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Protein

Matrix metalloproteinase

Gene

MMP25

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Ca2+UniRule annotation
  • Zn2+UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, MetalloproteaseUniRule annotationSAAS annotation, Protease
LigandCalciumUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Protein family/group databases

MEROPSiM10.973

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix metalloproteinaseUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:MMP25Imported
Synonyms:MMP20Imported, mmp20Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000008516.16
HGNCiHGNC:14246 MMP25

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000008516

Chemistry databases

DrugBankiDB01039 Fenofibrate
DB13873 Fenofibric acid

PTM / Processingi

Keywords - PTMi

ZymogenUniRule annotation

Proteomic databases

PeptideAtlasiO43923
PRIDEiO43923

Expressioni

Gene expression databases

BgeeiENSG00000008516
ExpressionAtlasiO43923 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 177ZnMcInterPro annotationAdd BLAST143

Sequence similaritiesi

Belongs to the peptidase M10A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
GeneTreeiENSGT00760000118870
HOGENOMiHOG000206992
HOVERGENiHBG052975

Family and domain databases

Gene3Di3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR024079 MetalloPept_cat_dom_sf
IPR028733 MMP25
IPR001818 Pept_M10_metallopeptidase
IPR021190 Pept_M10A
IPR006026 Peptidase_Metallo
PANTHERiPTHR10201:SF142 PTHR10201:SF142, 1 hit
PfamiView protein in Pfam
PF00413 Peptidase_M10, 1 hit
PRINTSiPR00138 MATRIXIN
SMARTiView protein in SMART
SM00235 ZnMc, 1 hit

Sequencei

Sequence statusi: Complete.

O43923-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPGTVATMR KPRCSLPDVL GVAGLVRRRR RYALSGSVWK KRTLTWRVRS
60 70 80 90 100
FPQSSQLSQE TVRVLMSYAL MAWGMESGLT FHEVDSPQGQ EPDILIDFAR
110 120 130 140 150
AFHQDSYPFD GLGGTLAHAF FPGEHPISGD THFDDEETWT FGSKASQQLE
160 170 180
QELAGGSPVD EELGFSRGWR VNPLGPGSPE RLS
Length:183
Mass (Da):20,354
Last modified:June 1, 1998 - v1
Checksum:i2F844C2B8338787B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108134 Genomic DNA No translation available.
AJ003144 mRNA Translation: CAA05900.1
AJ003147 Genomic DNA Translation: CAA05902.1
UniGeneiHs.654979

Genome annotation databases

EnsembliENST00000612971; ENSP00000482854; ENSG00000008516
UCSCiuc059ptq.1 human

Similar proteinsi

Entry informationi

Entry nameiO43923_HUMAN
AccessioniPrimary (citable) accession number: O43923
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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