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O43929

- ORC4_HUMAN

UniProt

O43929 - ORC4_HUMAN

Protein

Origin recognition complex subunit 4

Gene

ORC4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 2 (07 Jun 2005)
      Previous versions | rss
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    Functioni

    Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi67 – 748ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA replication origin binding Source: UniProtKB
    3. nucleoside-triphosphatase activity Source: InterPro
    4. nucleotide binding Source: UniProtKB
    5. protein binding Source: IntAct

    GO - Biological processi

    1. DNA replication Source: Reactome
    2. DNA replication initiation Source: UniProtKB
    3. G1/S transition of mitotic cell cycle Source: Reactome
    4. mitotic cell cycle Source: Reactome

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_1095. Activation of the pre-replicative complex.
    REACT_1156. Orc1 removal from chromatin.
    REACT_1181. Association of licensing factors with the pre-replicative complex.
    REACT_1321. E2F-enabled inhibition of pre-replication complex formation.
    REACT_1707. CDC6 association with the ORC:origin complex.
    REACT_1949. CDT1 association with the CDC6:ORC:origin complex.
    REACT_207. Removal of licensing factors from origins.
    REACT_2243. Assembly of the pre-replicative complex.
    REACT_567. Assembly of the ORC complex at the origin of replication.
    REACT_6769. Activation of ATR in response to replication stress.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Origin recognition complex subunit 4
    Gene namesi
    Name:ORC4
    Synonyms:ORC4L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:8490. ORC4.

    Subcellular locationi

    GO - Cellular componenti

    1. nuclear origin of replication recognition complex Source: UniProtKB
    2. nucleoplasm Source: Reactome
    3. nucleus Source: UniProtKB
    4. origin recognition complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Meier-Gorlin syndrome 2 (MGORS2) [MIM:613800]: A syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti174 – 1741Y → C in MGORS2. 2 Publications
    VAR_065486

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi73 – 731K → A or E: Impairs ORC complex formation. 1 Publication
    Mutagenesisi159 – 1602DE → AA: Impairs ORC complex formation.

    Keywords - Diseasei

    Disease mutation, Dwarfism

    Organism-specific databases

    MIMi613800. phenotype.
    Orphaneti2554. Ear-patella-short stature syndrome.
    PharmGKBiPA32811.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 436436Origin recognition complex subunit 4PRO_0000127087Add
    BLAST

    Proteomic databases

    MaxQBiO43929.
    PaxDbiO43929.
    PeptideAtlasiO43929.
    PRIDEiO43929.

    PTM databases

    PhosphoSiteiO43929.

    Expressioni

    Gene expression databases

    ArrayExpressiO43929.
    BgeeiO43929.
    CleanExiHS_ORC4L.
    GenevestigatoriO43929.

    Organism-specific databases

    HPAiCAB015124.

    Interactioni

    Subunit structurei

    Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ORC2Q134166EBI-374889,EBI-374957
    ORC3Q9UBD512EBI-374889,EBI-374916
    ORC5O439132EBI-374889,EBI-374928

    Protein-protein interaction databases

    BioGridi111042. 30 interactions.
    DIPiDIP-29690N.
    IntActiO43929. 20 interactions.
    MINTiMINT-1201591.

    Structurei

    3D structure databases

    ProteinModelPortaliO43929.
    SMRiO43929. Positions 43-215.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ORC4 family.Curated

    Phylogenomic databases

    eggNOGiNOG289784.
    HOGENOMiHOG000007226.
    HOVERGENiHBG000253.
    InParanoidiO43929.
    KOiK02606.
    OMAiFQKFIQR.
    OrthoDBiEOG72NRPZ.
    PhylomeDBiO43929.
    TreeFamiTF101094.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR016527. ORC4.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PIRSFiPIRSF007858. ORC4. 1 hit.
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O43929-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSRKSKSNS LIHTECLSQV QRILRERFCR QSPHSNLFGV QVQYKHLSEL    50
    LKRTALHGES NSVLIIGPRG SGKTMLINHA LKELMEIEEV SENVLQVHLN 100
    GLLQINDKIA LKEITRQLNL ENVVGDKVFG SFAENLSFLL EALKKGDRTS 150
    SCPVIFILDE FDLFAHHKNQ TLLYNLFDIS QSAQTPIAVI GLTCRLDILE 200
    LLEKRVKSRF SHRQIHLMNS FGFPQYVKIF KEQLSLPAEF PDKVFAEKWN 250
    ENVQYLSEDR SVQEVLQKHF NISKNLRSLH MLLMLALNRV TASHPFMTAV 300
    DLMEASQLCS MDSKANIVHG LSVLEICLII AMKHLNDIYE EEPFNFQMVY 350
    NEFQKFVQRK AHSVYNFEKP VVMKAFEHLQ QLELIKPMER TSGNSQREYQ 400
    LMKLLLDNTQ IMNALQKYPN CPTDVRQWAT SSLSWL 436
    Length:436
    Mass (Da):50,377
    Last modified:June 7, 2005 - v2
    Checksum:iA7020B6690E30B4E
    GO
    Isoform 2 (identifier: O43929-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-84: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:352
    Mass (Da):40,870
    Checksum:iEE1B23556EB4AA9E
    GO
    Isoform 3 (identifier: O43929-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-74: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:362
    Mass (Da):42,034
    Checksum:iFB95A4CFA5AB1CB3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti135 – 1351N → S in BAH12887. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti56 – 561L → V.1 Publication
    Corresponds to variant rs2307397 [ dbSNP | Ensembl ].
    VAR_014523
    Natural varianti78 – 781N → S.4 Publications
    Corresponds to variant rs2307394 [ dbSNP | Ensembl ].
    VAR_019235
    Natural varianti174 – 1741Y → C in MGORS2. 2 Publications
    VAR_065486

