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O44326

- HMP2_CAEEL

UniProt

O44326 - HMP2_CAEEL

Protein

Protein humpback-2

Gene

hmp-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Required for cell migration during body enclosure and cell shape changes during body elongation.1 Publication

    GO - Molecular functioni

    1. alpha-catenin binding Source: WormBase
    2. cadherin binding Source: WormBase
    3. protein binding Source: UniProtKB
    4. protein domain specific binding Source: WormBase
    5. protein kinase binding Source: WormBase
    6. structural molecule activity Source: RefGenome
    7. transcription coactivator activity Source: WormBase

    GO - Biological processi

    1. cell migration Source: WormBase
    2. cell migration involved in gastrulation Source: WormBase
    3. cell morphogenesis Source: RefGenome
    4. cytoskeletal anchoring at plasma membrane Source: RefGenome
    5. embryo development ending in birth or egg hatching Source: WormBase
    6. embryonic body morphogenesis Source: WormBase
    7. morphogenesis of embryonic epithelium Source: RefGenome
    8. negative regulation of heart induction by canonical Wnt signaling pathway Source: RefGenome
    9. negative regulation of transcription from RNA polymerase II promoter Source: RefGenome
    10. nervous system development Source: RefGenome
    11. oocyte development Source: RefGenome
    12. positive regulation of transcription from RNA polymerase II promoter Source: WormBase
    13. regulation of actin cytoskeleton organization by cell-cell adhesion Source: WormBase
    14. regulation of protein localization Source: WormBase

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    SignaLinkiO44326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein humpback-2
    Gene namesi
    Name:hmp-2
    ORF Names:K05C4.6
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome I

    Organism-specific databases

    WormBaseiK05C4.6a; CE19974; WBGene00001979; hmp-2.

    Subcellular locationi

    Cell junctionadherens junction 1 Publication

    GO - Cellular componenti

    1. basolateral plasma membrane Source: RefGenome
    2. catenin complex Source: WormBase
    3. cell-cell adherens junction Source: WormBase
    4. cytoplasmic side of plasma membrane Source: RefGenome
    5. cytosol Source: RefGenome
    6. desmosome Source: RefGenome
    7. fascia adherens Source: RefGenome
    8. nucleus Source: WormBase
    9. transcription factor complex Source: RefGenome
    10. Z disc Source: RefGenome
    11. zonula adherens Source: RefGenome

    Keywords - Cellular componenti

    Cell junction

    Pathology & Biotechi

    Disruption phenotypei

    Worms have strong elongation defects.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 678678Protein humpback-2PRO_0000268647Add
    BLAST

    Proteomic databases

    PaxDbiO44326.

    Expressioni

    Tissue specificityi

    Epidermal cells.1 Publication

    Developmental stagei

    Present in all embryonic blastomeres at early stages of development (at protein level).1 Publication

    Interactioni

    Subunit structurei

    Interacts with hmr-1. May interact with hmp-1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    hmr-1Q967F45EBI-317320,EBI-2528888

    Protein-protein interaction databases

    BioGridi38723. 20 interactions.
    DIPiDIP-27261N.
    IntActiO44326. 4 interactions.
    MINTiMINT-1079247.
    STRINGi6239.K05C4.6.

    Structurei

    3D structure databases

    ProteinModelPortaliO44326.
    SMRiO44326. Positions 69-604.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati153 – 19240ARM 1Add
    BLAST
    Repeati280 – 31940ARM 2Add
    BLAST
    Repeati320 – 35940ARM 3Add
    BLAST
    Repeati362 – 40342ARM 4Add
    BLAST
    Repeati409 – 44840ARM 5Add
    BLAST

