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Protein

UNC93-like protein MFSD11

Gene

MFSD11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UNC93-like protein MFSD11
Alternative name(s):
Major facilitator superfamily domain-containing protein 11
Protein ET
Gene namesi
Name:MFSD11
Synonyms:ET
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:25458. MFSD11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21
Transmembranei359 – 379HelicalSequence analysisAdd BLAST21
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Transmembranei410 – 430HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79157.
OpenTargetsiENSG00000092931.
PharmGKBiPA162395841.

Polymorphism and mutation databases

BioMutaiMFSD11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003050191 – 449UNC93-like protein MFSD11Add BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi40N-linked (GlcNAc...)Sequence analysis1
Modified residuei204PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO43934.
PeptideAtlasiO43934.
PRIDEiO43934.

PTM databases

iPTMnetiO43934.
PhosphoSitePlusiO43934.

Expressioni

Gene expression databases

BgeeiENSG00000092931.
CleanExiHS_MFSD11.
ExpressionAtlasiO43934. baseline and differential.
GenevisibleiO43934. HS.

Organism-specific databases

HPAiHPA022001.

Interactioni

Protein-protein interaction databases

BioGridi122575. 4 interactors.
MINTiMINT-4726565.

Structurei

3D structure databases

ProteinModelPortaliO43934.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the unc-93 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3098. Eukaryota.
ENOG410ZITE. LUCA.
GeneTreeiENSGT00390000012918.
HOGENOMiHOG000008022.
HOVERGENiHBG052950.
InParanoidiO43934.
OMAiKFIQSIM.
OrthoDBiEOG091G089A.
PhylomeDBiO43934.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR010291. Ion_channel_UNC-93.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF05978. UNC-93. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43934-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPESKKLFN IIILGVAFMF MFTAFQTCGN VAQTVIRSLN RTDFHGSGYT
60 70 80 90 100
SMAIIYGVFS ASNLITPSVV AIVGPQLSMF ASGLFYSMYI AVFIQPFPWS
110 120 130 140 150
FYTASVFIGI AAAVLWTAQG NCLTINSDEH SIGRNSGIFW ALLQSSLFFG
160 170 180 190 200
NLYIYFAWQG KTQISESDRR TVFIALTVIS LVGTVLFFLI RKPDSENVLG
210 220 230 240 250
EDESSDDQDM EVNESAQNNL TKAVDAFKKS FKLCVTKEML LLSITTAYTG
260 270 280 290 300
LELTFFSGVY GTCIGATNKF GAEEKSLIGL SGIFIGIGEI LGGSLFGLLS
310 320 330 340 350
KNNRFGRNPV VLLGILVHFI AFYLIFLNMP GDAPIAPVKG TDSSAYIKSS
360 370 380 390 400
KEVAILCSFL LGLGDSCFNT QLLSILGFLY SEDSAPAFAI FKFVQSICAA
410 420 430 440
VAFFYSNYLL LHWQLLVMVI FGFFGTISFF TVEWEAAAFV ARGSDYRSI
Length:449
Mass (Da):49,202
Last modified:October 2, 2007 - v2
Checksum:iB45219CA5894FCDC
GO
Isoform 2 (identifier: O43934-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-165: Missing.

Show »
Length:397
Mass (Da):43,322
Checksum:i75DA3D5BBF3E3B51
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035151428S → F.1 PublicationCorresponds to variant rs3198672dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028187114 – 165Missing in isoform 2. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015184 mRNA. Translation: AAB92495.1.
AF015185 mRNA. Translation: AAB92496.1.
AF015186 mRNA. Translation: AAB92497.1.
AK000233 mRNA. Translation: BAA91025.1.
CH471099 Genomic DNA. Translation: EAW89449.1.
CH471099 Genomic DNA. Translation: EAW89452.1.
BC002753 mRNA. Translation: AAH02753.1.
BC062563 mRNA. Translation: AAH62563.1.
CCDSiCCDS11750.1. [O43934-1]
CCDS56045.1. [O43934-2]
RefSeqiNP_001229461.1. NM_001242532.1. [O43934-1]
NP_001229462.1. NM_001242533.1. [O43934-1]
NP_001229463.1. NM_001242534.1. [O43934-1]
NP_001229464.1. NM_001242535.1. [O43934-1]
NP_001229465.1. NM_001242536.1. [O43934-2]
NP_001229466.1. NM_001242537.1. [O43934-2]
NP_077287.1. NM_024311.3. [O43934-1]
XP_016880555.1. XM_017025066.1. [O43934-1]
XP_016880556.1. XM_017025067.1. [O43934-1]
UniGeneiHs.732019.
Hs.73965.

Genome annotation databases

EnsembliENST00000336509; ENSP00000337240; ENSG00000092931. [O43934-1]
ENST00000355954; ENSP00000348225; ENSG00000092931. [O43934-2]
ENST00000586622; ENSP00000466613; ENSG00000092931. [O43934-1]
ENST00000588460; ENSP00000464932; ENSG00000092931. [O43934-1]
ENST00000590514; ENSP00000468309; ENSG00000092931. [O43934-1]
ENST00000593181; ENSP00000466782; ENSG00000092931. [O43934-2]
ENST00000621483; ENSP00000485005; ENSG00000092931. [O43934-1]
GeneIDi79157.
KEGGihsa:79157.
UCSCiuc002jta.3. human. [O43934-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015184 mRNA. Translation: AAB92495.1.
AF015185 mRNA. Translation: AAB92496.1.
AF015186 mRNA. Translation: AAB92497.1.
AK000233 mRNA. Translation: BAA91025.1.
CH471099 Genomic DNA. Translation: EAW89449.1.
CH471099 Genomic DNA. Translation: EAW89452.1.
BC002753 mRNA. Translation: AAH02753.1.
BC062563 mRNA. Translation: AAH62563.1.
CCDSiCCDS11750.1. [O43934-1]
CCDS56045.1. [O43934-2]
RefSeqiNP_001229461.1. NM_001242532.1. [O43934-1]
NP_001229462.1. NM_001242533.1. [O43934-1]
NP_001229463.1. NM_001242534.1. [O43934-1]
NP_001229464.1. NM_001242535.1. [O43934-1]
NP_001229465.1. NM_001242536.1. [O43934-2]
NP_001229466.1. NM_001242537.1. [O43934-2]
NP_077287.1. NM_024311.3. [O43934-1]
XP_016880555.1. XM_017025066.1. [O43934-1]
XP_016880556.1. XM_017025067.1. [O43934-1]
UniGeneiHs.732019.
Hs.73965.

3D structure databases

ProteinModelPortaliO43934.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122575. 4 interactors.
MINTiMINT-4726565.

PTM databases

iPTMnetiO43934.
PhosphoSitePlusiO43934.

Polymorphism and mutation databases

BioMutaiMFSD11.

Proteomic databases

PaxDbiO43934.
PeptideAtlasiO43934.
PRIDEiO43934.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336509; ENSP00000337240; ENSG00000092931. [O43934-1]
ENST00000355954; ENSP00000348225; ENSG00000092931. [O43934-2]
ENST00000586622; ENSP00000466613; ENSG00000092931. [O43934-1]
ENST00000588460; ENSP00000464932; ENSG00000092931. [O43934-1]
ENST00000590514; ENSP00000468309; ENSG00000092931. [O43934-1]
ENST00000593181; ENSP00000466782; ENSG00000092931. [O43934-2]
ENST00000621483; ENSP00000485005; ENSG00000092931. [O43934-1]
GeneIDi79157.
KEGGihsa:79157.
UCSCiuc002jta.3. human. [O43934-1]

Organism-specific databases

CTDi79157.
DisGeNETi79157.
GeneCardsiMFSD11.
H-InvDBHIX0014205.
HGNCiHGNC:25458. MFSD11.
HPAiHPA022001.
neXtProtiNX_O43934.
OpenTargetsiENSG00000092931.
PharmGKBiPA162395841.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3098. Eukaryota.
ENOG410ZITE. LUCA.
GeneTreeiENSGT00390000012918.
HOGENOMiHOG000008022.
HOVERGENiHBG052950.
InParanoidiO43934.
OMAiKFIQSIM.
OrthoDBiEOG091G089A.
PhylomeDBiO43934.

Miscellaneous databases

ChiTaRSiMFSD11. human.
GenomeRNAii79157.
PROiO43934.

Gene expression databases

BgeeiENSG00000092931.
CleanExiHS_MFSD11.
ExpressionAtlasiO43934. baseline and differential.
GenevisibleiO43934. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR010291. Ion_channel_UNC-93.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF05978. UNC-93. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMFS11_HUMAN
AccessioniPrimary (citable) accession number: O43934
Secondary accession number(s): O43442, Q9NXI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 2, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Despite its name, it is related to the unc-93 family and not to the major facilitator superfamily.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.