O43927 (CXL13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-X-C motif chemokine 13

Alternative name(s):
Angie
B cell-attracting chemokine 1
Short name=BCA-1
B lymphocyte chemoattractant
CXC chemokine BLC
Small-inducible cytokine B13

Gene names

Name:	CXCL13
Synonyms:	BCA1, BLC, SCYB13

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	109 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.
Subcellular location	Secreted.
Tissue specificity	Highest levels in liver, followed by spleen, lymph node, appendix and stomach. Low levels in salivary gland, mammary gland and fetal spleen.
Sequence similarities	Belongs to the intercrine alpha (chemokine CxC) family.

Ontologies

Keywords
Biological process	Chemotaxis Inflammatory response
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	B cell chemotaxis Inferred from direct assay Ref.2. Source: BHF-UCL B cell chemotaxis across high endothelial venule Inferred from electronic annotation. Source: Compara activation of Rap GTPase activity Inferred from sequence or structural similarity. Source: BHF-UCL cell-cell signaling Inferred from direct assay PubMed 11554781. Source: BHF-UCL chronic inflammatory response Non-traceable author statement PubMed 15284119. Source: BHF-UCL defense response to bacterium Inferred from direct assay PubMed 17562761. Source: BHF-UCL elevation of cytosolic calcium ion concentration Inferred from direct assay PubMed 11554781. Source: BHF-UCL endothelial cell chemotaxis to fibroblast growth factor Inferred from direct assay PubMed 11708770. Source: BHF-UCL germinal center formation Non-traceable author statement PubMed 16543475. Source: BHF-UCL lymph node development Inferred from electronic annotation. Source: Compara lymphocyte chemotaxis across high endothelial venule Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of apoptotic process Non-traceable author statement PubMed 15580304. Source: BHF-UCL negative regulation of endothelial cell chemotaxis to fibroblast growth factor Inferred from direct assay PubMed 11708770. Source: BHF-UCL positive regulation of T cell chemotaxis Inferred from direct assay PubMed 11554781. Source: BHF-UCL positive regulation of cell-cell adhesion mediated by integrin Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of integrin activation Inferred from sequence or structural similarity. Source: BHF-UCL regulation of angiogenesis Non-traceable author statement PubMed 11708770. Source: BHF-UCL regulation of humoral immune response Non-traceable author statement PubMed 16531331. Source: BHF-UCL
Cellular_component	extracellular region Inferred from direct assay PubMed 17562761PubMed 17652619. Source: BHF-UCL extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	CCR10 chemokine receptor binding Inferred from direct assay PubMed 10706668. Source: BHF-UCL CXCR5 chemokine receptor binding Inferred from direct assay Ref.2. Source: BHF-UCL chemokine activity Inferred from direct assay PubMed 11554781. Source: BHF-UCL fibroblast growth factor binding Inferred from direct assay PubMed 11708770. Source: BHF-UCL heparin binding Inferred from direct assay PubMed 11708770. Source: BHF-UCL protein heterodimerization activity Inferred from direct assay PubMed 11708770. Source: BHF-UCL receptor agonist activity Inferred from direct assay PubMed 11554781. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 109	87	C-X-C motif chemokine 13		PRO_0000005113
Amino acid modifications
	Disulfide bond	33 ↔ 60		By similarity
	Disulfide bond	35 ↔ 76		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O43927 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 4057FCA8EFF658A8	FASTA	109	12,664
	10 20 30 40 50 60 MKFISTSLLL MLLVSSLSPV QGVLEVYYTS LRCRCVQESS VFIPRRFIDR IQILPRGNGC 70 80 90 100 PRKEIIVWKK NKSIVCVDPQ AEWIQRMMEV LRKRSSSTLP VPVFKRKIP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1." Gunn M.D., Ngo V.N., Ansel K.M., Ekland E.H., Cyster J.G., Williams L.T. Nature 391:799-803(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5." Legler D.F., Loetscher M., Stuber Roos R., Clark-Lewis I., Baggiolini M., Moser B. J. Exp. Med. 187:655-660(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Peripheral blood leukocyte.
[3]	Napolitano M., Spinetti G., Gaetano C., Capogrossi C.M. Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Peripheral blood.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skeletal muscle.
+	Additional computationally mapped references.

Web resources

Wikipedia

CXCL13 entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF044197 mRNA. Translation: AAC14402.1. AJ002211 mRNA. Translation: CAA05250.1. AF029894 mRNA. Translation: AAC17980.1. BC012589 mRNA. Translation: AAH12589.1.
IPI	IPI00015163.
RefSeq	NP_006410.1. NM_006419.2.
UniGene	Hs.100431.
3D structure databases
ProteinModelPortal	O43927.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5914N.
IntAct	O43927. 2 interactions.
MINT	MINT-123997.
STRING	9606.ENSP00000286758.
PTM databases
PhosphoSite	O43927.
Proteomic databases
PaxDb	O43927.
PRIDE	O43927.
Protocols and materials databases
DNASU	10563.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000286758; ENSP00000286758; ENSG00000156234.
GeneID	10563.
KEGG	hsa:10563.
UCSC	uc003hkr.3. human.
Organism-specific databases
CTD	10563.
GeneCards	GC04P078343.
HGNC	HGNC:10639. CXCL13.
HPA	HPA052613.
MIM	605149. gene.
neXtProt	NX_O43927.
PharmGKB	PA35570.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG41531.
HOGENOM	HOG000220915.
HOVERGEN	HBG098474.
InParanoid	O43927.
KO	K10032.
OMA	EIIVWKK.
OrthoDB	EOG4G1MJ2.
PhylomeDB	O43927.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	O43927.
Bgee	O43927.
CleanEx	HS_CXCL13.
Genevestigator	O43927.
GermOnline	ENSG00000156234. Homo sapiens.
Family and domain databases
InterPro	IPR001089. Chemokine_CXC. IPR018048. Chemokine_CXC_CS. IPR001811. Chemokine_IL8-like_dom. [Graphical view]
PANTHER	PTHR10179. PTHR10179. 1 hit.
Pfam	PF00048. IL8. 1 hit. [Graphical view]
PRINTS	PR00437. SMALLCYTKCXC.
SMART	SM00199. SCY. 1 hit. [Graphical view]
SUPFAM	SSF54117. Chemokine_IL8. 1 hit.
PROSITE	PS00471. SMALL_CYTOKINES_CXC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	10563.
NextBio	40089.
SOURCE	Search...

Entry information

Entry name

CXL13_HUMAN

Accession

Primary (citable) accession number: O43927

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	June 1, 1998
Last modified:	May 1, 2013
This is version 116 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.