PYK

Functionⁱ

Catalytic activityⁱ

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactorⁱ

Protein has several cofactor binding sites:

Pathwayⁱ: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:

Glyceraldehyde-3-phosphate dehydrogenase (ETH_00008865)
Phosphoglycerate kinase (ETH_00040900), Phosphoglycerate kinase (ETH_00015140), Phosphoglycerate kinase (ETH_00027415), Phosphoglycerate kinase
no protein annotated in this organism
Enolase (ENO)
Pyruvate kinase (PYK), Pyruvate kinase (ETH_00011145), Pyruvate kinase

This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	86	SubstrateBy similarity	1
Metal bindingⁱ	88	PotassiumBy similarity	1
Metal bindingⁱ	90	PotassiumBy similarity	1
Metal bindingⁱ	121	PotassiumBy similarity	1
Metal bindingⁱ	122	Potassium; via carbonyl oxygenBy similarity	1
Siteⁱ	275	Transition state stabilizerBy similarity	1
Metal bindingⁱ	277	MagnesiumBy similarity	1
Binding siteⁱ	300	Substrate; via amide nitrogenBy similarity	1
Metal bindingⁱ	301	MagnesiumBy similarity	1
Binding siteⁱ	301	Substrate; via amide nitrogenBy similarity	1
Binding siteⁱ	333	SubstrateBy similarity	1

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
kinase activity Source: UniProtKB-KW
magnesium ion binding Source: InterPro
potassium ion binding Source: InterPro
pyruvate kinase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Transferase
Biological process	Glycolysis
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

BRENDAⁱ	2.7.1.40 2046
UniPathwayⁱ	UPA00109; UER00188

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Pyruvate kinase (EC:2.7.1.40) Short name: PK
Gene namesⁱ	Name:PYK
Organismⁱ	Eimeria tenella (Coccidian parasite)
Taxonomic identifierⁱ	5802 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Alveolata › Apicomplexa › Conoidasida › Coccidia › Eucoccidiorida › Eimeriorina › Eimeriidae › Eimeria

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000112100	1 – 531	Pyruvate kinaseAdd BLAST		531

Interactionⁱ

Subunit structureⁱ

Homotetramer.By similarity

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O44006
SMRⁱ	O44006
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the pyruvate kinase family.Curated

Family and domain databases

Gene3Dⁱ	2.40.33.101 hit 3.40.1380.201 hit
InterProⁱ	View protein in InterPro IPR001697 Pyr_Knase IPR015813 Pyrv/PenolPyrv_Kinase-like_dom IPR011037 Pyrv_Knase-like_insert_dom_sf IPR018209 Pyrv_Knase_AS IPR015793 Pyrv_Knase_brl IPR015795 Pyrv_Knase_C IPR036918 Pyrv_Knase_C_sf IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERⁱ	PTHR11817 PTHR11817, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00224 PK, 1 hit PF02887 PK_C, 1 hit
PRINTSⁱ	PR01050 PYRUVTKNASE
SUPFAMⁱ	SSF50800 SSF50800, 1 hit SSF51621 SSF51621, 2 hits SSF52935 SSF52935, 1 hit
TIGRFAMsⁱ	TIGR01064 pyruv_kin, 1 hit
PROSITEⁱ	View protein in PROSITE PS00110 PYRUVATE_KINASE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O44006-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MANPTHSQVV AAPDSSGRLL RLVSASSVMM QLLGKSTNIR MSQILEHHED 
        60         70         80         90        100
EDFSAHRTKI VCTMGPSCWD VDKMVQLIDA GMNVCRLNFS HGDHEAHGRV 
       110        120        130        140        150
VKNLQEALKQ RPGKRVALLL DTKGPEIRTG MLEGDKPIEL HAGDMLKIVT 
       160        170        180        190        200
DYSFVGNKSC IACSYEKLPS SVKPGNTILI ADGSLSVEVV ECGKDYVMTR 
       210        220        230        240        250
VMNPAIIGNK KNMNLPGVKV DLPVIGEKDK NDILNFGIPM GCNFIAASFV 
       260        270        280        290        300
QSADDVRYIR SILGTKGRNI KIIPKIENVE GLLNFDEILQ EADGIMIARG 
       310        320        330        340        350
DLGMEIPPEK VFLAQKMMIS KCNVAGKPVI TATQMLESMT KNPRPTRAEA 
       360        370        380        390        400
ADVANAVLDG TDCVMLSGET ANGSFPVQAV TVMSRVCFEA EGCIDYQQVF 
       410        420        430        440        450
RATCQATMTP IDTQEAVARA AVETAQSINA SLILALTETG RTARLIAKYR 
       460        470        480        490        500
PMQPILALSA SEETIKQLQV IRGVTTFLVP TFQGTDQLIR NALSAAKELQ 
       510        520        530 
LVSEGDSIVA VHGIKEEVAG WSNLLKVLVV E

