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O43927

- CXL13_HUMAN

UniProt

O43927 - CXL13_HUMAN

Protein

C-X-C motif chemokine 13

Gene

CXCL13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.

    GO - Molecular functioni

    1. CCR10 chemokine receptor binding Source: BHF-UCL
    2. chemokine activity Source: BHF-UCL
    3. CXCR3 chemokine receptor binding Source: BHF-UCL
    4. CXCR5 chemokine receptor binding Source: BHF-UCL
    5. fibroblast growth factor binding Source: BHF-UCL
    6. heparin binding Source: BHF-UCL
    7. protein heterodimerization activity Source: BHF-UCL
    8. receptor agonist activity Source: BHF-UCL

    GO - Biological processi

    1. activation of Rap GTPase activity Source: BHF-UCL
    2. B cell chemotaxis Source: BHF-UCL
    3. B cell chemotaxis across high endothelial venule Source: Ensembl
    4. cell-cell signaling Source: BHF-UCL
    5. cell surface receptor signaling pathway Source: BHF-UCL
    6. chronic inflammatory response Source: BHF-UCL
    7. defense response to bacterium Source: BHF-UCL
    8. endothelial cell chemotaxis to fibroblast growth factor Source: BHF-UCL
    9. germinal center formation Source: BHF-UCL
    10. immune response Source: BHF-UCL
    11. lymph node development Source: Ensembl
    12. lymphocyte chemotaxis across high endothelial venule Source: BHF-UCL
    13. negative regulation of endothelial cell chemotaxis to fibroblast growth factor Source: BHF-UCL
    14. positive regulation of cell-cell adhesion mediated by integrin Source: BHF-UCL
    15. positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
    16. positive regulation of integrin activation Source: BHF-UCL
    17. positive regulation of T cell chemotaxis Source: BHF-UCL
    18. regulation of angiogenesis Source: BHF-UCL
    19. regulation of humoral immune response Source: BHF-UCL

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C motif chemokine 13
    Alternative name(s):
    Angie
    B cell-attracting chemokine 1
    Short name:
    BCA-1
    B lymphocyte chemoattractant
    CXC chemokine BLC
    Small-inducible cytokine B13
    Gene namesi
    Name:CXCL13
    Synonyms:BCA1, BLC, SCYB13
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:10639. CXCL13.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: BHF-UCL
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35570.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 10987C-X-C motif chemokine 13PRO_0000005113Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 60By similarity
    Disulfide bondi35 ↔ 76By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiO43927.
    PaxDbiO43927.
    PRIDEiO43927.

    PTM databases

    PhosphoSiteiO43927.

    Expressioni

    Tissue specificityi

    Highest levels in liver, followed by spleen, lymph node, appendix and stomach. Low levels in salivary gland, mammary gland and fetal spleen.

    Gene expression databases

    ArrayExpressiO43927.
    BgeeiO43927.
    CleanExiHS_CXCL13.
    GenevestigatoriO43927.

    Organism-specific databases

    HPAiHPA052613.

    Interactioni

    Protein-protein interaction databases

    BioGridi115814. 4 interactions.
    DIPiDIP-5914N.
    IntActiO43927. 2 interactions.
    MINTiMINT-123997.
    STRINGi9606.ENSP00000286758.

    Structurei

    3D structure databases

    ProteinModelPortaliO43927.
    SMRiO43927. Positions 31-98.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG41531.
    HOGENOMiHOG000220915.
    HOVERGENiHBG098474.
    InParanoidiO43927.
    KOiK10032.
    OrthoDBiEOG7P8PBQ.
    PhylomeDBiO43927.
    TreeFamiTF335204.

    Family and domain databases

    InterProiIPR001089. Chemokine_CXC.
    IPR018048. Chemokine_CXC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PANTHERiPTHR10179. PTHR10179. 1 hit.
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    PRINTSiPR00437. SMALLCYTKCXC.
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O43927-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFISTSLLL MLLVSSLSPV QGVLEVYYTS LRCRCVQESS VFIPRRFIDR    50
    IQILPRGNGC PRKEIIVWKK NKSIVCVDPQ AEWIQRMMEV LRKRSSSTLP 100
    VPVFKRKIP 109
    Length:109
    Mass (Da):12,664
    Last modified:June 1, 1998 - v1
    Checksum:i4057FCA8EFF658A8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF044197 mRNA. Translation: AAC14402.1.
    AJ002211 mRNA. Translation: CAA05250.1.
    AF029894 mRNA. Translation: AAC17980.1.
    BC012589 mRNA. Translation: AAH12589.1.
    CCDSiCCDS3582.1.
    RefSeqiNP_006410.1. NM_006419.2.
    XP_006714126.1. XM_006714063.1.
    UniGeneiHs.100431.

    Genome annotation databases

    EnsembliENST00000286758; ENSP00000286758; ENSG00000156234.
    GeneIDi10563.
    KEGGihsa:10563.
    UCSCiuc003hkr.3. human.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CXCL13 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF044197 mRNA. Translation: AAC14402.1 .
    AJ002211 mRNA. Translation: CAA05250.1 .
    AF029894 mRNA. Translation: AAC17980.1 .
    BC012589 mRNA. Translation: AAH12589.1 .
    CCDSi CCDS3582.1.
    RefSeqi NP_006410.1. NM_006419.2.
    XP_006714126.1. XM_006714063.1.
    UniGenei Hs.100431.

    3D structure databases

    ProteinModelPortali O43927.
    SMRi O43927. Positions 31-98.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115814. 4 interactions.
    DIPi DIP-5914N.
    IntActi O43927. 2 interactions.
    MINTi MINT-123997.
    STRINGi 9606.ENSP00000286758.

    PTM databases

    PhosphoSitei O43927.

    Proteomic databases

    MaxQBi O43927.
    PaxDbi O43927.
    PRIDEi O43927.

    Protocols and materials databases

    DNASUi 10563.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000286758 ; ENSP00000286758 ; ENSG00000156234 .
    GeneIDi 10563.
    KEGGi hsa:10563.
    UCSCi uc003hkr.3. human.

    Organism-specific databases

    CTDi 10563.
    GeneCardsi GC04P078343.
    HGNCi HGNC:10639. CXCL13.
    HPAi HPA052613.
    MIMi 605149. gene.
    neXtProti NX_O43927.
    PharmGKBi PA35570.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41531.
    HOGENOMi HOG000220915.
    HOVERGENi HBG098474.
    InParanoidi O43927.
    KOi K10032.
    OrthoDBi EOG7P8PBQ.
    PhylomeDBi O43927.
    TreeFami TF335204.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii CXCL13.
    GenomeRNAii 10563.
    NextBioi 40089.
    PROi O43927.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43927.
    Bgeei O43927.
    CleanExi HS_CXCL13.
    Genevestigatori O43927.

    Family and domain databases

    InterProi IPR001089. Chemokine_CXC.
    IPR018048. Chemokine_CXC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    PANTHERi PTHR10179. PTHR10179. 1 hit.
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    PRINTSi PR00437. SMALLCYTKCXC.
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00471. SMALL_CYTOKINES_CXC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1."
      Gunn M.D., Ngo V.N., Ansel K.M., Ekland E.H., Cyster J.G., Williams L.T.
      Nature 391:799-803(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5."
      Legler D.F., Loetscher M., Stuber Roos R., Clark-Lewis I., Baggiolini M., Moser B.
      J. Exp. Med. 187:655-660(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Peripheral blood leukocyte.
    3. Napolitano M., Spinetti G., Gaetano C., Capogrossi C.M.
      Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Peripheral blood.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skeletal muscle.

    Entry informationi

    Entry nameiCXL13_HUMAN
    AccessioniPrimary (citable) accession number: O43927
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3