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Protein

Tyrosine-protein phosphatase

Gene

CELE_M04G7.2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei460Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-CEL-1250196. SHC1 events in ERBB2 signaling.
R-CEL-202427. Phosphorylation of CD3 and TCR zeta chains.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphataseUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
ORF Names:CELE_M04G7.2Imported, M04G7.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiM04G7.2a; CE17191; WBGene00019773.

PTM / Processingi

Proteomic databases

PaxDbiO44180.

Expressioni

Gene expression databases

BgeeiWBGene00019773.
ExpressionAtlasiO44180. baseline and differential.

Interactioni

Protein-protein interaction databases

DIPiDIP-25589N.
MINTiMINT-1125593.
STRINGi6239.M04G7.2.

Structurei

3D structure databases

ProteinModelPortaliO44180.
SMRiO44180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini266 – 521Tyrosine-protein phosphataseInterPro annotationAdd BLAST256
Domaini440 – 512TYR_PHOSPHATASE_2InterPro annotationAdd BLAST73

Phylogenomic databases

eggNOGiKOG0789. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00900000140780.
HOGENOMiHOG000019820.
InParanoidiO44180.
OMAiCINTHFK.
OrthoDBiEOG091G0I33.
PhylomeDBiO44180.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
PfamiView protein in Pfam
PF00102. Y_phosphatase. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiView protein in SMART
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiView protein in PROSITE
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.

Sequencei

Sequence statusi: Complete.

O44180-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMFNRKAKQ EVTKKPEASN GSKNSKSTFV NSKSPNQKRR EVKKSDSDTE
60 70 80 90 100
SSHKNTRRTK PVPVPAASSN SKGSNEKHKR KSVQQVVKKV VNHIPFSPSK
110 120 130 140 150
QPKSTSTPPV SEGNRKRLAM ADVSINQLES EMDSFVKKIE PNERRATQYI
160 170 180 190 200
HSNSLSRSNE AVPPGNVKTS QQKADHHLIR TTRSLIGLDG ETEAVYSKAT
210 220 230 240 250
KASPDKGKLT ADSPSSRRTS KSLEENSSET TNDSISLADD EETREAYRKL
260 270 280 290 300
FKDFAMSSQK MTLDDFKQEF SNLPGDPPSD LCTVFNHPVN NKKNRYSNIP
310 320 330 340 350
CLDISRVQLK FKMPNKNSTD YIHANYIRSP FLKRGYILTQ GPKKETRADF
360 370 380 390 400
WRMIWQENTT AIVMLCQFLE TNREKCAEYF PRNAHCCLQF DKFSVNYEDS
410 420 430 440 450
TVNKSLVTTR LNLSYEGETR LITHWLWKEW PDWQVPESSE VMLKILRKIR
460 470 480 490 500
ARSTPPVIHC SAGVGRSGTL MAVEIALQSI HTHFTLPDIK QIVSHLRVTG
510 520 530 540 550
RAASVQTLQQ YMLIWKVLLD FGVAYKQITE ELAEKFNSTY RRSLRSINGT
Length:550
Mass (Da):62,630
Last modified:June 1, 1998 - v1
Checksum:iC0C47350F967CD64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD73113.1.
PIRiT32543.
RefSeqiNP_499934.1. NM_067533.3.
UniGeneiCel.23813.

Genome annotation databases

EnsemblMetazoaiM04G7.2a; M04G7.2a; WBGene00019773.
GeneIDi187449.
UCSCiM04G7.2. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiO44180_CAEEL
AccessioniPrimary (citable) accession number: O44180
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: November 22, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported