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O44119 (TPM_HOMAM) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tropomyosin
Alternative name(s):
Allergen=Hom a 1
Gene names
Name:TM1
OrganismHomarus americanus (American lobster)
Taxonomic identifier6706 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataAstacideaNephropoideaNephropidaeHomarus

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.

Subunit structure

Homodimer By similarity.

Domain

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Allergenic properties

Causes an allergic reaction in human.

Sequence similarities

Belongs to the tropomyosin family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DiseaseAllergen
   DomainCoiled coil
Repeat
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Slow muscle 1 (identifier: O44119-1)

Also known as: STM1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Fast muscle type (identifier: O44119-2)

Also known as: FTM;

The sequence of this isoform differs from the canonical sequence as follows:
     39-79: TEEEIRITHK...KLEEKEKALQ → SEEEVHNLQK...QLEEKDKALS

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 284284Tropomyosin
PRO_0000205674

Regions

Coiled coil1 – 284284

Natural variations

Alternative sequence39 – 7941TEEEI…EKALQ → SEEEVHNLQKRMQQLENDLD QVQESLLKANTQLEEKDKAL S in isoform Fast muscle type.
VSP_006615

Sequences

Sequence LengthMass (Da)Tools
Isoform Slow muscle 1 (STM1) [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: C238DDB4E693243A

FASTA28432,907
        10         20         30         40         50         60 
MDAIKKKMQA MKLEKDNAMD RADTLEQQNK EANIRAEKTE EEIRITHKKM QQVENELDQV 

        70         80         90        100        110        120 
QEQLSLANTK LEEKEKALQN AEGEVAALNR RIQLLEEDLE RSEERLNTAT TKLAEASQAA 

       130        140        150        160        170        180 
DESERMRKVL ENRSLSDEER MDALENQLKE ARFLAEEADR KYDEVARKLA MVEADLERAE 

       190        200        210        220        230        240 
ERAETGESKI VELEEELRVV GNNLKSLEVS EEKANQREEA YKEQIKTLAN KLKAAEARAE 

       250        260        270        280 
FAERSVQKLQ KEVDRLEDEL VNEKEKYKSI TDELDQTFSE LSGY 

« Hide

Isoform Fast muscle type (FTM) [UniParc].

Checksum: 3786F60C224BC359
Show »

FASTA28432,836

References

[1]"Cloning of tropomyosins from lobster (Homarus americanus) striated muscles: fast and slow isoforms may be generated from the same transcript."
Mykles D.L., Cotton J.L.S., Taniguchi H., Sano K., Maeda Y.
J. Muscle Res. Cell Motil. 19:105-115(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS FAST MUSCLE TYPE AND SLOW MUSCLE 1).
Tissue: Skeletal muscle.
[2]"Production and crystallization of lobster muscle tropomyosin expressed in Sf9 cells."
Miegel A., Sano K., Yamamoto K., Maeda K., Maeda Y., Taniguchi H., Yao M., Wakatsuki S.
FEBS Lett. 394:201-205(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF034953 mRNA. Translation: AAC48287.1.
AF034954 mRNA. Translation: AAC48288.1.
PIRS74168.

3D structure databases

ProteinModelPortalO44119.
SMRO44119. Positions 1-283.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome3320. Hom a 1.0101.
3321. Hom a 1.0102.
410. Hom a 1.

Proteomic databases

PRIDEO44119.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000533. Tropomyosin.
[Graphical view]
PfamPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSPR00194. TROPOMYOSIN.
PROSITEPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTPM_HOMAM
AccessionPrimary (citable) accession number: O44119
Secondary accession number(s): O44120
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 1998
Last modified: April 3, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries