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O44326

- HMP2_CAEEL

UniProt

O44326 - HMP2_CAEEL

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Protein
Protein humpback-2
Gene
hmp-2, K05C4.6
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for cell migration during body enclosure and cell shape changes during body elongation.1 Publication

GO - Molecular functioni

  1. alpha-catenin binding Source: WormBase
  2. cadherin binding Source: WormBase
  3. protein binding Source: UniProtKB
  4. protein domain specific binding Source: WormBase
  5. protein kinase binding Source: WormBase
  6. structural molecule activity Source: RefGenome
  7. transcription coactivator activity Source: WormBase

GO - Biological processi

  1. cell migration Source: WormBase
  2. cell migration involved in gastrulation Source: WormBase
  3. cell morphogenesis Source: RefGenome
  4. cytoskeletal anchoring at plasma membrane Source: RefGenome
  5. embryo development ending in birth or egg hatching Source: WormBase
  6. embryonic body morphogenesis Source: WormBase
  7. morphogenesis of embryonic epithelium Source: RefGenome
  8. negative regulation of heart induction by canonical Wnt signaling pathway Source: RefGenome
  9. negative regulation of transcription from RNA polymerase II promoter Source: RefGenome
  10. nervous system development Source: RefGenome
  11. oocyte development Source: RefGenome
  12. positive regulation of transcription from RNA polymerase II promoter Source: WormBase
  13. regulation of actin cytoskeleton organization by cell-cell adhesion Source: WormBase
  14. regulation of protein localization Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

SignaLinkiO44326.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein humpback-2
Gene namesi
Name:hmp-2
ORF Names:K05C4.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiK05C4.6a; CE19974; WBGene00001979; hmp-2.

Subcellular locationi

Cell junctionadherens junction 1 Publication

GO - Cellular componenti

  1. Z disc Source: RefGenome
  2. basolateral plasma membrane Source: RefGenome
  3. catenin complex Source: WormBase
  4. cell-cell adherens junction Source: WormBase
  5. cytoplasmic side of plasma membrane Source: RefGenome
  6. cytosol Source: RefGenome
  7. desmosome Source: RefGenome
  8. fascia adherens Source: RefGenome
  9. nucleus Source: WormBase
  10. transcription factor complex Source: RefGenome
  11. zonula adherens Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell junction

Pathology & Biotechi

Disruption phenotypei

Worms have strong elongation defects.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 678678Protein humpback-2
PRO_0000268647Add
BLAST

Proteomic databases

PaxDbiO44326.

Expressioni

Tissue specificityi

Epidermal cells.1 Publication

Developmental stagei

Present in all embryonic blastomeres at early stages of development (at protein level).1 Publication

Interactioni

Subunit structurei

Interacts with hmr-1. May interact with hmp-1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
hmr-1Q967F45EBI-317320,EBI-2528888

Protein-protein interaction databases

BioGridi38723. 19 interactions.
DIPiDIP-27261N.
IntActiO44326. 4 interactions.
MINTiMINT-1079247.
STRINGi6239.K05C4.6.

Structurei

3D structure databases

ProteinModelPortaliO44326.
SMRiO44326. Positions 69-604.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati153 – 19240ARM 1
Add
BLAST
Repeati280 – 31940ARM 2
Add
BLAST
Repeati320 – 35940ARM 3
Add
BLAST
Repeati362 – 40342ARM 4
Add
BLAST
Repeati409 – 44840ARM 5
Add
BLAST

Sequence similaritiesi

Belongs to the beta-catenin family.
Contains 5 ARM repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG297695.
GeneTreeiENSGT00730000110821.
HOGENOMiHOG000021706.
InParanoidiO44326.
PhylomeDBiO44326.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view]
PfamiPF00514. Arm. 1 hit.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O44326-1 [UniParc]FASTAAdd to Basket

