Reviewed,
UniProtKB/Swiss-Prot O44451 (ODPB_CAEEL)
Last modified
November 25, 2008.
Version 55.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial EC=1.2.4.1 | ||
| Gene names |
| ||
| Organism | Caenorhabditis elegans [Complete proteome] | ||
| Taxonomic identifier | 6239 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 352 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. |
| Catalytic activity | Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2). |
| Cofactor | Thiamine pyrophosphate By similarity. |
| Subunit structure | Tetramer of 2 alpha and 2 beta subunits By similarity. |
| Subcellular location | Mitochondrion matrixBy similarity. |
Ontologies
Keywords | |
|---|---|
| Biological process | Glycolysis |
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Ligand | Pyruvate Thiamine pyrophosphate |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Direct protein sequencing |
Gene Ontology (GO) | |
| Biological process | embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase glycolysisInferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW positive regulation of growth rateInferred from mutant phenotype. Source: WormBase |
| Cellular component | mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct pyruvate dehydrogenase (acetyl-transferring) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| O45924 | 1 | EBI-326559,EBI-330432 | ||
| mdf-2 | Q9NGT3 | 1 | EBI-326559,EBI-328699 | |
| sdz-38 | Q09620 | 1 | EBI-326559,EBI-332504 |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
| [2] | Bienvenut W.V. Submitted (SEP-2005) to UniProtKB Cited for: PROTEIN SEQUENCE OF 130-137; 237-246 AND 262-272, MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| AF038606 Genomic DNA. Translation: AAB92024.2. | |
| PIR | T32598. |
| RefSeq | NP_500340.1. |
| UniGene | Cel.7275 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1NI4 based on UniProtKB P11177. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:24348N. |
| IntAct | O44451. |
Genome annotation databases | |
| Ensembl | C04C3.3. Caenorhabditis elegans. [Contig view] |
| GeneID | 177108. |
| KEGG | cel:C04C3.3. |
Organism-specific databases | |
| WormBase | WBGene00015413. C04C3.3. |
| WormPep | C04C3.3. CE27647. [WorfDB] |
Gene expression databases | |
| ArrayExpress | O44451. |
Family and domain databases | |
| InterPro | IPR005476. Transketo_C. IPR005475. Transketo_Cen_R. IPR015941. Transketolase_C-like. [Graphical view] |
| Gene3D | G3DSA:3.40.50.920. Transketo_C_like. 1 hit. |
| Pfam | PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 895372. |
Entry information
| Entry name | ODPB_CAEEL | ||||||||
| Accession | Primary (citable) accession number: O44451 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |

Clusters with


