Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Slimb

Gene

slmb

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • border follicle cell migration Source: FlyBase
  • chorion-containing eggshell formation Source: FlyBase
  • circadian rhythm Source: FlyBase
  • dorsal appendage formation Source: FlyBase
  • establishment of epithelial cell polarity Source: FlyBase
  • germarium-derived egg chamber formation Source: FlyBase
  • germarium-derived female germ-line cyst encapsulation Source: FlyBase
  • germarium-derived female germ-line cyst formation Source: FlyBase
  • locomotor rhythm Source: FlyBase
  • negative regulation of apoptotic process Source: FlyBase
  • negative regulation of cell proliferation Source: FlyBase
  • negative regulation of glial cell proliferation Source: FlyBase
  • negative regulation of insulin receptor signaling pathway Source: FlyBase
  • negative regulation of nurse cell apoptotic process Source: FlyBase
  • negative regulation of smoothened signaling pathway Source: FlyBase
  • negative regulation of TOR signaling Source: FlyBase
  • neuron remodeling Source: FlyBase
  • oocyte axis specification Source: FlyBase
  • oocyte localization involved in germarium-derived egg chamber formation Source: FlyBase
  • ovarian follicle cell development Source: FlyBase
  • ovarian follicle cell stalk formation Source: FlyBase
  • pole plasm oskar mRNA localization Source: FlyBase
  • protein ubiquitination Source: FlyBase
  • proteolysis Source: FlyBase
  • regulation of centriole replication Source: FlyBase
  • regulation of chromosome condensation Source: FlyBase
  • regulation of establishment of cell polarity Source: FlyBase
  • regulation of mitotic nuclear division Source: FlyBase
  • regulation of proteolysis Source: FlyBase
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: FlyBase

Enzyme and pathway databases

ReactomeiR-DME-1169091 Activation of NF-kappaB in B cells
R-DME-174113 SCF-beta-TrCP mediated degradation of Emi1
R-DME-195253 Degradation of beta-catenin by the destruction complex
R-DME-209360 Ubiquitination and proteolysis of phosphorylated CI
R-DME-209461 Ubiquitination and degradation of phosphorylated ARM
R-DME-3769402 Deactivation of the beta-catenin transactivating complex
R-DME-432524 Degradation of PER
R-DME-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-DME-5610780 Degradation of GLI1 by the proteasome
R-DME-5610785 GLI3 is processed to GLI3R by the proteasome
R-DME-5676590 NIK-->noncanonical NF-kB signaling
R-DME-8951664 Neddylation
R-DME-9020702 Interleukin-1 signaling
R-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiO44382

Names & Taxonomyi

Protein namesi
Submitted name:
SlimbImported
Gene namesi
Name:slmbImported
Synonyms:slimbImported
ORF Names:CG3412Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0283468 slmb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiO44382

Expressioni

Gene expression databases

BgeeiFBgn0023423
ExpressionAtlasiO44382 differential

Interactioni

GO - Molecular functioni

  • phosphoprotein binding Source: FlyBase
  • protein dimerization activity Source: InterPro

Protein-protein interaction databases

ELMiO44382
IntActiO44382, 7 interactors
MINTiO44382

Structurei

3D structure databases

ProteinModelPortaliO44382
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini206 – 497WD_REPEATS_REGIONInterPro annotationAdd BLAST292
Repeati206 – 245WDPROSITE-ProRule annotationAdd BLAST40
Repeati246 – 285WDPROSITE-ProRule annotationAdd BLAST40
Repeati286 – 325WDPROSITE-ProRule annotationAdd BLAST40
Repeati329 – 368WDPROSITE-ProRule annotationAdd BLAST40
Repeati369 – 408WDPROSITE-ProRule annotationAdd BLAST40
Repeati409 – 440WDPROSITE-ProRule annotationAdd BLAST32
Repeati458 – 488WDPROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

WD repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0281 Eukaryota
ENOG410XTA8 LUCA
HOGENOMiHOG000102803

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR021977 Beta-TrCP_D
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12125 Beta-TrCP_D, 1 hit
PF12937 F-box-like, 1 hit
PF00400 WD40, 6 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM01028 Beta-TrCP_D, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 5 hits
PS50082 WD_REPEATS_2, 7 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

O44382-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKMETDKIM DETNSNAQAF TTTMLYDPVR KKDSSPTYQT ERELCFQYFT
60 70 80 90 100
QWSESGQVDF VEHLLSRMCH YQHGQINAYL KPMLQRDFIT LLPIKGLDHI
110 120 130 140 150
GENILSYLDA ESLKSSELVC KEWLRVISEG MLWKKLIERK VRTDSLWRGL
160 170 180 190 200
AERRNWMQYL FKPRPGQTQR PHSFHRELFP KIMNDIDSIE NNWRTGRHML
210 220 230 240 250
RRINCRSENS KGVYCLQYDD GKIVSGLRDN TIKIWDRTDL QCVKTLMGHT
260 270 280 290 300
GSVLCLQYDD KVIISGSSDS TVRVWDVNTG EMVNTLIHHC EAVLHLRFNN
310 320 330 340 350
GMMVTCSKDR SIAVWDMTSP SEITLRRVLV GHRAAVNVVD FDEKYIVSAS
360 370 380 390 400
GDRTIKVWST STCEFVRTLN GHKRGIACLQ YRDRLVVSGS SDNSIRLWDI
410 420 430 440 450
ECGACLRVLE GHEELVRCIR FDTKRIVSGA YDGKIKVWDL VAALDPRAAS
460 470 480 490 500
NTLCLNTLVE HTGRVFRLQF DEFQIVSSSH DDTILIWDFL NFTPNENKTG
510
RTPSPALMEH
Length:510
Mass (Da):58,952
Last modified:June 1, 1998 - v1
Checksum:iDBB0243D3730A5E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032878 mRNA Translation: AAC38852.1

Similar proteinsi

Entry informationi

Entry nameiO44382_DROME
AccessioniPrimary (citable) accession number: O44382
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: April 25, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health