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O43927 (CXL13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-X-C motif chemokine 13
Alternative name(s):
Angie
B cell-attracting chemokine 1
Short name=BCA-1
B lymphocyte chemoattractant
CXC chemokine BLC
Small-inducible cytokine B13
Gene names
Name:CXCL13
Synonyms:BCA1, BLC, SCYB13
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length109 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.

Subcellular location

Secreted.

Tissue specificity

Highest levels in liver, followed by spleen, lymph node, appendix and stomach. Low levels in salivary gland, mammary gland and fetal spleen.

Sequence similarities

Belongs to the intercrine alpha (chemokine CxC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processB cell chemotaxis

Inferred from direct assay Ref.2. Source: BHF-UCL

B cell chemotaxis across high endothelial venule

Inferred from electronic annotation. Source: Ensembl

activation of Rap GTPase activity

Inferred from sequence or structural similarity. Source: BHF-UCL

cell surface receptor signaling pathway

Inferred from direct assay PubMed 11554781. Source: BHF-UCL

cell-cell signaling

Inferred from direct assay PubMed 11554781. Source: BHF-UCL

chronic inflammatory response

Non-traceable author statement PubMed 15284119. Source: BHF-UCL

defense response to bacterium

Inferred from direct assay PubMed 17562761. Source: BHF-UCL

endothelial cell chemotaxis to fibroblast growth factor

Inferred from direct assay PubMed 11708770. Source: BHF-UCL

germinal center formation

Non-traceable author statement PubMed 16543475. Source: BHF-UCL

immune response

Inferred by curator PubMed 11554781. Source: BHF-UCL

lymph node development

Inferred from electronic annotation. Source: Ensembl

lymphocyte chemotaxis across high endothelial venule

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of endothelial cell chemotaxis to fibroblast growth factor

Inferred from direct assay PubMed 11708770. Source: BHF-UCL

positive regulation of T cell chemotaxis

Inferred from direct assay PubMed 11554781. Source: BHF-UCL

positive regulation of cell-cell adhesion mediated by integrin

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of cytosolic calcium ion concentration

Inferred from direct assay PubMed 11554781. Source: BHF-UCL

positive regulation of integrin activation

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of angiogenesis

Non-traceable author statement PubMed 11708770. Source: BHF-UCL

regulation of humoral immune response

Non-traceable author statement PubMed 16531331. Source: BHF-UCL

   Cellular_componentextracellular region

Inferred from direct assay PubMed 17562761PubMed 17652619. Source: BHF-UCL

extracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionCCR10 chemokine receptor binding

Inferred from direct assay PubMed 10706668. Source: BHF-UCL

CXCR3 chemokine receptor binding

Inferred from physical interaction PubMed 11554781. Source: BHF-UCL

CXCR5 chemokine receptor binding

Inferred from direct assay Ref.2. Source: BHF-UCL

chemokine activity

Inferred from direct assay PubMed 11554781. Source: BHF-UCL

fibroblast growth factor binding

Inferred from direct assay PubMed 11708770. Source: BHF-UCL

heparin binding

Inferred from direct assay PubMed 11708770. Source: BHF-UCL

protein heterodimerization activity

Inferred from direct assay PubMed 11708770. Source: BHF-UCL

receptor agonist activity

Inferred from direct assay PubMed 11554781. Source: BHF-UCL

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 10987C-X-C motif chemokine 13
PRO_0000005113

Amino acid modifications

Disulfide bond33 ↔ 60 By similarity
Disulfide bond35 ↔ 76 By similarity

Sequences

Sequence LengthMass (Da)Tools
O43927 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 4057FCA8EFF658A8

FASTA10912,664
        10         20         30         40         50         60 
MKFISTSLLL MLLVSSLSPV QGVLEVYYTS LRCRCVQESS VFIPRRFIDR IQILPRGNGC 

        70         80         90        100 
PRKEIIVWKK NKSIVCVDPQ AEWIQRMMEV LRKRSSSTLP VPVFKRKIP 

« Hide

References

« Hide 'large scale' references
[1]"A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1."
Gunn M.D., Ngo V.N., Ansel K.M., Ekland E.H., Cyster J.G., Williams L.T.
Nature 391:799-803(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5."
Legler D.F., Loetscher M., Stuber Roos R., Clark-Lewis I., Baggiolini M., Moser B.
J. Exp. Med. 187:655-660(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Peripheral blood leukocyte.
[3]Napolitano M., Spinetti G., Gaetano C., Capogrossi C.M.
Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Peripheral blood.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skeletal muscle.
+Additional computationally mapped references.

Web resources

Wikipedia

CXCL13 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF044197 mRNA. Translation: AAC14402.1.
AJ002211 mRNA. Translation: CAA05250.1.
AF029894 mRNA. Translation: AAC17980.1.
BC012589 mRNA. Translation: AAH12589.1.
CCDSCCDS3582.1.
RefSeqNP_006410.1. NM_006419.2.
XP_006714126.1. XM_006714063.1.
UniGeneHs.100431.

3D structure databases

ProteinModelPortalO43927.
SMRO43927. Positions 31-98.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115814. 4 interactions.
DIPDIP-5914N.
IntActO43927. 2 interactions.
MINTMINT-123997.
STRING9606.ENSP00000286758.

PTM databases

PhosphoSiteO43927.

Proteomic databases

MaxQBO43927.
PaxDbO43927.
PRIDEO43927.

Protocols and materials databases

DNASU10563.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000286758; ENSP00000286758; ENSG00000156234.
GeneID10563.
KEGGhsa:10563.
UCSCuc003hkr.3. human.

Organism-specific databases

CTD10563.
GeneCardsGC04P078343.
HGNCHGNC:10639. CXCL13.
HPAHPA052613.
MIM605149. gene.
neXtProtNX_O43927.
PharmGKBPA35570.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41531.
HOGENOMHOG000220915.
HOVERGENHBG098474.
InParanoidO43927.
KOK10032.
OrthoDBEOG7P8PBQ.
PhylomeDBO43927.
TreeFamTF335204.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressO43927.
BgeeO43927.
CleanExHS_CXCL13.
GenevestigatorO43927.

Family and domain databases

InterProIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERPTHR10179. PTHR10179. 1 hit.
PfamPF00048. IL8. 1 hit.
[Graphical view]
PRINTSPR00437. SMALLCYTKCXC.
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCXCL13.
GenomeRNAi10563.
NextBio40089.
PROO43927.
SOURCESearch...

Entry information

Entry nameCXL13_HUMAN
AccessionPrimary (citable) accession number: O43927
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM