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Protein
Submitted name:

Putative guanine nucleotide exchange factor RhoGEF2

Gene

RhoGEF2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • Rho guanyl-nucleotide exchange factor activity Source: FlyBase

GO - Biological processi

  • actin cytoskeleton reorganization Source: FlyBase
  • actin filament organization Source: FlyBase
  • actin-mediated cell contraction Source: FlyBase
  • anterior midgut invagination Source: FlyBase
  • cell elongation involved in imaginal disc-derived wing morphogenesis Source: FlyBase
  • cellularization Source: FlyBase
  • gastrulation Source: FlyBase
  • germ-band extension Source: FlyBase
  • intracellular signal transduction Source: InterPro
  • morphogenesis of embryonic epithelium Source: FlyBase
  • pole cell development Source: FlyBase
  • positive regulation of Rho protein signal transduction Source: FlyBase
  • posterior midgut invagination Source: FlyBase
  • pseudocleavage involved in syncytial blastoderm formation Source: FlyBase
  • regulation of axonogenesis Source: FlyBase
  • regulation of cell shape Source: FlyBase
  • regulation of embryonic cell shape Source: FlyBase
  • regulation of myosin II filament organization Source: FlyBase
  • spiracle morphogenesis, open tracheal system Source: FlyBase
  • ventral furrow formation Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

Metal-bindingSAAS annotation, ZincSAAS annotation

Enzyme and pathway databases

ReactomeiR-DME-193634. Axonal growth inhibition (RHOA activation).
R-DME-193648. NRAGE signals death through JNK.
R-DME-194840. Rho GTPase cycle.
R-DME-416482. G alpha (12/13) signalling events.
SignaLinkiO44113.

Names & Taxonomyi

Protein namesi
Submitted name:
Putative guanine nucleotide exchange factor RhoGEF2Imported
Gene namesi
Name:RhoGEF2Imported
Synonyms:rhoGEF2Imported
ORF Names:CG9635Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0023172. RhoGEF2.

Subcellular locationi

GO - Cellular componenti

  • actin cap Source: FlyBase
  • actomyosin contractile ring Source: FlyBase
  • apical cortex Source: FlyBase
  • apical part of cell Source: FlyBase
  • apical plasma membrane Source: FlyBase
  • basal part of cell Source: FlyBase
  • lateral plasma membrane Source: FlyBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiO44113.
PRIDEiO44113.

Expressioni

Gene expression databases

BgeeiFBgn0023172.
ExpressionAtlasiO44113. differential.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0086124.

