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Protein

Small nuclear ribonucleoprotein Sm D3

Gene

SmD3

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • central nervous system development Source: FlyBase
  • lymph gland development Source: FlyBase
  • mitotic cell cycle Source: FlyBase
  • mRNA splicing, via spliceosome Source: FlyBase
  • muscle organ development Source: FlyBase
  • neuron differentiation Source: FlyBase
  • oogenesis Source: FlyBase
  • peripheral nervous system development Source: FlyBase
  • pole plasm oskar mRNA localization Source: FlyBase
  • spliceosomal complex assembly Source: GO_Central
  • spliceosomal snRNP assembly Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-DME-72163 mRNA Splicing - Major Pathway
R-DME-72165 mRNA Splicing - Minor Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Small nuclear ribonucleoprotein Sm D3
Short name:
Sm-D3
Alternative name(s):
snRNP core protein D3
Gene namesi
Name:SmD3
Synonyms:guf2
ORF Names:CG8427
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0023167 SmD3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001222181 – 151Small nuclear ribonucleoprotein Sm D3Add BLAST151

Post-translational modificationi

Methylated on arginine residues by Art5 and Art7; methylation is not required for assembly and biogenesis of snRNPs.1 Publication

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiO44437
PRIDEiO44437

Expressioni

Gene expression databases

BgeeiFBgn0023167
ExpressionAtlasiO44437 baseline and differential
GenevisibleiO44437 DM

Interactioni

Subunit structurei

Interacts with the SMN complex.1 Publication

Protein-protein interaction databases

BioGridi62087, 10 interactors
DIPiDIP-19470N
IntActiO44437, 26 interactors
STRINGi7227.FBpp0087094

Structurei

3D structure databases

ProteinModelPortaliO44437
SMRiO44437
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati108 – 10912
Repeati110 – 11122
Repeati112 – 11332

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni108 – 1133 X 2 AA tandem repeats of R-G6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi84 – 120Arg/Lys-rich (basic)Add BLAST37

Sequence similaritiesi

Belongs to the snRNP core protein family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3172 Eukaryota
COG1958 LUCA
GeneTreeiENSGT00610000086153
InParanoidiO44437
KOiK11088
OMAiIMRANAR
OrthoDBiEOG091G0ZWE
PhylomeDBiO44437

Family and domain databases

CDDicd01721 Sm_D3, 1 hit
InterProiView protein in InterPro
IPR027141 LSm4/Sm_D1/D3
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
IPR034099 SmD3
PANTHERiPTHR23338 PTHR23338, 1 hit
PfamiView protein in Pfam
PF01423 LSM, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit

Sequencei

Sequence statusi: Complete.

O44437-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIGVPIKVL HEAEGHIITC ETITGEVYRG KLIEAEDNMN CQMTQITVTY
60 70 80 90 100
RDGRTANLEN VYIRGSKIRF LILPDMLKNA PMFKKQTGKG LGGTAGRGKA
110 120 130 140 150
AILRAQARGR GRGGPPGGGR GTGGPPGAPG GSGGRGAWQG GPTGGRGRGG

L
Length:151
Mass (Da):15,582
Last modified:June 1, 1998 - v1
Checksum:i65F0B899EACA1C77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038598 mRNA Translation: AAB92621.1
AE013599 Genomic DNA Translation: AAF58566.1
AY113465 mRNA Translation: AAM29470.1
RefSeqiNP_725106.1, NM_165866.3
UniGeneiDm.19912

Genome annotation databases

EnsemblMetazoaiFBtr0087986; FBpp0087094; FBgn0023167
GeneIDi36306
KEGGidme:Dmel_CG8427

Similar proteinsi

Entry informationi

Entry nameiSMD3_DROME
AccessioniPrimary (citable) accession number: O44437
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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