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8484Missing in isoform 2. 1 PublicationVSP_045199Add
    BLAST
    Alternative sequencei1 – 7474Missing in isoform 3. 1 PublicationVSP_046437Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022108 mRNA. Translation: AAC01957.1.
    AF047598 mRNA. Translation: AAC80282.1.
    AF132596 mRNA. Translation: AAD22110.1.
    AY600302 Genomic DNA. Translation: AAS94326.1.
    AK295721 mRNA. Translation: BAH12166.1.
    AK298862 mRNA. Translation: BAH12887.1.
    AC009480 Genomic DNA. No translation available.
    AC019226 Genomic DNA. No translation available.
    CH471058 Genomic DNA. Translation: EAX11555.1.
    CH471058 Genomic DNA. Translation: EAX11556.1.
    CH471058 Genomic DNA. Translation: EAX11557.1.
    CH471058 Genomic DNA. Translation: EAX11558.1.
    BC014847 mRNA. Translation: AAH14847.1.
    CCDSiCCDS2187.1. [O43929-1]
    CCDS54404.1. [O43929-2]
    CCDS54405.1. [O43929-3]
    RefSeqiNP_001177808.1. NM_001190879.2. [O43929-1]
    NP_001177810.1. NM_001190881.2. [O43929-2]
    NP_001177811.1. NM_001190882.2. [O43929-3]
    NP_002543.2. NM_002552.4. [O43929-1]
    NP_859525.1. NM_181741.3. [O43929-1]
    NP_859526.1. NM_181742.3. [O43929-1]
    XP_006712619.1. XM_006712556.1. [O43929-2]
    UniGeneiHs.558364.

    Genome annotation databases

    EnsembliENST00000264169; ENSP00000264169; ENSG00000115947. [O43929-1]
    ENST00000392857; ENSP00000376597; ENSG00000115947. [O43929-1]
    ENST00000535373; ENSP00000441953; ENSG00000115947. [O43929-1]
    ENST00000536575; ENSP00000441502; ENSG00000115947. [O43929-2]
    ENST00000540442; ENSP00000438326; ENSG00000115947. [O43929-3]
    GeneIDi5000.
    KEGGihsa:5000.
    UCSCiuc002twi.3. human. [O43929-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022108 mRNA. Translation: AAC01957.1 .
    AF047598 mRNA. Translation: AAC80282.1 .
    AF132596 mRNA. Translation: AAD22110.1 .
    AY600302 Genomic DNA. Translation: AAS94326.1 .
    AK295721 mRNA. Translation: BAH12166.1 .
    AK298862 mRNA. Translation: BAH12887.1 .
    AC009480 Genomic DNA. No translation available.
    AC019226 Genomic DNA. No translation available.
    CH471058 Genomic DNA. Translation: EAX11555.1 .
    CH471058 Genomic DNA. Translation: EAX11556.1 .
    CH471058 Genomic DNA. Translation: EAX11557.1 .
    CH471058 Genomic DNA. Translation: EAX11558.1 .
    BC014847 mRNA. Translation: AAH14847.1 .
    CCDSi CCDS2187.1. [O43929-1 ]
    CCDS54404.1. [O43929-2 ]
    CCDS54405.1. [O43929-3 ]
    RefSeqi NP_001177808.1. NM_001190879.2. [O43929-1 ]
    NP_001177810.1. NM_001190881.2. [O43929-2 ]
    NP_001177811.1. NM_001190882.2. [O43929-3 ]
    NP_002543.2. NM_002552.4. [O43929-1 ]
    NP_859525.1. NM_181741.3. [O43929-1 ]
    NP_859526.1. NM_181742.3. [O43929-1 ]
    XP_006712619.1. XM_006712556.1. [O43929-2 ]
    UniGenei Hs.558364.

