UniProtKB - O44006 (KPYK_EIMTE)
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Protein
Pyruvate kinase
Gene
PYK
Organism
Eimeria tenella (Coccidian parasite)
Status
Functioni
Catalytic activityi
ATP + pyruvate = ADP + phosphoenolpyruvate.
Cofactori
Protein has several cofactor binding sites:: glycolysis Pathwayi
This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.Proteins known to be involved in the 5 steps of the subpathway in this organism are:
- Glyceraldehyde-3-phosphate dehydrogenase (ETH_00008865)
- Phosphoglycerate kinase (ETH_00040900), Phosphoglycerate kinase (ETH_00015140), Phosphoglycerate kinase (ETH_00027415), Phosphoglycerate kinase
- no protein annotated in this organism
- Enolase (ENO)
- Pyruvate kinase (PYK), Pyruvate kinase (ETH_00011145), Pyruvate kinase
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 86 | SubstrateBy similarity | 1 | |
Metal bindingi | 88 | PotassiumBy similarity | 1 | |
Metal bindingi | 90 | PotassiumBy similarity | 1 | |
Metal bindingi | 121 | PotassiumBy similarity | 1 | |
Metal bindingi | 122 | Potassium; via carbonyl oxygenBy similarity | 1 | |
Sitei | 275 | Transition state stabilizerBy similarity | 1 | |
Metal bindingi | 277 | MagnesiumBy similarity | 1 | |
Binding sitei | 300 | Substrate; via amide nitrogenBy similarity | 1 | |
Metal bindingi | 301 | MagnesiumBy similarity | 1 | |
Binding sitei | 301 | Substrate; via amide nitrogenBy similarity | 1 | |
Binding sitei | 333 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- kinase activity Source: UniProtKB-KW
- magnesium ion binding Source: InterPro
- potassium ion binding Source: InterPro
- pyruvate kinase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Glycolysis |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate |
Enzyme and pathway databases
BRENDAi | 2.7.1.40 2046 |
UniPathwayi | UPA00109; UER00188 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PYK |
Organismi | Eimeria tenella (Coccidian parasite) |
Taxonomic identifieri | 5802 [NCBI] |
Taxonomic lineagei | Eukaryota › Alveolata › Apicomplexa › Conoidasida › Coccidia › Eucoccidiorida › Eimeriorina › Eimeriidae › Eimeria |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000112100 | 1 – 531 | Pyruvate kinaseAdd BLAST | 531 |
Interactioni
Subunit structurei
Homotetramer.By similarity
Structurei
3D structure databases
ProteinModelPortali | O44006 |
SMRi | O44006 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the pyruvate kinase family.Curated
Family and domain databases
Gene3Di | 2.40.33.101 hit 3.40.1380.201 hit |
InterProi | View protein in InterPro IPR001697 Pyr_Knase IPR015813 Pyrv/PenolPyrv_Kinase-like_dom IPR011037 Pyrv_Knase-like_insert_dom_sf IPR018209 Pyrv_Knase_AS IPR015793 Pyrv_Knase_brl IPR015795 Pyrv_Knase_C IPR036918 Pyrv_Knase_C_sf IPR015806 Pyrv_Knase_insert_dom_sf |
PANTHERi | PTHR11817 PTHR11817, 1 hit |
Pfami | View protein in Pfam PF00224 PK, 1 hit PF02887 PK_C, 1 hit |
PRINTSi | PR01050 PYRUVTKNASE |
SUPFAMi | SSF50800 SSF50800, 1 hit SSF51621 SSF51621, 2 hits SSF52935 SSF52935, 1 hit |
TIGRFAMsi | TIGR01064 pyruv_kin, 1 hit |
PROSITEi | View protein in PROSITE PS00110 PYRUVATE_KINASE, 1 hit |
i Sequence
Sequence statusi: Complete.
O44006-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MANPTHSQVV AAPDSSGRLL RLVSASSVMM QLLGKSTNIR MSQILEHHED
60 70 80 90 100
EDFSAHRTKI VCTMGPSCWD VDKMVQLIDA GMNVCRLNFS HGDHEAHGRV
110 120 130 140 150
VKNLQEALKQ RPGKRVALLL DTKGPEIRTG MLEGDKPIEL HAGDMLKIVT
160 170 180 190 200
DYSFVGNKSC IACSYEKLPS SVKPGNTILI ADGSLSVEVV ECGKDYVMTR
210 220 230 240 250
VMNPAIIGNK KNMNLPGVKV DLPVIGEKDK NDILNFGIPM GCNFIAASFV
260 270 280 290 300
QSADDVRYIR SILGTKGRNI KIIPKIENVE GLLNFDEILQ EADGIMIARG
310 320 330 340 350
DLGMEIPPEK VFLAQKMMIS KCNVAGKPVI TATQMLESMT KNPRPTRAEA
360 370 380 390 400
ADVANAVLDG TDCVMLSGET ANGSFPVQAV TVMSRVCFEA EGCIDYQQVF
410 420 430 440 450
RATCQATMTP IDTQEAVARA AVETAQSINA SLILALTETG RTARLIAKYR
460 470 480 490 500
PMQPILALSA SEETIKQLQV IRGVTTFLVP TFQGTDQLIR NALSAAKELQ
510 520 530
LVSEGDSIVA VHGIKEEVAG WSNLLKVLVV E
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF043910 mRNA Translation: AAC02529.1 |
RefSeqi | XP_013232798.1, XM_013377344.1 |
Genome annotation databases
GeneIDi | 25251418 |
Similar proteinsi
Entry informationi
Entry namei | KPYK_EIMTE | |
Accessioni | O44006Primary (citable) accession number: O44006 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | June 1, 1998 | |
Last modified: | February 28, 2018 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |