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Protein

Putative serine/threonine-protein kinase PRKY

Gene

PRKY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei78 – 781ATPPROSITE-ProRule annotation
Active sitei172 – 1721Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi55 – 639ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: ProtInc

GO - Biological processi

  1. protein phosphorylation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiO43930.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative serine/threonine-protein kinase PRKY (EC:2.7.11.1)
Gene namesi
Name:PRKY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:9444. PRKY.

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving PRKY is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKX. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 277277Putative serine/threonine-protein kinase PRKYPRO_0000086584Add
BLAST

Proteomic databases

PaxDbiO43930.
PRIDEiO43930.

PTM databases

PhosphoSiteiO43930.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

CleanExiHS_PRKY.
GenevestigatoriO43930.

Interactioni

Protein-protein interaction databases

IntActiO43930. 1 interaction.
STRINGi9606.ENSP00000372489.

Structurei

3D structure databases

ProteinModelPortaliO43930.
SMRiO43930. Positions 5-272.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 277229Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233033.
HOVERGENiHBG108317.
InParanoidiO43930.
PhylomeDBiO43930.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAPGPAQAA AAESNSREVT EDAADWAPAL CPSPEARSPE APAYRLQDCD
60 70 80 90 100
ALVTMGTGTF GRVHLVKEKT AKHFFALKVM SIPDVIRRKQ EQHVHNEKSV
110 120 130 140 150
LKEVSHPFLI RLFWTWHEER FLYMLMEYVP GGELFSYLRN RGHFSSTTGL
160 170 180 190 200
FYSAEIICAI EYLHSKEIVY RDLKPENILL DRDGHIKLTD FGFAKKLVDR
210 220 230 240 250
TWTLCGTPEY LAPEVIQSKG HGRAVDWWAL GILIFEMLSG FPPFFDDNPF
260 270
GIYQKILAGK LYFPRHLDFH VKTGRMM
Length:277
Mass (Da):31,708
Last modified:June 1, 1998 - v1
Checksum:i8DC7B21124BF8EAF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 702KT → FR in CAA71508 (PubMed:9154127).Curated
Sequence conflicti88 – 903RKQ → NSG in CAA71509 (PubMed:9154127).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13927
, Y13928, Y13929, Y13930, Y13931, Y13932 Genomic DNA. Translation: CAA74244.1.
Y15801 mRNA. Translation: CAA75792.1.
BC074851 mRNA. Translation: AAH74851.1.
BC074852 mRNA. Translation: AAH74852.1.
Y10484 mRNA. Translation: CAA71508.1.
Y10485 mRNA. Translation: CAA71509.1.
UniGeneiHs.584730.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13927
, Y13928, Y13929, Y13930, Y13931, Y13932 Genomic DNA. Translation: CAA74244.1.
Y15801 mRNA. Translation: CAA75792.1.
BC074851 mRNA. Translation: AAH74851.1.
BC074852 mRNA. Translation: AAH74852.1.
Y10484 mRNA. Translation: CAA71508.1.
Y10485 mRNA. Translation: CAA71509.1.
UniGeneiHs.584730.

3D structure databases

ProteinModelPortaliO43930.
SMRiO43930. Positions 5-272.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO43930. 1 interaction.
STRINGi9606.ENSP00000372489.

PTM databases

PhosphoSiteiO43930.

Proteomic databases

PaxDbiO43930.
PRIDEiO43930.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiGC0YP007142.
HGNCiHGNC:9444. PRKY.
MIMi400008. gene.
neXtProtiNX_O43930.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233033.
HOVERGENiHBG108317.
InParanoidiO43930.
PhylomeDBiO43930.

Enzyme and pathway databases

SignaLinkiO43930.

Miscellaneous databases

PROiO43930.
SOURCEiSearch...

Gene expression databases

CleanExiHS_PRKY.
GenevestigatoriO43930.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females."
    Schiebel K., Winkelmann M., Mertz A., Xu X., Page D.C., Weil D., Petit C., Rappold G.A.
    Hum. Mol. Genet. 6:1985-1989(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHROMOSOMAL TRANSLOCATION WITH PRKX.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. "FISH localization of the human Y-homologue of protein kinase PRKX to Yp11.2 and two pseudogenes to 15q26 and Xq12->13."
    Schiebel K., Mertz A., Winkelmann M., Glaeser B., Schempp W., Rappold G.
    Cytogenet. Cell Genet. 76:49-52(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 68-178.
    Tissue: Fetal brain.
  4. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPRKY_HUMAN
AccessioniPrimary (citable) accession number: O43930
Secondary accession number(s): O15348, O15349
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 1998
Last modified: January 7, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. Highly similar to PRKX in the pseudoautosomal region of the X chromosome, the transcripts specific of that gene are potential candidates for nonsense-mediated decay.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.