Reviewed, UniProtKB/Swiss-Prot O43930 (PRKY_HUMAN)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase PRKY
    EC=2.7.11.1

Gene names

Name:

PRKY

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Involvement in disease	A chromosomal aberration involving PRKY is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKX. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. cAMP subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Coding sequence diversity	Chromosomal rearrangement
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Ref.3 Traceable author statement. Source: ProtInc
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Ref.3 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Serine/threonine-protein kinase PRKY		PRO_0000086584
Regions
	Domain	49 – 277	229	Protein kinase
	Nucleotide binding	55 – 63	9	ATP By similarity
Sites
	Active site	172	1	Proton acceptor By similarity
	Binding site	78	1	ATP By similarity
Experimental info
	Sequence conflict	69 – 70	2	KT → FR in CAA71508. Ref.3
	Sequence conflict	88 – 90	3	RKQ → NSG in CAA71509. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	O43930-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 8DC7B21124BF8EAF	FASTA	277	31,708
	10 20 30 40 50 60 MEAPGPAQAA AAESNSREVT EDAADWAPAL CPSPEARSPE APAYRLQDCD ALVTMGTGTF 70 80 90 100 110 120 GRVHLVKEKT AKHFFALKVM SIPDVIRRKQ EQHVHNEKSV LKEVSHPFLI RLFWTWHEER 130 140 150 160 170 180 FLYMLMEYVP GGELFSYLRN RGHFSSTTGL FYSAEIICAI EYLHSKEIVY RDLKPENILL 190 200 210 220 230 240 DRDGHIKLTD FGFAKKLVDR TWTLCGTPEY LAPEVIQSKG HGRAVDWWAL GILIFEMLSG 250 260 270 FPPFFDDNPF GIYQKILAGK LYFPRHLDFH VKTGRMM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females." Schiebel K., Winkelmann M., Mertz A., Xu X., Page D.C., Weil D., Petit C., Rappold G.A. Hum. Mol. Genet. 6:1985-1989(1997) [PubMed: 9302280] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHROMOSOMAL TRANSLOCATION WITH PRKX.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[3]	"FISH localization of the human Y-homologue of protein kinase PRKX to Yp11.2 and two pseudogenes to 15q26 and Xq12->13." Schiebel K., Mertz A., Winkelmann M., Glaeser B., Schempp W., Rappold G. Cytogenet. Cell Genet. 76:49-52(1997) [PubMed: 9154127] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 68-178. Tissue: Fetal brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y13927 , Y13928, Y13929, Y13930, Y13931, Y13932 Genomic DNA. Translation: CAA74244.1. Y15801 mRNA. Translation: CAA75792.1. BC074851 mRNA. Translation: AAH74851.1. BC074852 mRNA. Translation: AAH74852.1. Y10484 mRNA. Translation: CAA71508.1. Y10485 mRNA. Translation: CAA71509.1.
IPI	IPI00288889.
UniGene	Hs.632287
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	O43930.
PTM databases
PhosphoSite	O43930.
Proteomic databases
PRIDE	O43930.
Genome annotation databases
Ensembl	ENST00000311978; ENSP00000310643; ENSG00000099725; Homo sapiens. [Genome view] ENST00000362758; ENSP00000372489; ENSG00000099725; Homo sapiens. [Genome view]
UCSC	uc004fre.1. human.
Organism-specific databases
GeneCards	GC0YP007185.
H-InvDB	HIX0056698.
HGNC	HGNC:9444. PRKY.
MIM	400008. gene.
PharmGKB	PA33789.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O43930.
HOVERGEN	O43930.
OMA	GHFSNST
OrthoDB	EOG9MKR1W
Enzyme and pathway databases
BRENDA	2.7.11.1. 247.
Gene expression databases
ArrayExpress	O43930.
Bgee	O43930.
CleanEx	HS_PRKY.
Genevestigator	O43930.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	21824.
SOURCE	Search...

Entry information

Entry name

PRKY_HUMAN

Accession

Primary (citable) accession number: O43930
Secondary accession number(s): O15348, O15349

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	June 1, 1998
Last modified:	November 24, 2009
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.