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Reviewed, UniProtKB/Swiss-Prot O44220 (C12B1_DROAC)

Last modified June 16, 2009. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytochrome P450 12b1, mitochondrial
    EC=1.14.-.-
Alternative name(s):
    CYPXIIB1
Gene names
Name: Cyp12b1
OrganismDrosophila acanthoptera (Fruit fly)
Taxonomic identifier51166 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila

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Protein attributes

Sequence length532 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Probably involved in steroid hormones biosynthesis.

Cofactor

Heme group By similarity.

Subcellular location

Mitochondrion Probable.

Sequence similarities

Belongs to the cytochrome P450 family.

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Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionelectron carrier activity

Inferred from electronic annotation. Source: InterPro

heme binding

Inferred from electronic annotation. Source: InterPro

monooxygenase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion By similarity
Chain? – 532Cytochrome P450 12b1, mitochondrialPRO_0000003610

Sites

Metal binding4801Iron (heme axial ligand) Potential

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Sequences

Sequence LengthMass (Da)Tools
O44220-1 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 2E94D7FC66FDF569

FASTA53262,031
        10         20         30         40         50         60 
MWKFAIHSQQ PFCWQQLCNR RHLYVGNVQQ QTHLELLDAA PTRSDDEWLQ AKPYEKVPGP 

        70         80         90        100        110        120 
GTWQVLSYFL PGGKQYNTNL IQMNRRMREW YGDIYRFPGL MGKQDVIFTY NPNDFELTYR 

       130        140        150        160        170        180 
NEGVWPIRIG LESFTYYRKV HRPEVFGSIG GLVSEQGKDW AHIRNKVNPV QMRVQNVRQN 

       190        200        210        220        230        240 
LPQIDQISRE FVDKLDTLRD PVTHILNDNF HEQLKMWAFE SISFVALNTR MGLLSDRPDP 

       250        260        270        280        290        300 
NAARLAEHMT DFFNYSFKYD VQPSIWPYYK TPGFKKFLQT YDKITEITTA YIDEAIKRFE 

       310        320        330        340        350        360 
IEKDSGNECV LQQLLSLNKK VAVVMAMYML MAGIDTTSSA FVTILYHLAR NPHKQRQLHR 

       370        380        390        400        410        420 
ERRRILPDSD EPLTPENTKN MPYLRACIKE CMRITSITPG NFRIATKDLV LSGYRVPRGE 

       430        440        450        460        470        480 
GVLMGVLELS NSEKYFGQSG QFMPERWLKA DTDPDVKACP AARSRNPFVY LAFGFGPRTC 

       490        500        510        520        530 
IGKRIAELEM ETLLTRLLRR YQVSWLAEMP LQYESNIILS PHGIYVQVRA AC

« Hide

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References

[1]"Isolation and sequence analysis of cytochrome P450 12B1: the first mitochondrial insect P450 with homology to 1 alpha,25 dihydroxy-D3 24-hydroxylase."
Danielson P.B., Fogleman J.C.
Insect Biochem. Mol. Biol. 27:595-604(1997) [PubMed: 9304797] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: A584.2.

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Cross-references

Sequence databases

U78485 mRNA. Translation: AAB88725.1.

3D structure databases

ModBaseSearch...

Organism-specific databases

FlyBaseFBgn0022933. Daca\Cyp12b1.

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR017973. Cyt_P450_C.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHERPTHR19383. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameC12B1_DROAC
AccessionPrimary (citable) accession number: O44220
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents