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Protein

Proteasome subunit alpha type-1

Gene

pas-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-CEL-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-CEL-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-CEL-195253. Degradation of beta-catenin by the destruction complex.
R-CEL-382556. ABC-family proteins mediated transport.
R-CEL-4608870. Asymmetric localization of PCP proteins.
R-CEL-4641258. Degradation of DVL.
R-CEL-5632684. Hedgehog 'on' state.
R-CEL-5689603. UCH proteinases.
R-CEL-5689880. Ub-specific processing proteases.
R-CEL-68949. Orc1 removal from chromatin.
R-CEL-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-CEL-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-CEL-8941858. Regulation of RUNX3 expression and activity.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Protein family/group databases

MEROPSiT01.976.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-1 (EC:3.4.25.1)
Alternative name(s):
Proteasome subunit alpha 6
Gene namesi
Name:pas-6
ORF Names:CD4.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiCD4.6; CE16954; WBGene00003927; pas-6.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001240661 – 260Proteasome subunit alpha type-1Add BLAST260

Proteomic databases

EPDiO44156.
PaxDbiO44156.
PeptideAtlasiO44156.
PRIDEiO44156.

2D gel databases

World-2DPAGEi0020:O44156.

Expressioni

Gene expression databases

BgeeiWBGene00003927.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi43992. 11 interactors.
IntActiO44156. 10 interactors.
MINTiMINT-210737.
STRINGi6239.CD4.6.2.

Structurei

3D structure databases

ProteinModelPortaliO44156.
SMRiO44156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0863. Eukaryota.
COG0638. LUCA.
GeneTreeiENSGT00550000074855.
HOGENOMiHOG000091080.
InParanoidiO44156.
KOiK02725.
OMAiFMKQQCL.
OrthoDBiEOG091G0DNK.
PhylomeDBiO44156.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR023332. Proteasome_alpha-type.
IPR000426. Proteasome_asu_N.
IPR001353. Proteasome_sua/b.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
SMARTiView protein in SMART
SM00948. Proteasome_A_N. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiView protein in PROSITE
PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O44156-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRNQYDGDV TVWSPQGRLH QVEYAVEAMK QGSATVGIKS ETHAVIVALK
60 70 80 90 100
RAQNDLSSHQ KKVYEIDTHA GVSIAGLLSD GRILARYLQT ECSSWRWDYK
110 120 130 140 150
QAVPIKKLAE SMQLKLQANT QYYGRRPFGV GILIAGYDKD GAHIIQTDPS
160 170 180 190 200
AEVVSMHGTS IGARSQSART YLERNVDNFE KSTPEQLIVH ALLALRDTLP
210 220 230 240 250
AEENLNAQNT SIGIVGKDSP FSLLEDAQVA VHLNQVSTHP RTTGGAAAAA
260
APGGAEPMQM
Length:260
Mass (Da):28,311
Last modified:June 1, 1998 - v1
Checksum:iD8EEEF5E480F8F70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080609 Genomic DNA. Translation: CCD65121.1.
PIRiT32525.
RefSeqiNP_504472.1. NM_072071.5.
UniGeneiCel.6749.

Genome annotation databases

EnsemblMetazoaiCD4.6; CD4.6; WBGene00003927.
GeneIDi178943.
KEGGicel:CELE_CD4.6.
UCSCiCD4.6.1. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPSA1_CAEEL
AccessioniPrimary (citable) accession number: O44156
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: June 1, 1998
Last modified: June 7, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families