Reviewed, UniProtKB/Swiss-Prot O44156 (PSA1_CAEEL)

Names and origin

Protein names

Recommended name:
    Proteasome subunit alpha type-1
    EC=3.4.25.1
Alternative name(s):
    Proteasome subunit alpha 6

Gene names

Name:	pas-6
ORF Names:	CD4.6

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.
Catalytic activity	Cleavage of peptide bonds with very broad specificity.
Subunit structure	The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the peptidase T1A family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus Proteasome
Molecular function	Hydrolase Protease Threonine protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase growth Inferred from mutant phenotype. Source: WormBase locomotion Inferred from mutant phenotype. Source: WormBase molting cycle, collagen and cuticulin-based cuticle Inferred from mutant phenotype. Source: WormBase nematode larval development Inferred from mutant phenotype. Source: WormBase reproduction Inferred from mutant phenotype. Source: WormBase ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell proteasome core complex Inferred from electronic annotation. Source: InterPro
Molecular function	threonine-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 260	260	Proteasome subunit alpha type-1		PRO_0000124066

Sequences

	Sequence		Length	Mass (Da)
	O44156-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: D8EEEF5E480F8F70	FASTA	260	28,311
	10 20 30 40 50 60 MFRNQYDGDV TVWSPQGRLH QVEYAVEAMK QGSATVGIKS ETHAVIVALK RAQNDLSSHQ 70 80 90 100 110 120 KKVYEIDTHA GVSIAGLLSD GRILARYLQT ECSSWRWDYK QAVPIKKLAE SMQLKLQANT 130 140 150 160 170 180 QYYGRRPFGV GILIAGYDKD GAHIIQTDPS AEVVSMHGTS IGARSQSART YLERNVDNFE 190 200 210 220 230 240 KSTPEQLIVH ALLALRDTLP AEENLNAQNT SIGIVGKDSP FSLLEDAQVA VHLNQVSTHP 250 260 RTTGGAAAAA APGGAEPMQM

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF036694 Genomic DNA. Translation: AAB88344.1.
PIR	T32525.
RefSeq	NP_504472.1.
UniGene	Cel.6749
3D structure databases
HSSP	HSSP built from PDB template 1RYP based on UniProtKB P40302.
ModBase	Search...
Protein-protein interaction databases
IntAct	O44156. 11 interactions.
STRING	O44156.
Protein family/group databases
MEROPS	T01.976.
Genome annotation databases
Ensembl	CD4.6.1; CD4.6.1; CD4.6; Caenorhabditis elegans. [Genome view] CD4.6.2; CD4.6.2; CD4.6; Caenorhabditis elegans. [Genome view]
GeneID	178943.
KEGG	cel:CD4.6.
UCSC	CD4.6.1. c. elegans.
Organism-specific databases
CTD	178943.
WormBase	WBGene00003927. pas-6.
WormPep	CD4.6. CE16954. [WorfDB]
Phylogenomic databases
OMA	YAVEAMK.
Enzyme and pathway databases
BRENDA	3.4.25.1. 672.
Gene expression databases
ArrayExpress	O44156.
Family and domain databases
InterPro	IPR000426. Proteasome_asu_CS. IPR001353. Proteasome_sua/b. [Graphical view]
Pfam	PF00227. Proteasome. 1 hit. PF10584. Proteasome_A_N. 1 hit. [Graphical view]
PROSITE	PS00388. PROTEASOME_A. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	903228.

Entry information

Entry name

PSA1_CAEEL

Accession

Primary (citable) accession number: O44156

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 8, 2000
Last sequence update:	June 1, 1998
Last modified:	November 3, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project