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Protein

Acyl-CoA Delta(11) desaturase

Gene

D11DS

Organism
Trichoplusia ni (Cabbage looper)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the formation of Delta(11) fatty acyl precursors in the pheromone gland.1 Publication

Catalytic activityi

An acyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = an (11Z)-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O.1 Publication

Cofactori

Fe cationBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-18385.
BRENDAi1.14.19.5. 6461.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA Delta(11) desaturase (EC:1.14.19.51 Publication)
Alternative name(s):
Acyl-CoA Delta-11 desaturase
Short name:
Delta(11)-desaturase
Gene namesi
Name:D11DS
Synonyms:PGD11DS
OrganismiTrichoplusia ni (Cabbage looper)
Taxonomic identifieri7111 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaNoctuoideaNoctuidaePlusiinaeTrichoplusia

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854101 – 349Acyl-CoA Delta(11) desaturaseAdd BLAST349

Expressioni

Tissue specificityi

Adult female pheromone gland. Increases by two or three orders of magnitude during the first 2 days after adult eclosion.1 Publication

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi86 – 91Histidine box-16
Motifi123 – 127Histidine box-25
Motifi263 – 267Histidine box-35

Domaini

The histidine box domains may contain the active site and/or be involved in metal ion binding.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd03505. Delta9-FADS-like. 1 hit.
InterProiIPR015876. Acyl-CoA_DS.
IPR005804. FA_desaturase_dom.
IPR001522. FADS-1_CS.
[Graphical view]
PANTHERiPTHR11351. PTHR11351. 1 hit.
PfamiPF00487. FA_desaturase. 1 hit.
[Graphical view]
PRINTSiPR00075. FACDDSATRASE.
PROSITEiPS00476. FATTY_ACID_DESATUR_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O44390-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVMAQTVQE TATVLEEEAR TVTLVAPKTT PRKYKYIYTN FLTFSYAHLA
60 70 80 90 100
ALYGLYLCFT SAKWETLLFS FVLFHMSNIG ITAGAHRLWT HKTFKAKLPL
110 120 130 140 150
EIVLMIFNSL AFQNTAITWA REHRLHHKYS DTDADPHNAS RGFFYSHVGW
160 170 180 190 200
LLVKKHPDVL KYGKTIDMSD VYNNPVLKFQ KKYAVPLIGT VCFALPTLIP
210 220 230 240 250
VYCWGESWNN AWHIALFRYI FNLNVTFLVN SAAHIWGNKP YDKSILPAQN
260 270 280 290 300
LLVSFLASGE GFHNYHHVFP WDYRTAELGN NFLNLTTLFI DFCAWFGWAY
310 320 330 340
DLKSVSEDII KQRAKRTGDG SSGVIWGWDD KDMDRDIKSK ANIFYAKKE
Length:349
Mass (Da):40,243
Last modified:January 1, 1999 - v2
Checksum:iF91AF7A2F59F0450
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22V → M in AAK21863 (PubMed:11483431).Curated1
Sequence conflicti116A → V in AAK21863 (PubMed:11483431).Curated1
Sequence conflicti125 – 135LHHKYSDTDAD → YITNTAILMLI in AAK21863 (PubMed:11483431).CuratedAdd BLAST11
Sequence conflicti257A → T in AAK21864 (PubMed:11483431).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035375 mRNA. Translation: AAD03775.1.
AF297114 Genomic DNA. Translation: AAK21864.1.
AF297113 Genomic DNA. Translation: AAK21863.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035375 mRNA. Translation: AAD03775.1.
AF297114 Genomic DNA. Translation: AAK21864.1.
AF297113 Genomic DNA. Translation: AAK21863.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-18385.
BRENDAi1.14.19.5. 6461.

Family and domain databases

CDDicd03505. Delta9-FADS-like. 1 hit.
InterProiIPR015876. Acyl-CoA_DS.
IPR005804. FA_desaturase_dom.
IPR001522. FADS-1_CS.
[Graphical view]
PANTHERiPTHR11351. PTHR11351. 1 hit.
PfamiPF00487. FA_desaturase. 1 hit.
[Graphical view]
PRINTSiPR00075. FACDDSATRASE.
PROSITEiPS00476. FATTY_ACID_DESATUR_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACO11_TRINI
AccessioniPrimary (citable) accession number: O44390
Secondary accession number(s): Q9BKA3, Q9BKA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: January 1, 1999
Last modified: November 30, 2016
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.