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O43976

- PMM_BABBO

UniProt

O43976 - PMM_BABBO

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Protein

Phosphomannomutase

Gene

PMM

Organism
Babesia bovis
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei9 – 91NucleophileBy similarity
Active sitei11 – 111Proton donor/acceptorSequence Analysis
Binding sitei121 – 1211SubstrateBy similarity
Binding sitei132 – 1321SubstrateBy similarity
Binding sitei139 – 1391SubstrateBy similarity
Binding sitei179 – 1791SubstrateBy similarity
Binding sitei181 – 1811SubstrateBy similarity

GO - Molecular functioni

  1. phosphomannomutase activity Source: UniProtKB-EC

GO - Biological processi

  1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
  2. mannose biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase (EC:5.4.2.8)
Gene namesi
Name:PMM
OrganismiBabesia bovis
Taxonomic identifieri5865 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaPiroplasmidaBabesiidaeBabesia

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246PhosphomannomutasePRO_0000199697Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO43976.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic PMM family.Curated

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

Sequencei

Sequence statusi: Complete.

O43976-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRQMLIFDM DGTLTDPVQV INNDVKDILR RCKRKNFEIA VVSGSKYEKI
60 70 80 90 100
KGQLNDGFID EFDYVFSENG TQVYVKNVLV KSLDITEAIP ETKLRKMVEF
110 120 130 140 150
CLRYIADLDI PTKRGTFIEH RKSLINICPP GRNCSMVDRR RFVEYDSIHH
160 170 180 190 200
VRQKLIQVLK SQFDSDDCPL SFVAGGQISI DVYPKAWSKS IALSHIGKCD
210 220 230 240
VIHFFGDNTR EGGNDFEIYN HPDVIGHTVT GYKDLVNQLE ELLAKS
Length:246
Mass (Da):28,167
Last modified:June 1, 1998 - v1
Checksum:i3A0FC96439CF0A80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027149 Genomic DNA. Translation: AAC27385.1.
AF028591 mRNA. Translation: AAC27390.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027149 Genomic DNA. Translation: AAC27385.1 .
AF028591 mRNA. Translation: AAC27390.1 .

3D structure databases

ProteinModelPortali O43976.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00126 ; UER00424 .

Family and domain databases

Gene3Di 3.40.50.1000. 2 hits.
InterProi IPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view ]
PANTHERi PTHR10466. PTHR10466. 1 hit.
Pfami PF03332. PMM. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR01484. HAD-SF-IIB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Structure, sequence, and transcriptional analysis of the Babesia bovis rap-1 multigene locus."
    Suarez C.E., Palmer G.H., Hotzel I., McElwain T.F.
    Mol. Biochem. Parasitol. 93:215-224(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: Mexico Mo7.

Entry informationi

Entry nameiPMM_BABBO
AccessioniPrimary (citable) accession number: O43976
Secondary accession number(s): O15780
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3