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Protein

C-X-C motif chemokine 13

Gene

CXCL13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.

GO - Molecular functioni

  1. CCR10 chemokine receptor binding Source: BHF-UCL
  2. chemokine activity Source: BHF-UCL
  3. CXCR3 chemokine receptor binding Source: BHF-UCL
  4. CXCR5 chemokine receptor binding Source: BHF-UCL
  5. fibroblast growth factor binding Source: BHF-UCL
  6. heparin binding Source: BHF-UCL
  7. protein heterodimerization activity Source: BHF-UCL
  8. receptor agonist activity Source: BHF-UCL

GO - Biological processi

  1. activation of Rap GTPase activity Source: BHF-UCL
  2. B cell chemotaxis Source: BHF-UCL
  3. B cell chemotaxis across high endothelial venule Source: Ensembl
  4. cell-cell signaling Source: BHF-UCL
  5. cell surface receptor signaling pathway Source: BHF-UCL
  6. chemokine-mediated signaling pathway Source: GO_Central
  7. chronic inflammatory response Source: BHF-UCL
  8. defense response to bacterium Source: BHF-UCL
  9. endothelial cell chemotaxis to fibroblast growth factor Source: BHF-UCL
  10. germinal center formation Source: BHF-UCL
  11. G-protein coupled receptor signaling pathway Source: GO_Central
  12. immune response Source: BHF-UCL
  13. inflammatory response Source: GO_Central
  14. lymph node development Source: Ensembl
  15. lymphocyte chemotaxis across high endothelial venule Source: BHF-UCL
  16. negative regulation of endothelial cell chemotaxis to fibroblast growth factor Source: BHF-UCL
  17. positive regulation of cell-cell adhesion mediated by integrin Source: BHF-UCL
  18. positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
  19. positive regulation of integrin activation Source: BHF-UCL
  20. positive regulation of T cell chemotaxis Source: BHF-UCL
  21. regulation of angiogenesis Source: BHF-UCL
  22. regulation of cell proliferation Source: GO_Central
  23. regulation of humoral immune response Source: BHF-UCL
  24. response to lipopolysaccharide Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 13
Alternative name(s):
Angie
B cell-attracting chemokine 1
Short name:
BCA-1
B lymphocyte chemoattractant
CXC chemokine BLC
Small-inducible cytokine B13
Gene namesi
Name:CXCL13
Synonyms:BCA1, BLC, SCYB13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:10639. CXCL13.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: BHF-UCL
  2. extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35570.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 10987C-X-C motif chemokine 13PRO_0000005113Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 60By similarity
Disulfide bondi35 ↔ 76By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiO43927.
PaxDbiO43927.
PRIDEiO43927.

PTM databases

PhosphoSiteiO43927.

Expressioni

Tissue specificityi

Highest levels in liver, followed by spleen, lymph node, appendix and stomach. Low levels in salivary gland, mammary gland and fetal spleen.

Gene expression databases

BgeeiO43927.
CleanExiHS_CXCL13.
ExpressionAtlasiO43927. baseline and differential.
GenevestigatoriO43927.

Organism-specific databases

HPAiHPA052613.

Interactioni

Protein-protein interaction databases

BioGridi115814. 4 interactions.
DIPiDIP-5914N.
IntActiO43927. 2 interactions.
MINTiMINT-123997.
STRINGi9606.ENSP00000286758.

Structurei

3D structure databases

ProteinModelPortaliO43927.
SMRiO43927. Positions 31-98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41531.
HOGENOMiHOG000220915.
HOVERGENiHBG098474.
InParanoidiO43927.
KOiK10032.
OMAiNGCPRKE.
OrthoDBiEOG7P8PBQ.
PhylomeDBiO43927.
TreeFamiTF335204.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43927-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFISTSLLL MLLVSSLSPV QGVLEVYYTS LRCRCVQESS VFIPRRFIDR
60 70 80 90 100
IQILPRGNGC PRKEIIVWKK NKSIVCVDPQ AEWIQRMMEV LRKRSSSTLP

VPVFKRKIP
Length:109
Mass (Da):12,664
Last modified:June 1, 1998 - v1
Checksum:i4057FCA8EFF658A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044197 mRNA. Translation: AAC14402.1.
AJ002211 mRNA. Translation: CAA05250.1.
AF029894 mRNA. Translation: AAC17980.1.
BC012589 mRNA. Translation: AAH12589.1.
CCDSiCCDS3582.1.
RefSeqiNP_006410.1. NM_006419.2.
XP_006714126.1. XM_006714063.1.
UniGeneiHs.100431.

Genome annotation databases

EnsembliENST00000286758; ENSP00000286758; ENSG00000156234.
GeneIDi10563.
KEGGihsa:10563.
UCSCiuc003hkr.3. human.

Cross-referencesi

Web resourcesi

Wikipedia

CXCL13 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044197 mRNA. Translation: AAC14402.1.
AJ002211 mRNA. Translation: CAA05250.1.
AF029894 mRNA. Translation: AAC17980.1.
BC012589 mRNA. Translation: AAH12589.1.
CCDSiCCDS3582.1.
RefSeqiNP_006410.1. NM_006419.2.
XP_006714126.1. XM_006714063.1.
UniGeneiHs.100431.

3D structure databases

ProteinModelPortaliO43927.
SMRiO43927. Positions 31-98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115814. 4 interactions.
DIPiDIP-5914N.
IntActiO43927. 2 interactions.
MINTiMINT-123997.
STRINGi9606.ENSP00000286758.

PTM databases

PhosphoSiteiO43927.

Proteomic databases

MaxQBiO43927.
PaxDbiO43927.
PRIDEiO43927.

Protocols and materials databases

DNASUi10563.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286758; ENSP00000286758; ENSG00000156234.
GeneIDi10563.
KEGGihsa:10563.
UCSCiuc003hkr.3. human.

Organism-specific databases

CTDi10563.
GeneCardsiGC04P078343.
HGNCiHGNC:10639. CXCL13.
HPAiHPA052613.
MIMi605149. gene.
neXtProtiNX_O43927.
PharmGKBiPA35570.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG41531.
HOGENOMiHOG000220915.
HOVERGENiHBG098474.
InParanoidiO43927.
KOiK10032.
OMAiNGCPRKE.
OrthoDBiEOG7P8PBQ.
PhylomeDBiO43927.
TreeFamiTF335204.

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiCXCL13.
GenomeRNAii10563.
NextBioi40089.
PROiO43927.
SOURCEiSearch...

Gene expression databases

BgeeiO43927.
CleanExiHS_CXCL13.
ExpressionAtlasiO43927. baseline and differential.
GenevestigatoriO43927.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1."
    Gunn M.D., Ngo V.N., Ansel K.M., Ekland E.H., Cyster J.G., Williams L.T.
    Nature 391:799-803(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5."
    Legler D.F., Loetscher M., Stuber Roos R., Clark-Lewis I., Baggiolini M., Moser B.
    J. Exp. Med. 187:655-660(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Peripheral blood leukocyte.
  3. Napolitano M., Spinetti G., Gaetano C., Capogrossi C.M.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Peripheral blood.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle.

Entry informationi

Entry nameiCXL13_HUMAN
AccessioniPrimary (citable) accession number: O43927
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: February 4, 2015
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.