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Protein

Tropomyosin

Gene

TM1

Organism
Homarus americanus (American lobster)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin
Alternative name(s):
Allergen: Hom a 1
Gene namesi
Name:TM1
OrganismiHomarus americanus (American lobster)
Taxonomic identifieri6706 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataAstacideaNephropoideaNephropidaeHomarus

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3320. Hom a 1.0101.
3321. Hom a 1.0102.
410. Hom a 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284TropomyosinPRO_0000205674Add
BLAST

Proteomic databases

PRIDEiO44119.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO44119.
SMRiO44119. Positions 1-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1 – 284284Add
BLAST

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil, Repeat

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Slow muscle 1 (identifier: O44119-1) [UniParc]FASTAAdd to basket

Also known as: STM1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDAIKKKMQA MKLEKDNAMD RADTLEQQNK EANIRAEKTE EEIRITHKKM
60 70 80 90 100
QQVENELDQV QEQLSLANTK LEEKEKALQN AEGEVAALNR RIQLLEEDLE
110 120 130 140 150
RSEERLNTAT TKLAEASQAA DESERMRKVL ENRSLSDEER MDALENQLKE
160 170 180 190 200
ARFLAEEADR KYDEVARKLA MVEADLERAE ERAETGESKI VELEEELRVV
210 220 230 240 250
GNNLKSLEVS EEKANQREEA YKEQIKTLAN KLKAAEARAE FAERSVQKLQ
260 270 280
KEVDRLEDEL VNEKEKYKSI TDELDQTFSE LSGY
Length:284
Mass (Da):32,907
Last modified:June 1, 1998 - v1
Checksum:iC238DDB4E693243A
GO
Isoform Fast muscle type (identifier: O44119-2) [UniParc]FASTAAdd to basket

Also known as: FTM

The sequence of this isoform differs from the canonical sequence as follows:
     39-79: TEEEIRITHK...KLEEKEKALQ → SEEEVHNLQK...QLEEKDKALS

Show »
Length:284
Mass (Da):32,836
Checksum:i3786F60C224BC359
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei39 – 7941TEEEI…EKALQ → SEEEVHNLQKRMQQLENDLD QVQESLLKANTQLEEKDKAL S in isoform Fast muscle type. 1 PublicationVSP_006615Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034953 mRNA. Translation: AAC48287.1.
AF034954 mRNA. Translation: AAC48288.1.
PIRiS74168.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034953 mRNA. Translation: AAC48287.1.
AF034954 mRNA. Translation: AAC48288.1.
PIRiS74168.

3D structure databases

ProteinModelPortaliO44119.
SMRiO44119. Positions 1-283.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3320. Hom a 1.0101.
3321. Hom a 1.0102.
410. Hom a 1.

Proteomic databases

PRIDEiO44119.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of tropomyosins from lobster (Homarus americanus) striated muscles: fast and slow isoforms may be generated from the same transcript."
    Mykles D.L., Cotton J.L.S., Taniguchi H., Sano K., Maeda Y.
    J. Muscle Res. Cell Motil. 19:105-115(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS FAST MUSCLE TYPE AND SLOW MUSCLE 1).
    Tissue: Skeletal muscle.
  2. "Production and crystallization of lobster muscle tropomyosin expressed in Sf9 cells."
    Miegel A., Sano K., Yamamoto K., Maeda K., Maeda Y., Taniguchi H., Yao M., Wakatsuki S.
    FEBS Lett. 394:201-205(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).

Entry informationi

Entry nameiTPM_HOMAM
AccessioniPrimary (citable) accession number: O44119
Secondary accession number(s): O44120
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 1998
Last modified: October 1, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.