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Protein

60S ribosomal protein L5

Gene

RpL5

Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L5
Gene namesi
Name:RpL5
ORF Names:AGAP009031
OrganismiAnopheles gambiae (African malaria mosquito)
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
Proteomesi
  • UP000007062 Componentsi: Chromosome 3R, Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001314411 – 32560S ribosomal protein L5Add BLAST325

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU).By similarity

Structurei

3D structure databases

ProteinModelPortaliO44248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000105947.
InParanoidiO44248.
KOiK02932.
OrthoDBiEOG091G0GZO.

Family and domain databases

HAMAPiMF_01337_A. Ribosomal_L18_A. 1 hit.
InterProiView protein in InterPro
IPR005485. Rbsml_L5_euk/L18_arc.
IPR025607. Rbsml_L5e/L18P_C.
PANTHERiPTHR23410. PTHR23410. 1 hit.
PfamiView protein in Pfam
PF14204. Ribosomal_L18_c. 1 hit.
PF17144. Ribosomal_L5e. 1 hit.
PRINTSiPR00058. RIBOSOMALL5.

Sequencei

Sequence statusi: Complete.

O44248-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFVKVVKNK QYFKRYQVRF RRRREGKTDY YARKRLIFQD KNKYNTPKFR
60 70 80 90 100
LIVRLSNRDI TCQIAYARIE GDRIVCAAYS HELPRYGVKV GLTNYAAAYC
110 120 130 140 150
TGLLVARRIL QKLRLDTLYA GCTDVTGEEY LVEPVDEGPA AFRCYLDVGL
160 170 180 190 200
ARTTTGARVF GAMKGAVDGG LNIPHSVKRF PGYSAENKSF NAEMHRDHIF
210 220 230 240 250
GLHVANYMRT LEEEDEEAFK RQFSKYISLG IKADDIENIY KNAHASIRIP
260 270 280 290 300
PSRRNPRRRS PRSGGRWPSC RSPPARRRSR STRPTSWPRS RPTSKPKRPR
310 320
RRRPFFFSSW WCIILVLPCS SPVRR
Length:325
Mass (Da):37,782
Last modified:July 10, 2007 - v3
Checksum:i9C04C249A89B3C42
GO

Sequence cautioni

The sequence EAA14773 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67A → R in AAB97731 (Ref. 1) Curated1
Sequence conflicti157A → S in AAB97731 (Ref. 1) Curated1
Sequence conflicti248R → RK in AAB97731 (Ref. 1) Curated1
Sequence conflicti298R → RL in AAB97731 (Ref. 1) Curated1
Sequence conflicti324 – 325RR → QG in AAB97731 (Ref. 1) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002238 mRNA. Translation: AAB97731.1.
AAAB01008984 Genomic DNA. Translation: EAA14773.3. Sequence problems.
RefSeqiXP_319782.3. XM_319782.5.

Genome annotation databases

EnsemblMetazoaiAGAP009031-RA; AGAP009031-PA; AGAP009031.
GeneIDi1279989.
KEGGiaga:AgaP_AGAP009031.

Similar proteinsi

Entry informationi

Entry nameiRL5_ANOGA
AccessioniPrimary (citable) accession number: O44248
Secondary accession number(s): Q5TNI8, Q7PWA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 10, 2007
Last modified: August 30, 2017
This is version 94 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families