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O44119

- TPM_HOMAM

UniProt

O44119 - TPM_HOMAM

Protein

Tropomyosin

Gene

TM1

Organism
Homarus americanus (American lobster)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tropomyosin
    Alternative name(s):
    Allergen: Hom a 1
    Gene namesi
    Name:TM1
    OrganismiHomarus americanus (American lobster)
    Taxonomic identifieri6706 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataAstacideaNephropoideaNephropidaeHomarus

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei3320. Hom a 1.0101.
    3321. Hom a 1.0102.
    410. Hom a 1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 284284TropomyosinPRO_0000205674Add
    BLAST

    Proteomic databases

    PRIDEiO44119.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO44119.
    SMRiO44119. Positions 1-283.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1 – 284284Add
    BLAST

    Domaini

    The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

    Sequence similaritiesi

    Belongs to the tropomyosin family.Curated

    Keywords - Domaini

    Coiled coil, Repeat

    Family and domain databases

    InterProiIPR000533. Tropomyosin.
    [Graphical view]
    PfamiPF00261. Tropomyosin. 1 hit.
    [Graphical view]
    PRINTSiPR00194. TROPOMYOSIN.
    PROSITEiPS00326. TROPOMYOSIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Slow muscle 1 (identifier: O44119-1) [UniParc]FASTAAdd to Basket

    Also known as: STM1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDAIKKKMQA MKLEKDNAMD RADTLEQQNK EANIRAEKTE EEIRITHKKM    50
    QQVENELDQV QEQLSLANTK LEEKEKALQN AEGEVAALNR RIQLLEEDLE 100
    RSEERLNTAT TKLAEASQAA DESERMRKVL ENRSLSDEER MDALENQLKE 150
    ARFLAEEADR KYDEVARKLA MVEADLERAE ERAETGESKI VELEEELRVV 200
    GNNLKSLEVS EEKANQREEA YKEQIKTLAN KLKAAEARAE FAERSVQKLQ 250
    KEVDRLEDEL VNEKEKYKSI TDELDQTFSE LSGY 284
    Length:284
    Mass (Da):32,907
    Last modified:June 1, 1998 - v1
    Checksum:iC238DDB4E693243A
    GO
    Isoform Fast muscle type (identifier: O44119-2) [UniParc]FASTAAdd to Basket

    Also known as: FTM

    The sequence of this isoform differs from the canonical sequence as follows:
         39-79: TEEEIRITHK...KLEEKEKALQ → SEEEVHNLQK...QLEEKDKALS

    Show »
    Length:284
    Mass (Da):32,836
    Checksum:i3786F60C224BC359
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei39 – 7941TEEEI…EKALQ → SEEEVHNLQKRMQQLENDLD QVQESLLKANTQLEEKDKAL S in isoform Fast muscle type. 1 PublicationVSP_006615Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF034953 mRNA. Translation: AAC48287.1.
    AF034954 mRNA. Translation: AAC48288.1.
    PIRiS74168.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF034953 mRNA. Translation: AAC48287.1 .
    AF034954 mRNA. Translation: AAC48288.1 .
    PIRi S74168.

    3D structure databases

    ProteinModelPortali O44119.
    SMRi O44119. Positions 1-283.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 3320. Hom a 1.0101.
    3321. Hom a 1.0102.
    410. Hom a 1.

    Proteomic databases

    PRIDEi O44119.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR000533. Tropomyosin.
    [Graphical view ]
    Pfami PF00261. Tropomyosin. 1 hit.
    [Graphical view ]
    PRINTSi PR00194. TROPOMYOSIN.
    PROSITEi PS00326. TROPOMYOSIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of tropomyosins from lobster (Homarus americanus) striated muscles: fast and slow isoforms may be generated from the same transcript."
      Mykles D.L., Cotton J.L.S., Taniguchi H., Sano K., Maeda Y.
      J. Muscle Res. Cell Motil. 19:105-115(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS FAST MUSCLE TYPE AND SLOW MUSCLE 1).
      Tissue: Skeletal muscle.
    2. "Production and crystallization of lobster muscle tropomyosin expressed in Sf9 cells."
      Miegel A., Sano K., Yamamoto K., Maeda K., Maeda Y., Taniguchi H., Yao M., Wakatsuki S.
      FEBS Lett. 394:201-205(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).

    Entry informationi

    Entry nameiTPM_HOMAM
    AccessioniPrimary (citable) accession number: O44119
    Secondary accession number(s): O44120
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3