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Protein
Submitted name:

Lateral-signal-Induced Phosphatase

Gene

lip-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • embryo development ending in birth or egg hatching Source: WormBase
  • germ cell development Source: WormBase
  • negative regulation of MAP kinase activity Source: WormBase
  • negative regulation of meiotic cell cycle Source: WormBase
  • negative regulation of Ras protein signal transduction Source: WormBase
  • Notch signaling pathway Source: WormBase
  • oocyte development Source: WormBase
  • regulation of cell fate specification Source: WormBase
  • regulation of vulval development Source: WormBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-CEL-112409. RAF-independent MAPK1/3 activation.
R-CEL-202670. ERKs are inactivated.
R-CEL-5675221. Negative regulation of MAPK pathway.
SignaLinkiO44128.

Names & Taxonomyi

Protein namesi
Submitted name:
Lateral-signal-Induced PhosphataseImported
Gene namesi
Name:lip-1Imported
ORF Names:C05B10.1Imported, CELE_C05B10.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC05B10.1a; CE31151; WBGene00003043; lip-1.

Subcellular locationi

GO - Cellular componenti

  • plasma membrane Source: WormBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiO44128.
PaxDbiO44128.
PRIDEiO44128.

Expressioni

Gene expression databases

ExpressionAtlasiO44128. baseline.

Interactioni

Protein-protein interaction databases

IntActiO44128. 1 interaction.
STRINGi6239.C05B10.1.

Structurei

3D structure databases

ProteinModelPortaliO44128.
SMRiO44128. Positions 184-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini184 – 326143Tyrosine-protein phosphataseInterPro annotationAdd
BLAST
Domaini248 – 30861TYR_PHOSPHATASE_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.SAAS annotation
Contains tyrosine-protein phosphatase domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG1717. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118902.
HOGENOMiHOG000114628.
InParanoidiO44128.
OMAiSPSCAIE.
OrthoDBiEOG793B7W.
PhylomeDBiO44128.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 2 hits.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
PR01764. MAPKPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O44128-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTHLPSTSQ NGEEISAEQF NRIFHERNVI VLDCRSNGDS VKRANRFFCS
60 70 80 90 100
LRLPALLQRR LMGGSMRLST VPDLKDLNNS PDQCPEVLLI PGDSEQDEQL
110 120 130 140 150
SAALARNLKS NHYRHFVLGE PVKTLLSQFP TLRDAADENW NTTFQMNSMP
160 170 180 190 200
GQASGQQASS GPLLNLNQLR LEGEDQGGKQ RAEFPVKLTN FLYLGNAETA
210 220 230 240 250
KNRDVLKKYS ISHVINVTSN LPNTFEEDPN MRYLRISADD NASHNLTKFF
260 270 280 290 300
PEAISFIDDA RRNDSACLVH CLAGISRSVT ICLAYLMKTE MCTLDSAYEW
310 320 330 340 350
VQKRNASIAP NFHFMGQLTD YEKMLGLNSN RVGVSRQAVN FDVHFFCIFK
360
LKKKEENSPE SRILAETAV
Length:369
Mass (Da):41,586
Last modified:October 1, 2002 - v2
Checksum:i5A13DEA9C5198A17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD63076.1.
PIRiT32494.
RefSeqiNP_501053.2. NM_068652.2.
UniGeneiCel.20225.

Genome annotation databases

EnsemblMetazoaiC05B10.1a; C05B10.1a; WBGene00003043.
GeneIDi191704.
UCSCiC05B10.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD63076.1.
PIRiT32494.
RefSeqiNP_501053.2. NM_068652.2.
UniGeneiCel.20225.

3D structure databases

ProteinModelPortaliO44128.
SMRiO44128. Positions 184-328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO44128. 1 interaction.
STRINGi6239.C05B10.1.

Proteomic databases

EPDiO44128.
PaxDbiO44128.
PRIDEiO44128.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC05B10.1a; C05B10.1a; WBGene00003043.
GeneIDi191704.
UCSCiC05B10.1. c. elegans.

Organism-specific databases

CTDi191704.
WormBaseiC05B10.1a; CE31151; WBGene00003043; lip-1.

Phylogenomic databases

eggNOGiKOG1717. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118902.
HOGENOMiHOG000114628.
InParanoidiO44128.
OMAiSPSCAIE.
OrthoDBiEOG793B7W.
PhylomeDBiO44128.

Enzyme and pathway databases

ReactomeiR-CEL-112409. RAF-independent MAPK1/3 activation.
R-CEL-202670. ERKs are inactivated.
R-CEL-5675221. Negative regulation of MAPK pathway.
SignaLinkiO44128.

Gene expression databases

ExpressionAtlasiO44128. baseline.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 2 hits.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
PR01764. MAPKPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiO44128_CAEEL
AccessioniPrimary (citable) accession number: O44128
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.