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Reviewed, UniProtKB/Swiss-Prot O44111 (URIC_DROSU)

Last modified June 16, 2009. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Uricase
    EC=1.7.3.3
Alternative name(s):
    Urate oxidase
Gene names
Name: Uro
Synonyms: UO
OrganismDrosophila subobscura (Fruit fly)
Taxonomic identifier7241 [NCBI]
Taxonomic lineageEukaryotaMetazoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length339 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which spontaneously decomposes to form allantoin.

Catalytic activity

Urate + O2 + H2O = 5-hydroxyisourate + H2O2.

Pathway

Purine metabolism; uric acid degradation; (S)-allantoin from uric acid: step 1/3.

Subcellular location

Peroxisome.

Developmental stage

Third instar larvae and adult.

Sequence similarities

Belongs to the uricase family.

Ontologies

Keywords
   Biological processPurine metabolism
   Cellular componentPeroxisome
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

purine base metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentperoxisome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionurate oxidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 339›339Uricase
PRO_0000165993

Regions

Region266 – 2672Substrate binding By similarity
Motif337 – 3393Microbody targeting signal Potential

Sites

Active site2181Charge relay system By similarity
Active site2671Charge relay system By similarity
Binding site781Substrate By similarity
Binding site2181Substrate By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
O44111-1 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 34439F6B6078DC6E

FASTA33938,437
        10         20         30         40         50         60 
LRQPSSASNR TAASLDGQET PFQYEITDHG YGKDAVKVLH VSRKGPVHTI QEFEVGTHLK 

        70         80         90        100        110        120 
LYSKKDYYQG NNSDIVATDS QKNTVYLLAK KYGIESPEKF ALLLGQHFLN KYSHVEEAHV 

       130        140        150        160        170        180 
HVETYPWQRV CQEETKASTT VGQGSCNFSS IDNRSLHNHA FIFTPTALHY CDVVIXRQDP 

       190        200        210        220        230        240 
KQTVITGIKG LRVLKTTQSS FVNFVNDEXR SLPDQYDRIF STVVDCSWEY SDTDTVNFSR 

       250        260        270        280        290        300 
AWQQVKNIIL RNFAGDPQVG VSSPSVQHTL YLSEKQVLDV IPQVSVISMT MPNKHYFNFD 

       310        320        330 
TKPFQQIVPG DNNEVFIPVD KPHGTIYAQL ARKNLNSHL 

« Hide

References

[1]"The molecular clock revisited: the rate of synonymous vs. replacement change in Drosophila."
Zeng L.-W., Comeron J.M., Chen B., Kreitman M.
Genetica 102:369-382(1998) [PubMed: 9720289] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

AF025816 mRNA. Translation: AAB87901.1.

3D structure databases

HSSPHSSP built from PDB template 1UOX based on UniProtKB Q00511.
ModBaseSearch...

Organism-specific databases

FlyBaseFBgn0021077. Dsub\Uro.

Enzyme and pathway databases

BRENDA1.7.3.3. 270690.

Family and domain databases

InterProIPR002042. Uricase.
[Graphical view]
Gene3DG3DSA:3.10.270.10. Uricase. 1 hit.
PANTHERPTHR10395:SF1. Uricase. 1 hit.
PfamPF01014. Uricase. 2 hits.
[Graphical view]
PRINTSPR00093. URICASE.
ProDomPD003367. Uricase. 2 hits.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR03383. urate_oxi. 1 hit.
PROSITEPS00366. URICASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameURIC_DROSU
AccessionPrimary (citable) accession number: O44111
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents