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Protein

Protein DGCR14 homolog

Gene

Es2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • mRNA splicing, via spliceosome Source: FlyBase
  • nervous system development Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein DGCR14 homolog
Alternative name(s):
Protein Es2
dEs2
Gene namesi
Name:Es2
ORF Names:CG1474
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0023506. Es2.

Subcellular locationi

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: FlyBase
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Protein DGCR14 homologPRO_0000079875Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei409 – 4091Phosphoserine1 Publication
Modified residuei411 – 4111Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO44424.

PTM databases

iPTMnetiO44424.

Expressioni

Gene expression databases

BgeeiFBgn0023506.
GenevisibleiO44424. DM.

Interactioni

Protein-protein interaction databases

BioGridi58239. 33 interactions.
DIPiDIP-18468N.
IntActiO44424. 5 interactions.
MINTiMINT-278142.
STRINGi7227.FBpp0071145.

Family & Domainsi

Sequence similaritiesi

Belongs to the DGCR14 family.Curated

Phylogenomic databases

eggNOGiKOG2627. Eukaryota.
ENOG410YVA8. LUCA.
GeneTreeiENSGT00390000009387.
InParanoidiO44424.
KOiK13118.
OMAiEAFSPIM.
OrthoDBiEOG091G0C2M.
PhylomeDBiO44424.

Family and domain databases

InterProiIPR019148. Nuclear_protein_DGCR14.
[Graphical view]
PfamiPF09751. Es2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O44424-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATTRTPAT PGTPGTPGSL AMEVARVQNS ALAEFKKPTA MVRHKNKPKI
60 70 80 90 100
LTEEKYIEEM SKIIQRDFFP DLERLRAQND YLDAESRRDF VQMAEIRERY
110 120 130 140 150
SLGRISGTGR STSRRNNAMS PATFETPVSQ AKCSNTPLPN SRATDTPFST
160 170 180 190 200
DGSEKSDAEG RDTTAKLSLD AFLQKYTSED NQSFQEIIET AEAKLRQKYA
210 220 230 240 250
VLYNHEKLSA EQLQRALMLP SIETQFEEPD PLRKIETWNY TNMNSIMYVP
260 270 280 290 300
DGVEYTEEER VQLAERKQSI QHNATRLPDE AKHREMDTKK LNDEVPQNGA
310 320 330 340 350
GGATATPKVR GFDLLRSPSP RPGEAFSPIM TWGEIDGTPF RLDGGDTPLR
360 370 380 390 400
PTQGPSFRIN ENSRRENIAI ALAERVSERM RNQKQMALDT ARRNIGSPLI
410 420 430 440 450
RTNMERLASM SPAAQLLATG KLGIRGTPRL RHTPSPMSGR KRKVTPGVVR
460 470 480 490 500
STNTPILGEP KPKQQAKIST PAKNVTIDTG STLTDDLLKI PTKRRTAADF

F
Length:501
Mass (Da):56,019
Last modified:June 16, 2003 - v2
Checksum:i796B217E368AB78F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti142 – 1421R → W in AAL39937 (PubMed:12537569).Curated
Sequence conflicti166 – 1672KL → NV in AAC04785 (PubMed:9499415).Curated
Sequence conflicti381 – 3833RNQ → PNP in AAC04785 (PubMed:9499415).Curated
Sequence conflicti469 – 4691S → N in AAC04785 (PubMed:9499415).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF46375.1.
AY069792 mRNA. Translation: AAL39937.1.
AF037257 mRNA. Translation: AAC04785.1.
RefSeqiNP_572480.1. NM_132252.5.
UniGeneiDm.31045.

Genome annotation databases

EnsemblMetazoaiFBtr0071198; FBpp0071145; FBgn0023506.
GeneIDi31780.
KEGGidme:Dmel_CG1474.
UCSCiCG1474-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF46375.1.
AY069792 mRNA. Translation: AAL39937.1.
AF037257 mRNA. Translation: AAC04785.1.
RefSeqiNP_572480.1. NM_132252.5.
UniGeneiDm.31045.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi58239. 33 interactions.
DIPiDIP-18468N.
IntActiO44424. 5 interactions.
MINTiMINT-278142.
STRINGi7227.FBpp0071145.

PTM databases

iPTMnetiO44424.

Proteomic databases

PaxDbiO44424.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0071198; FBpp0071145; FBgn0023506.
GeneIDi31780.
KEGGidme:Dmel_CG1474.
UCSCiCG1474-RA. d. melanogaster.

Organism-specific databases

CTDi109579.
FlyBaseiFBgn0023506. Es2.

Phylogenomic databases

eggNOGiKOG2627. Eukaryota.
ENOG410YVA8. LUCA.
GeneTreeiENSGT00390000009387.
InParanoidiO44424.
KOiK13118.
OMAiEAFSPIM.
OrthoDBiEOG091G0C2M.
PhylomeDBiO44424.

Miscellaneous databases

GenomeRNAii31780.
PROiO44424.

Gene expression databases

BgeeiFBgn0023506.
GenevisibleiO44424. DM.

Family and domain databases

InterProiIPR019148. Nuclear_protein_DGCR14.
[Graphical view]
PfamiPF09751. Es2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDGC14_DROME
AccessioniPrimary (citable) accession number: O44424
Secondary accession number(s): Q8T9F3, Q9W3F2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: September 7, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.