMAiRMRHHCL.
OrthoDBiEOG091G0D37.
PhylomeDBiO44451.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 1 hit.
InterProiIPR029061. THDP-binding.
IPR009014. Transketo_C/PFOR_II.
IPR005475. Transketolase-like_Pyr-bd.
IPR033248. Transketolase_C.
IPR033247. Transketolase_fam.
[Graphical view]
PANTHERiPTHR11624. PTHR11624. 1 hit.
PfamiPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
SSF52922. SSF52922. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O44451-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRKCGNLF VARLAGTSTR AASTMTVRDA LNQAMDEEIK RDDRVFLMGE
60 70 80 90 100
EVAQYDGAYK ISKGLWKKHG DKRVVDTPIT EMGFAGIAVG AAFAGLRPIC
110 120 130 140 150
EFMTFNFSMQ AIDQIINSAA KTYYMSAGRV PVPIVFRGPN GAAAGVAAQH
160 170 180 190 200
SQDFSAWYAH CPGLKVVCPY SAEDAKGLLK AAIRDDNPVV FLENEILYGQ
210 220 230 240 250
SFPVGDEVLS DDFVVPIGKA KIERAGDHVT IVSYSRGVEF SLEAAKQLEA
260 270 280 290 300
IGVSAEVINL RSLRPFDFES IRQSVHKTHH LVSVETGWPF AGIGSEIAAQ
310 320 330 340 350
VMESDVFDQL DAPLLRVTGV DVPMPYTQTL EAAALPTAEH VVKAVKKSLN

IA
Length:352
Mass (Da):38,141
Last modified:October 1, 2001 - v2
Checksum:i37F4A4A28C8ADECA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080230 Genomic DNA. Translation: CCD62196.1.
PIRiT32598.
RefSeqiNP_500340.1. NM_067939.5.
UniGeneiCel.7275.

Genome annotation databases

EnsemblMetazoaiC04C3.3; C04C3.3; WBGene00015413.
GeneIDi177108.
KEGGicel:CELE_C04C3.3.
UCSCiC04C3.3.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080230 Genomic DNA. Translation: CCD62196.1.
PIRiT32598.
RefSeqiNP_500340.1. NM_067939.5.
UniGeneiCel.7275.

3D structure databases

ProteinModelPortaliO44451.
SMRiO44451.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi42248. 6 interactors.
DIPiDIP-24348N.
IntActiO44451. 5 interactors.
MINTiMINT-1052850.
STRINGi6239.C04C3.3.2.

Proteomic databases

EPDiO44451.
PaxDbiO44451.
PeptideAtlasiO44451.
PRIDEiO44451.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC04C3.3; C04C3.3; WBGene00015413.
GeneIDi177108.
KEGGicel:CELE_C04C3.3.
UCSCiC04C3.3.1. c. elegans.

Organism-specific databases

CTDi177108.
WormBaseiC04C3.3; CE27647; WBGene00015413; pdhb-1.

Phylogenomic databases

eggNOGiKOG0524. Eukaryota.
COG0022. LUCA.
GeneTreeiENSGT00530000063423.
HOGENOMiHOG000281450.
InParanoidiO44451.
KOiK00162.
OMAiRMRHHCL.
OrthoDBiEOG091G0D37.
PhylomeDBiO44451.

Enzyme and pathway databases

ReactomeiR-CEL-204174. Regulation of pyruvate dehydrogenase (PDH) complex.
R-CEL-389661. Glyoxylate metabolism and glycine degradation.
R-CEL-5362517. Signaling by Retinoic Acid.
R-CEL-70268. Pyruvate metabolism.

Miscellaneous databases

PROiO44451.

Gene expression databases

BgeeiWBGene00015413.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 1 hit.
InterProiIPR029061. THDP-binding.
IPR009014. Transketo_C/PFOR_II.
IPR005475. Transketolase-like_Pyr-bd.
IPR033248. Transketolase_C.
IPR033247. Transketolase_fam.
[Graphical view]
PANTHERiPTHR11624. PTHR11624. 1 hit.
PfamiPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
SSF52922. SSF52922. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiODPB_CAEEL
AccessioniPrimary (citable) accession number: O44451
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 1, 2001
Last modified: November 30, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.