Length:531

Mass (Da):57,591

Last modified:June 1, 1998 - v1

Checksum:ⁱC02B2399B863EE08

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF043910 mRNA Translation: AAC02529.1
NCBI Reference Sequences More...RefSeqⁱ	XP_013232798.1, XM_013377344.1

Genome annotation databases

GeneIDⁱ	25251418

GeneIDⁱ

25251418

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
O44006	U6KYP2	Eimeria tenella (Coccidian parasite)	531	UniRef100_O44006	Cluster: Pyruvate kinase	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
O44006	U6KYP2 U6JY93 U6MS68 U6GJV2 U6LYS6 A0A1D3D230 U6GDK5 H9B9H5	Eimeria tenella (Coccidian parasite) Eimeria mitis Eimeria necatrix Eimeria praecox Eimeria brunetti Cyclospora cayetanensis Eimeria acervulina (Coccidian parasite)	531	UniRef90_O44006	Cluster: Pyruvate kinase	9

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
O44006	U6KYP2 U6JY93 H9B9H5 U6MS68 U6GDK5 U6LYS6 U6GJV2 A0A1D3D230 A0A0M0K9Y7 A0A077Y682 +106	Eimeria tenella (Coccidian parasite) Eimeria mitis Eimeria necatrix Eimeria acervulina (Coccidian parasite) Eimeria brunetti Eimeria praecox Cyclospora cayetanensis Chrysochromulina sp. CCMP291 Plasmodium yoelii Plasmodium yoelii yoelii And more	531	UniRef50_O44006	Cluster: Pyruvate kinase	117

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF043910 mRNA Translation: AAC02529.1
NCBI Reference Sequences More...RefSeqⁱ	XP_013232798.1, XM_013377344.1

3D structure databases

ProteinModelPortalⁱ	O44006
SMRⁱ	O44006
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	25251418

GeneIDⁱ

25251418

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00188
BRENDAⁱ	2.7.1.40 2046

Family and domain databases

Gene3Dⁱ	2.40.33.101 hit 3.40.1380.201 hit
InterProⁱ	View protein in InterPro IPR001697 Pyr_Knase IPR015813 Pyrv/PenolPyrv_Kinase-like_dom IPR011037 Pyrv_Knase-like_insert_dom_sf IPR018209 Pyrv_Knase_AS IPR015793 Pyrv_Knase_brl IPR015795 Pyrv_Knase_C IPR036918 Pyrv_Knase_C_sf IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERⁱ	PTHR11817 PTHR11817, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00224 PK, 1 hit PF02887 PK_C, 1 hit
PRINTSⁱ	PR01050 PYRUVTKNASE
SUPFAMⁱ	SSF50800 SSF50800, 1 hit SSF51621 SSF51621, 2 hits SSF52935 SSF52935, 1 hit
TIGRFAMsⁱ	TIGR01064 pyruv_kin, 1 hit
PROSITEⁱ	View protein in PROSITE PS00110 PYRUVATE_KINASE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KPYK_EIMTE
Accessionⁱ	O44006Primary (citable) accession number: O44006
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	June 1, 1998
	Last modified:	February 28, 2018
	This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)

UniProtKB - O44006 (KPYK_EIMTE)

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Pyruvate kinase

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Functionⁱ

Catalytic activityⁱ

Cofactorⁱ

Pathwayⁱ: glycolysis

Sites

GO - Molecular functionⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

PTM / Processingⁱ

Molecule processing

Interactionⁱ

Subunit structureⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O44006 (KPYK_EIMTE)

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Pyruvate kinase

PYK

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

Pathwayⁱ: glycolysis

GO - Molecular functionⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