    Sequence similaritiesi

    Belongs to the beta-catenin family.Curated
    Contains 5 ARM repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG297695.
    GeneTreeiENSGT00730000110821.
    HOGENOMiHOG000021706.
    InParanoidiO44326.
    PhylomeDBiO44326.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR013284. Beta-catenin.
    [Graphical view]
    PfamiPF00514. Arm. 1 hit.
    [Graphical view]
    PRINTSiPR01869. BCATNINFAMLY.
    SMARTiSM00185. ARM. 5 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.
    PROSITEiPS50176. ARM_REPEAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O44326-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLHSTNSYS IFTDHEVETR TSRIRSAMFP DWIPPTSAAE ATNSTTSIVE    50
    MMQMPTQQLK QSVMDLLTYE GSNDMSGLSL PDLVKLMCDH DESVVARAVH 100
    RAYMLSREDP NFFNAPGFDH RSFVEALMAA SKSSNVNVRR NAIGALSHMS 150
    EQRGGPLLIF RSGGLAEIIR MLYDSLESVV HYAVTTLRNL LMHVSDSRAQ 200
    ARALNAVEAL TPHLHKTNPK LLAQVADGLY FLLIDDAPSK ITFLSLLGPQ 250
    ILVSILREYS DHRKLIYTVV RCIRSLSVCP SNKPALISLG CLPALYVELC 300
    TAKDERSQTA ILVAMRNLSD SATNEENLTQ LIIKLLEIIR VANDGMTACA 350
    CGTLSNLTCN NTRNKQTVCS HGGIDALVTA IRRLPEVEEV TEPALCALRH 400
    CTARHSLAEE AQSELRFCQA FPVILDQLET LRTPVIKAAL GVIRNSALLQ 450
    TNLIELTQEQ TANGHTAVSL TMDILRRAIT AIEENPDIAV DGVPMWGVIE 500
    GAVSALHQLA NHPAVAAACC DDIGQVGNPE CPPFLDLLHR LLAHPRLGSM 550
    DDEVLEREIL GLLYQLSKRP DGARAVESTG VSALLMESRG SQYKSVVTYA 600
    NGVLSNLKRG DSAAIMNMSN SYDYEMSGSA ADWQRDGLER ELFAEMYPTN 650
    DGGHSESINM ALNNSQMRPN HNWYDTDL 678
    Length:678
    Mass (Da):74,511
    Last modified:June 1, 1998 - v1
    Checksum:iE6C7ED51F6241232
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF016853 mRNA. Translation: AAB94552.1.
    Z81564 Genomic DNA. Translation: CAB04572.1.
    PIRiT23341.
    RefSeqiNP_001252426.1. NM_001265497.1.
    UniGeneiCel.7074.

    Genome annotation databases

    EnsemblMetazoaiK05C4.6a.1; K05C4.6a.1; WBGene00001979.
    K05C4.6a.2; K05C4.6a.2; WBGene00001979.
    GeneIDi173338.
    KEGGicel:CELE_K05C4.6.
    UCSCiK05C4.6. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF016853 mRNA. Translation: AAB94552.1 .
    Z81564 Genomic DNA. Translation: CAB04572.1 .
    PIRi T23341.
    RefSeqi NP_001252426.1. NM_001265497.1.
    UniGenei Cel.7074.

    3D structure databases

    ProteinModelPortali O44326.
    SMRi O44326. Positions 69-604.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 38723. 20 interactions.
    DIPi DIP-27261N.
    IntActi O44326. 4 interactions.
    MINTi MINT-1079247.
    STRINGi 6239.K05C4.6.

    Proteomic databases

    PaxDbi O44326.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai K05C4.6a.1 ; K05C4.6a.1 ; WBGene00001979 .
    K05C4.6a.2 ; K05C4.6a.2 ; WBGene00001979 .
    GeneIDi 173338.
    KEGGi cel:CELE_K05C4.6.
    UCSCi K05C4.6. c. elegans.

    Organism-specific databases

    CTDi 173338.
    WormBasei K05C4.6a ; CE19974 ; WBGene00001979 ; hmp-2.

    Phylogenomic databases

    eggNOGi NOG297695.
    GeneTreei ENSGT00730000110821.
    HOGENOMi HOG000021706.
    InParanoidi O44326.
    PhylomeDBi O44326.

    Enzyme and pathway databases

    SignaLinki O44326.

    Miscellaneous databases

    NextBioi 879233.
    PROi O44326.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR013284. Beta-catenin.
    [Graphical view ]
    Pfami PF00514. Arm. 1 hit.
    [Graphical view ]
    PRINTSi PR01869. BCATNINFAMLY.
    SMARTi SM00185. ARM. 5 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    PROSITEi PS50176. ARM_REPEAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A putative catenin-cadherin system mediates morphogenesis of the Caenorhabditis elegans embryo."
      Costa M., Raich W., Agbunag C., Leung B., Hardin J., Priess J.R.
      J. Cell Biol. 141:297-308(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    3. "Distinct beta-catenins mediate adhesion and signalling functions in C. elegans."
      Korswagen H.C., Herman M.A., Clevers H.C.
      Nature 406:527-532(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HMR-1.
    4. "The divergent Caenorhabditis elegans beta-catenin proteins BAR-1, WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancy in vivo."
      Natarajan L., Witwer N.E., Eisenmann D.M.
      Genetics 159:159-172(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: POSSIBLE INTERACTION WITH HMP-1.

    Entry informationi

    Entry nameiHMP2_CAEEL
    AccessioniPrimary (citable) accession number: O44326
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3