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Protein
Submitted name:

Slimb

Gene

slmb

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • phosphoprotein binding Source: FlyBase

GO - Biological processi

  • border follicle cell migration Source: FlyBase
  • chorion-containing eggshell formation Source: FlyBase
  • circadian rhythm Source: FlyBase
  • dorsal appendage formation Source: FlyBase
  • establishment of epithelial cell polarity Source: FlyBase
  • germarium-derived egg chamber formation Source: FlyBase
  • germarium-derived female germ-line cyst encapsulation Source: FlyBase
  • germarium-derived female germ-line cyst formation Source: FlyBase
  • learning or memory Source: FlyBase
  • locomotor rhythm Source: FlyBase
  • negative regulation of apoptotic process Source: FlyBase
  • negative regulation of cell proliferation Source: FlyBase
  • negative regulation of glial cell proliferation Source: FlyBase
  • negative regulation of insulin receptor signaling pathway Source: FlyBase
  • negative regulation of nurse cell apoptotic process Source: FlyBase
  • negative regulation of smoothened signaling pathway Source: FlyBase
  • negative regulation of TOR signaling Source: FlyBase
  • negative regulation of transforming growth factor beta receptor signaling pathway Source: FlyBase
  • negative regulation of Wnt signaling pathway Source: FlyBase
  • neuron remodeling Source: FlyBase
  • olfactory learning Source: FlyBase
  • oocyte axis specification Source: FlyBase
  • oocyte localization involved in germarium-derived egg chamber formation Source: FlyBase
  • ovarian follicle cell development Source: FlyBase
  • ovarian follicle cell stalk formation Source: FlyBase
  • pole plasm oskar mRNA localization Source: FlyBase
  • protein ubiquitination Source: FlyBase
  • proteolysis Source: FlyBase
  • regulation of centriole replication Source: FlyBase
  • regulation of chromosome condensation Source: FlyBase
  • regulation of establishment of cell polarity Source: FlyBase
  • regulation of mitotic nuclear division Source: FlyBase
  • regulation of proteolysis Source: FlyBase
  • regulation of smoothened signaling pathway Source: FlyBase
  • regulation of Wnt signaling pathway Source: FlyBase
  • release of cytoplasmic sequestered NF-kappaB Source: FlyBase
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-1169091. Activation of NF-kappaB in B cells.
R-DME-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-DME-195253. Degradation of beta-catenin by the destruction complex.
R-DME-202424. Downstream TCR signaling.
R-DME-2871837. FCERI mediated NF-kB activation.
R-DME-3769402. Deactivation of the beta-catenin transactivating complex.
R-DME-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-DME-5607764. CLEC7A (Dectin-1) signaling.
R-DME-5610780. Degradation of GLI1 by the proteasome.
R-DME-5610785. GLI3 is processed to GLI3R by the proteasome.
R-DME-5676590. NIK-->noncanonical NF-kB signaling.
R-DME-983168. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinkiO44382.

Names & Taxonomyi

Protein namesi
Submitted name:
SlimbImported
Gene namesi
Name:slmbImported
Synonyms:slimbImported
ORF Names:CG3412Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0283468. slmb.

Subcellular locationi

GO - Cellular componenti

  • SCF ubiquitin ligase complex Source: FlyBase
  • ubiquitin ligase complex Source: FlyBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiO44382.
PRIDEiO44382.

Expressioni

Gene expression databases

BgeeiFBgn0023423.

Interactioni

GO - Molecular functioni

  • phosphoprotein binding Source: FlyBase

Protein-protein interaction databases

IntActiO44382. 3 interactors.
STRINGi7227.FBpp0303082.

Structurei

3D structure databases

ProteinModelPortaliO44382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini206 – 497WD_REPEATS_REGIONInterPro annotationAdd BLAST292

Phylogenomic databases

eggNOGiKOG0281. Eukaryota.
ENOG410XTA8. LUCA.
HOGENOMiHOG000102803.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR021977. Beta-TrCP_D.
IPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12125. Beta-TrCP_D. 1 hit.
PF12937. F-box-like. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM01028. Beta-TrCP_D. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O44382-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKMETDKIM DETNSNAQAF TTTMLYDPVR KKDSSPTYQT ERELCFQYFT
60 70 80 90 100
QWSESGQVDF VEHLLSRMCH YQHGQINAYL KPMLQRDFIT LLPIKGLDHI
110 120 130 140 150
GENILSYLDA ESLKSSELVC KEWLRVISEG MLWKKLIERK VRTDSLWRGL
160 170 180 190 200
AERRNWMQYL FKPRPGQTQR PHSFHRELFP KIMNDIDSIE NNWRTGRHML
210 220 230 240 250
RRINCRSENS KGVYCLQYDD GKIVSGLRDN TIKIWDRTDL QCVKTLMGHT
260 270 280 290 300
GSVLCLQYDD KVIISGSSDS TVRVWDVNTG EMVNTLIHHC EAVLHLRFNN
310 320 330 340 350
GMMVTCSKDR SIAVWDMTSP SEITLRRVLV GHRAAVNVVD FDEKYIVSAS
360 370 380 390 400
GDRTIKVWST STCEFVRTLN GHKRGIACLQ YRDRLVVSGS SDNSIRLWDI
410 420 430 440 450
ECGACLRVLE GHEELVRCIR FDTKRIVSGA YDGKIKVWDL VAALDPRAAS
460 470 480 490 500
NTLCLNTLVE HTGRVFRLQF DEFQIVSSSH DDTILIWDFL NFTPNENKTG
510
RTPSPALMEH
Length:510
Mass (Da):58,952
Last modified:June 1, 1998 - v1
Checksum:iDBB0243D3730A5E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032878 mRNA. Translation: AAC38852.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032878 mRNA. Translation: AAC38852.1.

3D structure databases

ProteinModelPortaliO44382.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO44382. 3 interactors.
STRINGi7227.FBpp0303082.

Proteomic databases

PaxDbiO44382.
PRIDEiO44382.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0283468. slmb.

Phylogenomic databases

eggNOGiKOG0281. Eukaryota.
ENOG410XTA8. LUCA.
HOGENOMiHOG000102803.

Enzyme and pathway databases

ReactomeiR-DME-1169091. Activation of NF-kappaB in B cells.
R-DME-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-DME-195253. Degradation of beta-catenin by the destruction complex.
R-DME-202424. Downstream TCR signaling.
R-DME-2871837. FCERI mediated NF-kB activation.
R-DME-3769402. Deactivation of the beta-catenin transactivating complex.
R-DME-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-DME-5607764. CLEC7A (Dectin-1) signaling.
R-DME-5610780. Degradation of GLI1 by the proteasome.
R-DME-5610785. GLI3 is processed to GLI3R by the proteasome.
R-DME-5676590. NIK-->noncanonical NF-kB signaling.
R-DME-983168. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinkiO44382.

Gene expression databases

BgeeiFBgn0023423.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR021977. Beta-TrCP_D.
IPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12125. Beta-TrCP_D. 1 hit.
PF12937. F-box-like. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM01028. Beta-TrCP_D. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO44382_DROME
AccessioniPrimary (citable) accession number: O44382
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.