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O44049

- O44049_TRYRA

UniProt

O44049 - O44049_TRYRA

Protein
Submitted name:

Sialidase

Gene
N/A
Organism
Trypanosoma rangeli
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
    2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
    3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    GlycosidaseImported, Hydrolase

    Protein family/group databases

    CAZyiGH33. Glycoside Hydrolase Family 33.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    SialidaseImported (EC:3.2.1.18Imported)
    OrganismiTrypanosoma rangeliImported
    Taxonomic identifieri5698 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaHerpetosoma

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222 PotentialImportedAdd
    BLAST
    Chaini23 – 660638sialidaseImportedPRO_5000145206Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi37 – 371N-linked (GlcNAc...)Imported
    Glycosylationi46 – 461N-linked (GlcNAc...)Imported
    Glycosylationi137 – 1371N-linked (GlcNAc...)Imported
    Glycosylationi451 – 4511N-linked (GlcNAc...)Imported
    Glycosylationi636 – 6361N-linked (GlcNAc...)Imported

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1MZ5X-ray2.20A23-660[»]
    1MZ6X-ray2.90A23-660[»]
    1N1SX-ray1.64A23-660[»]
    1N1TX-ray1.60A23-660[»]
    1N1VX-ray2.10A23-660[»]
    1N1YX-ray2.80A23-660[»]
    1WCSX-ray2.80A23-660[»]
    2A75X-ray1.95A23-660[»]
    2AGSX-ray1.70A23-660[»]
    2FHRX-ray2.20A23-660[»]
    ProteinModelPortaliO44049.
    SMRiO44049. Positions 21-653.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO44049.

    Family & Domainsi

    Keywords - Domaini

    SignalImported

    Family and domain databases

    Gene3Di2.120.10.10. 1 hit.
    2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR026856. Sialidase_fam.
    IPR008377. Sialidase_trypan.
    IPR011040. Sialidases.
    [Graphical view]
    PANTHERiPTHR10628. PTHR10628. 1 hit.
    PTHR10628:SF5. PTHR10628:SF5. 1 hit.
    PRINTSiPR01803. TCSIALIDASE.
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF50939. SSF50939. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O44049-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWLAVFVPL FLMACASEPA SALAPGSSRV ELFKRKNSTV PFEESNGTIR    50
    ERVVHSFRIP TIVNVDGVMV ATADARYETS FDNSFIETAV KYSVDDGATW 100
    NTQIAIKNSR ASSVSRVMDA TVIVKGNKLY ILVGSFNKTR NSWTQHRDGS 150
    DWEPLLVVGE VTKSAANGKT TATISWGKPV SLKPLFPAEF DGILTKEFIG 200
    GVGAAIVGSN GNLVYPVQIA DMGGRVFTKI MYSEDDGNTW KFAEGRSKFG 250
    CSEPAVLEWE GKLIINNRVD GNRRLVYESS DMGKTWVEAL GTLSHVWTNS 300
    PTSNQQDCQS SFVAVTIEGK RVMLFTHPLN LKGRWMRDRL HLWMTDNQRI 350
    FDVGQISIGD ENSGYSSVLY KDDKLYSLHE INTNDVYSLV FVRFIGELQL 400
    MKSVVRTWKE EDNHLASICT PVVPATPPSK GGCGAAVPTA GLVGFLSHSA 450
    NGSVWEDVYR CVDANVANAE RVPNGLKFNG VGGGAVWPVA RQGQTRRYQF 500
    ANYRFTLVAT VTIDELPKGT SPLLGAGLEG PGDAKLLGLS YDKNRQWRPL 550
    YGAAPASPTG SWELHKKYHV VLTMADRQGS VYVDGQPLAG SGNTVVRGAT 600
    LPDISHFYIG GPRSKGAPTD SRVTVTNIVL YNRRLNSSEI RTLFLSQDMI 650
    GTDGGAGTAA 660
    Length:660
    Mass (Da):71,965
    Last modified:June 1, 1998 - v1
    Checksum:iB5D55765DC4423D0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U83180 Genomic DNA. Translation: AAC95493.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U83180 Genomic DNA. Translation: AAC95493.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1MZ5 X-ray 2.20 A 23-660 [» ]
    1MZ6 X-ray 2.90 A 23-660 [» ]
    1N1S X-ray 1.64 A 23-660 [» ]
    1N1T X-ray 1.60 A 23-660 [» ]
    1N1V X-ray 2.10 A 23-660 [» ]
    1N1Y X-ray 2.80 A 23-660 [» ]
    1WCS X-ray 2.80 A 23-660 [» ]
    2A75 X-ray 1.95 A 23-660 [» ]
    2AGS X-ray 1.70 A 23-660 [» ]
    2FHR X-ray 2.20 A 23-660 [» ]
    ProteinModelPortali O44049.
    SMRi O44049. Positions 21-653.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH33. Glycoside Hydrolase Family 33.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei O44049.

    Family and domain databases

    Gene3Di 2.120.10.10. 1 hit.
    2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR026856. Sialidase_fam.
    IPR008377. Sialidase_trypan.
    IPR011040. Sialidases.
    [Graphical view ]
    PANTHERi PTHR10628. PTHR10628. 1 hit.
    PTHR10628:SF5. PTHR10628:SF5. 1 hit.
    PRINTSi PR01803. TCSIALIDASE.
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF50939. SSF50939. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Trypanosoma rangeli sialidase: cloning, expression and similarity to T. cruzi trans-sialidase."
      Buschiazzo A., Campetella O., Frasch A.C.
      Glycobiology 7:1167-1173(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: LDGImported.
    2. "Structural basis of sialyltransferase activity in trypanosomal sialidases."
      Buschiazzo A., Tavares G.A., Campetella O., Spinelli S., Cremona M.L., Paris G., Amaya M.F., Frasch A.C., Alzari P.M.
      EMBO J. 19:16-24(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 23-660, GLYCOSYLATION AT ASN-37; ASN-46; ASN-137; ASN-451 AND ASN-636.
    3. "The high resolution structures of free and inhibitor-bound Trypanosoma rangeli sialidase and its comparison with T. cruzi trans-sialidase."
      Amaya M.F., Buschiazzo A., Nguyen T., Alzari P.M.
      J. Mol. Biol. 325:773-784(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 23-660.
    4. "A sialidase mutant displaying trans-sialidase activity."
      Paris G., Ratier L., Amaya M.F., Nguyen T., Alzari P.M., Frasch A.C.
      J. Mol. Biol. 345:923-934(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 23-660.
    5. "Structural and kinetic analysis of two covalent sialosyl-enzyme intermediates on Trypanosoma rangeli sialidase."
      Watts A.G., Oppezzo P., Withers S.G., Alzari P.M., Buschiazzo A.
      J. Biol. Chem. 281:4149-4155(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 23-660.

    Entry informationi

    Entry nameiO44049_TRYRA
    AccessioniPrimary (citable) accession number: O44049
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3