« Hide

MLLHSTNSYS IFTDHEVETR TSRIRSAMFP DWIPPTSAAE ATNSTTSIVE    50
MMQMPTQQLK QSVMDLLTYE GSNDMSGLSL PDLVKLMCDH DESVVARAVH 100
RAYMLSREDP NFFNAPGFDH RSFVEALMAA SKSSNVNVRR NAIGALSHMS 150
EQRGGPLLIF RSGGLAEIIR MLYDSLESVV HYAVTTLRNL LMHVSDSRAQ 200
ARALNAVEAL TPHLHKTNPK LLAQVADGLY FLLIDDAPSK ITFLSLLGPQ 250
ILVSILREYS DHRKLIYTVV RCIRSLSVCP SNKPALISLG CLPALYVELC 300
TAKDERSQTA ILVAMRNLSD SATNEENLTQ LIIKLLEIIR VANDGMTACA 350
CGTLSNLTCN NTRNKQTVCS HGGIDALVTA IRRLPEVEEV TEPALCALRH 400
CTARHSLAEE AQSELRFCQA FPVILDQLET LRTPVIKAAL GVIRNSALLQ 450
TNLIELTQEQ TANGHTAVSL TMDILRRAIT AIEENPDIAV DGVPMWGVIE 500
GAVSALHQLA NHPAVAAACC DDIGQVGNPE CPPFLDLLHR LLAHPRLGSM 550
DDEVLEREIL GLLYQLSKRP DGARAVESTG VSALLMESRG SQYKSVVTYA 600
NGVLSNLKRG DSAAIMNMSN SYDYEMSGSA ADWQRDGLER ELFAEMYPTN 650
DGGHSESINM ALNNSQMRPN HNWYDTDL 678
Length:678
Mass (Da):74,511
Last modified:June 1, 1998 - v1
Checksum:iE6C7ED51F6241232
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF016853 mRNA. Translation: AAB94552.1.
Z81564 Genomic DNA. Translation: CAB04572.1.
PIRiT23341.
RefSeqiNP_001252426.1. NM_001265497.1.
UniGeneiCel.7074.

Genome annotation databases

EnsemblMetazoaiK05C4.6a.1; K05C4.6a.1; WBGene00001979.
K05C4.6a.2; K05C4.6a.2; WBGene00001979.
GeneIDi173338.
KEGGicel:CELE_K05C4.6.
UCSCiK05C4.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF016853 mRNA. Translation: AAB94552.1 .
Z81564 Genomic DNA. Translation: CAB04572.1 .
PIRi T23341.
RefSeqi NP_001252426.1. NM_001265497.1.
UniGenei Cel.7074.

3D structure databases

ProteinModelPortali O44326.
SMRi O44326. Positions 69-604.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 38723. 19 interactions.
DIPi DIP-27261N.
IntActi O44326. 4 interactions.
MINTi MINT-1079247.
STRINGi 6239.K05C4.6.

Proteomic databases

PaxDbi O44326.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai K05C4.6a.1 ; K05C4.6a.1 ; WBGene00001979 .
K05C4.6a.2 ; K05C4.6a.2 ; WBGene00001979 .
GeneIDi 173338.
KEGGi cel:CELE_K05C4.6.
UCSCi K05C4.6. c. elegans.

Organism-specific databases

CTDi 173338.
WormBasei K05C4.6a ; CE19974 ; WBGene00001979 ; hmp-2.

Phylogenomic databases

eggNOGi NOG297695.
GeneTreei ENSGT00730000110821.
HOGENOMi HOG000021706.
InParanoidi O44326.
PhylomeDBi O44326.

Enzyme and pathway databases

SignaLinki O44326.

Miscellaneous databases

NextBioi 879233.
PROi O44326.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view ]
Pfami PF00514. Arm. 1 hit.
[Graphical view ]
PRINTSi PR01869. BCATNINFAMLY.
SMARTi SM00185. ARM. 5 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
PROSITEi PS50176. ARM_REPEAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A putative catenin-cadherin system mediates morphogenesis of the Caenorhabditis elegans embryo."
    Costa M., Raich W., Agbunag C., Leung B., Hardin J., Priess J.R.
    J. Cell Biol. 141:297-308(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "Distinct beta-catenins mediate adhesion and signalling functions in C. elegans."
    Korswagen H.C., Herman M.A., Clevers H.C.
    Nature 406:527-532(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HMR-1.
  4. "The divergent Caenorhabditis elegans beta-catenin proteins BAR-1, WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancy in vivo."
    Natarajan L., Witwer N.E., Eisenmann D.M.
    Genetics 159:159-172(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE INTERACTION WITH HMP-1.

Entry informationi

Entry nameiHMP2_CAEEL
AccessioniPrimary (citable) accession number: O44326
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 1998
Last modified: June 11, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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