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O43976 (PMM_BABBO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphomannomutase

EC=5.4.2.8
Gene names
Name:PMM
OrganismBabesia bovis
Taxonomic identifier5865 [NCBI]
Taxonomic lineageEukaryotaAlveolataApicomplexaAconoidasidaPiroplasmidaBabesiidaeBabesia

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity.

Catalytic activity

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the eukaryotic PMM family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionIsomerase
Gene Ontology (GO)
   Biological_processGDP-mannose biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

mannose biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphomannomutase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 246246Phosphomannomutase
PRO_0000199697

Sites

Active site91Nucleophile By similarity
Active site111Proton donor/acceptor Potential
Binding site1211Substrate By similarity
Binding site1321Substrate By similarity
Binding site1391Substrate By similarity
Binding site1791Substrate By similarity
Binding site1811Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
O43976 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 3A0FC96439CF0A80

FASTA24628,167
        10         20         30         40         50         60 
MVRQMLIFDM DGTLTDPVQV INNDVKDILR RCKRKNFEIA VVSGSKYEKI KGQLNDGFID 

        70         80         90        100        110        120 
EFDYVFSENG TQVYVKNVLV KSLDITEAIP ETKLRKMVEF CLRYIADLDI PTKRGTFIEH 

       130        140        150        160        170        180 
RKSLINICPP GRNCSMVDRR RFVEYDSIHH VRQKLIQVLK SQFDSDDCPL SFVAGGQISI 

       190        200        210        220        230        240 
DVYPKAWSKS IALSHIGKCD VIHFFGDNTR EGGNDFEIYN HPDVIGHTVT GYKDLVNQLE 


ELLAKS 

« Hide

References

[1]"Structure, sequence, and transcriptional analysis of the Babesia bovis rap-1 multigene locus."
Suarez C.E., Palmer G.H., Hotzel I., McElwain T.F.
Mol. Biochem. Parasitol. 93:215-224(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: Mexico Mo7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF027149 Genomic DNA. Translation: AAC27385.1.
AF028591 mRNA. Translation: AAC27390.1.

3D structure databases

ProteinModelPortalO43976.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00126; UER00424.

Family and domain databases

Gene3D3.40.50.1000. 2 hits.
InterProIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERPTHR10466. PTHR10466. 1 hit.
PfamPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 1 hit.
TIGRFAMsTIGR01484. HAD-SF-IIB. 1 hit.
ProtoNetSearch...

Entry information

Entry namePMM_BABBO
AccessionPrimary (citable) accession number: O43976
Secondary accession number(s): O15780
Entry history
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: June 1, 1998
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways