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O44006 (KPYK_EIMTE) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate kinase

Short name=PK
EC=2.7.1.40
Gene names
Name:PYK
OrganismEimeria tenella (Coccidian parasite)
Taxonomic identifier5802 [NCBI]
Taxonomic lineageEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaEimeriidaeEimeria

Protein attributes

Sequence length531 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactor

Magnesium.

Potassium.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the pyruvate kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 531531Pyruvate kinase
PRO_0000112100

Sites

Metal binding881Potassium By similarity
Metal binding901Potassium By similarity
Metal binding1211Potassium By similarity
Metal binding1221Potassium; via carbonyl oxygen By similarity
Metal binding2771Magnesium By similarity
Metal binding3011Magnesium By similarity
Binding site861Substrate By similarity
Binding site3001Substrate; via amide nitrogen By similarity
Binding site3011Substrate; via amide nitrogen By similarity
Binding site3331Substrate By similarity
Site2751Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
O44006 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: C02B2399B863EE08

FASTA53157,591
        10         20         30         40         50         60 
MANPTHSQVV AAPDSSGRLL RLVSASSVMM QLLGKSTNIR MSQILEHHED EDFSAHRTKI 

        70         80         90        100        110        120 
VCTMGPSCWD VDKMVQLIDA GMNVCRLNFS HGDHEAHGRV VKNLQEALKQ RPGKRVALLL 

       130        140        150        160        170        180 
DTKGPEIRTG MLEGDKPIEL HAGDMLKIVT DYSFVGNKSC IACSYEKLPS SVKPGNTILI 

       190        200        210        220        230        240 
ADGSLSVEVV ECGKDYVMTR VMNPAIIGNK KNMNLPGVKV DLPVIGEKDK NDILNFGIPM 

       250        260        270        280        290        300 
GCNFIAASFV QSADDVRYIR SILGTKGRNI KIIPKIENVE GLLNFDEILQ EADGIMIARG 

       310        320        330        340        350        360 
DLGMEIPPEK VFLAQKMMIS KCNVAGKPVI TATQMLESMT KNPRPTRAEA ADVANAVLDG 

       370        380        390        400        410        420 
TDCVMLSGET ANGSFPVQAV TVMSRVCFEA EGCIDYQQVF RATCQATMTP IDTQEAVARA 

       430        440        450        460        470        480 
AVETAQSINA SLILALTETG RTARLIAKYR PMQPILALSA SEETIKQLQV IRGVTTFLVP 

       490        500        510        520        530 
TFQGTDQLIR NALSAAKELQ LVSEGDSIVA VHGIKEEVAG WSNLLKVLVV E 

« Hide

References

[1]"Molecular cloning of the gene for pyruvate kinase of Eimeria tenella."
Labbe M., Ouarzane M., Bourdieu C., Pery P.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: PAPt38.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF043910 mRNA. Translation: AAC02529.1.

3D structure databases

ProteinModelPortalO44006.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.7.1.40. 2046.
UniPathwayUPA00109; UER00188.

Family and domain databases

Gene3D2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERPTHR11817. PTHR11817. 1 hit.
PfamPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSPR01050. PYRUVTKNASE.
SUPFAMSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsTIGR01064. pyruv_kin. 1 hit.
PROSITEPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPYK_EIMTE
AccessionPrimary (citable) accession number: O44006
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: October 16, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways