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O43976

- PMM_BABBO

UniProt

O43976 - PMM_BABBO

Protein

Phosphomannomutase

Gene

PMM

Organism
Babesia bovis
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

    Catalytic activityi

    Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei9 – 91NucleophileBy similarity
    Active sitei11 – 111Proton donor/acceptorSequence Analysis
    Binding sitei121 – 1211SubstrateBy similarity
    Binding sitei132 – 1321SubstrateBy similarity
    Binding sitei139 – 1391SubstrateBy similarity
    Binding sitei179 – 1791SubstrateBy similarity
    Binding sitei181 – 1811SubstrateBy similarity

    GO - Molecular functioni

    1. phosphomannomutase activity Source: UniProtKB-EC

    GO - Biological processi

    1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
    2. mannose biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Enzyme and pathway databases

    UniPathwayiUPA00126; UER00424.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphomannomutase (EC:5.4.2.8)
    Gene namesi
    Name:PMM
    OrganismiBabesia bovis
    Taxonomic identifieri5865 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaPiroplasmidaBabesiidaeBabesia

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 246246PhosphomannomutasePRO_0000199697Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO43976.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eukaryotic PMM family.Curated

    Family and domain databases

    Gene3Di3.40.50.1000. 2 hits.
    InterProiIPR023214. HAD-like_dom.
    IPR006379. HAD-SF_hydro_IIB.
    IPR005002. PMM.
    [Graphical view]
    PANTHERiPTHR10466. PTHR10466. 1 hit.
    PfamiPF03332. PMM. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O43976-1 [UniParc]FASTAAdd to Basket

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    MVRQMLIFDM DGTLTDPVQV INNDVKDILR RCKRKNFEIA VVSGSKYEKI    50
    KGQLNDGFID EFDYVFSENG TQVYVKNVLV KSLDITEAIP ETKLRKMVEF 100
    CLRYIADLDI PTKRGTFIEH RKSLINICPP GRNCSMVDRR RFVEYDSIHH 150
    VRQKLIQVLK SQFDSDDCPL SFVAGGQISI DVYPKAWSKS IALSHIGKCD 200
    VIHFFGDNTR EGGNDFEIYN HPDVIGHTVT GYKDLVNQLE ELLAKS 246
    Length:246
    Mass (Da):28,167
    Last modified:June 1, 1998 - v1
    Checksum:i3A0FC96439CF0A80
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF027149 Genomic DNA. Translation: AAC27385.1.
    AF028591 mRNA. Translation: AAC27390.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF027149 Genomic DNA. Translation: AAC27385.1 .
    AF028591 mRNA. Translation: AAC27390.1 .

    3D structure databases

    ProteinModelPortali O43976.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00126 ; UER00424 .

    Family and domain databases

    Gene3Di 3.40.50.1000. 2 hits.
    InterProi IPR023214. HAD-like_dom.
    IPR006379. HAD-SF_hydro_IIB.
    IPR005002. PMM.
    [Graphical view ]
    PANTHERi PTHR10466. PTHR10466. 1 hit.
    Pfami PF03332. PMM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR01484. HAD-SF-IIB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Structure, sequence, and transcriptional analysis of the Babesia bovis rap-1 multigene locus."
      Suarez C.E., Palmer G.H., Hotzel I., McElwain T.F.
      Mol. Biochem. Parasitol. 93:215-224(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: Mexico Mo7.

    Entry informationi

    Entry nameiPMM_BABBO
    AccessioniPrimary (citable) accession number: O43976
    Secondary accession number(s): O15780
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 2, 2004
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3