    3D structure databases

    ProteinModelPortali O43929.
    SMRi O43929. Positions 43-215.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111042. 30 interactions.
    DIPi DIP-29690N.
    IntActi O43929. 20 interactions.
    MINTi MINT-1201591.

    PTM databases

    PhosphoSitei O43929.

    Proteomic databases

    MaxQBi O43929.
    PaxDbi O43929.
    PeptideAtlasi O43929.
    PRIDEi O43929.

    Protocols and materials databases

    DNASUi 5000.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264169 ; ENSP00000264169 ; ENSG00000115947 . [O43929-1 ]
    ENST00000392857 ; ENSP00000376597 ; ENSG00000115947 . [O43929-1 ]
    ENST00000535373 ; ENSP00000441953 ; ENSG00000115947 . [O43929-1 ]
    ENST00000536575 ; ENSP00000441502 ; ENSG00000115947 . [O43929-2 ]
    ENST00000540442 ; ENSP00000438326 ; ENSG00000115947 . [O43929-3 ]
    GeneIDi 5000.
    KEGGi hsa:5000.
    UCSCi uc002twi.3. human. [O43929-1 ]

    Organism-specific databases

    CTDi 5000.
    GeneCardsi GC02M148691.
    HGNCi HGNC:8490. ORC4.
    HPAi CAB015124.
    MIMi 603056. gene.
    613800. phenotype.
    neXtProti NX_O43929.
    Orphaneti 2554. Ear-patella-short stature syndrome.
    PharmGKBi PA32811.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG289784.
    HOGENOMi HOG000007226.
    HOVERGENi HBG000253.
    InParanoidi O43929.
    KOi K02606.
    OMAi FQKFIQR.
    OrthoDBi EOG72NRPZ.
    PhylomeDBi O43929.
    TreeFami TF101094.

    Enzyme and pathway databases

    Reactomei REACT_1095. Activation of the pre-replicative complex.
    REACT_1156. Orc1 removal from chromatin.
    REACT_1181. Association of licensing factors with the pre-replicative complex.
    REACT_1321. E2F-enabled inhibition of pre-replication complex formation.
    REACT_1707. CDC6 association with the ORC:origin complex.
    REACT_1949. CDT1 association with the CDC6:ORC:origin complex.
    REACT_207. Removal of licensing factors from origins.
    REACT_2243. Assembly of the pre-replicative complex.
    REACT_567. Assembly of the ORC complex at the origin of replication.
    REACT_6769. Activation of ATR in response to replication stress.

    Miscellaneous databases

    ChiTaRSi ORC4. human.
    GeneWikii ORC4.
    ORC4L.
    GenomeRNAii 5000.
    NextBioi 19248.
    PROi O43929.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43929.
    Bgeei O43929.
    CleanExi HS_ORC4L.
    Genevestigatori O43929.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR016527. ORC4.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PIRSFi PIRSF007858. ORC4. 1 hit.
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of HsORC4, a member of the human origin of replication recognition complex."
      Quintana D.G., Hou Z.H., Thome K.C., Hendricks M., Saha P., Dutta A.
      J. Biol. Chem. 272:28247-28251(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-78.
    2. "The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p."
      Komrskova T., Yang H., Gavin K., Pappin D., Canas B., Kobayashi R., Hunt T., Stillman B.
      Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-78.
    3. "cDNA cloning of a homolog for S. cerevisiae ORC4 from H. sapiens."
      Dean F.B., O'Donnell M.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-78.
    4. NIEHS SNPs program
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-56.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Hippocampus.
    6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-78.
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    9. "The ORC1 cycle in human cells: II. Dynamic changes in the human ORC complex during the cell cycle."
      Ohta S., Tatsumi Y., Fujita M., Tsurimoto T., Obuse C.
      J. Biol. Chem. 278:41535-41540(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE ORC COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY, ASSEMBLY OF THE ORC COMPLEX.
    10. "ATP-dependent assembly of the human origin recognition complex."
      Siddiqui K., Stillman B.
      J. Biol. Chem. 282:32370-32383(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: RECONSTITUTION OF THE ORC COMPLEX, DISASSEMBLY OF THE ORC COMPLEX, MUTAGENESIS OF LYS-73 AND 159-ASP-GLU-160.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing."
      Chan K.M., Zhang Z.
      J. Biol. Chem. 287:15024-15033(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, BINDING TO HISTONE H3 AND H4 TRIMETHYLATION MARKS.
    14. Cited for: VARIANT MGORS2 CYS-174.
    15. Cited for: VARIANT MGORS2 CYS-174.

    Entry informationi

    Entry nameiORC4_HUMAN
    AccessioniPrimary (citable) accession number: O43929
    Secondary accession number(s): B7Z3D0
    , B7Z5F1, D3DP86, F5H069, Q96C42
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 133 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3