O43930 (PRKY_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative serine/threonine-protein kinase PRKY
EC=2.7.11.1

Gene names

Name:

PRKY

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Tissue specificity	Ubiquitous. Ref.4
Involvement in disease	A chromosomal aberration involving PRKY is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKX. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females.
Sequence similarities	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. Contains 1 protein kinase domain.
Caution	Could be the product of a pseudogene. Highly similar to PRKX in the pseudoautosomal region of the X chromosome, the transcripts specific of that gene are potential candidates for nonsense-mediated decay.

Ontologies

Keywords
Coding sequence diversity	Chromosomal rearrangement
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Traceable author statement Ref.3. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Putative serine/threonine-protein kinase PRKY		PRO_0000086584
Regions
	Domain	49 – 277	229	Protein kinase
	Nucleotide binding	55 – 63	9	ATP By similarity
Sites
	Active site	172	1	Proton acceptor By similarity
	Binding site	78	1	ATP By similarity
Experimental info
	Sequence conflict	69 – 70	2	KT → FR in CAA71508. Ref.3
	Sequence conflict	88 – 90	3	RKQ → NSG in CAA71509. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	O43930 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 8DC7B21124BF8EAF	FASTA	277	31,708
	10 20 30 40 50 60 MEAPGPAQAA AAESNSREVT EDAADWAPAL CPSPEARSPE APAYRLQDCD ALVTMGTGTF 70 80 90 100 110 120 GRVHLVKEKT AKHFFALKVM SIPDVIRRKQ EQHVHNEKSV LKEVSHPFLI RLFWTWHEER 130 140 150 160 170 180 FLYMLMEYVP GGELFSYLRN RGHFSSTTGL FYSAEIICAI EYLHSKEIVY RDLKPENILL 190 200 210 220 230 240 DRDGHIKLTD FGFAKKLVDR TWTLCGTPEY LAPEVIQSKG HGRAVDWWAL GILIFEMLSG 250 260 270 FPPFFDDNPF GIYQKILAGK LYFPRHLDFH VKTGRMM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females." Schiebel K., Winkelmann M., Mertz A., Xu X., Page D.C., Weil D., Petit C., Rappold G.A. Hum. Mol. Genet. 6:1985-1989(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHROMOSOMAL TRANSLOCATION WITH PRKX.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[3]	"FISH localization of the human Y-homologue of protein kinase PRKX to Yp11.2 and two pseudogenes to 15q26 and Xq12->13." Schiebel K., Mertz A., Winkelmann M., Glaeser B., Schempp W., Rappold G. Cytogenet. Cell Genet. 76:49-52(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 68-178. Tissue: Fetal brain.
[4]	"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes." Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. , Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H., Wilson R.K., Rozen S., Page D.C. Nature 423:825-837(2003) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y13927 , Y13928, Y13929, Y13930, Y13931, Y13932 Genomic DNA. Translation: CAA74244.1. Y15801 mRNA. Translation: CAA75792.1. BC074851 mRNA. Translation: AAH74851.1. BC074852 mRNA. Translation: AAH74852.1. Y10484 mRNA. Translation: CAA71508.1. Y10485 mRNA. Translation: CAA71509.1.
IPI	IPI00288889.
UniGene	Hs.584730.
3D structure databases
ProteinModelPortal	O43930.
ModBase	Search...
Protein-protein interaction databases
IntAct	O43930. 1 interaction.
STRING	9606.ENSP00000372489.
PTM databases
PhosphoSite	O43930.
Proteomic databases
PaxDb	O43930.
PRIDE	O43930.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC0YP007142.
HGNC	HGNC:9444. PRKY.
MIM	400008. gene.
neXtProt	NX_O43930.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000233033.
HOVERGEN	HBG108317.
InParanoid	O43930.
OrthoDB	EOG4FTW1P.
PhylomeDB	O43930.
Gene expression databases
CleanEx	HS_PRKY.
Genevestigator	O43930.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

PRKY_HUMAN

Accession

Primary (citable) accession number: O43930
Secondary accession number(s): O15348, O15349

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	June 1, 1998
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.