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O44049

- O44049_TRYRA

UniProt

O44049 - O44049_TRYRA

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Protein
Submitted name:

Sialidase

Gene
N/A
Organism
Trypanosoma rangeli
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseImported, Hydrolase

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Submitted name:
SialidaseImported (EC:3.2.1.18Imported)
OrganismiTrypanosoma rangeliImported
Taxonomic identifieri5698 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaHerpetosoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 PotentialImportedAdd
BLAST
Chaini23 – 660638sialidaseImportedPRO_5000145206Add
BLAST

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MZ5X-ray2.20A23-660[»]
1MZ6X-ray2.90A23-660[»]
1N1SX-ray1.64A23-660[»]
1N1TX-ray1.60A23-660[»]
1N1VX-ray2.10A23-660[»]
1N1YX-ray2.80A23-660[»]
1WCSX-ray2.80A23-660[»]
2A75X-ray1.95A23-660[»]
2AGSX-ray1.70A23-660[»]
2FHRX-ray2.20A23-660[»]
ProteinModelPortaliO44049.
SMRiO44049. Positions 21-653.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO44049.

Family & Domainsi

Keywords - Domaini

SignalImported

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR026856. Sialidase_fam.
IPR008377. Sialidase_trypan.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PTHR10628:SF5. PTHR10628:SF5. 1 hit.
PRINTSiPR01803. TCSIALIDASE.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O44049-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSWLAVFVPL FLMACASEPA SALAPGSSRV ELFKRKNSTV PFEESNGTIR
60 70 80 90 100
ERVVHSFRIP TIVNVDGVMV ATADARYETS FDNSFIETAV KYSVDDGATW
110 120 130 140 150
NTQIAIKNSR ASSVSRVMDA TVIVKGNKLY ILVGSFNKTR NSWTQHRDGS
160 170 180 190 200
DWEPLLVVGE VTKSAANGKT TATISWGKPV SLKPLFPAEF DGILTKEFIG
210 220 230 240 250
GVGAAIVGSN GNLVYPVQIA DMGGRVFTKI MYSEDDGNTW KFAEGRSKFG
260 270 280 290 300
CSEPAVLEWE GKLIINNRVD GNRRLVYESS DMGKTWVEAL GTLSHVWTNS
310 320 330 340 350
PTSNQQDCQS SFVAVTIEGK RVMLFTHPLN LKGRWMRDRL HLWMTDNQRI
360 370 380 390 400
FDVGQISIGD ENSGYSSVLY KDDKLYSLHE INTNDVYSLV FVRFIGELQL
410 420 430 440 450
MKSVVRTWKE EDNHLASICT PVVPATPPSK GGCGAAVPTA GLVGFLSHSA
460 470 480 490 500
NGSVWEDVYR CVDANVANAE RVPNGLKFNG VGGGAVWPVA RQGQTRRYQF
510 520 530 540 550
ANYRFTLVAT VTIDELPKGT SPLLGAGLEG PGDAKLLGLS YDKNRQWRPL
560 570 580 590 600
YGAAPASPTG SWELHKKYHV VLTMADRQGS VYVDGQPLAG SGNTVVRGAT
610 620 630 640 650
LPDISHFYIG GPRSKGAPTD SRVTVTNIVL YNRRLNSSEI RTLFLSQDMI
660
GTDGGAGTAA
Length:660
Mass (Da):71,965
Last modified:June 1, 1998 - v1
Checksum:iB5D55765DC4423D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83180 Genomic DNA. Translation: AAC95493.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83180 Genomic DNA. Translation: AAC95493.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1MZ5 X-ray 2.20 A 23-660 [» ]
1MZ6 X-ray 2.90 A 23-660 [» ]
1N1S X-ray 1.64 A 23-660 [» ]
1N1T X-ray 1.60 A 23-660 [» ]
1N1V X-ray 2.10 A 23-660 [» ]
1N1Y X-ray 2.80 A 23-660 [» ]
1WCS X-ray 2.80 A 23-660 [» ]
2A75 X-ray 1.95 A 23-660 [» ]
2AGS X-ray 1.70 A 23-660 [» ]
2FHR X-ray 2.20 A 23-660 [» ]
ProteinModelPortali O44049.
SMRi O44049. Positions 21-653.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei O44049.

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR026856. Sialidase_fam.
IPR008377. Sialidase_trypan.
IPR011040. Sialidases.
[Graphical view ]
PANTHERi PTHR10628. PTHR10628. 1 hit.
PTHR10628:SF5. PTHR10628:SF5. 1 hit.
PRINTSi PR01803. TCSIALIDASE.
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Trypanosoma rangeli sialidase: cloning, expression and similarity to T. cruzi trans-sialidase."
    Buschiazzo A., Campetella O., Frasch A.C.
    Glycobiology 7:1167-1173(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: LDGImported.
  2. "Structural basis of sialyltransferase activity in trypanosomal sialidases."
    Buschiazzo A., Tavares G.A., Campetella O., Spinelli S., Cremona M.L., Paris G., Amaya M.F., Frasch A.C., Alzari P.M.
    EMBO J. 19:16-24(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 23-660, ACTIVE SITE, GLYCOSYLATION AT ASN-37; ASN-46; ASN-137; ASN-451 AND ASN-636.
  3. "The high resolution structures of free and inhibitor-bound Trypanosoma rangeli sialidase and its comparison with T. cruzi trans-sialidase."
    Amaya M.F., Buschiazzo A., Nguyen T., Alzari P.M.
    J. Mol. Biol. 325:773-784(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 23-660, ACTIVE SITE.
  4. "A sialidase mutant displaying trans-sialidase activity."
    Paris G., Ratier L., Amaya M.F., Nguyen T., Alzari P.M., Frasch A.C.
    J. Mol. Biol. 345:923-934(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 23-660, ACTIVE SITE.
  5. "Structural and kinetic analysis of two covalent sialosyl-enzyme intermediates on Trypanosoma rangeli sialidase."
    Watts A.G., Oppezzo P., Withers S.G., Alzari P.M., Buschiazzo A.
    J. Biol. Chem. 281:4149-4155(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 23-660, ACTIVE SITE.

Entry informationi

Entry nameiO44049_TRYRA
AccessioniPrimary (citable) accession number: O44049
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: November 26, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3