Structurei

3D structure databases

ProteinModelPortaliO44113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini260 – 33677PDZ (DHR)InterPro annotationAdd
BLAST
Domaini1150 – 120051Phorbol-ester/DAG-typeInterPro annotationAdd
BLAST
Domaini1538 – 1733196DH (DBL-homology)InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1525 – 155228Sequence analysisAdd
BLAST
Coiled coili2463 – 249028Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.UniRule annotation
Contains DH (DBL-homology) domain.SAAS annotation
Contains PH domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IR0U. Eukaryota.
ENOG411079M. LUCA.
OrthoDBiEOG091G0AME.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000219. DH-domain.
IPR001478. PDZ.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR016137. RGS.
IPR015212. RGS-like_dom.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF00595. PDZ. 1 hit.
PF09128. RGS-like. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00228. PDZ. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48097. SSF48097. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50106. PDZ. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O44113-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDPSIKKRL LDLYTDEHEY DEVQEIPEES SIQPPETSTS HTSTNGSSHS
60 70 80 90 100
GPGTATGPGA TSAGPSAGAP QSPVIVVDSV PELPAPKQKS VKNSKSKQKQ
110 120 130 140 150
KQLANKSKIP RSPSLASSLS SLASSLSGHR DRDKDRDKDR ENQNAVPPQT
160 170 180 190 200
PPLPPSYKQN QMNGDSTAAA GGGVSAPATP TTANNNNASH NNGSIMGGGV
210 220 230 240 250
QLNQSDNSNP VLQAPGERSS LNLTPLSRDL SGGHTQESTT PATTPSTPSL
260 270 280 290 300
ALPKNFQYLT LTVRKDSNGY GMKVSGDNPV FVESVKPGGA AEIAGLVAGD
310 320 330 340 350
MILRVNGHEV RLEKHPTVVG LIKASTTVEL AVKRSQKLTR PSSVSVVTPS
360 370 380 390 400
TPILSGRDRT ASITGPQPVD SIKRREMETY KIQTLQKMLE QEKLNLERLK
410 420 430 440 450
SDQNNPSYKL SEANIRKLRE QLHQVGAEDA PTVKLQAAAG NKNTALLTPN
460 470 480 490 500
QIQHLSASAT HSNQQFHHLH HHHNLHNNNY PPQQQPASTS PAFLSLLPRS
510 520 530 540 550
LSSLSLGTRK NKTEKDLTTS SPFGLTTDFL QQQRMSHQAE SMSQSMHQHT
560 570 580 590 600
STPTSQQFFH PHQQQHRFKE TGPTSKGKNK FLISRSLIEE DVPPPLPQRN
610 620 630 640 650
PPRQLNLDLK NGNASPGGSH LVAPVSDLDR ATSPQLNRSQ QQQLPRSTDN
660 670 680 690 700
SPSNAKSKRS KIKTKALSDP KMSTQMFLQM ESASAAGAAG GSIEVDGGPP
710 720 730 740 750
PLPPRLPGMM TEDMSRGSCQ NLAQPNSVGT AFNYPLVSTT TAVQNDNLNI
760 770 780 790 800
AFPLSQRPNI VQQLQQYQQQ QQHQMSGGQA TGALGQTPNL GKNKHRRVGS
810 820 830 840 850
SPDNMHPRHP DRITKTTSGS WEIVEKDGES SPPGTPPPPY LSSSHMTVLE
860 870 880 890 900
DPNENNRGAA AAGPGVFIES HQFTPMAGAS SPIPISLHSN HMHAAQSNDT
910 920 930 940 950
QKEIISMEDE NSDLDEPFID ENGPFNNLTR LLEAENVTFL AIFLNYVISN
960 970 980 990 1000
SDPAPLLFYL ITELYKEGTS KDMRKWAYEI HSTFLVPRAP LSWYRQDESL
1010 1020 1030 1040 1050
AREVDNVLQL EYDKVEILRT VFLRSRKRAK DLISEQLREF QQKRTAGLGT
1060 1070 1080 1090 1100
IYGPTDDKLA EAKTDKLREQ IIDKYLMPNL HALIEDENGS PPEDVRKVAL
1110 1120 1130 1140 1150
CSALSTVIYR IFNTRPPPSS IVERVHHFVS RDKSFKSRIM GKNRKMNVRG
1160 1170 1180 1190 1200
HPLVLRQYYE VTHCNHCQTI IWGVSPQGYH CTDCKLNIHR QCSKVVDESC
1210 1220 1230 1240 1250
PGPLPQAKRL AHNDKISKFM GKIRPRTSDV IGNEKRSRQD EELNVELTPD
1260 1270 1280 1290 1300
RGQASIVRQP SDRRPDANIS IRSNGNTSCN TSGLNTTDLQ SSFHGSCAND
1310 1320 1330 1340 1350
SINPGGGAGC NMDLSTSVAS TTPSTSGSVA AGLSAFAELN ALDTVDKEAR
1360 1370 1380 1390 1400
RERYSQHPKH KSAPVSVNWS ESYKERLSNK RNRNSRRKTS DPSLSSRPND
1410 1420 1430 1440 1450
EQLDLGLSNA TYVGSSNSSL SSAGGTESPS TSMEHFAAPG AAGGVQVPPM
1460 1470 1480 1490 1500
GLNQNQHPHL LIQQHAQQYC QQDSFQAGLA GAAGSSAASN SSFWNAGHPL
1510 1520 1530 1540 1550
PVARWTLESE DEDDVNEADW SSMVAAEVSA ALTDAEKKRQ EIINEIYQTE
1560 1570 1580 1590 1600
RNHVRTLKLL DRLFFLPLYE SGLLSQDHLL LLFPPALLSL REIHGAFEQS
1610 1620 1630 1640 1650
LKQRRIEHNH VVNTIGDLLA DMFDGQSGVV LCEFAAQFCA RQQIALEALK
1660 1670 1680 1690 1700
EKRNKDEMLQ KLLKKSESHK ACRRLELKDL LPTVLQRLTK YPLLFENLYK
1710 1720 1730 1740 1750
VTVRLLPENT TEAEAIQRAV ESSKRILVEV NQAVRTAEDA HKLQNIQRKL
1760 1770 1780 1790 1800
DRSSYDKEEF KKLDLTQHHL IHDGNLTIKK NPSVQLHGLL FENMIVLLTK
1810 1820 1830 1840 1850
QDDKYYLKNL HTPLSITNKP VSPIMSIDAD TLIRQEAADK NSFFLIKMKT
1860 1870 1880 1890 1900
SQMLELRAPS SSECKTWFKH FSDVAARQSK NRSKNASSNH DTSISDPALA
1910 1920 1930 1940 1950
AIPHSNTKES LELSTDTVQP LAATATLTTT PLAPMLPIAT VTPAPATNNS
1960 1970 1980 1990 2000
NVSSLTGVQL RNPQRDATAS ESDADYVNTP KPRSSQNEVN RTMSIRSTGE
2010 2020 2030 2040 2050
PIQKYSANGT EANDVTLRHS QSTRESVRPG STGEERNSTY GMVGGNSKRD
2060 2070 2080 2090 2100
SASIVCSNNS NNTRTLLMQS PLVDPTAIQV SISPAHTAEP VLTPGEKLRR
2110 2120 2130 2140 2150
LDASIRNDLL EKQKIICDIF RLPVEHYDQI VDIAMMPEAP KDSADIALAA
2160 2170 2180 2190 2200
YDQIQTLTKM LNEYMHVTPE QEVSAVSTAV CGHCHEKEKL RKKVAPSSSF
2210 2220 2230 2240 2250
SSSPPPLPPP NRQHAQAQAQ IPPSRLMPKL QTLDLDEVAI HEDDDGYCEI
2260 2270 2280 2290 2300
DELRLPAIPS KPHERPTTPL APFNTEPKTS QSVIDASKRQ STDAVPEGLL
2310 2320 2330 2340 2350
EQEPLEGDKT ETKGEDNEVK TVPSDKLSES CNEERQCVEA DITKEVADPT
2360 2370 2380 2390 2400
TSKNEAAASV DELPSQSREI KTAENASKSV ADKKEDNEET IEEGVASTVD
2410 2420 2430 2440 2450
SSTQTSPTES PKETDKLTGG SSSTCGPNRI QHASVLEPSV PCHALSSIVT
2460 2470 2480 2490 2500
ILNEQISMLL PKINERDMER ERLRKENQHL RELLSALHDR QRVDEVKETP
2510 2520 2530 2540 2550
FDLKKLMHAE DVEFDDDIDA ISNSSLTPTP TPIPTASPSA SGQVETAEAM

RITSTEDEE
Length:2,559
Mass (Da):280,949
Last modified:June 1, 1998 - v1
Checksum:i7BC661AA1E6EB40E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031930 mRNA. Translation: AAB88816.1.
PIRiT09144.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031930 mRNA. Translation: AAB88816.1.
PIRiT09144.

3D structure databases

ProteinModelPortaliO44113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0086124.

Proteomic databases

PaxDbiO44113.
PRIDEiO44113.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0023172. RhoGEF2.

Phylogenomic databases

eggNOGiENOG410IR0U. Eukaryota.
ENOG411079M. LUCA.
OrthoDBiEOG091G0AME.

Enzyme and pathway databases

ReactomeiR-DME-193634. Axonal growth inhibition (RHOA activation).
R-DME-193648. NRAGE signals death through JNK.
R-DME-194840. Rho GTPase cycle.
R-DME-416482. G alpha (12/13) signalling events.
SignaLinkiO44113.

Miscellaneous databases

ChiTaRSiRhoGEF2. fly.

Gene expression databases

BgeeiFBgn0023172.
ExpressionAtlasiO44113. differential.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000219. DH-domain.
IPR001478. PDZ.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR016137. RGS.
IPR015212. RGS-like_dom.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF00595. PDZ. 1 hit.
PF09128. RGS-like. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00228. PDZ. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48097. SSF48097. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50106. PDZ. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO44113_DROME
AccessioniPrimary (citable) accession number: O44113
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.