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Protein

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

Gene

pdhb-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.By similarity

Cofactori

thiamine diphosphateBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei81Thiamine pyrophosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

ReactomeiR-CEL-204174 Regulation of pyruvate dehydrogenase (PDH) complex
R-CEL-389661 Glyoxylate metabolism and glycine degradation
R-CEL-5362517 Signaling by Retinoic Acid
R-CEL-70268 Pyruvate metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (EC:1.2.4.1)
Short name:
PDHE1-B
Gene namesi
Name:pdhb-1
ORF Names:C04C3.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC04C3.3 ; CE27647 ; WBGene00015413 ; pdhb-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 21MitochondrionSequence analysisAdd BLAST21
ChainiPRO_000004263822 – 352Pyruvate dehydrogenase E1 component subunit beta, mitochondrialAdd BLAST331

Proteomic databases

EPDiO44451
PaxDbiO44451
PeptideAtlasiO44451
PRIDEiO44451

Expressioni

Gene expression databases

BgeeiWBGene00015413

Interactioni

Subunit structurei

Tetramer of 2 alpha and 2 beta subunits.By similarity

Protein-protein interaction databases

BioGridi422486 interactors.
DIPiDIP-24348N
IntActiO44451 7 interactors.
STRINGi6239.C04C3.3.2

Structurei

3D structure databases

ProteinModelPortaliO44451
SMRiO44451
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0524 Eukaryota
COG0022 LUCA
GeneTreeiENSGT00530000063423
HOGENOMiHOG000281450
InParanoidiO44451
KOiK00162
OMAiSRMRHHC
OrthoDBiEOG091G0D37
PhylomeDBiO44451

Family and domain databases

Gene3Di3.40.50.9201 hit
InterProiView protein in InterPro
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005475 Transketolase-like_Pyr-bd
IPR033248 Transketolase_C
PfamiView protein in Pfam
PF02779 Transket_pyr, 1 hit
PF02780 Transketolase_C, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit
SSF52922 SSF52922, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O44451-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRKCGNLF VARLAGTSTR AASTMTVRDA LNQAMDEEIK RDDRVFLMGE
60 70 80 90 100
EVAQYDGAYK ISKGLWKKHG DKRVVDTPIT EMGFAGIAVG AAFAGLRPIC
110 120 130 140 150
EFMTFNFSMQ AIDQIINSAA KTYYMSAGRV PVPIVFRGPN GAAAGVAAQH
160 170 180 190 200
SQDFSAWYAH CPGLKVVCPY SAEDAKGLLK AAIRDDNPVV FLENEILYGQ
210 220 230 240 250
SFPVGDEVLS DDFVVPIGKA KIERAGDHVT IVSYSRGVEF SLEAAKQLEA
260 270 280 290 300
IGVSAEVINL RSLRPFDFES IRQSVHKTHH LVSVETGWPF AGIGSEIAAQ
310 320 330 340 350
VMESDVFDQL DAPLLRVTGV DVPMPYTQTL EAAALPTAEH VVKAVKKSLN

IA
Length:352
Mass (Da):38,141
Last modified:October 1, 2001 - v2
Checksum:i37F4A4A28C8ADECA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080230 Genomic DNA Translation: CCD62196.1
PIRiT32598
RefSeqiNP_500340.1, NM_067939.5
UniGeneiCel.7275

Genome annotation databases

EnsemblMetazoaiC04C3.3; C04C3.3; WBGene00015413
GeneIDi177108
KEGGicel:CELE_C04C3.3
UCSCiC04C3.3.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiODPB_CAEEL
AccessioniPrimary (citable) accession number: O44451
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 1, 2001
Last modified: March 28, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome