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Protein

Matrix metalloproteinase

Gene

mmp20

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Ca2+UniRule annotation
  • Zn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, MetalloproteaseUniRule annotationSAAS annotation, Protease
LigandCalciumUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Protein family/group databases

MEROPSiM10.973.

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix metalloproteinaseUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:mmp20Imported
Synonyms:MMP20Imported, MMP25Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000008516.16.
HGNCiHGNC:14246. MMP25.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000008516.

Chemistry databases

DrugBankiDB01039. Fenofibrate.

PTM / Processingi

Keywords - PTMi

ZymogenUniRule annotation

Expressioni

Gene expression databases

BgeeiENSG00000008516.
ExpressionAtlasiO43923. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 177ZnMcInterPro annotationAdd BLAST143

Sequence similaritiesi

Belongs to the peptidase M10A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00760000118870.
HOGENOMiHOG000206992.
HOVERGENiHBG052975.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiView protein in InterPro
IPR024079. MetalloPept_cat_dom.
IPR028733. MMP25.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR006026. Peptidase_Metallo.
PANTHERiPTHR10201:SF205. PTHR10201:SF205. 1 hit.
PfamiView protein in Pfam
PF00413. Peptidase_M10. 1 hit.
PRINTSiPR00138. MATRIXIN.
SMARTiView protein in SMART
SM00235. ZnMc. 1 hit.

Sequencei

Sequence statusi: Complete.

O43923-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPGTVATMR KPRCSLPDVL GVAGLVRRRR RYALSGSVWK KRTLTWRVRS
60 70 80 90 100
FPQSSQLSQE TVRVLMSYAL MAWGMESGLT FHEVDSPQGQ EPDILIDFAR
110 120 130 140 150
AFHQDSYPFD GLGGTLAHAF FPGEHPISGD THFDDEETWT FGSKASQQLE
160 170 180
QELAGGSPVD EELGFSRGWR VNPLGPGSPE RLS
Length:183
Mass (Da):20,354
Last modified:June 1, 1998 - v1
Checksum:i2F844C2B8338787B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108134 Genomic DNA. No translation available.
AJ003144 mRNA. Translation: CAA05900.1.
AJ003147 Genomic DNA. Translation: CAA05902.1.
UniGeneiHs.654979.

Genome annotation databases

EnsembliENST00000612971; ENSP00000482854; ENSG00000008516.
UCSCiuc059ptq.1. human.

Similar proteinsi

Entry informationi

Entry nameiO43923_HUMAN
AccessioniPrimary (citable) accession number: O43923
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: September 27, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported