Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Uncharacterized protein

Gene

egl-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  • phosphorelay sensor kinase activity Source: InterPro
  • potassium channel activity Source: WormBase
  • protein kinase binding Source: WormBase
  • voltage-gated potassium channel activity Source: GO_Central

GO - Biological processi

  • chemosensory behavior Source: WormBase
  • muscle contraction Source: WormBase
  • oviposition Source: WormBase
  • potassium ion transport Source: WormBase
  • regulation of membrane potential Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:egl-2Imported
ORF Names:CELE_F16B3.1Imported, F16B3.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF16B3.1a; CE24905; WBGene00001171; egl-2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei218 – 24023HelicalSequence analysisAdd
BLAST
Transmembranei360 – 38627HelicalSequence analysisAdd
BLAST
Transmembranei439 – 45719HelicalSequence analysisAdd
BLAST
Transmembranei464 – 48421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • intracellular Source: GOC
  • membrane Source: WormBase
  • microvillus membrane Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiO44164.
PRIDEiO44164.

Expressioni

Gene expression databases

ExpressionAtlasiO44164. baseline.

Interactioni

GO - Molecular functioni

  • protein kinase binding Source: WormBase

Protein-protein interaction databases

STRINGi6239.F16B3.1.

Structurei

3D structure databases

ProteinModelPortaliO44164.
SMRiO44164. Positions 14-134, 495-705.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 9079PAS (PER-ARNT-SIM)InterPro annotationAdd
BLAST
Domaini93 – 14553PAC (PAS-associated C-terminal)InterPro annotationAdd
BLAST
Domaini567 – 668102Cyclic nucleotide-bindingInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains cyclic nucleotide-binding domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0498. Eukaryota.
ENOG410XPSE. LUCA.
HOGENOMiHOG000230794.
InParanoidiO44164.
KOiK04908.
OMAiNKAEVVH.
OrthoDBiEOG7QG43V.
PhylomeDBiO44164.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003949. K_chnl_volt-dep_EAG.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01464. EAGCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O44164-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVGKRGLVA PQNTFLENVI RRCNNADTSF ILANAQVVDY PIVYCNDGFS
60 70 80 90 100
KLVGYTRAEI MQKPCSLAFM HGEHGEVGSL QKMQEALENA RTEQAEIGLC
110 120 130 140 150
KKNKTPIWLL VHLAPIKNHK DAVVLYLCQF KDITPLKQPL DDENNKGLSR
160 170 180 190 200
ILQIARIAKS KQQFNQIETK DLHKSPGNTS SNFNQVMNLG GDMLPQYRQE
210 220 230 240 250
TPKTSPHIIL HYSSFKTIWD WSILALTFYT AFMVPFNIAF KNSLRPFYLI
260 270 280 290 300
SSRENPGGGI DSVALMDSIV DVIFFADILL NFHTTFVGPG GEVVIEPSVI
310 320 330 340 350
RQNYFKSWFL IDLLSCLPYD IFYMFKRDDE RIGSLFSALK VVRLLRLGRV
360 370 380 390 400
ARKLDNYLEY GAATLLLLLC AYVIVAHWLA CVWFWIGDSE VRLKMDNLAL
410 420 430 440 450
PDGWLWKLSN DLRQHYNIPL SNKTTLVGGP SRTSAYISSL YYTMSCMSTV
460 470 480 490 500
GFGNIASNTD NEKIFGVCMM IISALLYAAI FGHMTTIIQQ MTSSTVRYHE
510 520 530 540 550
MISNVREFIK LQEIPKELAE RVMDYVVSTW AMTKGIDTAK VLGYCPKDMK
560 570 580 590 600
ADICVHLNRK VFNEHSCFRL ASDGCLRSLA MFLELNHAAP GDLLYHTGES
610 620 630 640 650
VDALWFVVSG SLEVIQDDEV VAILGKGDVF GDEFWKANGS TGQSAANVRA
660 670 680 690 700
LTYSDLHMIK KDKLMDVLDF YKAFANSFAR NMTLTYNLTH RMKFRKVADV
710 720 730 740 750
KREKELDAKR KNEKLTLPND HPIRKLLFRM RERHGPRIFP SPMFADIEKG
760 770 780 790 800
LKKSTEISRI SSLHSMIDET GGGGSSYVKS PRSKPKRPPL MKRQTVDEDA
810 820 830 840 850
LSRTSWGMDK KDREWSSLSN IKTEMKSKFD IIGERLTIIE QINSRLALLE
860 870 880 890 900
RVLIGNNGGA NTPSTMPVGS FSALNESGNR LTLDAAPVAR SVSWSEQHQP
910 920 930 940 950
HWQRTSTVPP LRELEAGEWE PPIREPTPNP STSSSRVPHI QIDEDGEARP

PTRTRI
Length:956
Mass (Da):108,091
Last modified:October 1, 2001 - v2
Checksum:iE998B7F2128054A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD69554.1.
PIRiT42394.
RefSeqiNP_503402.3. NM_071001.4.
UniGeneiCel.19583.

Genome annotation databases

EnsemblMetazoaiF16B3.1; F16B3.1; WBGene00001171.
F16B3.1a; F16B3.1a; WBGene00001171.
GeneIDi178624.
KEGGicel:CELE_F16B3.1.
UCSCiF16B3.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD69554.1.
PIRiT42394.
RefSeqiNP_503402.3. NM_071001.4.
UniGeneiCel.19583.

3D structure databases

ProteinModelPortaliO44164.
SMRiO44164. Positions 14-134, 495-705.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F16B3.1.

Proteomic databases

PaxDbiO44164.
PRIDEiO44164.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF16B3.1; F16B3.1; WBGene00001171.
F16B3.1a; F16B3.1a; WBGene00001171.
GeneIDi178624.
KEGGicel:CELE_F16B3.1.
UCSCiF16B3.1. c. elegans.

Organism-specific databases

CTDi178624.
WormBaseiF16B3.1a; CE24905; WBGene00001171; egl-2.

Phylogenomic databases

eggNOGiKOG0498. Eukaryota.
ENOG410XPSE. LUCA.
HOGENOMiHOG000230794.
InParanoidiO44164.
KOiK04908.
OMAiNKAEVVH.
OrthoDBiEOG7QG43V.
PhylomeDBiO44164.

Gene expression databases

ExpressionAtlasiO44164. baseline.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003949. K_chnl_volt-dep_EAG.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01464. EAGCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiO44164_CAEEL
AccessioniPrimary (citable) accession number: O44164
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: October 1, 2001
Last modified: July 6, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.