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Protein

C-X-C motif chemokine 13

Gene

CXCL13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.

GO - Molecular functioni

  • CCR10 chemokine receptor binding Source: BHF-UCL
  • chemokine activity Source: BHF-UCL
  • CXCR3 chemokine receptor binding Source: BHF-UCL
  • CXCR5 chemokine receptor binding Source: BHF-UCL
  • fibroblast growth factor binding Source: BHF-UCL
  • heparin binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL
  • receptor agonist activity Source: BHF-UCL

GO - Biological processi

  • activation of GTPase activity Source: BHF-UCL
  • B cell chemotaxis Source: BHF-UCL
  • B cell chemotaxis across high endothelial venule Source: Ensembl
  • cell-cell signaling Source: BHF-UCL
  • cell surface receptor signaling pathway Source: BHF-UCL
  • chemokine-mediated signaling pathway Source: GO_Central
  • chronic inflammatory response Source: BHF-UCL
  • defense response to bacterium Source: BHF-UCL
  • endothelial cell chemotaxis to fibroblast growth factor Source: BHF-UCL
  • germinal center formation Source: BHF-UCL
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • immune response Source: BHF-UCL
  • inflammatory response Source: GO_Central
  • lymph node development Source: Ensembl
  • lymphocyte chemotaxis across high endothelial venule Source: BHF-UCL
  • negative regulation of endothelial cell chemotaxis to fibroblast growth factor Source: BHF-UCL
  • positive regulation of cell-cell adhesion mediated by integrin Source: BHF-UCL
  • positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
  • positive regulation of integrin activation Source: BHF-UCL
  • positive regulation of T cell chemotaxis Source: BHF-UCL
  • regulation of angiogenesis Source: BHF-UCL
  • regulation of cell proliferation Source: GO_Central
  • regulation of humoral immune response Source: BHF-UCL
  • response to lipopolysaccharide Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

BioCyciZFISH:ENSG00000156234-MONOMER.
ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 13
Alternative name(s):
Angie
B cell-attracting chemokine 1
Short name:
BCA-1
B lymphocyte chemoattractant
CXC chemokine BLC
Small-inducible cytokine B13
Gene namesi
Name:CXCL13
Synonyms:BCA1, BLC, SCYB13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:10639. CXCL13.

Subcellular locationi

GO - Cellular componenti

  • cell Source: GOC
  • extracellular region Source: BHF-UCL
  • extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi10563.
OpenTargetsiENSG00000156234.
PharmGKBiPA35570.

Polymorphism and mutation databases

BioMutaiCXCL13.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000511323 – 109C-X-C motif chemokine 13Add BLAST87

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 60By similarity
Disulfide bondi35 ↔ 76By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO43927.
PeptideAtlasiO43927.
PRIDEiO43927.

PTM databases

iPTMnetiO43927.
PhosphoSitePlusiO43927.

Expressioni

Tissue specificityi

Highest levels in liver, followed by spleen, lymph node, appendix and stomach. Low levels in salivary gland, mammary gland and fetal spleen.

Gene expression databases

BgeeiENSG00000156234.
CleanExiHS_CXCL13.
ExpressionAtlasiO43927. baseline and differential.
GenevisibleiO43927. HS.

Organism-specific databases

HPAiHPA052613.

Interactioni

GO - Molecular functioni

  • CCR10 chemokine receptor binding Source: BHF-UCL
  • chemokine activity Source: BHF-UCL
  • CXCR3 chemokine receptor binding Source: BHF-UCL
  • CXCR5 chemokine receptor binding Source: BHF-UCL
  • fibroblast growth factor binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL
  • receptor agonist activity Source: BHF-UCL

Protein-protein interaction databases

BioGridi115814. 4 interactors.
DIPiDIP-5914N.
IntActiO43927. 3 interactors.
MINTiMINT-123997.
STRINGi9606.ENSP00000286758.

Structurei

Secondary structure

1109
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 26Combined sources4
Beta strandi35 – 37Combined sources3
Helixi45 – 47Combined sources3
Beta strandi48 – 54Combined sources7
Beta strandi60 – 62Combined sources3
Beta strandi64 – 69Combined sources6
Beta strandi74 – 77Combined sources4
Helixi82 – 93Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZAIX-ray1.95A23-109[»]
5CBAX-ray2.50E/F23-109[»]
5CBEX-ray2.40E/F23-109[»]
ProteinModelPortaliO43927.
SMRiO43927.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JEN1. Eukaryota.
ENOG4111E5H. LUCA.
GeneTreeiENSGT00530000064292.
HOGENOMiHOG000220915.
HOVERGENiHBG098474.
InParanoidiO43927.
KOiK10032.
OMAiNGCPRKE.
OrthoDBiEOG091G0XS0.
PhylomeDBiO43927.
TreeFamiTF335204.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43927-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFISTSLLL MLLVSSLSPV QGVLEVYYTS LRCRCVQESS VFIPRRFIDR
60 70 80 90 100
IQILPRGNGC PRKEIIVWKK NKSIVCVDPQ AEWIQRMMEV LRKRSSSTLP

VPVFKRKIP
Length:109
Mass (Da):12,664
Last modified:June 1, 1998 - v1
Checksum:i4057FCA8EFF658A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044197 mRNA. Translation: AAC14402.1.
AJ002211 mRNA. Translation: CAA05250.1.
AF029894 mRNA. Translation: AAC17980.1.
BC012589 mRNA. Translation: AAH12589.1.
CCDSiCCDS3582.1.
RefSeqiNP_006410.1. NM_006419.2.
XP_006714126.1. XM_006714063.3.
UniGeneiHs.100431.

Genome annotation databases

EnsembliENST00000286758; ENSP00000286758; ENSG00000156234.
GeneIDi10563.
KEGGihsa:10563.

Cross-referencesi

Web resourcesi

Wikipedia

CXCL13 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044197 mRNA. Translation: AAC14402.1.
AJ002211 mRNA. Translation: CAA05250.1.
AF029894 mRNA. Translation: AAC17980.1.
BC012589 mRNA. Translation: AAH12589.1.
CCDSiCCDS3582.1.
RefSeqiNP_006410.1. NM_006419.2.
XP_006714126.1. XM_006714063.3.
UniGeneiHs.100431.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZAIX-ray1.95A23-109[»]
5CBAX-ray2.50E/F23-109[»]
5CBEX-ray2.40E/F23-109[»]
ProteinModelPortaliO43927.
SMRiO43927.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115814. 4 interactors.
DIPiDIP-5914N.
IntActiO43927. 3 interactors.
MINTiMINT-123997.
STRINGi9606.ENSP00000286758.

PTM databases

iPTMnetiO43927.
PhosphoSitePlusiO43927.

Polymorphism and mutation databases

BioMutaiCXCL13.

Proteomic databases

PaxDbiO43927.
PeptideAtlasiO43927.
PRIDEiO43927.

Protocols and materials databases

DNASUi10563.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286758; ENSP00000286758; ENSG00000156234.
GeneIDi10563.
KEGGihsa:10563.

Organism-specific databases

CTDi10563.
DisGeNETi10563.
GeneCardsiCXCL13.
HGNCiHGNC:10639. CXCL13.
HPAiHPA052613.
MIMi605149. gene.
neXtProtiNX_O43927.
OpenTargetsiENSG00000156234.
PharmGKBiPA35570.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JEN1. Eukaryota.
ENOG4111E5H. LUCA.
GeneTreeiENSGT00530000064292.
HOGENOMiHOG000220915.
HOVERGENiHBG098474.
InParanoidiO43927.
KOiK10032.
OMAiNGCPRKE.
OrthoDBiEOG091G0XS0.
PhylomeDBiO43927.
TreeFamiTF335204.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000156234-MONOMER.
ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiCXCL13.
GenomeRNAii10563.
PROiO43927.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156234.
CleanExiHS_CXCL13.
ExpressionAtlasiO43927. baseline and differential.
GenevisibleiO43927. HS.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXL13_HUMAN
AccessioniPrimary (citable) accession number: O43927
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.