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O43930

- PRKY_HUMAN

UniProt

O43930 - PRKY_HUMAN

Protein

Putative serine/threonine-protein kinase PRKY

Gene

PRKY

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Protein uncertaini
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei78 – 781ATPPROSITE-ProRule annotation
    Active sitei172 – 1721Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi55 – 639ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: ProtInc

    GO - Biological processi

    1. protein phosphorylation Source: ProtInc

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiO43930.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative serine/threonine-protein kinase PRKY (EC:2.7.11.1)
    Gene namesi
    Name:PRKY
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:9444. PRKY.

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving PRKY is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKX. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 277277Putative serine/threonine-protein kinase PRKYPRO_0000086584Add
    BLAST

    Proteomic databases

    PaxDbiO43930.
    PRIDEiO43930.

    PTM databases

    PhosphoSiteiO43930.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    CleanExiHS_PRKY.
    GenevestigatoriO43930.

    Interactioni

    Protein-protein interaction databases

    IntActiO43930. 1 interaction.
    STRINGi9606.ENSP00000372489.

    Structurei

    3D structure databases

    ProteinModelPortaliO43930.
    SMRiO43930. Positions 5-272.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini49 – 277229Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233033.
    HOVERGENiHBG108317.
    InParanoidiO43930.
    PhylomeDBiO43930.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O43930-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAPGPAQAA AAESNSREVT EDAADWAPAL CPSPEARSPE APAYRLQDCD    50
    ALVTMGTGTF GRVHLVKEKT AKHFFALKVM SIPDVIRRKQ EQHVHNEKSV 100
    LKEVSHPFLI RLFWTWHEER FLYMLMEYVP GGELFSYLRN RGHFSSTTGL 150
    FYSAEIICAI EYLHSKEIVY RDLKPENILL DRDGHIKLTD FGFAKKLVDR 200
    TWTLCGTPEY LAPEVIQSKG HGRAVDWWAL GILIFEMLSG FPPFFDDNPF 250
    GIYQKILAGK LYFPRHLDFH VKTGRMM 277
    Length:277
    Mass (Da):31,708
    Last modified:June 1, 1998 - v1
    Checksum:i8DC7B21124BF8EAF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti69 – 702KT → FR in CAA71508. (PubMed:9154127)Curated
    Sequence conflicti88 – 903RKQ → NSG in CAA71509. (PubMed:9154127)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13927
    , Y13928, Y13929, Y13930, Y13931, Y13932 Genomic DNA. Translation: CAA74244.1.
    Y15801 mRNA. Translation: CAA75792.1.
    BC074851 mRNA. Translation: AAH74851.1.
    BC074852 mRNA. Translation: AAH74852.1.
    Y10484 mRNA. Translation: CAA71508.1.
    Y10485 mRNA. Translation: CAA71509.1.
    UniGeneiHs.584730.

    Keywords - Coding sequence diversityi

    Chromosomal rearrangement

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13927
    , Y13928 , Y13929 , Y13930 , Y13931 , Y13932 Genomic DNA. Translation: CAA74244.1 .
    Y15801 mRNA. Translation: CAA75792.1 .
    BC074851 mRNA. Translation: AAH74851.1 .
    BC074852 mRNA. Translation: AAH74852.1 .
    Y10484 mRNA. Translation: CAA71508.1 .
    Y10485 mRNA. Translation: CAA71509.1 .
    UniGenei Hs.584730.

    3D structure databases

    ProteinModelPortali O43930.
    SMRi O43930. Positions 5-272.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O43930. 1 interaction.
    STRINGi 9606.ENSP00000372489.

    PTM databases

    PhosphoSitei O43930.

    Proteomic databases

    PaxDbi O43930.
    PRIDEi O43930.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC0YP007142.
    HGNCi HGNC:9444. PRKY.
    MIMi 400008. gene.
    neXtProti NX_O43930.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233033.
    HOVERGENi HBG108317.
    InParanoidi O43930.
    PhylomeDBi O43930.

    Enzyme and pathway databases

    SignaLinki O43930.

    Miscellaneous databases

    PROi O43930.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_PRKY.
    Genevestigatori O43930.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females."
      Schiebel K., Winkelmann M., Mertz A., Xu X., Page D.C., Weil D., Petit C., Rappold G.A.
      Hum. Mol. Genet. 6:1985-1989(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHROMOSOMAL TRANSLOCATION WITH PRKX.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    3. "FISH localization of the human Y-homologue of protein kinase PRKX to Yp11.2 and two pseudogenes to 15q26 and Xq12->13."
      Schiebel K., Mertz A., Winkelmann M., Glaeser B., Schempp W., Rappold G.
      Cytogenet. Cell Genet. 76:49-52(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 68-178.
      Tissue: Fetal brain.
    4. Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiPRKY_HUMAN
    AccessioniPrimary (citable) accession number: O43930
    Secondary accession number(s): O15348, O15349
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene. Highly similar to PRKX in the pseudoautosomal region of the X chromosome, the transcripts specific of that gene are potential candidates for nonsense-mediated decay.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome Y
      Human chromosome Y: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3