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O44006

- KPYK_EIMTE

UniProt

O44006 - KPYK_EIMTE

Protein

Pyruvate kinase

Gene

PYK

Organism
Eimeria tenella (Coccidian parasite)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + pyruvate = ADP + phosphoenolpyruvate.

    Cofactori

    Magnesium.
    Potassium.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei86 – 861SubstrateBy similarity
    Metal bindingi88 – 881PotassiumBy similarity
    Metal bindingi90 – 901PotassiumBy similarity
    Metal bindingi121 – 1211PotassiumBy similarity
    Metal bindingi122 – 1221Potassium; via carbonyl oxygenBy similarity
    Sitei275 – 2751Transition state stabilizerBy similarity
    Metal bindingi277 – 2771MagnesiumBy similarity
    Binding sitei300 – 3001Substrate; via amide nitrogenBy similarity
    Metal bindingi301 – 3011MagnesiumBy similarity
    Binding sitei301 – 3011Substrate; via amide nitrogenBy similarity
    Binding sitei333 – 3331SubstrateBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. magnesium ion binding Source: InterPro
    3. potassium ion binding Source: InterPro
    4. pyruvate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

    Enzyme and pathway databases

    BRENDAi2.7.1.40. 2046.
    UniPathwayiUPA00109; UER00188.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate kinase (EC:2.7.1.40)
    Short name:
    PK
    Gene namesi
    Name:PYK
    OrganismiEimeria tenella (Coccidian parasite)
    Taxonomic identifieri5802 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaEimeriidaeEimeria

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 531531Pyruvate kinasePRO_0000112100Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO44006.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pyruvate kinase family.Curated

    Family and domain databases

    Gene3Di2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProiIPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view]
    PANTHERiPTHR11817. PTHR11817. 1 hit.
    PfamiPF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view]
    PRINTSiPR01050. PYRUVTKNASE.
    SUPFAMiSSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
    PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O44006-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANPTHSQVV AAPDSSGRLL RLVSASSVMM QLLGKSTNIR MSQILEHHED    50
    EDFSAHRTKI VCTMGPSCWD VDKMVQLIDA GMNVCRLNFS HGDHEAHGRV 100
    VKNLQEALKQ RPGKRVALLL DTKGPEIRTG MLEGDKPIEL HAGDMLKIVT 150
    DYSFVGNKSC IACSYEKLPS SVKPGNTILI ADGSLSVEVV ECGKDYVMTR 200
    VMNPAIIGNK KNMNLPGVKV DLPVIGEKDK NDILNFGIPM GCNFIAASFV 250
    QSADDVRYIR SILGTKGRNI KIIPKIENVE GLLNFDEILQ EADGIMIARG 300
    DLGMEIPPEK VFLAQKMMIS KCNVAGKPVI TATQMLESMT KNPRPTRAEA 350
    ADVANAVLDG TDCVMLSGET ANGSFPVQAV TVMSRVCFEA EGCIDYQQVF 400
    RATCQATMTP IDTQEAVARA AVETAQSINA SLILALTETG RTARLIAKYR 450
    PMQPILALSA SEETIKQLQV IRGVTTFLVP TFQGTDQLIR NALSAAKELQ 500
    LVSEGDSIVA VHGIKEEVAG WSNLLKVLVV E 531
    Length:531
    Mass (Da):57,591
    Last modified:June 1, 1998 - v1
    Checksum:iC02B2399B863EE08
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF043910 mRNA. Translation: AAC02529.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF043910 mRNA. Translation: AAC02529.1 .

    3D structure databases

    ProteinModelPortali O44006.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00188 .
    BRENDAi 2.7.1.40. 2046.

    Family and domain databases

    Gene3Di 2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProi IPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view ]
    PANTHERi PTHR11817. PTHR11817. 1 hit.
    Pfami PF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01050. PYRUVTKNASE.
    SUPFAMi SSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
    PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the gene for pyruvate kinase of Eimeria tenella."
      Labbe M., Ouarzane M., Bourdieu C., Pery P.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: PAPt38.

    Entry informationi

    Entry nameiKPYK_EIMTE
    AccessioniPrimary (citable) accession number: O44006
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3